POLR2C

General Information

Gene Name       : POLR2C
Gene ID             : ENSG00000102978.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLR2C)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLR2CENSG00000102978.1232.9440.5136.72ENCSR000AEF
HepG2POLR2CENSG00000102978.12126.0691.76108.91ENCSR985KAT
K562POLR2CENSG00000102978.1294.4172.1683.28ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLR2C is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLR2C RNA is bound by 21 proteins.  







eCLIP assay for POLR2C is not avaliable on ENCORE database.





21 proteins are bound to POLR2C RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr165750566957505719+3'-UTR4.374259.52232HepG2AKAP1
chr165750554557505582+3'-UTR4.5848257.51089K562UPF1
chr165750566257505726+3'-UTR3.210123.04054K562GTF2F1
chr165750572657505779+3'-UTR3.892478.41991HepG2AKAP1
chr165750009757500140+3'-UTR,CDS,intron-Proximal3.059624.30396K562UCHL5
chr165750545257505543+3'-UTR4.7683812.41848K562AKAP1
chr165750566457505722+3'-UTR7.2377864.38229K562FAM120A
chr165750579557505840+3'-UTR7.0213661.35746K562UPF1
chr165750572757505784+3'-UTR6.1554633.65928K562FAM120A
chr165750544957505523+3'-UTR5.7027128.06584HepG2UPF1
chr165750305057503101+3'-UTR,CDS,intron-Proximal4.959986.69228HepG2PRPF8
chr165750538457505443+3'-UTR3.1778713.65043K562FAM120A
chr165750544357505517+3'-UTR3.2485713.46276K562FAM120A
chr165750511657505184+3'-UTR3.691216.94885HepG2SUB1
chr165750544257505500+3'-UTR4.6756511.70635HepG2AKAP1
chr165750305057503106+3'-UTR,CDS,intron-Proximal3.188275.28960K562AQR
chr165750511057505266+3'-UTR3.460796.03035K562NOLC1
chr165750558857505628+3'-UTR3.642759.86979K562FAM120A
chr165750538757505452+3'-UTR3.692386.59901K562AKAP1
chr165750532957505442+3'-UTR4.0635015.01147HepG2AKAP1
chr165750572257505790+3'-UTR5.6364115.43167K562AKAP1
chr165750306757503120+3'-UTR,CDS,intron-Proximal3.280745.79046HepG2PPIG
chr165750558257505629+3'-UTR5.0429836.54811K562UPF1
chr165750301157503090+3'-UTR,CDS,intron-Proximal3.715044.57180HepG2AQR
chr165750502457505106+3'-UTR,CDS4.1735013.16793K562PABPC4
chr165750567057505707+3'-UTR3.8466911.37230K562AKAP1
chr165750566057505721+3'-UTR4.368809.57056HepG2FAM120A
chr165750566457505722+3'-UTR4.635569.59063HepG2UPF1
chr165750545957505508+3'-UTR5.7399560.17957K562UPF1
chr165750538057505456+3'-UTR4.84885400.00000K562UPF1
chr165750558357505623+3'-UTR4.541744.49605HepG2UPF1
chr165750550857505545+3'-UTR4.6494259.94180K562UPF1
chr165750521957505297+3'-UTR3.603456.70458HepG2AKAP1
chr165750008557500141+3'-UTR,CDS,intron-Proximal3.236253.50786HepG2G3BP1
chr165750559157505630+3'-UTR3.413104.08171K562YBX3
chr165750538557505449+3'-UTR4.6192916.62201HepG2UPF1
chr165750305457503130+3'-UTR,CDS,intron-Proximal3.3025512.83091HepG2BUD13
chr165750566557505723+3'-UTR6.93800113.16910K562UPF1
chr165749985957499913+3'-UTR,CDS,intron-Proximal3.533164.77019K562BUD13
chr165750552357505588+3'-UTR4.6083422.38676K562FAM120A
chr165750573357505795+3'-UTR5.6168211.24187HepG2UPF1
chr165750552357505578+3'-UTR5.6013813.33130HepG2UPF1
chr165750518457505316+3'-UTR5.0567415.97458HepG2UPF1
chr165750544957505494+3'-UTR3.704464.29911HepG2DDX55
chr165750581957505866+3'-UTR5.0987912.57892K562FAM120A
chr165750572357505795+3'-UTR8.26747151.91851K562UPF1
chr165750540357505456+3'-UTR4.037155.47880HepG2SUB1
chr165749658057496691+5'-UTR,CDS4.104335.32728HepG2DDX3X
chr165749658357496692+5'-UTR,CDS5.4607435.74103K562DDX3X
chr165749697957496990+CDS3.318344.11795K562YBX3
chr165749671457496772+CDS,intron-Proximal3.832273.96535HepG2AQR
chr165750414357504220+CDS,intron-Proximal4.512858.52787K562AQR
chr165750317757503246+CDS,intron-Proximal3.755577.29769HepG2PRPF8
chr165749697457497034+CDS,intron-Proximal5.3729612.43500HepG2PRPF8
chr165750362057503641+CDS,intron-Proximal4.322814.95438K562YBX3
chr165750403157504235+CDS,intron-Proximal5.8054812.49979HepG2AQR
chr165750490157504993+CDS3.565265.31167HepG2GRWD1
chr165749688957497007+CDS,intron-Proximal3.876327.50982HepG2AQR
chr165749684857497033+CDS,intron-Proximal3.839558.13013K562AQR
chr165749669257496723+CDS,intron-Proximal3.8374813.18683K562DDX3X
chr165749670657496757+CDS,intron-Proximal3.741445.62208HepG2PRPF8
chr165750386957503950+CDS,intron-Proximal3.9399310.98900HepG2PPIG
chr165749683557496889+intron-Distal,intron-Proximal3.574993.39008HepG2AQR
chr165749705757497173+intron-Distal,intron-Proximal3.767564.94928HepG2EFTUD2
chr165749705357497143+intron-Distal,intron-Proximal3.071133.40052K562EFTUD2
chr165749680657496925+intron-Distal,intron-Proximal3.332474.52939HepG2PRPF4
chr165749681057496872+intron-Distal,intron-Proximal5.541087.23906K562EFTUD2
chr165749682957496895+intron-Distal,intron-Proximal4.419623.85435K562PRPF8
chr165750016357500256+intron-Distal,intron-Proximal4.135685.99968K562PRPF8
chr165749680957496935+intron-Distal,intron-Proximal5.1428815.85929HepG2EFTUD2
chr165749699157497129+intron-Distal,intron-Proximal3.059157.14956K562PRPF8
chr165749681257496912+intron-Distal,intron-Proximal4.416547.99161HepG2PRPF8
chr165750482357504884+intron-Proximal4.137954.22551K562SF3B4
chr165750323957503291+intron-Proximal4.023756.72755HepG2RBM22
chr165749675757496771+intron-Proximal5.333596.69228HepG2PRPF8
chr165750299757503054+intron-Proximal3.854815.30739HepG2BUD13
chr165750411657504171+intron-Proximal5.564157.41664HepG2EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLR2C is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLR2C is not available on ENCORE database.

  • 77 RBPs can affect the levels of POLR2C.  








The Knockdown/knockout RNA-Seq assay for POLR2C is not available on ENCORE database.





77 RBPs can affect the gene expression of POLR2C :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLR2CENSG00000102978.82488.376902887.99970-0.214902.515301.85560HepG2AUH
POLR2CENSG00000102978.81254.282601719.35050-0.455002.337401.63780HepG2CNOT7
POLR2CENSG00000102978.8633.94560938.92260-0.566604.932504.03700HepG2CPSF6
POLR2CENSG00000102978.81065.575501531.53380-0.5233011.010509.56980HepG2DDX19B
POLR2CENSG00000102978.81005.013401742.24600-0.793709.038707.73370HepG2DDX55
POLR2CENSG00000102978.81157.806801330.06570-0.200102.077401.49700HepG2DNAJC2
POLR2CENSG00000102978.82099.026902588.45890-0.302401.859501.33150HepG2EIF4A3
POLR2CENSG00000102978.81956.780202512.86010-0.360805.723204.59410HepG2EIF4G1
POLR2CENSG00000102978.82487.934903315.81890-0.414408.170407.23100HepG2ETF1
POLR2CENSG00000102978.81858.116002422.85380-0.382902.840902.16720HepG2G3BP1
POLR2CENSG00000102978.8819.183501064.30920-0.377702.312001.72370HepG2GPKOW
POLR2CENSG00000102978.8915.419601354.86880-0.565606.405305.48140HepG2HNRNPA1
POLR2CENSG00000102978.81551.664802340.78790-0.5932013.0967011.36130HepG2HNRNPA2B1
POLR2CENSG00000102978.81227.486201507.00890-0.296002.201301.57550HepG2HNRNPC
POLR2CENSG00000102978.81529.659301802.57730-0.236902.567101.87520HepG2HNRNPF
POLR2CENSG00000102978.81250.084801497.04790-0.260102.876102.25890HepG2HNRNPU
POLR2CENSG00000102978.81878.998002477.20160-0.398702.515201.56960HepG2KHSRP
POLR2CENSG00000102978.82129.526802525.53560-0.246102.324201.62580HepG2NOL12
POLR2CENSG00000102978.8701.40290900.62970-0.360702.335401.64580HepG2NSUN2
POLR2CENSG00000102978.81832.789202394.80800-0.385903.014402.26210HepG2PABPC4
POLR2CENSG00000102978.81214.826401481.86130-0.286703.235902.32670HepG2PARN
POLR2CENSG00000102978.81810.069802363.64400-0.385006.830105.94440HepG2PCBP1
POLR2CENSG00000102978.81021.768001343.84010-0.395302.916002.08720HepG2PRPF8
POLR2CENSG00000102978.81792.770902405.05560-0.423907.904107.07620HepG2PTBP1
POLR2CENSG00000102978.81800.304402410.89700-0.421304.667503.91680HepG2PUF60
POLR2CENSG00000102978.81177.064301519.80490-0.368703.832102.84150HepG2RBM15
POLR2CENSG00000102978.81872.555502676.62970-0.5154011.4381010.48260HepG2NELFE
POLR2CENSG00000102978.81818.419702492.85570-0.455109.253508.22590HepG2RECQL
POLR2CENSG00000102978.81060.355901333.20630-0.330404.382003.60430HepG2SAFB2
POLR2CENSG00000102978.81973.161102504.04600-0.343805.606704.81530HepG2SF3B4
POLR2CENSG00000102978.81521.661701118.597500.443902.288801.58050HepG2SNRNP70
POLR2CENSG00000102978.82700.590403130.20140-0.213002.795602.29220HepG2SRFBP1
POLR2CENSG00000102978.82079.193102380.48270-0.195201.965701.42650HepG2SRSF5
POLR2CENSG00000102978.81661.426702126.31980-0.355906.041705.28220HepG2SRSF9
POLR2CENSG00000102978.81721.165502349.17020-0.448807.425206.58250HepG2TAF15
POLR2CENSG00000102978.81210.631301454.78240-0.265002.254301.79350HepG2TIAL1
POLR2CENSG00000102978.8947.205001290.69310-0.446403.944003.19930HepG2U2AF1
POLR2CENSG00000102978.81971.934102493.26580-0.338402.140101.40980HepG2UBE2L3
POLR2CENSG00000102978.81501.456001189.662600.335704.371803.64660HepG2UTP3
POLR2CENSG00000102978.81121.599301357.46580-0.275403.366002.63630HepG2ZC3H8
POLR2CENSG00000102978.81060.057701428.43090-0.430302.538701.30200HepG2ZRANB2
POLR2CENSG00000102978.83203.955901761.073000.8633029.5559027.79700K562AGGF1
POLR2CENSG00000102978.82791.636501935.276600.528507.331605.53330K562AKAP8
POLR2CENSG00000102978.83142.442801832.506700.7780014.7880013.07200K562AKAP8L
POLR2CENSG00000102978.85682.351002869.419400.9856023.6548022.12610K562AQR
POLR2CENSG00000102978.82802.247601922.798100.5433010.224408.33240K562ATP5C1
POLR2CENSG00000102978.82272.845801800.490300.336003.546202.34650K562DDX3X
POLR2CENSG00000102978.82163.193601669.390900.373706.036605.12620K562DDX47
POLR2CENSG00000102978.82192.617601825.474700.264302.932201.57220K562DDX6
POLR2CENSG00000102978.82836.518901971.717800.524608.974207.21810K562DKC1
POLR2CENSG00000102978.81745.691801387.923600.330802.372101.52840K562EFTUD2
POLR2CENSG00000102978.81616.263701914.46530-0.244302.511901.82110K562EIF2S2
POLR2CENSG00000102978.81582.060101301.453000.281602.049601.31630K562FIP1L1
POLR2CENSG00000102978.81346.71040994.981500.436604.057603.10010K562GPKOW
POLR2CENSG00000102978.83173.263702551.214100.314703.123602.32250K562GRSF1
POLR2CENSG00000102978.82151.556201372.664600.648302.755201.54130K562HNRNPA2B1
POLR2CENSG00000102978.82463.633001918.583700.360602.888301.62670K562HNRNPK
POLR2CENSG00000102978.81416.200801070.511300.403602.850501.90490K562HNRNPM
POLR2CENSG00000102978.82144.616401764.427200.281402.063001.37250K562HSPD1
POLR2CENSG00000102978.82490.846701921.203100.374502.551301.57860K562IGF2BP2
POLR2CENSG00000102978.82893.321301944.641000.573109.681207.88060K562KIF1C
POLR2CENSG00000102978.82676.387501861.586400.523702.771601.69450K562MAK16
POLR2CENSG00000102978.82467.506501526.982900.692306.621705.03830K562NAA15
POLR2CENSG00000102978.82260.153801878.350100.266902.579801.39290K562NCBP2
POLR2CENSG00000102978.82532.502601200.253201.077106.994305.18610K562PABPN1
POLR2CENSG00000102978.82011.916601477.475300.445304.461903.38380K562PPIG
POLR2CENSG00000102978.82453.003601426.535500.781903.549401.82720K562PPP1R8
POLR2CENSG00000102978.82508.549501350.611600.8931015.1498013.38070K562PRPF8
POLR2CENSG00000102978.83922.698001817.126501.1101026.4288024.74610K562PUS1
POLR2CENSG00000102978.82913.641501770.696100.7184011.7333010.52190K562RBM15
POLR2CENSG00000102978.81524.079101979.22330-0.377003.165001.98710K562NELFE
POLR2CENSG00000102978.82221.335601375.689500.691207.658306.28530K562RPS19
POLR2CENSG00000102978.82377.668801097.408901.115305.766303.82120K562SF1
POLR2CENSG00000102978.81102.600201403.19020-0.347804.038703.06220K562SF3A3
POLR2CENSG00000102978.82122.662901260.700900.751503.226101.86230K562SNRNP200
POLR2CENSG00000102978.81662.172301437.598900.209302.337901.46810K562SRPK2
POLR2CENSG00000102978.82560.326901922.965300.412905.044304.09330K562SRSF1
POLR2CENSG00000102978.82687.640701507.724900.833903.938702.11300K562SUPT6H
POLR2CENSG00000102978.82250.045001893.280300.249003.125601.77190K562TROVE2
POLR2CENSG00000102978.81283.602901742.58030-0.441005.582404.44160K562U2AF2
POLR2CENSG00000102978.82192.713301507.815300.5402012.3191010.93920K562UPF1
POLR2CENSG00000102978.83298.788301842.596700.840105.627803.59100K562UTP18
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLR2C is not available on ENCORE database.





1 RBPs can affect the splicing of POLR2C :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLR2CENSG00000102978.8chr16+574969405749697757496585574967225750008657500139-0.067000.006520.05785excludedK562AQR
A3SSPOLR2CENSG00000102978.8chr16+5750006657500139575000865750013957499864574999330.133000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLR2C is not avaliable on ENCORE database.