PTEN

General Information

Gene Name       : PTEN
Gene ID             : ENSG00000171862.10
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PTEN)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PTENENSG00000171862.1042.7536.0739.41ENCSR000AEF
HepG2PTENENSG00000171862.1019.5023.7321.62ENCSR985KAT
K562PTENENSG00000171862.1011.2710.5410.90ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PTEN is not avaliable on ENCORE database.



Proteins bound to RNA
  • PTEN RNA is bound by 15 proteins.  







eCLIP assay for PTEN is not avaliable on ENCORE database.





15 proteins are bound to PTEN RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr108962420089624252+5'-UTR,CDS3.781413.02321K562U2AF2
chr108962361389623664+5'-UTR4.094973.03355K562METAP2
chr108962388989623954+5'-UTR3.723647.98536K562RBM15
chr108962358489623702+5'-UTR3.314188.20131K562RBM15
chr108962370289623722+5'-UTR3.936565.71420K562RBM15
chr108962345289623507+5'-UTR4.4860412.43092HepG2DDX3X
chr108962350789623562+5'-UTR3.231046.27275HepG2DDX3X
chr108962372289623753+5'-UTR3.288114.68262K562RBM15
chr108971185489711916+CDS,intron-Proximal4.4286210.13167HepG2U2AF2
chr108967959489679683+intron-Distal3.816623.26999K562KHSRP
chr108963888689638963+intron-Distal3.158493.56114HepG2KHSRP
chr108963290289632954+intron-Distal4.514895.53165HepG2ILF3
chr108967223789672315+intron-Distal3.384126.39618K562KHSRP
chr108970595689706021+intron-Distal5.305479.34744HepG2LIN28B
chr108962512689625169+intron-Distal4.233663.60235HepG2HNRNPM
chr108969323389693289+intron-Distal3.777347.96049HepG2U2AF2
chr108966096489661014+intron-Distal3.988766.71225K562EXOSC5
chr108970120489701267+intron-Distal3.182843.07751K562KHSRP
chr108963501389635075+intron-Distal4.264244.56270HepG2KHSRP
chr108965387589654043+intron-Distal,intron-Proximal4.831268.27925K562KHSRP
chr108964545489645509+intron-Distal3.974753.16986HepG2QKI
chr108966431189664373+intron-Distal3.539494.19039HepG2PTBP1
chr108964548389645603+intron-Distal3.9384711.99276K562KHSRP
chr108964484689644953+intron-Distal3.532274.28919HepG2KHSRP
chr108966055089660598+intron-Distal5.064767.71416K562EXOSC5
chr108963880589638854+intron-Distal,intron-Proximal3.834623.31110K562TIA1
chr108966232689662409+intron-Distal4.000483.27829HepG2MATR3
chr108963742189637455+intron-Distal3.695185.32884K562KHSRP
chr108966736889667512+intron-Distal3.682853.14791K562HNRNPL
chr108966096489661010+intron-Distal4.335404.66737HepG2MATR3
chr108967343689673482+intron-Distal4.082984.03915HepG2SUGP2
chr108962705789627156+intron-Distal3.377828.86655K562KHSRP
chr108962522789625287+intron-Distal3.865775.95943HepG2HNRNPM
chr108963395989634047+intron-Distal3.039015.34873K562KHSRP
chr108963586389635922+intron-Distal3.425214.31768HepG2KHSRP
chr108966430989664372+intron-Distal4.573034.67693K562PTBP1
chr108969408389694169+intron-Distal4.820137.17304K562KHSRP
chr108963693689636968+intron-Distal3.138013.76473K562KHSRP
chr108963697189637014+intron-Distal4.1348912.61975HepG2U2AF2
chr108967259489672641+intron-Distal3.038093.07751K562KHSRP
chr108966006589660100+intron-Distal4.058413.07980HepG2HNRNPM
chr108963725089637317+intron-Distal3.209077.70554K562KHSRP
chr108962847489628626+intron-Distal3.627788.67954K562KHSRP
chr108969416989694228+intron-Distal4.632215.62258K562KHSRP
chr108964485689644947+intron-Distal3.666845.95946K562KHSRP
chr108967242889672485+intron-Distal4.525555.41654K562KHSRP
chr108963739489637421+intron-Distal3.185676.62024K562KHSRP
chr108962444289624526+intron-Distal3.231405.64972K562TIA1
chr108972149489721634+intron-Distal4.401098.54919HepG2PTBP1
chr108966006789660099+intron-Distal4.164773.59917K562EXOSC5
chr108963701489637063+intron-Distal5.5070512.94604HepG2U2AF2
chr108970126789701293+intron-Distal3.959323.45805K562KHSRP
chr108968283189682903+intron-Distal3.470733.59351HepG2MATR3
chr108963089189630980+intron-Distal3.8996812.13920K562KHSRP
chr108962708289627177+intron-Distal4.497534.29306HepG2KHSRP
chr108969509989695248+intron-Distal3.041464.18967K562KHSRP
chr108966144989661503+intron-Distal3.977533.04224HepG2SUGP2
chr108968092589680978+intron-Distal4.789863.42734K562PTBP1
chr108963384889633936+intron-Distal3.157826.00234K562KHSRP
chr108968457089684612+intron-Distal4.133213.78432HepG2MATR3
chr108967930989679375+intron-Distal3.144403.15317HepG2HNRNPL
chr108964244089642519+intron-Distal3.181025.40232HepG2U2AF2
chr108969411989694167+intron-Distal3.924715.60471HepG2U2AF2
chr108963715089637296+intron-Distal3.827679.56695HepG2KHSRP
chr108967279889672851+intron-Distal3.720303.26999K562KHSRP
chr108969406689694278+intron-Distal3.457278.74458HepG2KHSRP
chr108962845089628546+intron-Distal3.239294.88847HepG2QKI
chr108970594489706022+intron-Distal5.594798.79592K562LIN28B
chr108963738789637485+intron-Distal5.015687.00602HepG2KHSRP
chr108963693689637042+intron-Distal4.3967810.17146HepG2KHSRP
chr108963962489639715+intron-Distal3.870743.20552HepG2KHSRP
chr108969422889694287+intron-Distal3.270073.46531K562KHSRP
chr108964503989645119+intron-Distal3.416277.71234K562KHSRP
chr108967071989670810+intron-Distal4.058413.62366HepG2HNRNPM
chr108966619689666264+intron-Distal3.995403.02234K562KHSRP
chr108965459589654683+intron-Distal3.309074.70224K562KHSRP
chr108967926089679309+intron-Distal3.678973.02891HepG2HNRNPL
chr108964216589642363+intron-Distal4.160748.98664K562KHSRP
chr108966740989667532+intron-Distal3.156444.54315HepG2HNRNPL
chr108965451889654637+intron-Distal4.391654.83283HepG2KHSRP
chr108964588589646008+intron-Distal3.088786.39602K562KHSRP
chr108970133989701437+intron-Distal3.130663.51173HepG2U2AF2
chr108968092789680984+intron-Distal5.118497.45191HepG2PTBP1
chr108963356889633611+intron-Distal4.616374.64001HepG2U2AF2
chr108966207889662151+intron-Distal4.177543.01445K562EXOSC5
chr108971095889711045+intron-Distal3.855033.42844K562KHSRP
chr108964595289646089+intron-Distal4.161363.41738HepG2PTBP1
chr108963501289635094+intron-Distal5.002517.83372K562KHSRP
chr108963706789637129+intron-Distal3.381264.10408K562KHSRP
chr108966095789661010+intron-Distal4.030843.27946HepG2HNRNPM
chr108964516789645225+intron-Distal3.110983.93901K562KHSRP
chr108969303189693087+intron-Proximal4.849797.12263K562TIA1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PTEN is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PTEN is not available on ENCORE database.

  • 81 RBPs can affect the levels of PTEN.  








The Knockdown/knockout RNA-Seq assay for PTEN is not available on ENCORE database.





81 RBPs can affect the gene expression of PTEN :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PTENENSG00000171862.5544.71990768.80810-0.497104.095202.81530HepG2AATF
PTENENSG00000171862.5792.317601061.01410-0.421305.694804.88380HepG2ACO1
PTENENSG00000171862.51471.601902026.78710-0.461803.394602.81360HepG2AKAP1
PTENENSG00000171862.5649.539801065.94440-0.7146013.1457011.64040HepG2AKAP8L
PTENENSG00000171862.51324.255401761.33700-0.411502.512201.58880HepG2CCAR1
PTENENSG00000171862.51220.559201060.717800.202401.944501.37410HepG2CKAP4
PTENENSG00000171862.5807.811801475.54270-0.869206.876205.67030HepG2CNOT7
PTENENSG00000171862.5714.26340959.53340-0.425904.357003.08160HepG2YBX3
PTENENSG00000171862.5695.39350531.776300.386902.593601.54870HepG2CSTF2
PTENENSG00000171862.5523.21470960.86000-0.8769015.2100012.89190HepG2DDX1
PTENENSG00000171862.51197.83190830.117000.528905.898104.56640HepG2DDX24
PTENENSG00000171862.5921.513501667.66740-0.855809.775308.68980HepG2DDX6
PTENENSG00000171862.51578.062301015.086000.636503.501602.75310HepG2DKC1
PTENENSG00000171862.5662.64280942.17260-0.507806.161705.14590HepG2DNAJC21
PTENENSG00000171862.5706.74760933.87800-0.402005.309404.44980HepG2DNAJC2
PTENENSG00000171862.51200.765101603.37030-0.417203.248402.60840HepG2EIF2S1
PTENENSG00000171862.5467.75100770.59930-0.720204.397603.27720HepG2EIF3D
PTENENSG00000171862.51377.120801772.01000-0.363702.279701.69720HepG2EIF4A3
PTENENSG00000171862.51281.816601725.11470-0.428502.471301.81950HepG2EIF4B
PTENENSG00000171862.51863.015801483.914500.328103.419602.50460HepG2EIF4G1
PTENENSG00000171862.51929.803701421.539700.440903.905902.94780HepG2EIF4G2
PTENENSG00000171862.5827.905301036.74200-0.324502.449301.66270HepG2EWSR1
PTENENSG00000171862.5930.740001787.58940-0.9416013.8153012.39200HepG2FXR1
PTENENSG00000171862.51080.796201658.40610-0.617705.935804.97740HepG2G3BP1
PTENENSG00000171862.5977.656501405.89060-0.524104.297603.51130HepG2GPKOW
PTENENSG00000171862.51361.303101678.92490-0.302502.140801.52160HepG2HNRNPK
PTENENSG00000171862.51127.230101370.46210-0.281903.024402.32210HepG2HNRNPL
PTENENSG00000171862.5781.522001051.04580-0.427505.693504.84870HepG2HNRNPU
PTENENSG00000171862.5788.810801010.52750-0.357402.445601.30990HepG2LIN28B
PTENENSG00000171862.51192.696001798.26840-0.592405.315304.46530HepG2MATR3
PTENENSG00000171862.5549.67290806.53880-0.553202.917701.83750HepG2METAP2
PTENENSG00000171862.51315.243501840.66670-0.484904.022603.26410HepG2NCBP2
PTENENSG00000171862.51029.705401491.72430-0.534707.315506.08830HepG2NOL12
PTENENSG00000171862.51143.731501639.41260-0.519404.574303.65780HepG2PABPC4
PTENENSG00000171862.51449.452201656.32920-0.192501.837001.32520HepG2PCBP1
PTENENSG00000171862.51316.012601020.613000.366604.594603.62410HepG2PRPF4
PTENENSG00000171862.51672.262401084.193400.625104.170202.68940HepG2PRPF6
PTENENSG00000171862.51305.728701685.35250-0.368204.823804.14440HepG2PTBP1
PTENENSG00000171862.5905.220801423.90140-0.653509.252308.24880HepG2PUF60
PTENENSG00000171862.51268.560901511.44050-0.252702.641802.05930HepG2PUM1
PTENENSG00000171862.51243.974401510.39470-0.280002.734802.06810HepG2PUM2
PTENENSG00000171862.51456.598601080.702100.430504.589703.83400HepG2PUS1
PTENENSG00000171862.51427.42120995.341900.520002.542201.86600HepG2RAVER1
PTENENSG00000171862.51909.092701125.400400.762306.784605.78270HepG2RPLP0
PTENENSG00000171862.5607.39090749.77880-0.303801.833201.32280HepG2RPS19
PTENENSG00000171862.51133.317501481.59900-0.386602.131501.42870HepG2RPS3A
PTENENSG00000171862.5730.788201092.48150-0.580105.332803.82950HepG2RPS5
PTENENSG00000171862.5881.31930645.934700.448202.870802.07130HepG2RRP9
PTENENSG00000171862.5623.62450935.99780-0.585809.264508.19450HepG2SAFB2
PTENENSG00000171862.5418.28160752.59610-0.847408.001806.42940HepG2SERBP1
PTENENSG00000171862.51788.941801367.143700.387802.217401.61260HepG2SF3A3
PTENENSG00000171862.51409.586201754.71320-0.316004.106703.40980HepG2SF3B4
PTENENSG00000171862.5748.911201091.52330-0.543509.778008.68590HepG2SMN1
PTENENSG00000171862.51410.007601841.47260-0.385206.186905.51950HepG2SRFBP1
PTENENSG00000171862.51187.127601831.52280-0.6256014.3165013.42040HepG2SRSF1
PTENENSG00000171862.51931.805201428.906000.434902.808701.79880HepG2SRSF3
PTENENSG00000171862.51162.707501490.02600-0.357805.185004.47140HepG2SRSF9
PTENENSG00000171862.52086.490301598.815200.384006.645905.91560HepG2SSB
PTENENSG00000171862.51810.884801307.682900.469604.740303.82640HepG2TARDBP
PTENENSG00000171862.5847.759001421.95420-0.746103.449802.26320HepG2TBRG4
PTENENSG00000171862.51227.409501512.68110-0.301502.611801.79870HepG2TIA1
PTENENSG00000171862.5474.157401021.25610-1.1069022.1138020.95110HepG2TIAL1
PTENENSG00000171862.5873.919701030.41890-0.237702.182301.66960HepG2TRIM56
PTENENSG00000171862.51090.627801390.93840-0.350903.410902.42950HepG2TUFM
PTENENSG00000171862.51753.622901158.907400.597506.869705.89130HepG2U2AF1
PTENENSG00000171862.51600.795201007.198700.6683017.0592015.63410HepG2ZC3H8
PTENENSG00000171862.51075.364901333.46060-0.310304.309003.66620HepG2ZNF622
PTENENSG00000171862.51452.55590994.241500.546803.793502.25870HepG2ZRANB2
PTENENSG00000171862.51005.783701530.04710-0.605307.231106.13120K562AKAP8L
PTENENSG00000171862.51122.06040772.060700.539303.646502.64550K562BOP1
PTENENSG00000171862.5814.790101150.27920-0.497506.450104.72120K562CPEB4
PTENENSG00000171862.51316.74850820.924700.681609.873908.37810K562CPSF6
PTENENSG00000171862.5538.73320700.61800-0.379103.111102.26880K562EIF3G
PTENENSG00000171862.51559.946601315.546400.245702.641701.72170K562EIF4G2
PTENENSG00000171862.5769.17010547.226300.491103.445602.16840K562FKBP4
PTENENSG00000171862.5910.42150619.389300.555603.547002.00360K562FUS
PTENENSG00000171862.5580.24810788.10210-0.441704.230003.50460K562FXR1
PTENENSG00000171862.51245.30050808.659200.622804.704603.72710K562G3BP2
PTENENSG00000171862.5851.455901075.79920-0.337402.675201.63950K562HNRNPL
PTENENSG00000171862.51128.01300669.247500.753106.372704.89110K562KRR1
PTENENSG00000171862.51921.761001554.332800.306002.545201.52940K562MAK16
PTENENSG00000171862.5841.523901037.32670-0.301802.282601.45160K562MATR3
PTENENSG00000171862.52329.957101818.974500.357102.953502.00570K562MBNL1
PTENENSG00000171862.5683.336101009.81270-0.563406.580405.59020K562PTBP1
PTENENSG00000171862.51948.904601526.568900.352304.110002.79000K562PUM1
PTENENSG00000171862.5719.27330968.44660-0.429103.521402.56830K562RBM22
PTENENSG00000171862.5374.34760515.70610-0.462203.207602.13590K562RCC2
PTENENSG00000171862.5687.34640840.64470-0.290502.136201.38600K562SF3B4
PTENENSG00000171862.5571.78570989.92090-0.7918010.933209.53610K562SRSF1
PTENENSG00000171862.51142.76990890.309000.360104.376803.33030K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PTEN is not available on ENCORE database.





4 RBPs can affect the splicing of PTEN :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPTENENSG00000171862.5chr10+8971082589710942896927698969300889711874897120160.061000.001790.04917includedK562AKAP8L
SEPTENENSG00000171862.5chr10+897118748971201689692769896930088971760989717776-0.104000.000330.03224excludedHepG2TBRG4
SEPTENENSG00000171862.5chr10+8969177289691880896908028969084689692769896932440.081000.001220.03567includedHepG2SF3A3
SEPTENENSG00000171862.5chr10+8971082589710942896927698969300889711874897120160.134000.000970.01887includedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PTEN is not avaliable on ENCORE database.