POLR1C

General Information

Gene Name       : POLR1C
Gene ID             : ENSG00000171453.18
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLR1C)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLR1CENSG00000171453.1861.1443.5252.33ENCSR000AEF
HepG2POLR1CENSG00000171453.1857.7361.0959.41ENCSR985KAT
K562POLR1CENSG00000171453.18102.69121.91112.30ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLR1C is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLR1C RNA is bound by 15 proteins.  







eCLIP assay for POLR1C is not avaliable on ENCORE database.





15 proteins are bound to POLR1C RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr64348508243485170+3'-UTR,CDS,intron-Proximal3.734546.25527HepG2PRPF8
chr64348507843485117+3'-UTR,CDS,intron-Proximal3.416744.06757K562UCHL5
chr64348506843485117+3'-UTR,CDS,intron-Proximal4.653074.65563K562AQR
chr64348492543485070+3'-UTR,CDS,intron-Distal,intron-Proximal4.8413813.32540K562EFTUD2
chr64348905743489130+3'-UTR,intron-Distal3.810033.14999HepG2GRWD1
chr64348707043487109+3'-UTR,CDS,intron-Proximal3.575513.59112HepG2PPIG
chr64348918843489243+3'-UTR,intron-Distal,polyA_signal5.6990813.89399K562PUM2
chr64348899043489115+3'-UTR,CDS,intron-Distal3.138223.02046HepG2LARP4
chr64348501143485077+3'-UTR,CDS,intron-Proximal4.309434.49756K562BUD13
chr64348486343484917+CDS,intron-Distal,intron-Proximal3.059624.30396K562UCHL5
chr64348875743488783+CDS4.213113.11168K562ZNF622
chr64348777643487832+CDS,intron-Distal,intron-Proximal4.777345.95026HepG2U2AF2
chr64348486543484921+CDS,intron-Distal,intron-Proximal3.262453.47879HepG2PPIG
chr64348742643487487+CDS,intron-Proximal3.489484.35112K562U2AF1
chr64348742743487483+CDS,intron-Proximal3.229246.08780K562U2AF2
chr64348739143487450+CDS,intron-Proximal4.060563.74254HepG2SF3B4
chr64348744343487473+CDS,intron-Proximal3.005163.99124HepG2PPIG
chr64348578143485871+intron-Distal4.419643.60235HepG2HNRNPM
chr64348762643487707+intron-Distal,intron-Proximal4.600585.42080K562EFTUD2
chr64348734343487417+intron-Distal,intron-Proximal3.597543.19080K562U2AF2
chr64348763143487716+intron-Distal,intron-Proximal3.630366.40067K562PRPF8
chr64348859143488650+intron-Proximal3.361443.65493HepG2RBM5
chr64348513043485185+intron-Proximal4.280525.32062K562EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLR1C is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLR1C is not available on ENCORE database.

  • 83 RBPs can affect the levels of POLR1C.  








The Knockdown/knockout RNA-Seq assay for POLR1C is not available on ENCORE database.





83 RBPs can affect the gene expression of POLR1C :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLR1CENSG00000171453.131158.42270512.914701.1753014.6643013.53890HepG2AKAP1
POLR1CENSG00000171453.13609.94370421.129300.534305.515004.46660HepG2AKAP8L
POLR1CENSG00000171453.13800.78180538.791300.571603.406902.36800HepG2BCCIP
POLR1CENSG00000171453.13550.93670383.178400.523802.441001.87500HepG2BOP1
POLR1CENSG00000171453.13613.74770419.059000.550406.384605.44950HepG2CKAP4
POLR1CENSG00000171453.13485.50770387.680500.324502.398601.61710HepG2DDX19B
POLR1CENSG00000171453.13923.98640491.297000.911209.944308.82370HepG2DDX3X
POLR1CENSG00000171453.13320.98170436.09810-0.442203.077602.34010HepG2DNAJC21
POLR1CENSG00000171453.13364.59800236.071300.627003.606002.32880HepG2EFTUD2
POLR1CENSG00000171453.13402.39790229.894100.807605.593504.33790HepG2EIF3D
POLR1CENSG00000171453.13680.92200436.576300.641203.744302.95040HepG2EIF4B
POLR1CENSG00000171453.13516.81610679.65630-0.395202.601601.81040HepG2EIF4G2
POLR1CENSG00000171453.13577.44680409.589600.495403.784102.80630HepG2EWSR1
POLR1CENSG00000171453.13333.35500204.683000.703604.123103.01810HepG2GEMIN5
POLR1CENSG00000171453.13337.36640440.27570-0.384101.958301.40340HepG2HNRNPA1
POLR1CENSG00000171453.13443.03270640.61610-0.532005.828104.83680HepG2HNRNPF
POLR1CENSG00000171453.13636.83790425.090700.583104.339503.48100HepG2HNRNPK
POLR1CENSG00000171453.13232.17340380.62450-0.713202.084801.53030HepG2HNRNPLL
POLR1CENSG00000171453.13498.96920308.064100.695605.775104.46300HepG2HNRNPM
POLR1CENSG00000171453.13429.64810630.82050-0.554105.151804.19450HepG2IGF2BP1
POLR1CENSG00000171453.13660.39170485.702200.443102.239001.49950HepG2LARP4
POLR1CENSG00000171453.13892.29430455.127400.9711010.037708.89290HepG2MATR3
POLR1CENSG00000171453.13391.35910240.585800.701803.009701.91070HepG2METAP2
POLR1CENSG00000171453.13483.05040361.340400.418702.284301.54640HepG2MSI2
POLR1CENSG00000171453.13795.94410465.831700.772806.905105.92520HepG2NCBP2
POLR1CENSG00000171453.13205.19110337.45470-0.717702.073401.42140HepG2NSUN2
POLR1CENSG00000171453.13539.55120414.777600.379301.923901.31300HepG2PABPC4
POLR1CENSG00000171453.13679.66960470.832100.529506.131405.28340HepG2PCBP1
POLR1CENSG00000171453.13320.41870433.90100-0.437403.044302.27480HepG2PPIL4
POLR1CENSG00000171453.13500.61750680.76170-0.443403.394302.74300HepG2PUF60
POLR1CENSG00000171453.131027.79180722.636300.508108.002607.10300HepG2PUM1
POLR1CENSG00000171453.13666.29230421.864800.659303.099902.35640HepG2RAVER1
POLR1CENSG00000171453.131113.62390730.928600.607408.883008.07620HepG2RBM22
POLR1CENSG00000171453.13348.09800470.89710-0.435902.523701.87650HepG2RBM25
POLR1CENSG00000171453.13544.29160690.15240-0.342502.211601.59190HepG2RPLP0
POLR1CENSG00000171453.13278.89680414.37600-0.571202.610701.69110HepG2RPS10
POLR1CENSG00000171453.13383.51710223.724300.777505.875305.01890HepG2RPS19
POLR1CENSG00000171453.13626.42640404.137900.632203.906502.99200HepG2RRP9
POLR1CENSG00000171453.13286.87460433.23610-0.594705.400004.55250HepG2SAFB2
POLR1CENSG00000171453.13326.96640224.499100.542302.771001.83090HepG2SERBP1
POLR1CENSG00000171453.13874.40220357.236601.291307.737706.56970HepG2SF3A3
POLR1CENSG00000171453.13436.55960652.69850-0.580207.214606.16480HepG2SLBP
POLR1CENSG00000171453.13985.59780825.550300.255502.209101.74560HepG2SRFBP1
POLR1CENSG00000171453.13784.33070520.630300.591107.552306.86130HepG2SRSF1
POLR1CENSG00000171453.13396.37460629.39620-0.667108.295507.20200HepG2SRSF7
POLR1CENSG00000171453.13603.60380716.76150-0.247901.865501.42290HepG2SSB
POLR1CENSG00000171453.13194.88550301.47300-0.629403.645402.57680HepG2SUPT6H
POLR1CENSG00000171453.13372.91320527.34010-0.499902.845302.15990HepG2SUPV3L1
POLR1CENSG00000171453.13577.18590468.056900.302302.052001.55620HepG2TAF15
POLR1CENSG00000171453.13527.25390381.970200.464902.522701.92080HepG2U2AF1
POLR1CENSG00000171453.13449.93930311.493800.530403.002402.21450HepG2UCHL5
POLR1CENSG00000171453.13883.93700305.872101.5309041.0013039.09540HepG2UTP3
POLR1CENSG00000171453.13483.37200348.435200.472104.246903.60810HepG2ZNF622
POLR1CENSG00000171453.131036.60840654.370500.6636010.728009.70400K562AGGF1
POLR1CENSG00000171453.131052.34720680.894600.628006.891705.82260K562AKAP8L
POLR1CENSG00000171453.134211.024001708.682101.3012036.3920034.47100K562AQR
POLR1CENSG00000171453.13870.81470714.408200.285502.145401.34820K562ATP5C1
POLR1CENSG00000171453.13915.681901149.24680-0.327803.623302.51870K562BCLAF1
POLR1CENSG00000171453.13623.22320832.01620-0.416902.379701.57680K562BOP1
POLR1CENSG00000171453.13673.11400884.72240-0.394402.037501.35630K562CPSF6
POLR1CENSG00000171453.131547.321701254.451700.302603.545502.82020K562DDX47
POLR1CENSG00000171453.131205.76210732.738400.7185012.8030010.60960K562DKC1
POLR1CENSG00000171453.131218.85820971.048100.327802.349801.51000K562EFTUD2
POLR1CENSG00000171453.131077.151801438.45250-0.417305.520704.55630K562EIF2S2
POLR1CENSG00000171453.131062.03800671.104400.662109.387007.92260K562EIF3G
POLR1CENSG00000171453.13695.95370538.889700.368902.632401.37660K562EWSR1
POLR1CENSG00000171453.13658.53320900.08630-0.450802.653101.81640K562FMR1
POLR1CENSG00000171453.13582.22140762.86190-0.389902.257701.43650K562FTO
POLR1CENSG00000171453.131160.03720642.031800.8534016.9148015.53230K562FXR1
POLR1CENSG00000171453.132269.241301916.870700.243401.956501.31500K562GRSF1
POLR1CENSG00000171453.13500.43410789.65220-0.658003.957703.25940K562HNRNPC
POLR1CENSG00000171453.131482.918301026.473500.530603.455002.40400K562HNRNPM
POLR1CENSG00000171453.13978.306201203.52790-0.298902.684301.80530K562HNRNPU
POLR1CENSG00000171453.13922.35940722.625700.352002.332101.58420K562KIF1C
POLR1CENSG00000171453.131198.52820869.852500.462304.678703.57900K562MAGOH
POLR1CENSG00000171453.13884.60590567.412300.640504.362403.17860K562NAA15
POLR1CENSG00000171453.13846.51060993.76330-0.231402.215501.54030K562NSUN2
POLR1CENSG00000171453.131129.74270773.900900.545705.540804.14900K562PCBP2
POLR1CENSG00000171453.131760.601801416.698600.313402.429701.66460K562PPIG
POLR1CENSG00000171453.131731.79630944.937600.8739013.4159011.75520K562PRPF8
POLR1CENSG00000171453.131333.24860675.314300.9812014.4076013.20860K562PUS1
POLR1CENSG00000171453.13863.62330657.947600.392303.439502.79050K562RBM15
POLR1CENSG00000171453.131144.26020810.229200.497904.801603.65890K562RBM22
POLR1CENSG00000171453.131158.96710774.442000.581506.623604.95720K562SAFB
POLR1CENSG00000171453.131186.75330704.453800.7523012.5017010.60160K562SF3B4
POLR1CENSG00000171453.131427.52370828.548800.7848012.9512011.41960K562SRSF1
POLR1CENSG00000171453.131415.37120871.840000.6989011.372409.71880K562SYNCRIP
POLR1CENSG00000171453.13950.35640656.757300.533004.056502.67930K562U2AF1
POLR1CENSG00000171453.131022.00170678.163400.591607.560406.22950K562U2AF2
POLR1CENSG00000171453.13598.01520968.42690-0.695506.822505.14380K562UCHL5
POLR1CENSG00000171453.13840.268401053.70560-0.326503.632502.81760K562UPF1
POLR1CENSG00000171453.13621.46760901.62710-0.536905.510404.25520K562WDR3
POLR1CENSG00000171453.131409.523301925.12020-0.449703.295502.34420K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLR1C is not available on ENCORE database.





29 RBPs can affect the splicing of POLR1C :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLR1CENSG00000171453.13chr6+434880124348816543487803434879234348836243488512-0.063000.000160.00862excludedK562PRPF8
SEPOLR1CENSG00000171453.13chr6+434880124348825743487746434879234348836243488512-0.053000.000030.00062excludedK562AQR
A3SSPOLR1CENSG00000171453.13chr6+4348889443489055434889194348905543488622434887860.218000.000000.00000longerK562AQR
A3SSPOLR1CENSG00000171453.13chr6+4348778243487906434878034348790643487417434875760.067000.000000.00000longerK562AQR
A5SSPOLR1CENSG00000171453.13chr6+4348744343487643434874434348757643487803434879230.165000.000000.00000longerK562PUS1
A5SSPOLR1CENSG00000171453.13chr6+4348707043487319434870704348717843487443434876430.239000.000000.00000longerK562AQR
A5SSPOLR1CENSG00000171453.13chr6+4348802243488257434880224348816543488362434885120.085000.000000.00000longerK562AQR
A5SSPOLR1CENSG00000171453.13chr6+4348744343487643434874434348757643487803434879060.283000.000000.00000longerK562AQR
A5SSPOLR1CENSG00000171453.13chr6+4348744343487643434874434348757643487803434879230.077000.000000.00041longerK562AGGF1
A5SSPOLR1CENSG00000171453.13chr6+4348744343487643434874434348757643487803434879230.120000.000330.03114longerHepG2SF3B4
A5SSPOLR1CENSG00000171453.13chr6+4348744343487643434874434348757643487803434879230.069000.000000.00096longerK562UTP18
A5SSPOLR1CENSG00000171453.13chr6+434874434348764343487443434875764348780343487923-0.093000.000000.00053shorterK562SRSF1
A5SSPOLR1CENSG00000171453.13chr6+4348744343487643434874434348757643487803434879230.074000.000000.00012longerK562AKAP8L
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.152000.000000.00015includedK562SF3B4
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348764343487803434879230.216000.001060.05775includedK562DROSHA
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.221000.000000.00000includedK562PUS1
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.350000.000000.00000includedK562PUS1
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.070000.000110.00226includedHepG2SF3A3
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.065000.003370.03670includedHepG2SF3A3
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.138000.000400.07292includedK562IGF2BP2
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.122000.004710.08451includedHepG2UCHL5
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.056000.002320.06773includedHepG2TIA1
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.118000.002840.07729includedHepG2TIA1
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.078000.000750.01161includedHepG2PRPF8
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.166000.000160.00324includedHepG2PRPF8
RIPOLR1CENSG00000171453.13chr6+434874434348792343487443434875764348780343487923-0.093000.000120.00480excludedK562SRSF1
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.077000.000000.00006includedK562AGGF1
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.170000.000000.00000includedK562AGGF1
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.064000.001100.01577includedK562PRPF8
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.085000.002390.02957includedK562PRPF8
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.056000.000070.00337includedHepG2FTO
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.114000.001200.01537includedHepG2QKI
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.137000.000290.00942includedK562RBM22
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.104000.000000.00000includedK562AKAP8L
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.142000.000000.00000includedK562AKAP8L
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.062000.001150.01345includedHepG2TAF15
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.092000.010200.07786includedHepG2TAF15
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.077000.000010.00014includedK562RBM15
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.113000.000000.00001includedK562RBM15
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.119000.001230.02346includedHepG2G3BP1
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.086000.005760.07898includedK562U2AF1
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.136000.000510.01493includedHepG2KHSRP
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.082000.000370.03755includedK562XRCC6
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.105000.000740.01225includedK562U2AF2
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.086000.000020.00038includedHepG2SF3B4
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.190000.000000.00003includedHepG2SF3B4
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.131000.000210.00360includedHepG2HNRNPK
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.117000.000000.00001includedK562UTP18
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.148000.000000.00000includedK562UTP18
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.084000.000080.00144includedK562EFTUD2
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.202000.000000.00000includedK562AQR
RIPOLR1CENSG00000171453.13chr6+4348744343487923434874434348757643487803434879230.387000.000000.00000includedK562AQR
RIPOLR1CENSG00000171453.13chr6+4348744343488165434874434348792343488012434881650.064000.002160.06465includedHepG2XRN2
MXEPOLR1CENSG00000171453.13chr6+43488362434885124348866943488786434878034348792343488919434892640.070000.000010.000191includedK562AQR
MXEPOLR1CENSG00000171453.13chr6+4348801243488165434883624348851243487803434879234348866943488786-0.093000.003420.026102includedK562AQR
MXEPOLR1CENSG00000171453.13chr6+4348801243488165434883274348851243487775434879234348866943488786-0.085000.005780.040652includedK562AQR
MXEPOLR1CENSG00000171453.13chr6+4348801243488165434883394348851243487775434879234348866943488786-0.087000.004840.034902includedK562AQR
MXEPOLR1CENSG00000171453.13chr6+4348802243488165434883624348847143487782434879234348866943488786-0.698000.006650.045532includedK562AQR
MXEPOLR1CENSG00000171453.13chr6+4348805343488165434883624348847143487803434879234348866943488786-0.654000.004810.034712includedK562AQR
MXEPOLR1CENSG00000171453.13chr6+43488012434881654348836243488512434878034348792343488669434887860.137000.002210.071881includedHepG2BCCIP
MXEPOLR1CENSG00000171453.13chr6+43488012434881654348836243488512434878034348792343488669434887860.199000.000050.002421includedHepG2DDX55
MXEPOLR1CENSG00000171453.13chr6+43488012434881654348836243488512434878034348792343488669434887860.120000.005800.089411includedK562SUPV3L1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLR1C is not avaliable on ENCORE database.