SIMC1

General Information

Gene Name       : SIMC1
Gene ID             : ENSG00000170085.17
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SIMC1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SIMC1ENSG00000170085.1712.1511.2011.68ENCSR000AEF
HepG2SIMC1ENSG00000170085.1710.0910.8410.46ENCSR985KAT
K562SIMC1ENSG00000170085.1720.7724.4222.59ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SIMC1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SIMC1 RNA is bound by 5 proteins.  







eCLIP assay for SIMC1 is not avaliable on ENCORE database.





5 proteins are bound to SIMC1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr5175717303175717413+CDS,intron-Distal3.969208.28294K562YBX3
chr5175717154175717299+CDS,intron-Distal4.717425.93935K562IGF2BP2
chr5175675861175675916+intron-Distal5.6078411.00067K562EXOSC5
chr5175692938175693051+intron-Distal3.967773.22483K562SAFB2
chr5175768796175768896+intron-Distal5.5259710.09004HepG2QKI
chr5175676020175676082+intron-Distal4.410703.89085K562EXOSC5
chr5175678021175678113+intron-Distal4.431025.12361K562EXOSC5
chr5175768789175768938+intron-Distal5.767119.36266K562QKI
chr5175706238175706316+intron-Distal4.470025.12361K562EXOSC5
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SIMC1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SIMC1 is not available on ENCORE database.

  • 72 RBPs can affect the levels of SIMC1.  








The Knockdown/knockout RNA-Seq assay for SIMC1 is not available on ENCORE database.





72 RBPs can affect the gene expression of SIMC1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SIMC1ENSG00000170085.13399.88780538.31190-0.428802.236401.38600HepG2ABCF1
SIMC1ENSG00000170085.13212.47140346.25680-0.704606.071805.24140HepG2ACO1
SIMC1ENSG00000170085.13268.82950508.92190-0.920806.817006.02370HepG2AKAP1
SIMC1ENSG00000170085.13313.18190421.07700-0.427102.077501.39340HepG2ASCC1
SIMC1ENSG00000170085.13265.38740473.63400-0.835707.158106.24820HepG2BOP1
SIMC1ENSG00000170085.13326.91060445.59890-0.446802.641801.88770HepG2CALR
SIMC1ENSG00000170085.13200.49440400.05640-0.996607.973806.71210HepG2CIRBP
SIMC1ENSG00000170085.13154.29500329.20210-1.093306.314605.15970HepG2CNOT7
SIMC1ENSG00000170085.13297.59410441.02220-0.567504.578003.78790HepG2CELF1
SIMC1ENSG00000170085.13221.66230333.19260-0.588003.340402.60010HepG2DDX21
SIMC1ENSG00000170085.13352.78370487.48050-0.466602.470401.87640HepG2DDX3X
SIMC1ENSG00000170085.13139.58300247.44280-0.826003.591602.72540HepG2DDX55
SIMC1ENSG00000170085.13349.18480470.76290-0.431002.409501.46340HepG2DDX5
SIMC1ENSG00000170085.13186.02580280.53280-0.592702.906701.77130HepG2EFTUD2
SIMC1ENSG00000170085.13250.60700402.55810-0.683804.217103.49310HepG2EIF2S1
SIMC1ENSG00000170085.13171.68270273.16870-0.670003.102302.14930HepG2EIF3D
SIMC1ENSG00000170085.13231.12910444.84210-0.944607.023806.00630HepG2EIF4A3
SIMC1ENSG00000170085.13298.71940448.15120-0.585203.785902.84290HepG2EIF4G2
SIMC1ENSG00000170085.13389.41600543.55060-0.481102.468001.73750HepG2FIP1L1
SIMC1ENSG00000170085.13207.26900396.98990-0.937606.082004.47440HepG2FUS
SIMC1ENSG00000170085.13336.68100448.92350-0.415101.990701.40010HepG2FXR1
SIMC1ENSG00000170085.13274.66600416.39160-0.600303.490802.74720HepG2G3BP1
SIMC1ENSG00000170085.13681.86780492.905800.468102.792102.14850HepG2GPKOW
SIMC1ENSG00000170085.13212.99910289.55280-0.443001.863801.32160HepG2HNRNPA1
SIMC1ENSG00000170085.13327.38550435.80310-0.412702.573201.66850HepG2HNRNPA2B1
SIMC1ENSG00000170085.13197.61500322.08620-0.704804.022903.19770HepG2HNRNPC
SIMC1ENSG00000170085.13403.59910310.307100.379102.010501.39260HepG2HNRNPF
SIMC1ENSG00000170085.13309.24690421.75270-0.447602.290501.65120HepG2HNRNPK
SIMC1ENSG00000170085.13332.42580470.38900-0.500802.816902.18230HepG2HNRNPLL
SIMC1ENSG00000170085.13274.69750423.23490-0.623603.759302.98240HepG2IGF2BP2
SIMC1ENSG00000170085.13298.04480425.73580-0.514402.383301.46310HepG2KHSRP
SIMC1ENSG00000170085.13461.96750640.85910-0.472202.522501.73070HepG2LARP4
SIMC1ENSG00000170085.13324.37110449.08060-0.469302.380001.77030HepG2MAGOH
SIMC1ENSG00000170085.13325.74820451.57840-0.471202.266301.69130HepG2MATR3
SIMC1ENSG00000170085.13303.14340439.84720-0.537003.583002.66430HepG2MSI2
SIMC1ENSG00000170085.13297.97470462.20280-0.633303.920603.17030HepG2NCBP2
SIMC1ENSG00000170085.13354.96450470.20820-0.405602.627201.88420HepG2NOL12
SIMC1ENSG00000170085.13191.21200300.89370-0.654102.559901.71360HepG2PABPC1
SIMC1ENSG00000170085.13248.43930411.56320-0.728204.879003.93080HepG2PABPC4
SIMC1ENSG00000170085.13244.36220375.79540-0.620902.978501.90210HepG2PCBP2
SIMC1ENSG00000170085.13328.46820476.48890-0.536705.102804.34690HepG2PUM1
SIMC1ENSG00000170085.13249.28240352.67770-0.500603.524402.84770HepG2PUS1
SIMC1ENSG00000170085.13189.72840362.61070-0.934504.479003.59400HepG2RAVER1
SIMC1ENSG00000170085.13105.42020188.86740-0.841203.223802.38430HepG2RRP9
SIMC1ENSG00000170085.13236.60380394.59890-0.737903.736101.95470HepG2RTF1
SIMC1ENSG00000170085.13432.80470638.31470-0.560603.476202.71700HepG2SF3A3
SIMC1ENSG00000170085.13249.53380332.26170-0.413102.472401.85980HepG2SMN1
SIMC1ENSG00000170085.13324.77960411.54300-0.341601.781201.37780HepG2SRSF1
SIMC1ENSG00000170085.13277.95020443.18910-0.673106.178605.29610HepG2SRSF5
SIMC1ENSG00000170085.13324.07380464.17680-0.518402.379701.60790HepG2UBE2L3
SIMC1ENSG00000170085.13383.54580566.08880-0.561605.904204.94560HepG2UPF1
SIMC1ENSG00000170085.13366.23830546.53460-0.577505.585804.78350HepG2UTP3
SIMC1ENSG00000170085.13279.39500398.81540-0.513402.292001.32950HepG2XRCC6
SIMC1ENSG00000170085.13351.83500447.40720-0.346702.412501.77990HepG2ZC3H8
SIMC1ENSG00000170085.13349.06040622.58760-0.8348013.4228012.44510HepG2ZNF622
SIMC1ENSG00000170085.13914.623801313.49370-0.522202.704001.49900K562ABCF1
SIMC1ENSG00000170085.13515.29850824.25780-0.677709.589708.61370K562AGGF1
SIMC1ENSG00000170085.13532.64590857.66330-0.687207.580106.45130K562AKAP8L
SIMC1ENSG00000170085.13544.18410854.20000-0.650506.006404.70920K562BOP1
SIMC1ENSG00000170085.13431.70640576.69690-0.417802.660501.40830K562CIRBP
SIMC1ENSG00000170085.13672.68630908.20880-0.433103.842602.91900K562CPSF6
SIMC1ENSG00000170085.13935.262501107.87000-0.244302.100101.51950K562DDX47
SIMC1ENSG00000170085.13373.23120536.10570-0.522402.732801.46130K562EEF2
SIMC1ENSG00000170085.13368.50200554.51880-0.589603.637402.43520K562EIF3D
SIMC1ENSG00000170085.13748.087401101.93900-0.558807.299705.78640K562EIF4G2
SIMC1ENSG00000170085.13557.40260944.04590-0.760104.124303.07560K562FIP1L1
SIMC1ENSG00000170085.13474.24380783.36810-0.724106.836905.33180K562FTO
SIMC1ENSG00000170085.13249.84230349.69870-0.485102.840901.48130K562FUS
SIMC1ENSG00000170085.13604.21390474.282700.349201.859601.34370K562FXR1
SIMC1ENSG00000170085.13633.81500867.07530-0.452103.688002.77680K562GPKOW
SIMC1ENSG00000170085.13658.31080878.51910-0.416303.280202.45980K562GRSF1
SIMC1ENSG00000170085.13437.30480615.36660-0.492803.335902.68860K562HNRNPC
SIMC1ENSG00000170085.13391.03220537.99940-0.460302.422501.48110K562IGF2BP2
SIMC1ENSG00000170085.13311.51830499.25060-0.680405.038803.03700K562ILF3
SIMC1ENSG00000170085.13608.10110910.24530-0.581905.743604.45480K562KIF1C
SIMC1ENSG00000170085.13768.25970565.500900.442003.729302.74420K562MAGOH
SIMC1ENSG00000170085.13640.58770871.28810-0.443803.457302.21180K562MAK16
SIMC1ENSG00000170085.13543.31800846.37940-0.639506.621405.23770K562METAP2
SIMC1ENSG00000170085.13894.461801174.58130-0.393102.888901.73010K562MSI2
SIMC1ENSG00000170085.13605.63990806.73270-0.413604.351903.35780K562MTPAP
SIMC1ENSG00000170085.13748.434801071.56990-0.517802.902002.05970K562PPIG
SIMC1ENSG00000170085.13359.31350504.02900-0.488302.871502.10910K562PRPF8
SIMC1ENSG00000170085.13371.77890850.66920-1.1942017.0453015.73900K562PUS1
SIMC1ENSG00000170085.13490.68870828.76400-0.7562010.473909.34470K562RBM15
SIMC1ENSG00000170085.13717.99740884.46640-0.300802.523401.74220K562SF3A3
SIMC1ENSG00000170085.13636.31890477.051600.415502.704201.69510K562SRFBP1
SIMC1ENSG00000170085.13334.64370516.46000-0.626004.479803.15500K562UCHL5
SIMC1ENSG00000170085.13680.54920859.29300-0.336502.324201.54480K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SIMC1 is not available on ENCORE database.





4 RBPs can affect the splicing of SIMC1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESIMC1ENSG00000170085.13chr5+175716656175717958175665402175665640175722032175722265-0.228000.000750.02480excludedK562AKAP8L
SESIMC1ENSG00000170085.13chr5+1756973931756975231756654551756656401757166561757168020.616000.000150.04706includedK562WDR43
SESIMC1ENSG00000170085.13chr5+175716656175717958175665402175665640175722032175722265-0.177000.007250.08231excludedK562PUS1
SESIMC1ENSG00000170085.13chr5+175716656175717958175665402175665640175722032175722265-0.251000.001350.03422excludedK562RBM15

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SIMC1 is not avaliable on ENCORE database.