TMEM69

General Information

Gene Name       : TMEM69
Gene ID             : ENSG00000159596.6
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM69)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM69ENSG00000159596.670.3261.9266.12ENCSR000AEF
HepG2TMEM69ENSG00000159596.630.1237.9034.01ENCSR985KAT
K562TMEM69ENSG00000159596.693.39100.2496.81ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM69 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM69 RNA is bound by 8 proteins.  







eCLIP assay for TMEM69 is not avaliable on ENCORE database.





8 proteins are bound to TMEM69 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr14615963846159695+3'-UTR3.081855.09613K562IGF2BP2
chr14615661846156683+3'-UTR,intron-Distal,intron-Proximal3.284595.11990K562AQR
chr14615954146159622+3'-UTR,CDS3.329533.27682HepG2LARP4
chr14615673146156757+3'-UTR,CDS,intron-Distal3.349049.50094K562YBX3
chr14615983546159942+3'-UTR3.355518.80445K562TIA1
chr14615664546156686+3'-UTR,intron-Distal,intron-Proximal3.077987.24994K562YBX3
chr14615671746156731+3'-UTR,intron-Distal3.036296.98725K562YBX3
chr14615393046154016+5'-UTR,intron-Proximal4.784526.35567HepG2PRPF8
chr14615387746153949+5'-UTR,intron-Proximal4.1843212.79836K562DDX3X
chr14615394546153994+5'-UTR,intron-Proximal4.792564.86944K562AQR
chr14615676946156782+CDS,intron-Distal3.569015.37252K562YBX3
chr14615895346159011+CDS3.205825.65018K562IGF2BP2
chr14615904846159115+CDS3.150163.15019HepG2IGF2BP1
chr14615904146159060+CDS3.4509811.79280K562YBX3
chr14615900646159027+CDS3.9948514.89757K562YBX3
chr14615906046159089+CDS3.4672411.02820K562YBX3
chr14615894746159018+CDS3.850439.40356K562IGF2BP1
chr14615912846159178+CDS3.693573.18462K562IGF2BP2
chr14615902746159041+CDS3.3360310.79539K562YBX3
chr14615399446154081+intron-Distal,intron-Proximal3.289924.41130K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM69 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM69 is not available on ENCORE database.

  • 86 RBPs can affect the levels of TMEM69.  








The Knockdown/knockout RNA-Seq assay for TMEM69 is not available on ENCORE database.





86 RBPs can affect the gene expression of TMEM69 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM69ENSG00000159596.6908.158201281.17180-0.496403.466402.87980HepG2AKAP1
TMEM69ENSG00000159596.6783.189101117.12890-0.512407.735206.68010HepG2AUH
TMEM69ENSG00000159596.61140.38370641.161300.8307011.4218010.31740HepG2BOP1
TMEM69ENSG00000159596.6732.182001007.12820-0.460003.449002.59150HepG2CIRBP
TMEM69ENSG00000159596.6418.54710560.86160-0.422304.016203.03450HepG2DDX19B
TMEM69ENSG00000159596.6453.05770601.27660-0.408302.648601.98310HepG2DDX21
TMEM69ENSG00000159596.6625.126901227.25280-0.9732012.6785011.42930HepG2DDX3X
TMEM69ENSG00000159596.6642.625201054.26590-0.714206.252705.35350HepG2DDX6
TMEM69ENSG00000159596.6520.75530689.13450-0.404202.320401.47430HepG2EEF2
TMEM69ENSG00000159596.6638.493501013.46130-0.666506.212405.34240HepG2EIF2S1
TMEM69ENSG00000159596.6524.315001119.97920-1.0950013.7068012.30510HepG2EIF4A3
TMEM69ENSG00000159596.6781.705301090.48480-0.480302.708802.02700HepG2EIF4B
TMEM69ENSG00000159596.61041.276001282.68160-0.300802.875202.26410HepG2ETF1
TMEM69ENSG00000159596.6426.70110592.57600-0.473803.549902.60290HepG2EWSR1
TMEM69ENSG00000159596.6677.416201074.58380-0.665705.272604.23760HepG2FIP1L1
TMEM69ENSG00000159596.6584.40290742.83500-0.346102.288701.56820HepG2FUBP3
TMEM69ENSG00000159596.6839.646001130.05620-0.428503.113802.37930HepG2FXR1
TMEM69ENSG00000159596.6628.460101048.26970-0.738107.182606.13550HepG2G3BP1
TMEM69ENSG00000159596.6839.675701112.90290-0.406402.861601.95250HepG2G3BP2
TMEM69ENSG00000159596.6457.88190632.67130-0.466502.884901.84400HepG2GNB2L1
TMEM69ENSG00000159596.6356.97420709.95430-0.9919012.2300011.02830HepG2HNRNPA1
TMEM69ENSG00000159596.6466.38770789.69330-0.759808.008906.87490HepG2HNRNPC
TMEM69ENSG00000159596.6756.263801061.52220-0.489204.104103.26780HepG2HNRNPK
TMEM69ENSG00000159596.6571.84580784.47230-0.456105.209504.39820HepG2HNRNPU
TMEM69ENSG00000159596.6670.305501065.53490-0.668706.529805.53230HepG2IGF2BP2
TMEM69ENSG00000159596.6557.852701130.45090-1.0189013.3547011.95840HepG2MAGOH
TMEM69ENSG00000159596.6711.709901136.77080-0.675605.926605.02860HepG2MATR3
TMEM69ENSG00000159596.6540.280501163.54230-1.1067015.2052013.80100HepG2NCBP2
TMEM69ENSG00000159596.6463.19600724.64020-0.645603.276602.30620HepG2PABPC1
TMEM69ENSG00000159596.6719.942501036.18350-0.525304.180103.30420HepG2PABPC4
TMEM69ENSG00000159596.6936.226801097.05290-0.228702.109001.56730HepG2PCBP1
TMEM69ENSG00000159596.6403.88810707.21460-0.808205.708504.26310HepG2PCBP2
TMEM69ENSG00000159596.6631.881001116.22810-0.8209014.5805013.51640HepG2PTBP1
TMEM69ENSG00000159596.6585.48990871.31420-0.573505.677604.86380HepG2PUF60
TMEM69ENSG00000159596.6722.479601209.03940-0.7428012.2240011.04860HepG2QKI
TMEM69ENSG00000159596.6868.176101072.07030-0.304302.935902.40660HepG2RBM22
TMEM69ENSG00000159596.6764.828901097.22930-0.520705.741604.80210HepG2RBM25
TMEM69ENSG00000159596.6359.29820606.91150-0.756305.183903.72380HepG2RCC2
TMEM69ENSG00000159596.6775.441701242.30810-0.679906.796506.01380HepG2NELFE
TMEM69ENSG00000159596.6918.709401156.94440-0.332603.767703.06330HepG2RECQL
TMEM69ENSG00000159596.6400.95530670.37510-0.741504.683103.46640HepG2RPS10
TMEM69ENSG00000159596.6462.71850689.29580-0.575004.391903.39570HepG2RPS2
TMEM69ENSG00000159596.6549.08550796.17170-0.536003.178502.32240HepG2RPS3A
TMEM69ENSG00000159596.6380.69130839.95780-1.1417011.6086010.16430HepG2SF3A3
TMEM69ENSG00000159596.6750.999401162.25270-0.630009.714508.70620HepG2SF3B4
TMEM69ENSG00000159596.6601.39880814.69350-0.437905.461304.60940HepG2SMN1
TMEM69ENSG00000159596.61236.28200701.346600.817706.252605.06930HepG2SNRNP70
TMEM69ENSG00000159596.6965.403201210.83880-0.326803.930003.36320HepG2SRFBP1
TMEM69ENSG00000159596.6946.896901213.09320-0.357403.679803.15410HepG2SRSF1
TMEM69ENSG00000159596.6488.31940678.18630-0.473902.410401.48340HepG2SRSF3
TMEM69ENSG00000159596.6674.48570860.29200-0.351003.333402.65760HepG2SRSF5
TMEM69ENSG00000159596.6607.835501051.25090-0.7904016.1479015.12090HepG2SSB
TMEM69ENSG00000159596.6509.32100692.61250-0.443502.384201.37350HepG2STIP1
TMEM69ENSG00000159596.6771.62790978.39230-0.342503.783903.07690HepG2SUCLG1
TMEM69ENSG00000159596.6833.539401090.24510-0.387304.248903.57640HepG2TAF15
TMEM69ENSG00000159596.6786.970901001.92500-0.348402.836901.99030HepG2TIA1
TMEM69ENSG00000159596.6412.33810762.26010-0.8865012.5629011.63040HepG2TIAL1
TMEM69ENSG00000159596.6288.88760769.07550-1.4126035.1061033.38190HepG2TRIM56
TMEM69ENSG00000159596.6358.96610919.25030-1.3566021.9598020.12590HepG2U2AF1
TMEM69ENSG00000159596.6553.28050744.91330-0.429104.637403.77170HepG2UPF1
TMEM69ENSG00000159596.6897.79140719.185800.319903.122302.49240HepG2UTP3
TMEM69ENSG00000159596.6502.34910713.13800-0.505502.845301.72920HepG2XPO5
TMEM69ENSG00000159596.6601.18110819.26330-0.446505.759505.04540HepG2ZNF622
TMEM69ENSG00000159596.61611.768601999.09170-0.310702.030701.46840K562AKAP8L
TMEM69ENSG00000159596.61466.300002315.51540-0.659209.504708.52130K562AQR
TMEM69ENSG00000159596.61817.495402432.08750-0.420205.156604.09260K562CPSF6
TMEM69ENSG00000159596.6943.789401153.57760-0.289602.475401.48260K562CSTF2
TMEM69ENSG00000159596.61501.336902254.16080-0.586305.098203.07750K562DDX19B
TMEM69ENSG00000159596.6709.019901025.70190-0.532705.899604.31100K562DDX3X
TMEM69ENSG00000159596.6825.202201039.89460-0.333602.956701.59070K562DDX6
TMEM69ENSG00000159596.6791.843201177.70290-0.572704.308903.15270K562EFTUD2
TMEM69ENSG00000159596.61268.053101836.03480-0.534009.551208.33780K562EIF2S2
TMEM69ENSG00000159596.6774.694501261.20970-0.703105.074903.62140K562EIF3D
TMEM69ENSG00000159596.62673.210403168.42190-0.245202.902101.94120K562EIF4G2
TMEM69ENSG00000159596.61828.723102623.55610-0.520706.347205.02830K562FIP1L1
TMEM69ENSG00000159596.61709.865302474.61690-0.533306.257804.95510K562FMR1
TMEM69ENSG00000159596.61436.023402097.47220-0.546605.558504.21090K562FTO
TMEM69ENSG00000159596.61335.308001114.363300.260902.314701.75320K562FXR1
TMEM69ENSG00000159596.61738.026602322.03450-0.417904.462603.46010K562GPKOW
TMEM69ENSG00000159596.61952.813002446.62600-0.325203.262902.44420K562GRSF1
TMEM69ENSG00000159596.61327.012301754.80150-0.403104.127903.41380K562HNRNPC
TMEM69ENSG00000159596.61689.938702044.22930-0.274603.700202.77580K562MTPAP
TMEM69ENSG00000159596.61987.020002271.44130-0.193002.879102.11960K562NSUN2
TMEM69ENSG00000159596.6895.571201383.61510-0.627607.876306.19990K562PCBP2
TMEM69ENSG00000159596.61266.502901532.07620-0.274602.316701.58420K562POLR2G
TMEM69ENSG00000159596.6904.008401146.03420-0.342201.981301.34000K562PRPF8
TMEM69ENSG00000159596.61235.538801510.76840-0.290102.484301.84970K562PTBP1
TMEM69ENSG00000159596.61116.236801448.77840-0.376203.203802.29300K562RBM22
TMEM69ENSG00000159596.61152.503501435.36440-0.316602.829901.82730K562RCC2
TMEM69ENSG00000159596.61440.488702208.37570-0.616406.282304.78540K562SF3B1
TMEM69ENSG00000159596.6740.553501233.22730-0.7358012.0540010.18580K562SF3B4
TMEM69ENSG00000159596.61122.286701398.65380-0.317602.361301.40380K562SRSF5
TMEM69ENSG00000159596.62451.297203148.32020-0.361002.849001.57530K562STAU1
TMEM69ENSG00000159596.62058.058901536.754400.421305.384004.23110K562SYNCRIP
TMEM69ENSG00000159596.61087.368701498.95700-0.463104.246803.36390K562TARDBP
TMEM69ENSG00000159596.61094.531101445.89800-0.401704.098203.07360K562TIA1
TMEM69ENSG00000159596.61127.282701418.71770-0.331702.527601.49340K562TRA2A
TMEM69ENSG00000159596.6876.588401607.57180-0.8749014.1951011.64900K562TRIM56
TMEM69ENSG00000159596.6881.237001149.62940-0.383602.419301.40730K562U2AF1
TMEM69ENSG00000159596.6842.801501187.29060-0.494405.797104.63520K562U2AF2
TMEM69ENSG00000159596.62179.271402608.68180-0.259502.123601.37770K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM69 is not available on ENCORE database.





24 RBPs can affect the splicing of TMEM69 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM69ENSG00000159596.6chr1+4615667746156782461528854615394746158875461601150.070000.002130.03845includedK562SRSF1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.099000.000000.00169excludedK562FTO
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.249000.000000.00000excludedK562SF3B4
SETMEM69ENSG00000159596.6chr1+4615664546156782461528854615394746158875461601150.073000.000000.00015includedK562XRCC6
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.176000.000000.00000excludedHepG2HNRNPK
SETMEM69ENSG00000159596.6chr1+4615664546156782461528854615394746158875461601150.133000.000000.00050includedHepG2TBRG4
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.182000.004770.05125excludedHepG2U2AF2
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.115000.000000.00038excludedHepG2AKAP1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.119000.000000.00000excludedK562AQR
SETMEM69ENSG00000159596.6chr1+4615673246156782461528854615394746158875461601150.161000.000040.08954includedK562SDAD1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.205000.000000.00000excludedHepG2DDX3X
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.068000.000460.08072excludedK562HNRNPA1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.262000.000000.00000excludedHepG2NCBP2
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.144000.000000.00052excludedHepG2PTBP1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.107000.000100.00884excludedK562EFTUD2
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.139000.000020.00071excludedK562U2AF1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.073000.000180.03312excludedK562HNRNPM
SETMEM69ENSG00000159596.6chr1+4615664546156782461528854615394746158875461601150.120000.000000.00086includedHepG2LARP4
SETMEM69ENSG00000159596.6chr1+4615664546156782461528854615394746158875461601150.055000.003430.06625includedHepG2SRSF1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.120000.000000.00052excludedK562SRSF7
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.056000.001410.04884excludedK562TARDBP
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.092000.000000.00035excludedK562HNRNPU
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.130000.000000.00000excludedK562SF3B1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.123000.000000.00000excludedK562HNRNPK
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.142000.000320.01773excludedHepG2HNRNPU
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.136000.000780.03170excludedHepG2HNRNPC
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.083000.000010.00064excludedK562PTBP1
SETMEM69ENSG00000159596.6chr1+461566454615678246152885461539474615887546160115-0.124000.000000.00010excludedK562HNRNPC
A5SSTMEM69ENSG00000159596.6chr1+461538674615397546153867461539254615887546160115-0.062000.000070.00195shorterK562AQR
A5SSTMEM69ENSG00000159596.6chr1+461538674615397546153867461539254615664546156782-0.108000.000750.04643shorterHepG2SRSF1
A5SSTMEM69ENSG00000159596.6chr1+461538674615410446153867461539254615664546156782-0.175000.000030.00593shorterHepG2PCBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM69 is not avaliable on ENCORE database.