VPS35

General Information

Gene Name       : VPS35
Gene ID             : ENSG00000069329.17
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: VPS35)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878VPS35ENSG00000069329.1738.3734.4636.41ENCSR000AEF
HepG2VPS35ENSG00000069329.1743.1076.5859.84ENCSR985KAT
K562VPS35ENSG00000069329.1735.1438.6236.88ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for VPS35 is not avaliable on ENCORE database.



Proteins bound to RNA
  • VPS35 RNA is bound by 18 proteins.  







eCLIP assay for VPS35 is not avaliable on ENCORE database.





18 proteins are bound to VPS35 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr164669395546694010-3'-UTR,intron-Distal3.406654.21971K562TIA1
chr164670623446706311-3'-UTR,CDS,intron-Distal,intron-Proximal3.287863.47314HepG2G3BP1
chr164669255246692648-3'-UTR,intron-Distal5.6836612.33273K562UPF1
chr164670633546706384-3'-UTR,CDS,intron-Distal3.005873.07714K562YBX3
chr164669569546695774-3'-UTR,CDS,intron-Distal,intron-Proximal4.351914.25741HepG2G3BP1
chr164669396946694041-3'-UTR,intron-Distal3.356306.00615HepG2DDX55
chr164670620546706295-3'-UTR,CDS,intron-Distal,intron-Proximal3.022435.29017HepG2BCLAF1
chr164669384346693954-3'-UTR,intron-Distal3.6535316.66015K562FAM120A
chr164669423146694334-3'-UTR,intron-Distal3.119973.90734K562NOLC1
chr164670284146702962-3'-UTR,CDS,intron-Distal,intron-Proximal5.068808.37059HepG2G3BP1
chr164669692446697010-3'-UTR,CDS,intron-Distal4.691545.41965HepG2G3BP1
chr164669405846694096-3'-UTR,intron-Distal4.565009.01592K562PABPC4
chr164671536046715415-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.477445.45876HepG2BCLAF1
chr164670631146706384-3'-UTR,CDS,intron-Distal,intron-Proximal3.542744.97737HepG2G3BP1
chr164669395446694031-3'-UTR,intron-Distal3.072737.98666K562FAM120A
chr164669615246696192-3'-UTR,CDS,intron-Distal,intron-Proximal3.098433.22540HepG2G3BP1
chr164670823546708313-3'-UTR,CDS,intron-Distal3.270926.20049K562YBX3
chr164669421846694293-3'-UTR,intron-Distal4.1505812.43922HepG2SUB1
chr164670558246705686-3'-UTR,CDS,intron-Distal,intron-Proximal5.088364.68690HepG2PRPF8
chr164669411846694195-3'-UTR,intron-Distal3.221085.72056K562IGF2BP1
chr164671528846715343-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.650325.70180K562PUM2
chr164669420546694259-3'-UTR,intron-Distal4.385313.06406HepG2IGF2BP1
chr164669363346693686-3'-UTR,intron-Distal3.9596110.38566K562PUM2
chr164670289946702963-3'-UTR,CDS,intron-Distal3.196623.90824K562YBX3
chr164669255346692601-3'-UTR,intron-Distal3.636044.40891K562FAM120A
chr164671536546715413-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.393184.49055K562YBX3
chr164669429346694335-3'-UTR,intron-Distal3.443068.24811HepG2SUB1
chr164669702146697074-3'-UTR,CDS,intron-Distal3.126903.24162HepG2G3BP1
chr164669215746692240-3'-UTR,intron-Distal4.961153.81167HepG2SUB1
chr164669419546694281-3'-UTR,intron-Distal3.625945.70424K562IGF2BP1
chr164671125546711311-5'-UTR,CDS,intron-Distal,intron-Proximal3.341833.09866HepG2FXR2
chr164671123346711311-5'-UTR,CDS,intron-Distal,intron-Proximal5.386068.18835HepG2G3BP1
chr164671457946714592-5'-UTR,CDS,intron-Distal,intron-Proximal4.217534.72754K562YBX3
chr164671741046717472-5'-UTR,CDS,intron-Distal,intron-Proximal3.915513.38114HepG2GRWD1
chr164671302346713070-5'-UTR,CDS,intron-Distal,intron-Proximal3.525644.29172K562YBX3
chr164671050946710567-5'-UTR,CDS,intron-Distal3.505573.44691K562PUM2
chr164671285546712926-5'-UTR,CDS,intron-Distal4.189886.81811K562UCHL5
chr164671748646717519-5'-UTR,CDS,intron-Distal,intron-Proximal5.5042312.67847K562DDX3X
chr164671285446712940-5'-UTR,CDS,intron-Distal,intron-Proximal3.403178.14900HepG2G3BP1
chr164672297146723058-5'-UTR,CDS,intron-Distal3.783367.77750HepG2PRPF8
chr164672304246723093-5'-UTR,CDS,intron-Distal,intron-Proximal5.7171112.67847K562DDX3X
chr164671050446710575-5'-UTR,CDS,intron-Distal3.799286.16886K562YBX3
chr164671122946711310-5'-UTR,CDS,intron-Distal3.393144.22851HepG2BCLAF1
chr164671049446710509-5'-UTR,CDS,intron-Distal,intron-Proximal4.108793.15625K562PUM2
chr164672140646721504-intron-Distal4.245034.30850HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for VPS35 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for VPS35 is not available on ENCORE database.

  • 102 RBPs can affect the levels of VPS35.  








The Knockdown/knockout RNA-Seq assay for VPS35 is not available on ENCORE database.





102 RBPs can affect the gene expression of VPS35 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
VPS35ENSG00000069329.112440.400203619.65940-0.568706.446705.07570HepG2ABCF1
VPS35ENSG00000069329.112058.827903402.05330-0.7246027.5246026.07100HepG2ACO1
VPS35ENSG00000069329.113006.009204369.53950-0.539606.008504.87350HepG2ASCC1
VPS35ENSG00000069329.112435.429903256.25060-0.419002.619001.70930HepG2BCCIP
VPS35ENSG00000069329.112202.313602829.71760-0.361602.236801.42840HepG2BCLAF1
VPS35ENSG00000069329.112101.870003507.18900-0.7386012.7519011.59150HepG2BOP1
VPS35ENSG00000069329.112347.642503401.52770-0.5350017.6310016.26840HepG2CKAP4
VPS35ENSG00000069329.111762.020102736.58800-0.635104.251403.29740HepG2CNOT7
VPS35ENSG00000069329.112237.569503219.84260-0.525106.281305.27540HepG2CPSF6
VPS35ENSG00000069329.113377.411604628.14430-0.4545015.0298013.54080HepG2DAZAP1
VPS35ENSG00000069329.112870.375405058.85680-0.8176012.4852011.24500HepG2DDX3X
VPS35ENSG00000069329.112311.004003201.41940-0.470203.311902.47660HepG2DDX55
VPS35ENSG00000069329.112904.969404345.10090-0.580905.718904.85860HepG2DDX6
VPS35ENSG00000069329.112755.669103254.89840-0.240203.244302.52090HepG2DKC1
VPS35ENSG00000069329.112392.524203160.42060-0.401606.833605.76790HepG2DNAJC21
VPS35ENSG00000069329.112064.358303132.41450-0.6016021.3199019.66610HepG2DNAJC2
VPS35ENSG00000069329.112943.379204177.60840-0.505205.281404.47830HepG2EIF2S1
VPS35ENSG00000069329.112537.966604617.01800-0.8633011.8552010.56010HepG2EIF4A3
VPS35ENSG00000069329.112681.198404494.80030-0.745407.225506.14370HepG2EIF4B
VPS35ENSG00000069329.113316.530804565.85680-0.4612011.5962010.11650HepG2EIF4G1
VPS35ENSG00000069329.113303.467804373.81510-0.404904.333503.32920HepG2EIF4G2
VPS35ENSG00000069329.112680.366203324.60370-0.310802.872102.02190HepG2EWSR1
VPS35ENSG00000069329.113036.240704321.00070-0.509104.885604.01290HepG2G3BP1
VPS35ENSG00000069329.111799.234402533.05970-0.493503.127701.93970HepG2GRSF1
VPS35ENSG00000069329.112738.025903248.11670-0.246503.385302.31190HepG2HDGF
VPS35ENSG00000069329.112508.640203190.69710-0.347003.722102.98900HepG2HNRNPA1
VPS35ENSG00000069329.113163.821504253.34590-0.426909.276307.75580HepG2HNRNPA2B1
VPS35ENSG00000069329.112301.821403549.02800-0.624609.877408.63360HepG2HNRNPC
VPS35ENSG00000069329.112670.005803375.64310-0.338305.494704.52620HepG2HNRNPF
VPS35ENSG00000069329.113012.420504374.40260-0.538207.013405.93750HepG2HNRNPK
VPS35ENSG00000069329.113336.370904215.91750-0.337608.820907.68220HepG2HNRNPL
VPS35ENSG00000069329.112133.827203525.56630-0.7244025.4146023.72940HepG2HNRNPU
VPS35ENSG00000069329.112583.204903324.06680-0.363804.274503.39130HepG2IGF2BP1
VPS35ENSG00000069329.112778.685603601.25490-0.3741010.144408.83020HepG2ILF2
VPS35ENSG00000069329.113125.006704417.67350-0.499403.802302.60820HepG2KHSRP
VPS35ENSG00000069329.113322.280204659.18410-0.487904.886604.02260HepG2MAGOH
VPS35ENSG00000069329.113192.345504795.86890-0.587206.509005.55520HepG2NCBP2
VPS35ENSG00000069329.112195.392102843.49420-0.373203.508701.90990HepG2NIP7
VPS35ENSG00000069329.113192.077904589.25270-0.5238010.564409.10650HepG2NOL12
VPS35ENSG00000069329.113285.967504271.52970-0.378403.096802.33510HepG2PABPC4
VPS35ENSG00000069329.112869.005803489.74800-0.282604.386803.34970HepG2PARN
VPS35ENSG00000069329.113103.964704365.09160-0.4919010.168509.12180HepG2PCBP1
VPS35ENSG00000069329.112471.169303144.52920-0.347705.143804.16710HepG2PPIL4
VPS35ENSG00000069329.113732.743204441.44430-0.250803.488302.88930HepG2PTBP1
VPS35ENSG00000069329.115341.484804380.813700.285902.799102.19960HepG2PUF60
VPS35ENSG00000069329.113925.570804650.39240-0.244505.152004.39420HepG2PUM1
VPS35ENSG00000069329.112633.190604647.01710-0.8195022.6403020.84130HepG2PUM2
VPS35ENSG00000069329.113924.932103465.243200.179602.448401.85930HepG2PUS1
VPS35ENSG00000069329.113501.721904810.61920-0.458207.106006.17280HepG2QKI
VPS35ENSG00000069329.112865.609903792.01140-0.404103.767202.59880HepG2RBM27
VPS35ENSG00000069329.113673.463604943.06690-0.428307.457006.64550HepG2NELFE
VPS35ENSG00000069329.113662.838804603.49430-0.329805.240004.42600HepG2RECQL
VPS35ENSG00000069329.113044.136603636.06530-0.256301.997601.40630HepG2RPLP0
VPS35ENSG00000069329.111866.833602209.74930-0.243301.912201.39300HepG2RPS19
VPS35ENSG00000069329.112758.633003497.27540-0.342302.951902.12670HepG2RPS2
VPS35ENSG00000069329.112347.857203139.69200-0.4193010.218909.10180HepG2SAFB2
VPS35ENSG00000069329.112617.451303705.23470-0.501403.528902.76380HepG2SF3A3
VPS35ENSG00000069329.113327.817204624.47470-0.474709.200308.21910HepG2SF3B4
VPS35ENSG00000069329.112284.689303476.01320-0.605404.985003.66650HepG2SMNDC1
VPS35ENSG00000069329.116073.179505103.002900.251005.078104.45750HepG2SRFBP1
VPS35ENSG00000069329.113530.283604325.37370-0.293005.205004.38810HepG2SRSF5
VPS35ENSG00000069329.112557.446503316.38180-0.374906.699405.69400HepG2SRSF7
VPS35ENSG00000069329.113849.955204430.62880-0.202702.876702.35640HepG2SSB
VPS35ENSG00000069329.113781.287004919.17720-0.3795010.470709.39150HepG2SUCLG1
VPS35ENSG00000069329.111988.672102468.02290-0.311602.855401.89950HepG2SUPT6H
VPS35ENSG00000069329.113425.242404338.11460-0.340904.135003.47040HepG2TAF15
VPS35ENSG00000069329.112407.817203394.79070-0.495605.919404.91650HepG2TARDBP
VPS35ENSG00000069329.112311.754803425.86910-0.5675011.0105010.12730HepG2TIAL1
VPS35ENSG00000069329.112421.687803456.36220-0.5132013.4186012.31110HepG2TRIM56
VPS35ENSG00000069329.113587.678304279.81260-0.254502.478501.65460HepG2TUFM
VPS35ENSG00000069329.114098.441103126.604400.390403.689202.96780HepG2U2AF1
VPS35ENSG00000069329.111485.822001882.94110-0.341702.166401.49440HepG2UCHL5
VPS35ENSG00000069329.112442.435703285.97390-0.4280010.040108.85530HepG2UPF1
VPS35ENSG00000069329.111987.381902919.12900-0.554703.295702.19580HepG2UPF2
VPS35ENSG00000069329.112737.123203172.48290-0.213002.843102.23980HepG2UTP3
VPS35ENSG00000069329.112208.690003137.44360-0.506404.027803.16140HepG2XRN2
VPS35ENSG00000069329.113106.394802750.503600.175402.354201.72800HepG2ZC3H8
VPS35ENSG00000069329.113095.242303613.94620-0.223504.071003.44210HepG2ZNF622
VPS35ENSG00000069329.112879.458904570.95390-0.6667010.582708.28270K562ABCF1
VPS35ENSG00000069329.113783.624603194.786700.243903.587402.95610K562AGGF1
VPS35ENSG00000069329.113105.771604388.26810-0.498706.762405.91000K562AQR
VPS35ENSG00000069329.112297.272802638.38640-0.199702.327201.44820K562BCLAF1
VPS35ENSG00000069329.111712.111902198.27990-0.360602.287301.45640K562EFTUD2
VPS35ENSG00000069329.112189.695802616.65590-0.257003.202901.89000K562EIF2S1
VPS35ENSG00000069329.112769.541003280.38930-0.244202.895602.16300K562EIF2S2
VPS35ENSG00000069329.111831.798302354.04380-0.361902.270001.34420K562EIF3D
VPS35ENSG00000069329.112107.870002480.88310-0.235102.276301.54980K562EIF3G
VPS35ENSG00000069329.111545.715002488.79160-0.6872010.718709.08360K562EIF4A3
VPS35ENSG00000069329.111726.558102241.31250-0.376404.970503.35530K562EIF4B
VPS35ENSG00000069329.113552.169402725.526900.382102.409201.75580K562G3BP2
VPS35ENSG00000069329.112676.316404371.65590-0.7079012.4459010.82340K562GRSF1
VPS35ENSG00000069329.111554.562802436.91590-0.6485010.622909.51590K562HNRNPC
VPS35ENSG00000069329.111700.752702176.07600-0.355603.390402.11930K562HNRNPF
VPS35ENSG00000069329.112886.131003487.75440-0.273203.277002.30710K562HNRNPU
VPS35ENSG00000069329.112478.699203260.54430-0.395502.847301.80300K562IGF2BP2
VPS35ENSG00000069329.112461.074003427.28100-0.477806.439205.13000K562MAGOH
VPS35ENSG00000069329.112398.944203079.92170-0.360507.145105.89880K562MTPAP
VPS35ENSG00000069329.111850.095002399.23370-0.375002.897601.42330K562NUSAP1
VPS35ENSG00000069329.112354.623103049.53680-0.373104.001402.82030K562PCBP2
VPS35ENSG00000069329.112878.533503729.71750-0.373703.688802.72000K562PPIG
VPS35ENSG00000069329.111629.657602184.92450-0.423003.371202.35930K562PSIP1
VPS35ENSG00000069329.112590.631903329.77500-0.362104.325603.51240K562PTBP1
VPS35ENSG00000069329.115073.323306475.34760-0.352006.067804.62680K562PUM2
VPS35ENSG00000069329.114055.157803296.907800.298502.446701.92890K562PUS1
VPS35ENSG00000069329.113687.373803212.249500.198901.973201.45730K562RBM15
VPS35ENSG00000069329.112193.469103193.17190-0.541807.112805.68810K562RBM22
VPS35ENSG00000069329.112470.088803112.49210-0.333502.659801.32230K562RBM34
VPS35ENSG00000069329.111500.022601993.33580-0.410204.810703.50090K562RCC2
VPS35ENSG00000069329.112679.756403360.22890-0.326502.684501.61010K562NELFE
VPS35ENSG00000069329.112277.810103376.62600-0.5679013.3785011.69500K562SF3A3
VPS35ENSG00000069329.111427.161401889.64200-0.405003.875602.59880K562SRFBP1
VPS35ENSG00000069329.112783.770903459.40390-0.313503.150202.15700K562SRPK2
VPS35ENSG00000069329.112220.769503264.22490-0.555709.098207.82480K562SRSF1
VPS35ENSG00000069329.111859.372402361.08120-0.344603.496002.29320K562SRSF4
VPS35ENSG00000069329.112475.735903082.65410-0.316302.780301.72930K562SRSF5
VPS35ENSG00000069329.111488.611202071.63570-0.476802.549201.57900K562SUPV3L1
VPS35ENSG00000069329.112494.517902105.872200.244202.289901.54190K562SYNCRIP
VPS35ENSG00000069329.112149.552003303.74810-0.620108.264106.95660K562TARDBP
VPS35ENSG00000069329.112443.188703186.80150-0.383304.709003.59800K562TIA1
VPS35ENSG00000069329.112517.706503126.86950-0.312602.762801.67290K562TRA2A
VPS35ENSG00000069329.111835.321702232.48280-0.282602.224601.39000K562TRIM56
VPS35ENSG00000069329.113218.861003628.65610-0.172902.243001.59160K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for VPS35 is not available on ENCORE database.





4 RBPs can affect the splicing of VPS35 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEVPS35ENSG00000069329.11chr16-467158394671608746715288467154324671741946717518-0.174000.000000.00282excludedHepG2DKC1
SEVPS35ENSG00000069329.11chr16-467128544671308846711226467113104671458246714765-0.076000.000090.00157excludedK562AQR
SEVPS35ENSG00000069329.11chr16-4671583946716087467152884671543246717419467175190.088000.003000.07144includedHepG2SF3A3
SEVPS35ENSG00000069329.11chr16-467158394671608746715288467154324671741946717519-0.095000.001060.06330excludedHepG2SRSF9
A3SSVPS35ENSG00000069329.11chr16-4670561646705800467056164670577246706176467064060.064000.000000.00000longerK562AQR
A3SSVPS35ENSG00000069329.11chr16-4671299246713154467129924671306846714582467147650.060000.000000.00000longerK562AQR
A3SSVPS35ENSG00000069329.11chr16-4670284146703003467028414670296446705616467058000.070000.000000.00000longerK562AQR
MXEVPS35ENSG00000069329.11chr16-46712854467130884671458246714787467112264671131046715288467154120.058000.000000.000011includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for VPS35 is not avaliable on ENCORE database.