PML

General Information

Gene Name       : PML
Gene ID             : ENSG00000140464.19
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PML)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PMLENSG00000140464.199.4622.2715.87ENCSR000AEF
HepG2PMLENSG00000140464.197.893.985.93ENCSR985KAT
K562PMLENSG00000140464.1920.4413.9517.20ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
PMLRibo-STAMP-293TshRNAPML-BGRSLV04-37,PML-BGRSLV04-38NT-BGRSLV04-1,NT-BGRSLV04-2,SubmittedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PML is not avaliable on ENCORE database.



Proteins bound to RNA
  • PML RNA is bound by 9 proteins.  







eCLIP assay for PML is not avaliable on ENCORE database.





9 proteins are bound to PML RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr157432686274326953+3'-UTR,CDS,intron-Distal,intron-Proximal5.206366.83960K562AQR
chr157432849974328524+3'-UTR,intron-Distal3.806039.05325K562LIN28B
chr157432805174328141+3'-UTR,CDS,intron-Distal4.787396.57313K562RBM15
chr157432852474328557+3'-UTR,intron-Distal3.986466.76307K562LIN28B
chr157432830574328373+3'-UTR,CDS,intron-Distal,intron-Proximal4.355768.27548K562UPF1
chr157432803574328132+3'-UTR,CDS,intron-Distal3.6570714.35038K562UPF1
chr157432740574327445+3'-UTR,intron-Distal,intron-Proximal4.406954.46422K562UPF1
chr157432830974328360+3'-UTR,CDS,intron-Distal,intron-Proximal4.096654.30417K562YBX3
chr157431522374315300+CDS4.610084.41602K562FXR2
chr157431529674315576+CDS4.5688811.53481K562FMR1
chr157431536074315502+CDS4.435774.78507K562FXR2
chr157431558674315652+CDS4.013063.01428K562UCHL5
chr157429054074290623+CDS4.323346.58618K562FXR2
chr157431993074319970+intron-Distal4.553914.56348K562UPF1
chr157431854174318581+intron-Distal3.489866.04024K562UPF1
chr157431971374319895+intron-Distal4.4317414.25426K562AKAP1
chr157431870674318777+intron-Distal4.762343.78860K562AKAP1
chr157431980174319893+intron-Distal4.7966210.23575K562UPF1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PML is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PML is not available on ENCORE database.

  • 85 RBPs can affect the levels of PML.  








The Knockdown/knockout RNA-Seq assay for PML is not available on ENCORE database.





85 RBPs can affect the gene expression of PML :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PMLENSG00000140464.15506.31080382.682400.403803.222102.57370HepG2ACO1
PMLENSG00000140464.15238.52760155.105700.620802.976401.94390HepG2ADAR
PMLENSG00000140464.15375.08810577.58140-0.622804.915204.14700HepG2BOP1
PMLENSG00000140464.15753.99270557.965200.434302.249101.37860HepG2CCAR1
PMLENSG00000140464.15503.61120382.601400.396403.209102.50260HepG2CKAP4
PMLENSG00000140464.15138.42160212.88880-0.621002.451901.59670HepG2DDX24
PMLENSG00000140464.15386.21330200.350300.946805.262204.23630HepG2DDX55
PMLENSG00000140464.15226.81560156.168700.538302.675301.98060HepG2DNAJC21
PMLENSG00000140464.15301.35930154.824500.960805.956705.05280HepG2DNAJC2
PMLENSG00000140464.15390.00600553.49040-0.505104.908704.14850HepG2ETF1
PMLENSG00000140464.1584.11340166.73970-0.987204.385002.81150HepG2FKBP4
PMLENSG00000140464.15460.74260287.987600.677902.767702.07590HepG2FXR1
PMLENSG00000140464.15272.83080157.665200.791004.542903.74250HepG2HNRNPA1
PMLENSG00000140464.15309.02930175.385000.817102.646101.96660HepG2HNRNPC
PMLENSG00000140464.15386.02970274.561200.491503.724002.94970HepG2HNRNPL
PMLENSG00000140464.15348.55040174.224601.000307.562606.59900HepG2HNRNPU
PMLENSG00000140464.15429.16880318.976500.428002.730602.01160HepG2IGF2BP1
PMLENSG00000140464.15239.80110177.962700.430202.147201.49270HepG2ILF2
PMLENSG00000140464.15419.63840289.659400.534702.010701.46800HepG2MATR3
PMLENSG00000140464.15464.00660247.778400.905005.030603.11870HepG2NOLC1
PMLENSG00000140464.15381.45630184.064601.051203.223602.03680HepG2NONO
PMLENSG00000140464.15316.18670155.392401.024805.271404.28340HepG2PPIL4
PMLENSG00000140464.15242.44030154.457000.650302.127001.41460HepG2PRPF8
PMLENSG00000140464.15423.65720287.780200.557804.657203.98820HepG2PTBP1
PMLENSG00000140464.15388.50050302.858400.359202.278201.72950HepG2PUM1
PMLENSG00000140464.15398.19810302.638100.395802.154801.56020HepG2PUM2
PMLENSG00000140464.15300.70960169.198200.829603.624502.40900HepG2RCC2
PMLENSG00000140464.15400.12730211.163700.922005.194704.38280HepG2RPS19
PMLENSG00000140464.15288.04060192.138800.584002.326601.58910HepG2RPS2
PMLENSG00000140464.15125.28490218.11000-0.799803.248001.58810HepG2RTF1
PMLENSG00000140464.15260.61860155.147900.748205.233704.39800HepG2SAFB2
PMLENSG00000140464.15558.45740228.367501.290004.287702.51600HepG2SF1
PMLENSG00000140464.15686.40410489.482500.487702.324001.70600HepG2SF3A3
PMLENSG00000140464.15282.30610180.917100.641804.434503.65440HepG2SMN1
PMLENSG00000140464.15439.11890204.070201.105403.598902.05890HepG2SNRNP200
PMLENSG00000140464.15428.53000631.76670-0.560002.704301.93210HepG2SNRNP70
PMLENSG00000140464.15362.04180281.691600.361902.035801.48890HepG2SRSF5
PMLENSG00000140464.15399.37720318.237300.327502.064201.45350HepG2SRSF7
PMLENSG00000140464.15449.96760320.362600.490003.982803.26050HepG2SUCLG1
PMLENSG00000140464.15156.38640281.12440-0.846105.814805.05350HepG2TAF15
PMLENSG00000140464.15561.78160169.248301.7308031.1677029.81800HepG2TIAL1
PMLENSG00000140464.15313.09080170.807900.874108.053007.16960HepG2TRIM56
PMLENSG00000140464.15592.72820237.411401.319904.503303.23040HepG2U2AF2
PMLENSG00000140464.15466.73370295.024000.661703.818602.82930HepG2UBE2L3
PMLENSG00000140464.15297.39680196.305500.599202.176801.52760HepG2XRN2
PMLENSG00000140464.152617.416801443.730700.8582030.2944028.50530K562AGGF1
PMLENSG00000140464.152835.799401502.294600.916504.273903.45780K562AKAP8L
PMLENSG00000140464.151757.779301245.971600.496405.206804.44590K562AQR
PMLENSG00000140464.152219.608301576.320300.493604.667403.44590K562ATP5C1
PMLENSG00000140464.15898.36470695.591800.369003.730002.60700K562BCLAF1
PMLENSG00000140464.151367.69700847.344200.690604.821003.34310K562CCAR1
PMLENSG00000140464.15757.54230527.709900.521505.160303.65410K562CSTF2
PMLENSG00000140464.151382.826101681.87740-0.282502.291501.68940K562DDX47
PMLENSG00000140464.151362.90850948.700300.522603.657502.09370K562DHX30
PMLENSG00000140464.152024.632801616.405300.324802.609201.76290K562DKC1
PMLENSG00000140464.15879.56620606.175200.537004.149603.01250K562EFTUD2
PMLENSG00000140464.15957.79060771.486900.312002.613301.36300K562EWSR1
PMLENSG00000140464.151616.755601192.353900.439203.399501.97830K562EXOSC5
PMLENSG00000140464.151956.333301089.704500.844104.438502.78330K562HNRNPA2B1
PMLENSG00000140464.151096.65870900.735700.283801.908801.40160K562HNRNPC
PMLENSG00000140464.15614.72070839.38720-0.449402.916201.95700K562HNRNPM
PMLENSG00000140464.151833.592501300.970100.495007.653206.17490K562HNRNPU
PMLENSG00000140464.15991.161601383.73220-0.481404.568103.55200K562HSPD1
PMLENSG00000140464.151077.32320576.948200.900803.898202.59340K562IGF2BP2
PMLENSG00000140464.15820.71250586.737700.484104.167902.63560K562IGF2BP3
PMLENSG00000140464.152318.471801594.214300.540207.620706.08210K562KIF1C
PMLENSG00000140464.151042.84900803.704000.375703.097001.45550K562LSM11
PMLENSG00000140464.15803.26740606.110400.406203.187702.28250K562MAGOH
PMLENSG00000140464.152384.355001785.936100.416805.168803.84640K562MBNL1
PMLENSG00000140464.151876.421101251.820300.583904.769903.51120K562NAA15
PMLENSG00000140464.151838.446001624.122400.178702.213401.53850K562NSUN2
PMLENSG00000140464.151267.11020887.215800.514104.163302.24040K562NUSAP1
PMLENSG00000140464.151844.66860952.944900.952805.502303.97410K562PABPN1
PMLENSG00000140464.152049.479401132.711700.855404.017102.14170K562PPP1R8
PMLENSG00000140464.15757.91760589.883900.361501.946301.31030K562PRPF8
PMLENSG00000140464.151269.28690807.668300.652106.815405.28550K562PSIP1
PMLENSG00000140464.15762.86090588.892100.373302.898102.22100K562PTBP1
PMLENSG00000140464.151393.801201840.77670-0.401305.333603.81350K562PUM1
PMLENSG00000140464.153409.436301489.668801.1944016.1099014.84210K562PUS1
PMLENSG00000140464.152818.190201451.619600.9570015.2328013.82430K562RBM15
PMLENSG00000140464.15794.62570564.546400.493104.132403.08230K562RBM22
PMLENSG00000140464.151237.07750737.202500.7467011.354509.31820K562RCC2
PMLENSG00000140464.151408.416201036.738000.441902.469701.45050K562SAFB
PMLENSG00000140464.151613.371401000.911500.688702.786501.55310K562SNRNP200
PMLENSG00000140464.151038.64960698.816200.571605.654204.04040K562SRFBP1
PMLENSG00000140464.151232.72480938.811600.392803.434702.24430K562SRSF4
PMLENSG00000140464.15834.60280545.318300.613906.013704.36450K562SRSF5
PMLENSG00000140464.15970.80710584.245300.732508.147506.85370K562TARDBP
PMLENSG00000140464.15945.46620563.585800.746307.077405.66980K562TIA1
PMLENSG00000140464.151138.83180776.804200.551802.204301.37810K562TIAL1
PMLENSG00000140464.15894.81110553.182400.693703.263802.05960K562TRA2A
PMLENSG00000140464.151533.77170825.599800.8935011.498309.28180K562TRIM56
PMLENSG00000140464.15500.96870353.662000.502202.579401.52710K562U2AF1
PMLENSG00000140464.151795.548801473.537500.285002.443701.61860K562WDR3
PMLENSG00000140464.151322.054101532.33280-0.212902.303601.52530K562WDR43
PMLENSG00000140464.15869.80380615.589300.498603.578202.13920K562XRN2
PMLENSG00000140464.151146.834201403.48180-0.291402.107101.36410K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PML is not available on ENCORE database.





2 RBPs can affect the splicing of PML :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
RIPMLENSG00000140464.15chr15+743268187432873574326818743268717432751274328735-0.289000.001620.06648excludedHepG2SFPQ
RIPMLENSG00000140464.15chr15+743268187432873574326818743268717432751274328735-0.406000.000010.00044excludedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PML is not avaliable on ENCORE database.