SPTLC2

General Information

Gene Name       : SPTLC2
Gene ID             : ENSG00000100596.6
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SPTLC2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SPTLC2ENSG00000100596.615.8012.7914.29ENCSR000AEF
HepG2SPTLC2ENSG00000100596.610.0512.9611.51ENCSR985KAT
K562SPTLC2ENSG00000100596.69.108.969.03ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SPTLC2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SPTLC2 RNA is bound by 24 proteins.  







eCLIP assay for SPTLC2 is not avaliable on ENCORE database.





24 proteins are bound to SPTLC2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr147797433177974369-3'-UTR,intron-Distal3.706344.50550K562UPF1
chr147797447277974515-3'-UTR,intron-Distal3.572834.44982K562UPF1
chr147797841177978468-3'-UTR,intron-Distal5.2337430.25684K562PUM2
chr147797473577974782-3'-UTR,intron-Distal4.110996.48274K562UPF1
chr147797846877978504-3'-UTR,intron-Distal3.392313.99123K562PUM2
chr147797808177978154-3'-UTR,intron-Distal3.831943.54770K562IGF2BP1
chr147797770177977783-3'-UTR,intron-Distal4.999826.31097K562FAM120A
chr147797504177975070-3'-UTR,intron-Distal3.100463.85107K562UPF1
chr147797660577976659-3'-UTR,intron-Distal3.414716.98582K562UPF1
chr147797553477975612-3'-UTR,intron-Distal3.616419.26008K562YBX3
chr147797480077974890-3'-UTR,intron-Distal3.7675511.63263K562FAM120A
chr147797521477975268-3'-UTR,intron-Distal3.228886.06342K562UPF1
chr147797823177978348-3'-UTR,intron-Distal3.598065.09017HepG2UPF1
chr147797258177972636-3'-UTR,intron-Distal6.5622410.02027K562PUM2
chr147797862677978726-3'-UTR,CDS,intron-Distal,intron-Proximal4.319184.82934K562RBM15
chr147797826277978339-3'-UTR,intron-Distal4.521545.04042K562IGF2BP2
chr147797481777974891-3'-UTR,intron-Distal4.239899.04309K562UPF1
chr147797308877973153-3'-UTR,intron-Distal4.512754.77486K562YBX3
chr147797721777977242-3'-UTR,intron-Distal4.078933.20319K562UPF1
chr147797671577976782-3'-UTR,intron-Distal3.112256.65594K562UPF1
chr147797863377978718-3'-UTR,CDS,intron-Distal,intron-Proximal4.310874.16170K562UCHL5
chr147797849977978637-3'-UTR,CDS,intron-Distal,intron-Proximal3.876017.35476HepG2GRWD1
chr147797245677972500-3'-UTR,intron-Distal3.510183.95400K562UPF1
chr147797856777978622-3'-UTR,intron-Distal,intron-Proximal3.284546.87198K562RBM15
chr147797289577972964-3'-UTR,intron-Distal4.393185.43239K562YBX3
chr147797778377977897-3'-UTR,intron-Distal4.576258.21878K562FAM120A
chr147797820877978349-3'-UTR,intron-Distal4.252293.87385HepG2AKAP1
chr147797853277978614-3'-UTR,intron-Distal,intron-Proximal3.805545.77244K562UCHL5
chr147797845977978532-3'-UTR,intron-Distal3.344553.95937K562UCHL5
chr147808288278082957-5'-UTR,CDS,intron-Distal3.971835.77244K562UCHL5
chr147808285978083021-5'-UTR,CDS,intron-Distal3.845895.07887K562FXR2
chr147808294778083004-5'-UTR,intron-Distal5.5735913.97750HepG2DDX3X
chr147808289178082948-5'-UTR,CDS,intron-Distal3.971193.47325K562DDX3X
chr147808288278082988-5'-UTR,CDS,intron-Distal4.286465.23270K562GEMIN5
chr147808287978082932-5'-UTR,CDS,intron-Distal3.848783.56019HepG2GRWD1
chr147808284278082947-5'-UTR,CDS,intron-Distal3.8961111.34202HepG2DDX3X
chr147808294378083006-5'-UTR,intron-Distal3.149355.75243K562ZNF622
chr147808293278083007-5'-UTR,intron-Distal3.258464.06531HepG2GRWD1
chr147804531178045425-CDS,intron-Distal3.215568.83000K562UCHL5
chr147803679778036885-CDS,intron-Distal,intron-Proximal3.9434310.97054K562SF3B4
chr147802164078021705-CDS,intron-Distal,intron-Proximal3.539086.14048K562ZNF622
chr147803672978036855-CDS,intron-Distal,intron-Proximal3.9216611.69958K562ZNF622
chr147802164278021726-CDS,intron-Distal,intron-Proximal4.447364.31023HepG2LIN28B
chr147804531078045438-CDS,intron-Distal4.8998411.30042K562ZNF622
chr147806353278063728-CDS,intron-Distal,intron-Proximal3.300625.79905HepG2BCLAF1
chr147801852778018566-CDS,intron-Distal,intron-Proximal3.305323.61259K562ZNF622
chr147804322178043338-CDS,intron-Distal,intron-Proximal3.389234.35941K562KHSRP
chr147801845978018537-CDS,intron-Distal,intron-Proximal4.291073.89826HepG2BCLAF1
chr147803681478036911-CDS,intron-Distal,intron-Proximal4.417983.20724K562SMNDC1
chr147804528978045453-CDS,intron-Distal,intron-Proximal4.573879.30195HepG2BCLAF1
chr147802164178021741-CDS,intron-Distal,intron-Proximal4.440433.69113K562LIN28B
chr147802339678023453-CDS,intron-Distal3.881553.01428K562UCHL5
chr147802177878021861-CDS,intron-Distal3.289334.30396K562UCHL5
chr147804529578045440-CDS,intron-Distal,intron-Proximal3.270175.12345HepG2GRWD1
chr147805799478058070-intron-Distal3.682853.14791K562HNRNPL
chr147808049778080622-intron-Distal5.267116.85401K562QKI
chr147803688578036899-intron-Distal,intron-Proximal5.104395.40008K562SF3B4
chr147804293978043091-intron-Distal,intron-Proximal4.999056.73684K562KHSRP
chr147804289578043017-intron-Distal,intron-Proximal4.184883.89565K562PRPF8
chr147799774977997818-intron-Distal5.086595.52537K562CPSF6
chr147804302378043077-intron-Distal,intron-Proximal5.497357.23906K562EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SPTLC2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SPTLC2 is not available on ENCORE database.

  • 87 RBPs can affect the levels of SPTLC2.  








The Knockdown/knockout RNA-Seq assay for SPTLC2 is not available on ENCORE database.





87 RBPs can affect the gene expression of SPTLC2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SPTLC2ENSG00000100596.21006.69140716.442000.490603.370902.19430HepG2AATF
SPTLC2ENSG00000100596.2674.29620918.23630-0.445502.456501.57380HepG2BCCIP
SPTLC2ENSG00000100596.2357.96260811.96710-1.1816017.5586016.24090HepG2BOP1
SPTLC2ENSG00000100596.2798.48270952.97250-0.255202.443801.81110HepG2CKAP4
SPTLC2ENSG00000100596.2516.54120745.42000-0.529204.176903.34820HepG2CPSF6
SPTLC2ENSG00000100596.2616.44050840.49330-0.447304.665403.34580HepG2YBX3
SPTLC2ENSG00000100596.21434.060601101.725600.380204.784203.98140HepG2CELF1
SPTLC2ENSG00000100596.2639.08300881.52480-0.464006.430205.23860HepG2DDX19B
SPTLC2ENSG00000100596.2567.78410844.76550-0.573203.241301.85550HepG2DDX27
SPTLC2ENSG00000100596.2688.93880905.70260-0.394702.808801.78950HepG2DDX5
SPTLC2ENSG00000100596.2535.69220911.89000-0.7675012.7737011.53560HepG2DKC1
SPTLC2ENSG00000100596.2607.73330825.31010-0.441504.536103.65260HepG2DNAJC21
SPTLC2ENSG00000100596.2629.97540818.00970-0.376804.304903.52430HepG2DNAJC2
SPTLC2ENSG00000100596.2741.78890965.52100-0.380302.349101.79990HepG2EIF2S1
SPTLC2ENSG00000100596.21304.508901654.72180-0.343104.919304.15840HepG2ETF1
SPTLC2ENSG00000100596.21488.700601024.050000.539704.269603.33000HepG2FIP1L1
SPTLC2ENSG00000100596.2562.95490998.65920-0.827008.547107.41180HepG2G3BP1
SPTLC2ENSG00000100596.2619.32270844.96410-0.448202.808902.16360HepG2GPKOW
SPTLC2ENSG00000100596.2529.18990833.21660-0.654906.781105.83580HepG2HNRNPA1
SPTLC2ENSG00000100596.2830.104501006.97740-0.278702.457501.77890HepG2HNRNPF
SPTLC2ENSG00000100596.2839.780201079.13960-0.361804.848403.97410HepG2HNRNPL
SPTLC2ENSG00000100596.2715.10130920.66820-0.364503.828003.12550HepG2HNRNPU
SPTLC2ENSG00000100596.2704.60480991.58780-0.492905.157904.20030HepG2IGF2BP1
SPTLC2ENSG00000100596.2793.363501015.15520-0.355602.218101.60540HepG2IGF2BP2
SPTLC2ENSG00000100596.2663.64250940.43280-0.502908.089606.90350HepG2ILF2
SPTLC2ENSG00000100596.2841.507401395.27800-0.729506.619805.32280HepG2LARP4
SPTLC2ENSG00000100596.2835.392801076.80500-0.366202.276201.67920HepG2MAGOH
SPTLC2ENSG00000100596.2577.638901082.86650-0.906609.644408.52510HepG2MATR3
SPTLC2ENSG00000100596.2679.816901108.40230-0.705306.691405.72550HepG2NCBP2
SPTLC2ENSG00000100596.2923.482001174.70040-0.347103.381602.54040HepG2NOL12
SPTLC2ENSG00000100596.2722.02670987.23430-0.451303.087302.32670HepG2PABPC4
SPTLC2ENSG00000100596.2648.20430969.77390-0.581208.801207.81760HepG2PCBP1
SPTLC2ENSG00000100596.2617.64390963.45120-0.641404.141702.88800HepG2PCBP2
SPTLC2ENSG00000100596.2583.28440821.16320-0.493505.455804.45120HepG2PPIL4
SPTLC2ENSG00000100596.2872.134601121.34590-0.362602.951702.33970HepG2PUF60
SPTLC2ENSG00000100596.21536.356301190.348400.368006.314205.49450HepG2PUM1
SPTLC2ENSG00000100596.21508.716901189.485000.342903.353602.61680HepG2PUM2
SPTLC2ENSG00000100596.2809.93590970.81950-0.261402.468501.87790HepG2PUS1
SPTLC2ENSG00000100596.2582.72990929.71950-0.674003.516602.72440HepG2RAVER1
SPTLC2ENSG00000100596.21196.75550969.926100.303102.246301.63330HepG2RBM25
SPTLC2ENSG00000100596.2618.722001084.72320-0.8100010.671109.47910HepG2RPLP0
SPTLC2ENSG00000100596.2651.30910913.32870-0.487802.514001.61110HepG2RPS10
SPTLC2ENSG00000100596.2446.74580598.68000-0.422302.823802.20360HepG2RPS19
SPTLC2ENSG00000100596.2659.57430969.55990-0.555804.537803.52640HepG2RPS2
SPTLC2ENSG00000100596.2704.160601017.54070-0.531103.342302.46430HepG2RPS3A
SPTLC2ENSG00000100596.2452.19590689.02540-0.607603.962303.04300HepG2RRP9
SPTLC2ENSG00000100596.22040.728901562.045300.385506.529105.84920HepG2SRFBP1
SPTLC2ENSG00000100596.2776.565901356.17300-0.8044019.5399018.44260HepG2SSB
SPTLC2ENSG00000100596.21582.779801259.149200.329904.834304.05300HepG2SUCLG1
SPTLC2ENSG00000100596.2578.73840898.75090-0.635004.601903.76230HepG2SUPV3L1
SPTLC2ENSG00000100596.2563.67990894.61680-0.666408.636407.84220HepG2TIAL1
SPTLC2ENSG00000100596.2769.33030902.59720-0.230501.915301.42940HepG2TRIM56
SPTLC2ENSG00000100596.2865.202701159.54990-0.422502.784701.94440HepG2UBE2L3
SPTLC2ENSG00000100596.2330.00650530.93900-0.686105.121204.08010HepG2UCHL5
SPTLC2ENSG00000100596.2421.61030823.05470-0.965107.278305.59880HepG2UPF2
SPTLC2ENSG00000100596.2713.98190848.61580-0.249201.954101.43250HepG2UTP3
SPTLC2ENSG00000100596.2653.09420911.39710-0.480802.810701.70320HepG2XPO5
SPTLC2ENSG00000100596.2504.15450884.72090-0.811407.809106.60240HepG2XRN2
SPTLC2ENSG00000100596.21549.798802060.94180-0.411203.889903.21790K562AQR
SPTLC2ENSG00000100596.2553.62630879.13390-0.667206.281904.95490K562BOP1
SPTLC2ENSG00000100596.21816.533602206.48780-0.280602.649201.50600K562CCDC124
SPTLC2ENSG00000100596.21429.177301857.70360-0.378303.424401.98790K562CIRBP
SPTLC2ENSG00000100596.2643.55440934.75320-0.538505.613104.50370K562CPSF6
SPTLC2ENSG00000100596.23754.085703110.093900.271402.957401.95020K562CELF1
SPTLC2ENSG00000100596.21292.106401536.45300-0.249902.435001.30450K562DDX21
SPTLC2ENSG00000100596.2915.691301134.71230-0.309403.170801.74180K562DDX27
SPTLC2ENSG00000100596.21111.026701380.82720-0.313602.622001.61010K562DDX3X
SPTLC2ENSG00000100596.21283.604501980.64660-0.6258014.2424012.88040K562DDX47
SPTLC2ENSG00000100596.2825.144101196.45390-0.536003.578202.10200K562EEF2
SPTLC2ENSG00000100596.2764.577901156.05340-0.596505.917604.54900K562EFTUD2
SPTLC2ENSG00000100596.2924.003101254.90520-0.441605.136504.06640K562EIF3G
SPTLC2ENSG00000100596.21139.118901442.63920-0.340802.740701.92310K562EIF4A3
SPTLC2ENSG00000100596.23120.756602529.337800.303004.175403.02800K562EIF4G2
SPTLC2ENSG00000100596.21016.457201292.89970-0.347102.690701.85430K562FIP1L1
SPTLC2ENSG00000100596.21180.878201500.28670-0.345403.984103.27740K562FXR1
SPTLC2ENSG00000100596.21322.748001657.15340-0.325202.849601.39360K562G3BP1
SPTLC2ENSG00000100596.21788.719801358.087500.397302.374301.72680K562G3BP2
SPTLC2ENSG00000100596.21019.803601998.91720-0.9709020.0016017.85940K562GRSF1
SPTLC2ENSG00000100596.2690.880201063.42930-0.622205.387004.03390K562HNRNPM
SPTLC2ENSG00000100596.21370.519401831.09190-0.418005.764904.46250K562HNRNPU
SPTLC2ENSG00000100596.21259.508901821.64690-0.532406.714205.37850K562MAGOH
SPTLC2ENSG00000100596.21278.327801817.94950-0.508106.611805.10090K562MATR3
SPTLC2ENSG00000100596.2650.06000871.13170-0.422303.543502.54530K562METAP2
SPTLC2ENSG00000100596.21116.167101463.46470-0.390805.592504.46690K562MTPAP
SPTLC2ENSG00000100596.21177.625001440.54070-0.290702.468901.30950K562NCBP2
SPTLC2ENSG00000100596.21395.135401780.66030-0.352003.618902.06910K562PCBP1
SPTLC2ENSG00000100596.21086.239001620.81240-0.577407.106805.51390K562PCBP2
SPTLC2ENSG00000100596.21110.139001467.69820-0.402803.382202.45980K562PPIG
SPTLC2ENSG00000100596.2635.654101124.97120-0.823609.893808.46960K562PRPF8
SPTLC2ENSG00000100596.2757.15140977.11200-0.367902.839101.92020K562PSIP1
SPTLC2ENSG00000100596.2943.098401769.84500-0.9081019.0403017.37460K562PTBP1
SPTLC2ENSG00000100596.21536.146001905.32260-0.310702.543802.01830K562PUS1
SPTLC2ENSG00000100596.21100.758601697.06340-0.624508.023606.49480K562RBM22
SPTLC2ENSG00000100596.2699.74160891.64490-0.349602.669001.69550K562RCC2
SPTLC2ENSG00000100596.21382.699401785.88930-0.369203.023801.87600K562NELFE
SPTLC2ENSG00000100596.2559.375601145.96360-1.0347012.6221010.85180K562RPS19
SPTLC2ENSG00000100596.2827.111801210.03630-0.548904.645103.30390K562RPS3
SPTLC2ENSG00000100596.21883.760501604.493500.231402.284101.53750K562SF3A3
SPTLC2ENSG00000100596.2663.63970845.23930-0.349002.345201.41930K562SRFBP1
SPTLC2ENSG00000100596.2850.378701735.03950-1.0288022.6286020.60420K562SRSF1
SPTLC2ENSG00000100596.2633.494901089.31150-0.782007.979306.19980K562SUPV3L1
SPTLC2ENSG00000100596.21277.122801755.97020-0.459404.303503.41450K562TARDBP
SPTLC2ENSG00000100596.21135.081101534.11830-0.434607.573006.23710K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SPTLC2 is not available on ENCORE database.





1 RBPs can affect the splicing of SPTLC2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESPTLC2ENSG00000100596.2chr14-780287387802883278023383780234897803672678036851-0.105000.001850.02054excludedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SPTLC2 is not avaliable on ENCORE database.