SMG6

General Information

Gene Name       : SMG6
Gene ID             : ENSG00000070366.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SMG6)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SMG6ENSG00000070366.1310.2114.5612.39ENCSR000AEF
HepG2SMG6ENSG00000070366.1314.6811.1812.93ENCSR985KAT
K562SMG6ENSG00000070366.1310.019.339.67ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SMG6 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SMG6 RNA is bound by 26 proteins.  







eCLIP assay for SMG6 is not avaliable on ENCORE database.





26 proteins are bound to SMG6 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1719636981963877-3'-UTR,intron-Distal5.098065.93974HepG2UPF1
chr1719639201964002-3'-UTR,intron-Distal3.605424.66086HepG2AKAP1
chr1719637811963803-3'-UTR,intron-Distal4.800633.39700HepG2PCBP2
chr1719637741963868-3'-UTR,intron-Distal3.999504.74496HepG2DDX59
chr1719632191963308-3'-UTR,intron-Distal4.171147.15603K562UPF1
chr1719640851964136-3'-UTR,intron-Distal4.862246.02674K562UPF1
chr1719637511963808-3'-UTR,intron-Distal5.130337.60978K562UPF1
chr1719640921964193-3'-UTR,intron-Distal5.024757.53166HepG2AKAP1
chr1719638071963990-3'-UTR,intron-Distal6.1277756.90198HepG2PCBP2
chr1719645671964635-3'-UTR,intron-Distal,intron-Proximal3.581774.66086HepG2AKAP1
chr1720917132091805-3'-UTR,CDS,intron-Distal3.305334.48818HepG2GRWD1
chr1719644251964492-3'-UTR,intron-Distal4.397794.44583HepG2UPF1
chr1719644161964488-3'-UTR,intron-Distal4.698714.40113HepG2AKAP1
chr1719634221963499-3'-UTR,intron-Distal4.196523.64119HepG2UPF1
chr1719638081963895-3'-UTR,intron-Distal4.5351214.35538K562UPF1
chr1719640051964079-3'-UTR,intron-Distal4.385003.76295K562IGF2BP2
chr1719642261964327-3'-UTR,intron-Distal3.382395.89157HepG2AKAP1
chr1719642431964325-3'-UTR,intron-Distal3.356635.18546HepG2UPF1
chr1719640371964148-3'-UTR,intron-Distal4.969968.28148HepG2UPF1
chr1719638151963869-3'-UTR,intron-Distal4.467364.51674HepG2AKAP1
chr1719645481964662-3'-UTR,intron-Distal,intron-Proximal4.352499.06961HepG2UPF1
chr1721399012139955-5'-UTR,CDS,intron-Distal,intron-Proximal4.888895.65342K562AQR
chr1722069782207067-5'-UTR,CDS,intron-Distal,intron-Proximal3.997796.35651HepG2NCBP2
chr1721398832139932-5'-UTR,CDS,intron-Distal,intron-Proximal3.877164.96634HepG2PPIG
chr1720759342076043-CDS,intron-Distal,intron-Proximal4.636076.92104HepG2GRWD1
chr1719720291972093-CDS,intron-Distal,intron-Proximal4.044945.34978HepG2PRPF8
chr1720759502076046-CDS,intron-Distal,intron-Proximal3.073674.94718HepG2PPIG
chr1722037482203788-CDS,intron-Distal3.080343.55800HepG2BCLAF1
chr1722068782206946-CDS,intron-Distal,intron-Proximal4.819503.70131HepG2PRPF8
chr1721961702196265-CDS,intron-Distal3.325125.00751HepG2BCLAF1
chr1721859382186154-CDS,intron-Distal,intron-Proximal3.831893.05298K562GRWD1
chr1722028722202940-CDS,intron-Distal3.805545.08388K562UCHL5
chr1722027042202740-CDS,intron-Distal4.788543.33922HepG2EIF3H
chr1720759512076057-CDS,intron-Distal,intron-Proximal4.566135.24929K562ZNF622
chr1721961802196255-CDS,intron-Distal6.1067114.77023HepG2LIN28B
chr1721961642196241-CDS,intron-Distal,intron-Proximal3.031784.09741HepG2PPIG
chr1719850601985134-CDS,intron-Distal,intron-Proximal4.1323010.51866HepG2PRPF8
chr1721859302186070-CDS,intron-Distal,intron-Proximal3.219375.98862HepG2GRWD1
chr1721859482186050-CDS,intron-Distal3.105953.19733K562ZNF622
chr1721961742196260-CDS,intron-Distal5.6222827.75237K562LIN28B
chr1722029912203109-CDS,intron-Distal4.7460512.55461K562UCHL5
chr1722033102203371-CDS,intron-Distal3.814884.83483HepG2FXR2
chr1722033262203409-CDS,intron-Distal4.506664.13073HepG2GTF2F1
chr1722033162203398-CDS,intron-Distal3.200174.79706HepG2PRPF4
chr1722026922202735-CDS,intron-Distal3.668133.12746HepG2GRWD1
chr1721860752186154-CDS,intron-Distal,intron-Proximal3.936957.55042HepG2PPIG
chr1719851041985231-CDS,intron-Distal,intron-Proximal3.673686.13978HepG2PPIG
chr1722028812202931-CDS,intron-Distal3.143343.17233HepG2BCLAF1
chr1722029952203105-CDS,intron-Distal3.437138.84415HepG2BCLAF1
chr1722031432203200-CDS,intron-Distal3.496854.40383K562UCHL5
chr1720301342030265-intron-Distal4.336154.13603K562TARDBP
chr1720864852086557-intron-Distal4.213094.22415K562PTBP1
chr1720604302060482-intron-Distal4.204804.31871HepG2HNRNPM
chr1721476382147749-intron-Distal4.349554.40847HepG2PTBP1
chr1720392292039351-intron-Distal4.024373.37631K562HNRNPL
chr1720890232089115-intron-Distal4.164497.70131HepG2PCBP2
chr1720571522057232-intron-Distal3.199813.59783HepG2HNRNPK
chr1722007802200926-intron-Distal4.144494.13603K562TARDBP
chr1720102522010320-intron-Distal4.676393.83958HepG2QKI
chr1720861172086168-intron-Distal4.246323.74583HepG2PTBP1
chr1720890382089138-intron-Distal3.704833.06084HepG2HNRNPK
chr1720864892086558-intron-Distal4.2707910.33353HepG2PTBP1
chr1720353102035372-intron-Distal3.267023.21744HepG2HNRNPC
chr1719695801969663-intron-Distal4.218074.51091HepG2HNRNPL
chr1721825042182638-intron-Distal3.887055.03657K562PTBP1
chr1720563802056421-intron-Distal4.014263.66782HepG2HNRNPM
chr1721972482197329-intron-Distal4.521415.16513HepG2HNRNPM
chr1720196212019678-intron-Distal3.375675.30918HepG2ILF3
chr1721201172120181-intron-Distal3.288773.35103HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SMG6 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SMG6 is not available on ENCORE database.

  • 57 RBPs can affect the levels of SMG6.  








The Knockdown/knockout RNA-Seq assay for SMG6 is not available on ENCORE database.





57 RBPs can affect the gene expression of SMG6 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SMG6ENSG00000070366.91444.437501120.431100.366402.242901.39110HepG2ABCF1
SMG6ENSG00000070366.91134.97160842.662000.429506.125405.29270HepG2ACO1
SMG6ENSG00000070366.91031.87010846.626400.285402.704901.94600HepG2AKAP8L
SMG6ENSG00000070366.9858.250601295.84260-0.594406.578205.70200HepG2BOP1
SMG6ENSG00000070366.9682.44910895.17630-0.391503.163902.34410HepG2CALR
SMG6ENSG00000070366.9993.35690741.588200.421602.945602.14860HepG2CIRBP
SMG6ENSG00000070366.91024.10860779.344600.393905.346304.23800HepG2DDX19B
SMG6ENSG00000070366.91032.25660691.304900.578305.898904.95010HepG2DDX21
SMG6ENSG00000070366.91019.78530806.200800.339003.392902.65300HepG2DKC1
SMG6ENSG00000070366.9843.72880626.714700.428902.751501.83420HepG2EEF2
SMG6ENSG00000070366.9663.28940508.718000.382702.200601.38460HepG2EIF3D
SMG6ENSG00000070366.91537.32850824.628100.8985010.544409.31810HepG2EIF4A3
SMG6ENSG00000070366.91116.87250823.437000.439604.226703.19390HepG2EWSR1
SMG6ENSG00000070366.9435.86450566.84730-0.379102.335801.61020HepG2FUBP3
SMG6ENSG00000070366.91237.46710832.155500.572405.112904.19270HepG2FXR1
SMG6ENSG00000070366.91008.76670771.872400.386102.385601.76470HepG2G3BP1
SMG6ENSG00000070366.91054.27590819.538000.363302.356001.53820HepG2G3BP2
SMG6ENSG00000070366.9637.63600452.937400.493303.458002.44390HepG2GEMIN5
SMG6ENSG00000070366.9972.32020631.534600.622506.446305.52020HepG2HNRNPA1
SMG6ENSG00000070366.9996.03210702.467600.503704.442003.57860HepG2HNRNPC
SMG6ENSG00000070366.9870.23830697.823200.318403.115902.47530HepG2HNRNPU
SMG6ENSG00000070366.91210.67830784.565200.625806.114605.14810HepG2IGF2BP2
SMG6ENSG00000070366.91243.10460832.446700.578405.108104.22560HepG2MAGOH
SMG6ENSG00000070366.9899.42070763.988500.235301.853901.33980HepG2PCBP1
SMG6ENSG00000070366.91201.91100967.611400.312703.259702.42630HepG2PRPF4
SMG6ENSG00000070366.9982.82260777.397100.338203.591002.98560HepG2PTBP1
SMG6ENSG00000070366.91125.82330841.918300.419104.353103.59520HepG2QKI
SMG6ENSG00000070366.9985.158401190.67860-0.273402.308601.51680HepG2RBM15
SMG6ENSG00000070366.91637.499501266.449200.370604.752404.11970HepG2RBM22
SMG6ENSG00000070366.9995.43430764.103300.381503.159202.44350HepG2RBM25
SMG6ENSG00000070366.91288.64730865.159800.574709.200708.31690HepG2NELFE
SMG6ENSG00000070366.9988.90260805.794300.295302.695602.08620HepG2RECQL
SMG6ENSG00000070366.91467.033901150.332300.350802.786502.10140HepG2RPLP0
SMG6ENSG00000070366.9819.23670495.040800.726608.183707.19280HepG2RPS19
SMG6ENSG00000070366.91058.24940762.158400.473403.470302.57390HepG2RPS2
SMG6ENSG00000070366.9713.86060506.182300.495902.696901.90750HepG2RPS3A
SMG6ENSG00000070366.9502.66130621.44110-0.306002.369401.76650HepG2SAFB2
SMG6ENSG00000070366.91656.252001430.416100.211402.143301.68460HepG2SRFBP1
SMG6ENSG00000070366.91148.33310844.796100.442805.760505.14020HepG2SRSF1
SMG6ENSG00000070366.91166.49100937.665600.314903.575602.88050HepG2SRSF5
SMG6ENSG00000070366.9813.57880687.293100.243301.947001.46880HepG2SRSF9
SMG6ENSG00000070366.91740.215401241.954400.486609.310308.47700HepG2SSB
SMG6ENSG00000070366.91433.708601066.348500.427007.364906.43160HepG2SUCLG1
SMG6ENSG00000070366.9985.69700720.953100.451102.486101.84090HepG2SUPV3L1
SMG6ENSG00000070366.91384.07320678.057301.0293022.9709021.79180HepG2TIAL1
SMG6ENSG00000070366.91139.86750927.807600.296902.380601.57510HepG2TUFM
SMG6ENSG00000070366.9895.634901057.94330-0.240302.228001.59020HepG2UPF1
SMG6ENSG00000070366.9989.336701163.53780-0.234002.482401.95620HepG2ZNF622
SMG6ENSG00000070366.9711.34950901.51900-0.341802.350201.74670K562AKAP8L
SMG6ENSG00000070366.91174.56410957.912200.294102.931002.26140K562DDX47
SMG6ENSG00000070366.9739.76520524.933300.494802.897701.83640K562EIF3D
SMG6ENSG00000070366.9754.99300465.092400.698807.412006.07550K562EIF4A3
SMG6ENSG00000070366.9603.76460773.16130-0.356802.340101.56050K562FIP1L1
SMG6ENSG00000070366.9650.84250483.677300.428203.707403.02210K562FXR1
SMG6ENSG00000070366.9792.231001010.09150-0.350502.661801.91980K562GRSF1
SMG6ENSG00000070366.9928.86700495.344700.9069012.8443011.63480K562HNRNPC
SMG6ENSG00000070366.9824.143001048.23670-0.347002.437701.68700K562HSPD1
SMG6ENSG00000070366.9702.81530544.869900.367102.586801.77380K562MAGOH
SMG6ENSG00000070366.9809.597201071.80460-0.404803.754502.66830K562MBNL1
SMG6ENSG00000070366.9599.86270877.69690-0.549104.711903.60020K562PPIG
SMG6ENSG00000070366.9333.56210477.22790-0.516703.176002.37230K562PRPF8
SMG6ENSG00000070366.9679.02920529.399400.359002.590401.94440K562PTBP1
SMG6ENSG00000070366.9705.06640894.09600-0.342702.109901.62310K562PUS1
SMG6ENSG00000070366.9710.62060871.13160-0.293802.190101.65200K562RBM15
SMG6ENSG00000070366.9779.85390610.388000.353402.694701.88750K562SYNCRIP
SMG6ENSG00000070366.9571.75290427.179500.420402.137001.32570K562TIAL1
SMG6ENSG00000070366.91087.60250905.695400.264002.355901.68990K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SMG6 is not available on ENCORE database.





2 RBPs can affect the splicing of SMG6 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
MXESMG6ENSG00000070366.9chr17-19903681990592207595120761531989018198919520899562090125-0.249000.000230.012572includedHepG2SF3A3
MXESMG6ENSG00000070366.9chr17-19890181989195207595120761531985103198525020899562090125-0.202000.002650.054362includedHepG2DDX55

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SMG6 is not avaliable on ENCORE database.