MED8

General Information

Gene Name       : MED8
Gene ID             : ENSG00000159479.16
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: MED8)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MED8ENSG00000159479.1624.7325.5625.14ENCSR000AEF
HepG2MED8ENSG00000159479.1636.2335.9336.08ENCSR985KAT
K562MED8ENSG00000159479.1639.9740.5740.27ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MED8 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MED8 RNA is bound by 12 proteins.  







eCLIP assay for MED8 is not avaliable on ENCORE database.





12 proteins are bound to MED8 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr14384973843849798-3'-UTR,intron-Distal3.373039.82186K562UPF1
chr14385053943850724-3'-UTR,CDS,intron-Distal,intron-Proximal3.880936.31568HepG2LARP4
chr14385023743850272-3'-UTR,intron-Distal4.477917.83400K562UPF1
chr14384964643849699-3'-UTR,intron-Distal3.489208.00041K562UPF1
chr14385036743850414-3'-UTR,intron-Distal,intron-Proximal,polyA_site4.5377014.74404K562UPF1
chr14385042843850569-3'-UTR,intron-Distal4.083278.33109K562CPSF6
chr14385017443850223-3'-UTR,CDS,intron-Distal3.359773.38753K562FAM120A
chr14385016843850209-3'-UTR,CDS,intron-Distal4.063613.86978K562YBX3
chr14385028943850366-3'-UTR,intron-Distal,intron-Proximal4.100847.04160K562FAM120A
chr14385015243850237-3'-UTR,CDS,intron-Distal3.8325918.51029K562UPF1
chr14384986043849920-3'-UTR,intron-Distal4.0694616.21043K562UPF1
chr14385024343850289-3'-UTR,intron-Distal3.317323.37207K562FAM120A
chr14385055143850619-3'-UTR,intron-Distal,intron-Proximal3.864349.89108K562YBX3
chr14385029543850367-3'-UTR,intron-Distal,intron-Proximal3.5397015.92790K562UPF1
chr14385403743854157-5'-UTR,CDS,intron-Distal,intron-Proximal4.574993.59236HepG2AQR
chr14385397843854020-5'-UTR,CDS,intron-Distal,intron-Proximal3.668133.12746HepG2GRWD1
chr14385400243854076-5'-UTR,CDS,intron-Distal4.1968822.48532K562DDX3X
chr14385317343853212-5'-UTR,CDS,intron-Distal,intron-Proximal3.223453.32039HepG2PPIG
chr14385535843855467-5'-UTR,CDS,intron-Distal,intron-Proximal4.141203.45994HepG2NCBP2
chr14385407643854101-5'-UTR,CDS,intron-Distal,intron-Proximal3.9711911.03451K562DDX3X
chr14385542943855468-5'-UTR,CDS,intron-Distal,intron-Proximal4.198477.22925K562DDX3X
chr14385397743854024-5'-UTR,CDS,intron-Distal,intron-Proximal4.223454.08604HepG2PPIG
chr14385252543852557-CDS,intron-Distal,intron-Proximal4.034624.21087HepG2GRWD1
chr14385252843852554-CDS,intron-Distal,intron-Proximal3.870763.57722K562DDX24
chr14385176843851822-CDS,intron-Distal3.018216.18483K562YBX3
chr14385252743852622-CDS,intron-Distal,intron-Proximal3.7586410.86690HepG2PPIG
chr14385255443852637-CDS,intron-Distal,intron-Proximal3.198025.33841K562DDX24
chr14385157543851649-intron-Distal,intron-Proximal5.090315.17615K562AQR
chr14385507543855300-intron-Distal3.423245.59141HepG2PRPF4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MED8 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MED8 is not available on ENCORE database.

  • 75 RBPs can affect the levels of MED8.  








The Knockdown/knockout RNA-Seq assay for MED8 is not available on ENCORE database.





75 RBPs can affect the gene expression of MED8 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MED8ENSG00000159479.12565.76380954.37250-0.754406.422605.64940HepG2AKAP1
MED8ENSG00000159479.12619.26040789.65590-0.350701.983601.31450HepG2ASCC1
MED8ENSG00000159479.12986.03140750.229800.394202.633901.87830HepG2CIRBP
MED8ENSG00000159479.12452.16910627.58710-0.473002.037701.38700HepG2CNOT7
MED8ENSG00000159479.121163.54000897.801100.374004.346103.57320HepG2CELF1
MED8ENSG00000159479.12378.65170550.48960-0.539803.949003.15200HepG2DDX21
MED8ENSG00000159479.12499.02010914.20110-0.873409.317908.22790HepG2DDX3X
MED8ENSG00000159479.12396.48140614.90510-0.633104.120503.19700HepG2DDX55
MED8ENSG00000159479.12965.64920754.943800.355002.112601.58690HepG2EIF2S1
MED8ENSG00000159479.12578.76440952.37650-0.7186011.6298010.14900HepG2EIF4G1
MED8ENSG00000159479.12443.04010582.02760-0.393702.324001.31830HepG2ESF1
MED8ENSG00000159479.12268.55120435.65380-0.698002.202101.30460HepG2FTO
MED8ENSG00000159479.12700.04580887.16570-0.341803.084002.10390HepG2HNRNPA2B1
MED8ENSG00000159479.12324.41460470.51680-0.536403.121402.45760HepG2HNRNPLL
MED8ENSG00000159479.12488.34790798.37780-0.709205.132203.72670HepG2KHSRP
MED8ENSG00000159479.12528.11760733.65610-0.474202.581101.78050HepG2LARP4
MED8ENSG00000159479.12501.12840866.74950-0.790407.579106.55590HepG2NCBP2
MED8ENSG00000159479.12757.15570957.19250-0.338202.817402.04630HepG2NOL12
MED8ENSG00000159479.12307.78420417.18780-0.438802.103501.44750HepG2NSUN2
MED8ENSG00000159479.12591.77130771.86470-0.383302.232301.57890HepG2PABPC4
MED8ENSG00000159479.12636.19220801.74810-0.333703.097102.46050HepG2PCBP1
MED8ENSG00000159479.12650.01240883.56790-0.442904.322003.56610HepG2QKI
MED8ENSG00000159479.12804.81730537.160400.583202.721102.02180HepG2RAVER1
MED8ENSG00000159479.12757.692401002.25530-0.403603.851803.26710HepG2RBM22
MED8ENSG00000159479.12577.51840907.90950-0.652709.521808.62710HepG2NELFE
MED8ENSG00000159479.12609.49110845.55560-0.472305.405604.58010HepG2RECQL
MED8ENSG00000159479.12353.31810465.73080-0.398501.994101.38980HepG2SF3B1
MED8ENSG00000159479.12692.58990849.38150-0.294402.468501.90560HepG2SF3B4
MED8ENSG00000159479.12955.206801132.03310-0.245002.041301.59060HepG2SRFBP1
MED8ENSG00000159479.121091.39980886.551600.299802.790402.31550HepG2SRSF1
MED8ENSG00000159479.12643.59530902.20680-0.487305.843204.98310HepG2SRSF5
MED8ENSG00000159479.12539.69930721.24070-0.418304.422003.75470HepG2SRSF9
MED8ENSG00000159479.12486.47120796.81500-0.711909.572308.63130HepG2TAF15
MED8ENSG00000159479.12343.40540486.06660-0.501204.463903.64260HepG2ZC3H8
MED8ENSG00000159479.12693.20750577.104900.264402.177901.67580HepG2ZNF622
MED8ENSG00000159479.123127.894402546.164300.296804.967304.24370K562AGGF1
MED8ENSG00000159479.123641.298302797.925400.380004.246702.97430K562AKAP8
MED8ENSG00000159479.122841.188302064.933700.460304.850704.11300K562AQR
MED8ENSG00000159479.122143.981401692.880800.340702.941101.61640K562CIRBP
MED8ENSG00000159479.123122.444402547.635500.293402.740501.77000K562CELF1
MED8ENSG00000159479.122325.347702987.34910-0.361403.160501.59200K562DDX19B
MED8ENSG00000159479.121707.710601390.816700.296002.700001.67000K562DDX3X
MED8ENSG00000159479.121738.862301304.916800.414106.600705.65620K562DDX47
MED8ENSG00000159479.121727.754801410.136200.293003.284301.82940K562DDX6
MED8ENSG00000159479.123435.396002850.846600.269003.656402.62970K562DKC1
MED8ENSG00000159479.121796.397801527.829700.233502.592801.43260K562EIF2S1
MED8ENSG00000159479.121589.493301268.450700.325403.433001.96460K562EWSR1
MED8ENSG00000159479.121325.25230942.641800.491404.853103.70710K562FIP1L1
MED8ENSG00000159479.121033.290901511.18360-0.548405.960505.12160K562FXR1
MED8ENSG00000159479.121747.222801409.785000.309502.798401.72110K562HNRNPA1
MED8ENSG00000159479.121939.510701561.183100.313003.509502.50410K562HNRNPU
MED8ENSG00000159479.121828.124801277.960000.516405.644004.52370K562HSPD1
MED8ENSG00000159479.122067.304701579.474800.388202.643901.64770K562IGF2BP2
MED8ENSG00000159479.123393.577202811.629300.271302.863202.02130K562KIF1C
MED8ENSG00000159479.121173.20030843.062200.476602.800401.40420K562LARP7
MED8ENSG00000159479.121280.451301660.02110-0.374503.667902.69240K562MAGOH
MED8ENSG00000159479.123529.905102691.474100.391104.267502.85040K562MAK16
MED8ENSG00000159479.123871.962003149.744100.297702.340701.51580K562MBNL1
MED8ENSG00000159479.121268.603601028.933100.302003.300602.42060K562MTPAP
MED8ENSG00000159479.121748.512601450.949000.269002.478501.31640K562NCBP2
MED8ENSG00000159479.121024.844201423.75730-0.474303.805302.82980K562PCBP3
MED8ENSG00000159479.12777.499501092.09990-0.490205.355104.24280K562POLR2G
MED8ENSG00000159479.121366.562301070.148800.352602.754601.93560K562PPIG
MED8ENSG00000159479.121295.48200880.706200.556705.501704.44200K562PRPF8
MED8ENSG00000159479.121302.558501612.81040-0.308202.798402.13060K562PTBP1
MED8ENSG00000159479.123179.671602627.362500.275202.387001.87450K562PUS1
MED8ENSG00000159479.123102.125502560.079300.277003.434802.78610K562RBM15
MED8ENSG00000159479.121953.082201361.634400.520306.742904.56860K562RBM25
MED8ENSG00000159479.121034.134001627.46070-0.654207.743305.83930K562NELFE
MED8ENSG00000159479.121784.29820897.144800.9918013.8527011.99910K562RPS19
MED8ENSG00000159479.121264.225801636.09220-0.372002.647001.66890K562RPS3
MED8ENSG00000159479.121225.97050900.536000.445002.674401.36720K562RRP9
MED8ENSG00000159479.122456.900301470.161300.740802.969901.70840K562SF1
MED8ENSG00000159479.121331.740601128.107200.239302.242501.50240K562SF3A3
MED8ENSG00000159479.121217.975701579.34220-0.374803.542202.32940K562SRSF4
MED8ENSG00000159479.121243.105201001.859600.311202.785301.50370K562SSB
MED8ENSG00000159479.121876.665201391.499500.431403.251702.04530K562U2AF1
MED8ENSG00000159479.121892.134701437.310100.396504.677403.63900K562U2AF2
MED8ENSG00000159479.12978.780501212.15150-0.308503.105702.34580K562UPF1
MED8ENSG00000159479.121310.801801037.193600.337702.944702.04220K562WDR3
MED8ENSG00000159479.121296.657201078.603500.265503.043602.15710K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MED8 is not available on ENCORE database.





8 RBPs can affect the splicing of MED8 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMED8ENSG00000159479.12chr1-438539804385408443853173438533184385542943855479-0.056000.001230.02479excludedK562SF3B4
A3SSMED8ENSG00000159479.12chr1-438531734385331843853173438533004385398043854084-0.052000.000440.02695shorterK562SF3B4
A3SSMED8ENSG00000159479.12chr1-4385222343852450438522234385234143852528438526690.063000.000000.00000longerK562AQR
RIMED8ENSG00000159479.12chr1-4385164843852341438516484385189743852259438523410.177000.000950.04651includedHepG2SFPQ
RIMED8ENSG00000159479.12chr1-4385164843852341438516484385189743852259438523410.083000.000250.03942includedK562DDX55
RIMED8ENSG00000159479.12chr1-4385164843852341438516484385189743852259438523410.096000.000000.00000includedK562PUS1
RIMED8ENSG00000159479.12chr1-4385164843852341438516484385189743852259438523410.123000.000390.00623includedHepG2SF3A3
RIMED8ENSG00000159479.12chr1-4385164843852341438516484385189743852259438523410.114000.000000.00141includedK562TAF15
RIMED8ENSG00000159479.12chr1-4385164843852341438516484385189743852259438523410.089000.000040.00956includedHepG2DDX55
RIMED8ENSG00000159479.12chr1-4385164843852341438516484385189743852259438523410.058000.000000.00008includedK562UTP18
RIMED8ENSG00000159479.12chr1-4385164843852341438516484385189743852259438523410.081000.000000.00000includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MED8 is not avaliable on ENCORE database.