NEK4

General Information

Gene Name       : NEK4
Gene ID             : ENSG00000114904.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: NEK4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NEK4ENSG00000114904.1210.0512.9711.51ENCSR000AEF
HepG2NEK4ENSG00000114904.1214.6517.7016.18ENCSR985KAT
K562NEK4ENSG00000114904.129.5811.1510.37ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NEK4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • NEK4 RNA is bound by 2 proteins.  







eCLIP assay for NEK4 is not avaliable on ENCORE database.





2 proteins are bound to NEK4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr35277735052777456-CDS,intron-Distal,intron-Proximal3.402244.41784HepG2GRWD1
chr35280023852800320-CDS,intron-Distal,intron-Proximal3.676665.97823HepG2BCLAF1
chr35279995952800005-CDS,intron-Distal3.791075.06180HepG2BCLAF1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NEK4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NEK4 is not available on ENCORE database.

  • 85 RBPs can affect the levels of NEK4.  








The Knockdown/knockout RNA-Seq assay for NEK4 is not available on ENCORE database.





85 RBPs can affect the gene expression of NEK4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NEK4ENSG00000114904.8369.39240624.63510-0.757904.286702.19390HepG2AARS
NEK4ENSG00000114904.81175.18350830.154800.501304.069402.94130HepG2ABCF1
NEK4ENSG00000114904.8425.48430705.40770-0.7294011.1366010.08850HepG2ACO1
NEK4ENSG00000114904.8696.473601006.49570-0.531207.498506.45830HepG2AUH
NEK4ENSG00000114904.8385.81780637.29350-0.724004.806203.56930HepG2BCCIP
NEK4ENSG00000114904.8892.75690692.002700.367402.573901.99370HepG2BOP1
NEK4ENSG00000114904.8378.93600705.34600-0.8964016.3115014.98250HepG2CKAP4
NEK4ENSG00000114904.8470.94850734.46910-0.641103.542502.67040HepG2CNOT7
NEK4ENSG00000114904.8516.34990683.80070-0.405202.628301.55060HepG2CPSF7
NEK4ENSG00000114904.8679.82520851.46060-0.324802.751302.10990HepG2CELF1
NEK4ENSG00000114904.8800.88220522.664000.615605.822504.87860HepG2DDX21
NEK4ENSG00000114904.8656.43310511.274100.360502.328301.49730HepG2DDX24
NEK4ENSG00000114904.8262.72930626.57470-1.2539012.6553011.14690HepG2DDX55
NEK4ENSG00000114904.8508.91620822.64650-0.692805.353604.52040HepG2DDX6
NEK4ENSG00000114904.8323.37240477.31640-0.561702.979002.04590HepG2EIF3D
NEK4ENSG00000114904.8703.75210493.443100.512104.453903.11840HepG2EIF3G
NEK4ENSG00000114904.8465.64310851.00190-0.869906.817105.76880HepG2EIF4B
NEK4ENSG00000114904.81476.501501155.628100.353404.332503.60950HepG2ETF1
NEK4ENSG00000114904.8264.15070424.99910-0.686104.412503.27160HepG2GEMIN5
NEK4ENSG00000114904.8397.28400679.85360-0.775105.248403.71170HepG2GRSF1
NEK4ENSG00000114904.8223.16710609.70350-1.4500020.4886019.00810HepG2HNRNPA1
NEK4ENSG00000114904.8570.31840841.38970-0.561007.019205.64950HepG2HNRNPA2B1
NEK4ENSG00000114904.8348.97190678.18080-0.9586010.882609.58530HepG2HNRNPC
NEK4ENSG00000114904.8471.53820833.95520-0.8226015.6073014.12440HepG2HNRNPL
NEK4ENSG00000114904.8588.92780937.25610-0.670405.025203.38400HepG2HSPD1
NEK4ENSG00000114904.8371.65240688.15970-0.8888017.1034015.46430HepG2ILF2
NEK4ENSG00000114904.8607.57060836.40100-0.461102.461301.52620HepG2KHSRP
NEK4ENSG00000114904.8520.42260644.88810-0.309402.632901.63590HepG2KIF1C
NEK4ENSG00000114904.8451.82560637.47030-0.496602.950401.77940HepG2LARP7
NEK4ENSG00000114904.8294.44050499.57960-0.762703.788402.56400HepG2METAP2
NEK4ENSG00000114904.8697.41240908.00140-0.380702.207201.63970HepG2NCBP2
NEK4ENSG00000114904.8697.19110907.82000-0.380903.414902.56920HepG2NOL12
NEK4ENSG00000114904.8486.44870666.84690-0.455104.412403.37240HepG2PARN
NEK4ENSG00000114904.8565.68160777.73850-0.459305.047604.26520HepG2PCBP1
NEK4ENSG00000114904.8479.31370600.88440-0.326102.314101.63330HepG2PPIL4
NEK4ENSG00000114904.8840.97740642.036000.389303.833402.93630HepG2PRPF4
NEK4ENSG00000114904.8642.46230791.37230-0.300702.315601.80680HepG2PTBP1
NEK4ENSG00000114904.8708.52280919.93850-0.376704.486903.77150HepG2PUM1
NEK4ENSG00000114904.8715.66890919.26290-0.361202.951802.25830HepG2PUM2
NEK4ENSG00000114904.8736.90940965.88370-0.390404.001003.40770HepG2RBM22
NEK4ENSG00000114904.8499.98060768.65440-0.620503.498702.37600HepG2RBM27
NEK4ENSG00000114904.81139.09410880.726200.371003.993203.36500HepG2NELFE
NEK4ENSG00000114904.8968.53180636.293400.606003.651302.56690HepG2RPS10
NEK4ENSG00000114904.8344.04480464.41740-0.432802.518501.92960HepG2RPS19
NEK4ENSG00000114904.8347.65040478.23700-0.460102.056801.36920HepG2RRP9
NEK4ENSG00000114904.8873.76340680.268500.361002.394001.73590HepG2SF3B1
NEK4ENSG00000114904.8535.19790699.65420-0.386603.985603.23570HepG2SMN1
NEK4ENSG00000114904.8483.10800660.38230-0.451002.322501.45360HepG2SMNDC1
NEK4ENSG00000114904.8671.63720855.64680-0.349303.298102.62500HepG2SRSF5
NEK4ENSG00000114904.8644.24780772.99120-0.262801.941401.45710HepG2TAF15
NEK4ENSG00000114904.8239.37350418.10950-0.804605.280403.96660HepG2TFIP11
NEK4ENSG00000114904.8929.64810654.628800.505905.427204.77460HepG2TIAL1
NEK4ENSG00000114904.8404.23150660.47420-0.708309.727808.76850HepG2TRIM56
NEK4ENSG00000114904.8534.41110717.17750-0.424402.664902.04740HepG2U2AF1
NEK4ENSG00000114904.8643.80830896.16090-0.477103.009602.13760HepG2UBE2L3
NEK4ENSG00000114904.8212.87230368.50030-0.791705.333004.27360HepG2UCHL5
NEK4ENSG00000114904.8948.37310783.750700.275002.302901.74520HepG2UTP3
NEK4ENSG00000114904.8365.25250614.03490-0.749405.579604.56240HepG2XRN2
NEK4ENSG00000114904.8934.78200633.629700.560904.403903.58770HepG2ZC3H8
NEK4ENSG00000114904.8351.57540538.34510-0.614706.092405.30190K562AGGF1
NEK4ENSG00000114904.8387.95310560.16190-0.530003.989403.20310K562AKAP8L
NEK4ENSG00000114904.81003.64880779.432300.364702.680101.45920K562APOBEC3C
NEK4ENSG00000114904.8445.81710587.72460-0.398703.149102.17120K562ATP5C1
NEK4ENSG00000114904.8436.08130731.20540-0.745706.393904.09880K562CKAP4
NEK4ENSG00000114904.8536.15060669.33120-0.320102.128201.54490K562DDX47
NEK4ENSG00000114904.8473.33430606.14850-0.356802.123201.37660K562FIP1L1
NEK4ENSG00000114904.8609.81610352.495600.790709.625908.57830K562FXR1
NEK4ENSG00000114904.8509.60900773.14750-0.601402.745401.99180K562GRSF1
NEK4ENSG00000114904.8253.99930459.31410-0.854708.501806.71340K562HNRNPA1
NEK4ENSG00000114904.8185.09280398.67990-1.1070010.332109.23890K562HNRNPC
NEK4ENSG00000114904.8396.83970508.65030-0.358102.283601.47060K562HNRNPU
NEK4ENSG00000114904.8633.65320821.82720-0.375102.443501.69230K562HSPD1
NEK4ENSG00000114904.8418.32560594.50900-0.507103.743002.76370K562KIF1C
NEK4ENSG00000114904.8177.27180355.89400-1.005506.221304.76140K562KRR1
NEK4ENSG00000114904.8398.62490569.06120-0.513603.978702.61580K562MAK16
NEK4ENSG00000114904.8708.47910941.53800-0.410302.875001.71860K562MSI2
NEK4ENSG00000114904.8403.01250505.11490-0.325802.133301.41770K562MTPAP
NEK4ENSG00000114904.8406.89340561.26620-0.464004.266403.36180K562NSUN2
NEK4ENSG00000114904.8266.05500454.75930-0.773403.011601.96940K562PABPN1
NEK4ENSG00000114904.8470.02800688.07930-0.549804.454503.37780K562PPIG
NEK4ENSG00000114904.81276.65500963.772500.405503.384502.48180K562PUF60
NEK4ENSG00000114904.8374.35530555.60290-0.569603.946203.31420K562PUS1
NEK4ENSG00000114904.8385.92920541.28830-0.488103.912003.22390K562RBM15
NEK4ENSG00000114904.8211.84240347.41300-0.713703.815602.21460K562RBM25
NEK4ENSG00000114904.8433.66930553.76970-0.352702.516901.73650K562SF3A3
NEK4ENSG00000114904.8256.27840380.80770-0.571403.233302.30730K562SF3B4
NEK4ENSG00000114904.8329.34000469.49240-0.511503.541302.74870K562SRSF1
NEK4ENSG00000114904.8318.81930443.37680-0.475802.863401.79330K562SRSF5
NEK4ENSG00000114904.8321.78160429.28210-0.415802.922601.71860K562SRSF7
NEK4ENSG00000114904.8554.65660396.723800.483403.777002.81690K562SYNCRIP
NEK4ENSG00000114904.8342.60570475.17730-0.471902.825602.11170K562TARDBP
NEK4ENSG00000114904.8247.46490365.18570-0.561403.238202.19640K562TRIM56
NEK4ENSG00000114904.8230.17070355.05410-0.625303.332402.10900K562U2AF1
NEK4ENSG00000114904.8254.59420390.25110-0.616202.256901.34640K562UCHL5
NEK4ENSG00000114904.8476.51730595.11940-0.320702.377401.70910K562UPF1
NEK4ENSG00000114904.8606.35020822.55340-0.440003.604702.59450K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NEK4 is not available on ENCORE database.





3 RBPs can affect the splicing of NEK4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SENEK4ENSG00000114904.8chr3-527948105279495252785947527863525279748552797698-0.248000.000340.00487excludedK562AQR
SENEK4ENSG00000114904.8chr3-527754265277554352773444527736505277825452778321-0.337000.000000.00002excludedK562AQR
SENEK4ENSG00000114904.8chr3-5278134552781467527807495278092052783707527838450.338000.000810.03266includedHepG2HNRNPC
SENEK4ENSG00000114904.8chr3-5278134552781467527807495278092052783707527838450.692000.000000.00009includedK562HNRNPC
A3SSNEK4ENSG00000114904.8chr3-5279748552797698527974855279764052799902528000920.081000.017200.08390longerK562AQR
A3SSNEK4ENSG00000114904.8chr3-5277542652775543527754265277551552777367527774770.113000.019220.09218longerK562AQR
A3SSNEK4ENSG00000114904.8chr3-5277344452773669527734445277365052775426527755430.136000.000000.00003longerK562AQR
MXENEK4ENSG00000114904.8chr3-5277542652775515527773675277747752773444527736505277825452778321-0.699000.000670.021182includedK562FXR2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NEK4 is not avaliable on ENCORE database.