ERCC8

General Information

Gene Name       : ERCC8
Gene ID             : ENSG00000049167.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: ERCC8)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878ERCC8ENSG00000049167.1410.829.4610.14ENCSR000AEF
HepG2ERCC8ENSG00000049167.1411.7020.0615.88ENCSR985KAT
K562ERCC8ENSG00000049167.1413.8313.7013.77ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for ERCC8 is not avaliable on ENCORE database.



Proteins bound to RNA
  • ERCC8 RNA is bound by 9 proteins.  







eCLIP assay for ERCC8 is not avaliable on ENCORE database.





9 proteins are bound to ERCC8 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr56018684460186879-3'-UTR,CDS,intron-Distal4.198863.38968HepG2BCLAF1
chr56019411660194176-3'-UTR,CDS,intron-Distal,intron-Proximal3.399054.34695HepG2BCLAF1
chr56019545060195528-3'-UTR,CDS,intron-Distal,intron-Proximal3.083555.35431HepG2BCLAF1
chr56021792560217979-5'-UTR,CDS,intron-Distal3.083203.17233HepG2BCLAF1
chr56021415860214215-5'-UTR,CDS,intron-Distal3.144983.85381HepG2BCLAF1
chr56021392660214095-5'-UTR,CDS,intron-Distal,intron-Proximal4.591955.33214K562PRPF8
chr56021787760217925-5'-UTR,CDS,intron-Distal,intron-Proximal3.588874.74886HepG2BCLAF1
chr56022859260228674-intron-Distal3.214823.30286HepG2PTBP1
chr56022859760228711-intron-Distal5.081486.57498HepG2PCBP2
chr56022395660224077-intron-Distal4.038913.48210HepG2HNRNPL
chr56021056060210619-intron-Distal4.129994.37667K562SAFB2
chr56021259660212722-intron-Distal5.3479010.09004HepG2QKI
chr56021040760210461-intron-Distal3.267573.34920HepG2HLTF
chr56018698860187087-intron-Distal,intron-Proximal3.953133.90026K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for ERCC8 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for ERCC8 is not available on ENCORE database.

  • 77 RBPs can affect the levels of ERCC8.  








The Knockdown/knockout RNA-Seq assay for ERCC8 is not available on ENCORE database.





77 RBPs can affect the gene expression of ERCC8 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
ERCC8ENSG00000049167.9370.44250496.94330-0.423801.909301.45780HepG2AKAP1
ERCC8ENSG00000049167.9208.54470311.19710-0.577503.882102.98610HepG2AKAP8L
ERCC8ENSG00000049167.9385.73190552.54670-0.518504.815903.95180HepG2AUH
ERCC8ENSG00000049167.9380.13250265.713000.516501.986001.34240HepG2CNOT7
ERCC8ENSG00000049167.9157.40870240.48980-0.611502.660001.57680HepG2CPSF7
ERCC8ENSG00000049167.9288.71460421.50350-0.545904.117903.36390HepG2CELF1
ERCC8ENSG00000049167.9128.48840283.12740-1.139808.901507.75620HepG2DDX21
ERCC8ENSG00000049167.9183.39660408.92790-1.156909.102108.05100HepG2DDX6
ERCC8ENSG00000049167.9223.81450296.35260-0.405002.042901.44720HepG2DKC1
ERCC8ENSG00000049167.9106.12800278.48320-1.3918015.7224014.29470HepG2DNAJC2
ERCC8ENSG00000049167.9158.33920393.10490-1.3119011.8491010.67470HepG2EIF2S1
ERCC8ENSG00000049167.9126.11420201.01600-0.672602.520901.65350HepG2EIF3D
ERCC8ENSG00000049167.9320.68080434.42360-0.438002.098001.53890HepG2EIF4A3
ERCC8ENSG00000049167.9227.55360422.97910-0.894405.332104.39850HepG2EIF4B
ERCC8ENSG00000049167.9217.63940428.31970-0.976708.626207.21900HepG2EIF4G2
ERCC8ENSG00000049167.9501.77010634.39730-0.338402.289601.73390HepG2ETF1
ERCC8ENSG00000049167.9179.65360324.58700-0.853404.781603.33860HepG2FUS
ERCC8ENSG00000049167.9288.55270406.60590-0.494802.507401.87210HepG2G3BP1
ERCC8ENSG00000049167.9218.10570309.07690-0.502902.109801.54640HepG2GPKOW
ERCC8ENSG00000049167.9165.70580315.50970-0.929106.231205.22240HepG2HNRNPC
ERCC8ENSG00000049167.9218.01000412.84250-0.9212010.626409.38530HepG2HNRNPL
ERCC8ENSG00000049167.9194.33420294.95710-0.602002.855002.21670HepG2HNRNPLL
ERCC8ENSG00000049167.9241.33860313.42360-0.377101.968801.44810HepG2HNRNPU
ERCC8ENSG00000049167.9303.82020413.30400-0.444002.195801.58600HepG2IGF2BP2
ERCC8ENSG00000049167.9129.38590320.15140-1.3071016.6602015.03710HepG2ILF2
ERCC8ENSG00000049167.9150.68710242.79840-0.688202.081101.32720HepG2PABPC1
ERCC8ENSG00000049167.9268.09180401.92010-0.584203.341502.55240HepG2PABPC4
ERCC8ENSG00000049167.9210.27140310.23300-0.561103.602202.64780HepG2PARN
ERCC8ENSG00000049167.9177.01380430.02860-1.2806017.9287016.59950HepG2PCBP1
ERCC8ENSG00000049167.9211.12800279.54840-0.405002.005801.36910HepG2PPIL4
ERCC8ENSG00000049167.9152.53110228.68920-0.584302.185501.46480HepG2PRPF8
ERCC8ENSG00000049167.9251.39000437.55450-0.799507.818406.99320HepG2PTBP1
ERCC8ENSG00000049167.9286.85420455.07020-0.665805.419604.49510HepG2PUM2
ERCC8ENSG00000049167.9232.94150315.50990-0.437702.656102.04840HepG2PUS1
ERCC8ENSG00000049167.9311.51170530.23880-0.767408.085907.30850HepG2RBM22
ERCC8ENSG00000049167.9303.74210430.09640-0.501803.261702.53580HepG2RBM25
ERCC8ENSG00000049167.9198.89870291.24900-0.550202.144001.31140HepG2RPS10
ERCC8ENSG00000049167.9120.68400196.32130-0.702002.944201.97250HepG2SERBP1
ERCC8ENSG00000049167.9213.66650325.49470-0.607304.582603.79020HepG2SMN1
ERCC8ENSG00000049167.9338.30070598.88530-0.8240011.4586010.62750HepG2SRFBP1
ERCC8ENSG00000049167.9215.66500314.13000-0.542602.236101.34860HepG2SRSF3
ERCC8ENSG00000049167.9287.33240423.57670-0.559904.430403.67170HepG2SRSF5
ERCC8ENSG00000049167.9213.31490292.40820-0.455002.546901.87680HepG2SRSF7
ERCC8ENSG00000049167.9221.74730386.84620-0.802808.185707.32640HepG2SRSF9
ERCC8ENSG00000049167.9340.97370481.72180-0.498504.233703.49360HepG2SUCLG1
ERCC8ENSG00000049167.9199.27910287.47010-0.528602.437901.75130HepG2TARDBP
ERCC8ENSG00000049167.9179.11420304.54160-0.765805.480004.82470HepG2TIAL1
ERCC8ENSG00000049167.9163.08410307.27250-0.913908.385007.48800HepG2TRIM56
ERCC8ENSG00000049167.969.62010174.32400-1.324207.544906.28890HepG2UCHL5
ERCC8ENSG00000049167.9246.27800319.09840-0.373701.995201.38580HepG2UPF1
ERCC8ENSG00000049167.9159.19380335.94320-1.0774010.124809.12850K562AGGF1
ERCC8ENSG00000049167.9261.17200369.12860-0.499102.943001.91940K562AKAP8
ERCC8ENSG00000049167.9164.72620349.55860-1.085509.509508.21150K562AKAP8L
ERCC8ENSG00000049167.9334.30330551.98850-0.723505.848205.04940K562AQR
ERCC8ENSG00000049167.9259.48600366.76090-0.499203.281202.27990K562ATP5C1
ERCC8ENSG00000049167.9179.31800263.43670-0.554902.429901.61780K562BOP1
ERCC8ENSG00000049167.9153.20400231.67660-0.596703.103701.99410K562DDX3X
ERCC8ENSG00000049167.9162.24350241.32030-0.572802.573001.69610K562EFTUD2
ERCC8ENSG00000049167.9286.08540388.81980-0.442702.314201.64770K562EIF2S2
ERCC8ENSG00000049167.9173.77940284.98640-0.713603.973502.94460K562FMR1
ERCC8ENSG00000049167.9148.39790241.53550-0.702803.445302.41630K562FTO
ERCC8ENSG00000049167.9138.81180267.46860-0.946205.548804.42810K562GPKOW
ERCC8ENSG00000049167.9142.55630218.67820-0.617302.503301.93220K562HNRNPC
ERCC8ENSG00000049167.9208.70150354.93550-0.766105.814804.22510K562HNRNPL
ERCC8ENSG00000049167.9241.56600370.98820-0.619004.334203.27070K562KIF1C
ERCC8ENSG00000049167.9111.68300228.34460-1.031805.005303.70520K562KRR1
ERCC8ENSG00000049167.9240.45250355.11150-0.562503.192502.01340K562MAK16
ERCC8ENSG00000049167.9293.28700415.59780-0.502903.291502.28420K562MBNL1
ERCC8ENSG00000049167.9157.99280261.07280-0.724603.642102.62900K562METAP2
ERCC8ENSG00000049167.9419.17070657.40230-0.649205.235203.68830K562MSI2
ERCC8ENSG00000049167.9193.41700291.30230-0.590802.378701.57440K562NAA15
ERCC8ENSG00000049167.9204.16620310.60500-0.605304.324003.41410K562NSUN2
ERCC8ENSG00000049167.9133.40500235.97860-0.822802.708801.73220K562PABPN1
ERCC8ENSG00000049167.9111.85530196.05090-0.809603.382402.36720K562PSIP1
ERCC8ENSG00000049167.9544.02610701.30870-0.366402.731101.77760K562PUM2
ERCC8ENSG00000049167.9167.77840346.70530-1.047207.943607.07060K562PUS1
ERCC8ENSG00000049167.9158.37360337.77970-1.0928010.079708.97290K562RBM15
ERCC8ENSG00000049167.9147.47430254.31620-0.786203.825302.67040K562SF3B1
ERCC8ENSG00000049167.9138.30700247.84750-0.841602.727301.50930K562SNRNP200
ERCC8ENSG00000049167.9222.93470320.32970-0.522902.826202.11300K562SRSF1
ERCC8ENSG00000049167.9268.56640172.165300.641403.755702.79890K562SYNCRIP
ERCC8ENSG00000049167.9116.80500200.24850-0.777703.538602.44340K562TRIM56
ERCC8ENSG00000049167.9135.41160240.64050-0.829504.399603.08510K562UCHL5
ERCC8ENSG00000049167.9202.40040351.48360-0.796203.321101.86040K562UTP18
ERCC8ENSG00000049167.9380.77350621.84620-0.707606.962205.49420K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for ERCC8 is not available on ENCORE database.





6 RBPs can affect the splicing of ERCC8 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEERCC8ENSG00000049167.9chr5-6022793360227975602246906022478660240758602409000.189000.000010.00155includedK562XRCC6
SEERCC8ENSG00000049167.9chr5-602201176022033560217880602179826022469060224786-0.065000.001960.09160excludedHepG2NCBP2
SEERCC8ENSG00000049167.9chr5-6022011760220256602178806021798260224690602247860.135000.000040.00562includedHepG2HNRNPL
SEERCC8ENSG00000049167.9chr5-601867156018691360183266601833476019410260194227-0.219000.000090.01021excludedHepG2HNRNPL
SEERCC8ENSG00000049167.9chr5-6022793360227975602246906022478660240758602409000.113000.000450.08765includedHepG2FUS
SEERCC8ENSG00000049167.9chr5-6018609960186228601832666018334760186715601869130.303000.002730.04349includedK562HNRNPC
A3SSERCC8ENSG00000049167.9chr5-6019545360195622601954536019555460198268601983350.059000.012510.06403longerK562AQR
A3SSERCC8ENSG00000049167.9chr5-6019826860198414601982686019833560199474601995430.121000.000010.00013longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for ERCC8 is not avaliable on ENCORE database.