TMEM18

General Information

Gene Name       : TMEM18
Gene ID             : ENSG00000151353.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TMEM18)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TMEM18ENSG00000151353.1412.6717.1214.89ENCSR000AEF
HepG2TMEM18ENSG00000151353.1429.1237.8633.49ENCSR985KAT
K562TMEM18ENSG00000151353.1413.8714.6814.27ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TMEM18 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TMEM18 RNA is bound by 23 proteins.  







eCLIP assay for TMEM18 is not avaliable on ENCORE database.





23 proteins are bound to TMEM18 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2669490669656-3'-UTR,CDS,intron-Distal3.9083911.62230K562UCHL5
chr2669504669653-3'-UTR,CDS,intron-Distal3.207015.73053K562ZNF622
chr2669496669597-3'-UTR,CDS,intron-Distal4.2211916.40111HepG2PPIG
chr2669599669654-3'-UTR,CDS,intron-Distal3.474134.74886HepG2BCLAF1
chr2669754669804-3'-UTR,CDS,intron-Distal,intron-Proximal4.020123.66349K562LIN28B
chr2669013669073-3'-UTR,intron-Distal4.302663.54010K562UPF1
chr2675602675690-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.795906.88762HepG2SF3A3
chr2669502669591-3'-UTR,CDS,intron-Distal3.125054.50748HepG2GRWD1
chr2669490669562-3'-UTR,intron-Distal3.699654.65197HepG2LARP4
chr2669597669664-3'-UTR,CDS,intron-Distal,intron-Proximal3.303917.87154HepG2PPIG
chr2669804669851-3'-UTR,CDS,intron-Distal,intron-Proximal3.629213.02060K562LIN28B
chr2669591669659-3'-UTR,CDS,intron-Distal,intron-Proximal3.450084.48818HepG2GRWD1
chr2669569669667-3'-UTR,CDS,intron-Distal,intron-Proximal4.159803.88696K562GRWD1
chr2675472675557-5'-UTR,CDS,intron-Distal,intron-Proximal4.6072810.85246HepG2PRPF8
chr2676684676853-5'-UTR,intron-Distal,intron-Proximal4.379059.62219K562EWSR1
chr2676691676805-5'-UTR,intron-Distal,intron-Proximal3.403406.37265K562CSTF2T
chr2677286677389-5'-UTR,CDS,intron-Distal4.231814.77486K562YBX3
chr2672766672832-5'-UTR,CDS,intron-Distal,intron-Proximal4.1643710.51866HepG2PRPF8
chr2672789672860-5'-UTR,CDS,intron-Distal,intron-Proximal4.369844.16554HepG2PPIG
chr2676647676691-5'-UTR,intron-Distal,intron-Proximal4.5172210.78166HepG2CSTF2T
chr2676622676691-5'-UTR,CDS,intron-Distal,intron-Proximal5.160298.71133HepG2FAM120A
chr2676691676807-5'-UTR,intron-Distal,intron-Proximal4.5513619.64330HepG2CSTF2T
chr2676174676238-CDS,intron-Distal3.265987.48203HepG2CSTF2T
chr2673636673780-intron-Distal6.9521628.15000HepG2PCBP2
chr2676780676881-intron-Distal,intron-Proximal5.020928.13169HepG2PRPF4
chr2676954677009-intron-Distal4.218414.42691HepG2GTF2F1
chr2677199677266-intron-Distal4.266564.49655K562CSTF2T
chr2677183677261-intron-Distal4.7114028.15449HepG2CSTF2T
chr2676889676974-intron-Distal4.192433.34098HepG2HNRNPM
chr2673624673728-intron-Distal3.390584.09735K562ILF3
chr2676832676862-intron-Distal,intron-Proximal3.917754.45183HepG2CSTF2T
chr2676280676352-intron-Distal,intron-Proximal3.799389.58042HepG2CSTF2T
chr2676942677010-intron-Distal3.401518.00310HepG2FAM120A
chr2677196677259-intron-Distal3.212546.38416HepG2FAM120A
chr2676804676866-intron-Distal,intron-Proximal4.080563.97974HepG2RBFOX2
chr2673780673947-intron-Distal5.8051326.79427HepG2PCBP2
chr2676292676379-intron-Distal,intron-Proximal4.294414.69321HepG2GTF2F1
chr2676291676368-intron-Distal,intron-Proximal4.177676.90648HepG2FAM120A
chr2676751676799-intron-Distal,intron-Proximal4.181154.33692K562NONO
chr2676290676347-intron-Distal,intron-Proximal3.989833.80314K562CSTF2T
chr2677204677252-intron-Distal4.138174.14518HepG2GTF2F1
chr2676706676780-intron-Distal,intron-Proximal3.403483.72699HepG2PRPF4
chr2676767676869-intron-Distal,intron-Proximal3.793285.33957HepG2FASTKD2
chr2676816676879-intron-Distal,intron-Proximal4.339927.98928HepG2FAM120A
chr2676810676860-intron-Distal,intron-Proximal3.991293.17740K562CSTF2T
chr2676745676805-intron-Distal,intron-Proximal4.396474.98530K562DROSHA
chr2677213677270-intron-Distal4.072004.35952HepG2PRPF4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TMEM18 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TMEM18 is not available on ENCORE database.

  • 71 RBPs can affect the levels of TMEM18.  








The Knockdown/knockout RNA-Seq assay for TMEM18 is not available on ENCORE database.





71 RBPs can affect the gene expression of TMEM18 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TMEM18ENSG00000151353.10450.08290553.70740-0.298902.139501.59030HepG2ACO1
TMEM18ENSG00000151353.10883.669001175.88190-0.412202.520602.01060HepG2AKAP1
TMEM18ENSG00000151353.10651.90670972.90410-0.577604.866503.83780HepG2ASCC1
TMEM18ENSG00000151353.10326.65680426.60150-0.385101.952901.44250HepG2BOP1
TMEM18ENSG00000151353.10684.67820924.33870-0.433003.005202.20030HepG2CIRBP
TMEM18ENSG00000151353.10437.81240553.48100-0.338202.443801.81110HepG2CKAP4
TMEM18ENSG00000151353.10356.96700512.43090-0.521602.279701.59010HepG2CNOT7
TMEM18ENSG00000151353.10295.48890391.63620-0.406401.897601.31660HepG2CPSF6
TMEM18ENSG00000151353.10801.320001126.32130-0.491203.779203.05960HepG2DDX3X
TMEM18ENSG00000151353.10668.02040967.73260-0.534703.811003.09530HepG2DDX6
TMEM18ENSG00000151353.10532.56810930.10700-0.804408.233307.24860HepG2EIF2S1
TMEM18ENSG00000151353.10286.28150442.56300-0.628402.752401.58680HepG2EIF2S2
TMEM18ENSG00000151353.10553.289401000.87260-0.855206.994405.92980HepG2EIF4B
TMEM18ENSG00000151353.10723.476801010.90110-0.482606.010105.18160HepG2ETF1
TMEM18ENSG00000151353.10662.417301037.27840-0.647006.108705.10540HepG2FXR1
TMEM18ENSG00000151353.10631.11790962.07550-0.608205.063204.17580HepG2G3BP1
TMEM18ENSG00000151353.10733.363401021.56550-0.478203.755302.70710HepG2G3BP2
TMEM18ENSG00000151353.10301.02120396.31230-0.396802.522401.94370HepG2HNRNPU
TMEM18ENSG00000151353.10532.01760977.87460-0.878209.936808.74230HepG2IGF2BP2
TMEM18ENSG00000151353.10500.87800404.820500.307102.312201.63510HepG2ILF2
TMEM18ENSG00000151353.10661.35870983.67600-0.572803.800702.60690HepG2KHSRP
TMEM18ENSG00000151353.10561.28820744.74040-0.408002.041201.33700HepG2LARP4
TMEM18ENSG00000151353.10710.403901037.64180-0.546604.459303.62970HepG2MAGOH
TMEM18ENSG00000151353.10540.988401043.40230-0.9476010.398909.23730HepG2MATR3
TMEM18ENSG00000151353.10561.309001067.94200-0.9280010.802609.59280HepG2NCBP2
TMEM18ENSG00000151353.10520.42620950.89610-0.869609.680008.34920HepG2PABPC4
TMEM18ENSG00000151353.10440.85980992.47360-1.1707028.9196027.30850HepG2PCBP1
TMEM18ENSG00000151353.10374.33420524.25520-0.485902.239301.30300HepG2PCBP2
TMEM18ENSG00000151353.10479.83840353.479500.440803.291102.49290HepG2PPIL4
TMEM18ENSG00000151353.10424.174001009.89680-1.2515032.1288030.67360HepG2PTBP1
TMEM18ENSG00000151353.10400.32840658.60640-0.718207.171806.26830HepG2PUF60
TMEM18ENSG00000151353.10564.19930698.62950-0.308302.010401.43270HepG2PUM2
TMEM18ENSG00000151353.10503.728101093.70530-1.1185023.2170021.66580HepG2QKI
TMEM18ENSG00000151353.10600.30880992.62220-0.725509.321408.13980HepG2RBM25
TMEM18ENSG00000151353.10703.35050523.482700.426002.682601.70420HepG2RBM27
TMEM18ENSG00000151353.10640.300601123.90340-0.8117015.4762014.39220HepG2NELFE
TMEM18ENSG00000151353.10694.447201046.79010-0.592008.850507.84200HepG2RECQL
TMEM18ENSG00000151353.10288.97920387.57600-0.423502.253401.69270HepG2RPS19
TMEM18ENSG00000151353.10348.68880514.60710-0.561502.985102.15610HepG2RPS3A
TMEM18ENSG00000151353.10251.10710357.80400-0.510902.538301.78220HepG2RRP9
TMEM18ENSG00000151353.10652.601501051.40100-0.6880011.3318010.26070HepG2SF3B4
TMEM18ENSG00000151353.10523.284701097.44810-1.0685025.4796024.36130HepG2SRSF1
TMEM18ENSG00000151353.10449.42890892.84370-0.9903021.3027020.03480HepG2SRSF9
TMEM18ENSG00000151353.10603.82790986.46530-0.7081010.579109.59590HepG2TAF15
TMEM18ENSG00000151353.10561.77120906.38890-0.690108.935007.45060HepG2TIA1
TMEM18ENSG00000151353.10455.44640681.06470-0.580503.480402.53740HepG2UBE2L3
TMEM18ENSG00000151353.10417.58460551.30510-0.400803.360302.60340HepG2UPF1
TMEM18ENSG00000151353.101127.52460730.504300.626106.349905.52180K562AQR
TMEM18ENSG00000151353.10772.01090596.086900.373003.501002.78010K562DDX47
TMEM18ENSG00000151353.10600.53850430.430600.480403.586502.65540K562EIF4A3
TMEM18ENSG00000151353.10672.18690462.371100.539704.266603.19770K562FIP1L1
TMEM18ENSG00000151353.10588.40520443.983200.406203.210401.97920K562GLRX3
TMEM18ENSG00000151353.101005.11530713.163900.495004.262503.32780K562GRSF1
TMEM18ENSG00000151353.10717.19480505.990400.503204.463803.10470K562HNRNPA1
TMEM18ENSG00000151353.10587.11340393.761700.576203.187902.55300K562HNRNPC
TMEM18ENSG00000151353.10546.83170380.311500.523803.153902.15450K562HNRNPM
TMEM18ENSG00000151353.101013.39430626.870400.692907.410806.12490K562HSPD1
TMEM18ENSG00000151353.10274.23100381.35070-0.475702.682801.32090K562LARP7
TMEM18ENSG00000151353.10639.71170466.795800.454504.424503.42190K562MTPAP
TMEM18ENSG00000151353.10275.56190380.84930-0.466802.927502.10280K562POLR2G
TMEM18ENSG00000151353.10704.55410524.889400.424602.842402.00950K562PPIG
TMEM18ENSG00000151353.10443.38140330.726200.422802.004801.36050K562PRPF8
TMEM18ENSG00000151353.10965.32870673.325600.519604.513903.84390K562PUS1
TMEM18ENSG00000151353.10814.85060656.039900.312702.366101.81070K562RBM15
TMEM18ENSG00000151353.10478.37590339.261500.495603.433801.93600K562RBM25
TMEM18ENSG00000151353.10326.89090456.54420-0.481902.933001.80320K562NELFE
TMEM18ENSG00000151353.10522.04200338.092900.626603.370601.89630K562RRP9
TMEM18ENSG00000151353.10398.91220511.79210-0.359502.481201.70570K562SF3A3
TMEM18ENSG00000151353.10468.49810320.114400.549403.037201.96940K562SUPV3L1
TMEM18ENSG00000151353.10778.35450625.893600.314402.617301.38760K562TROVE2
TMEM18ENSG00000151353.10539.86390346.711000.638804.374802.93480K562U2AF1
TMEM18ENSG00000151353.10552.19100358.056800.624905.892504.72160K562U2AF2
TMEM18ENSG00000151353.10760.86530549.908500.468305.215704.26290K562UPF1
TMEM18ENSG00000151353.10646.75690470.535500.458803.658102.65280K562WDR3
TMEM18ENSG00000151353.101166.86440865.514000.430904.053802.48520K562WRN
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TMEM18 is not available on ENCORE database.





9 RBPs can affect the splicing of TMEM18 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETMEM18ENSG00000151353.10chr2-675757676238675509675630677288677406-0.118000.004760.07305excludedK562SRSF1
SETMEM18ENSG00000151353.10chr2-675757676238675509675630677288677406-0.152000.000190.03413excludedK562MATR3
SETMEM18ENSG00000151353.10chr2-675509675630669756669850677288677439-0.081000.000130.00641excludedK562AKAP8L
SETMEM18ENSG00000151353.10chr2-675509675630669756669850677288677439-0.325000.000000.00000excludedK562PUS1
SETMEM18ENSG00000151353.10chr2-672807672862669756669850677288677406-0.129000.001100.03680excludedK562UTP18
SETMEM18ENSG00000151353.10chr2-6757576762386755096756306772886774060.162000.000000.00050includedK562HNRNPU
SETMEM18ENSG00000151353.10chr2-675509675630669756669850677288677439-0.089000.000100.00423excludedK562RBM15
SETMEM18ENSG00000151353.10chr2-672807672862669756669850677288677439-0.214000.000000.00030excludedK562AGGF1
SETMEM18ENSG00000151353.10chr2-675757676238675509675630677288677406-0.061000.000490.06931excludedK562ZC3H8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TMEM18 is not avaliable on ENCORE database.