PDE4A

General Information

Gene Name       : PDE4A
Gene ID             : ENSG00000065989.15
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PDE4A)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PDE4AENSG00000065989.152.223.392.81ENCSR000AEF
HepG2PDE4AENSG00000065989.154.962.203.58ENCSR985KAT
K562PDE4AENSG00000065989.1511.9510.1811.06ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PDE4A is not avaliable on ENCORE database.



Proteins bound to RNA
  • PDE4A RNA is bound by 24 proteins.  







eCLIP assay for PDE4A is not avaliable on ENCORE database.





24 proteins are bound to PDE4A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr191057240810572474+3'-UTR,intron-Proximal5.093029.99483K562EFTUD2
chr191057249510572574+3'-UTR,CDS,intron-Proximal5.662139.95947K562SF3B4
chr191057251410572587+3'-UTR,CDS,intron-Proximal3.775873.00996K562BUD13
chr191057759010577689+3'-UTR,CDS4.729046.54449K562RBM15
chr191057944010579513+3'-UTR3.090896.66758K562ILF3
chr191057239110572473+3'-UTR,intron-Proximal4.258456.86590K562SF3B4
chr191057241210572472+3'-UTR,intron-Proximal4.103136.75234K562PRPF8
chr191057994810580060+3'-UTR4.424463.97692K562IGF2BP1
chr191057856010578607+3'-UTR,polyA_site7.0899116.14968K562CPEB4
chr191057967410579747+3'-UTR4.886477.72686K562ILF3
chr191057987010579933+3'-UTR4.9617819.70107K562PUM2
chr191056365710563690+5'-UTR,intron-Distal4.6457412.07343K562EIF4G2
chr191056383610563880+5'-UTR,intron-Distal5.4407317.75857K562EIF4G2
chr191056388010563914+5'-UTR,intron-Distal4.6299812.48021K562EIF4G2
chr191057007710570166+CDS,intron-Distal3.196623.87559K562YBX3
chr191056153010561604+CDS3.333623.07653K562ZNF622
chr191056558510565718+CDS,intron-Distal,intron-Proximal5.0830016.29828K562EFTUD2
chr191055970710559793+CDS,intron-Proximal4.5333811.37858K562SF3B4
chr191056870210568756+CDS,intron-Distal3.546183.01531K562YBX3
chr191055601810556080+intron-Distal3.943685.84562K562ILF3
chr191056344410563499+intron-Distal6.031816.87822K562AATF
chr191056317110563236+intron-Distal7.5956633.97467K562EIF4G2
chr191057351310573613+intron-Distal3.518753.59765K562ILF3
chr191056236010562409+intron-Distal5.9701711.47680K562EIF4G2
chr191054245710542526+intron-Distal3.789093.14687K562CSTF2T
chr191056455310564603+intron-Distal6.3456915.43836K562EIF4G2
chr191056422510564335+intron-Distal6.0459219.13481K562TARDBP
chr191056402010564082+intron-Distal,intron-Proximal6.7568622.92451K562EIF4G2
chr191056235110562420+intron-Distal3.718563.01619K562FUS
chr191056336910563427+intron-Distal4.918238.14280K562TARDBP
chr191056279510562818+intron-Distal4.998475.62492K562EIF4G2
chr191055409010554203+intron-Distal3.442413.84723K562ILF3
chr191054245410542520+intron-Distal3.918983.28464K562EWSR1
chr191054295010543021+intron-Distal4.075234.10339HepG2CSTF2T
chr191056344910563511+intron-Distal7.1247628.44227K562EIF4G2
chr191056883610568922+intron-Distal,intron-Proximal5.461815.58842K562EFTUD2
chr191053274410532848+intron-Distal4.317414.13641K562TARDBP
chr191056435210564400+intron-Distal6.6772419.42400K562EIF4G2
chr191055588510555951+intron-Distal4.433024.07991K562ILF3
chr191056279710562875+intron-Distal4.971137.52645K562TARDBP
chr191056452510564611+intron-Distal3.318383.50009K562CSTF2T
chr191056284510562894+intron-Distal4.099353.80512K562CSTF2T
chr191056326110563340+intron-Distal3.958366.86504K562TARDBP
chr191054408710544166+intron-Distal3.517784.70733K562HNRNPL
chr191055838210558537+intron-Distal4.135384.33150K562HNRNPK
chr191056317210563236+intron-Distal4.862047.52645K562TARDBP
chr191057132310571334+intron-Distal6.1241613.56104K562SF3B4
chr191055595110556018+intron-Distal4.766674.83729K562ILF3
chr191056234110562407+intron-Distal4.715656.96521K562TARDBP
chr191056561910565781+intron-Distal,intron-Proximal3.106236.49827K562PRPF8
chr191054222010542252+intron-Distal3.948323.53896K562NONO
chr191056413110564201+intron-Distal5.8885421.19135K562EIF4G2
chr191056229110562312+intron-Distal5.541559.37109K562EIF4G2
chr191056284810562906+intron-Distal6.8148220.42309K562EIF4G2
chr191054370910543768+intron-Distal4.102384.33692K562NONO
chr191056177110561832+intron-Distal3.819313.17740K562CSTF2T
chr191054482910544899+intron-Distal4.713094.90095K562PTBP1
chr191057205110572158+intron-Distal,intron-Proximal3.721133.85148K562GTF2F1
chr191057133410571407+intron-Distal5.6359018.10317K562SF3B4
chr191056257210562614+intron-Distal3.893093.43867K562CSTF2T
chr191054417910544271+intron-Distal3.512984.25660K562HNRNPL
chr191056317010563239+intron-Distal3.592413.15535K562EWSR1
chr191056344110563489+intron-Distal3.546445.27598K562TARDBP
chr191056433510564412+intron-Distal5.6614714.82580K562TARDBP
chr191056255110562630+intron-Distal5.1016910.02297K562EIF4G2
chr191056443810564562+intron-Distal4.7868813.73871K562TARDBP
chr191056344410563518+intron-Distal4.889103.77602K562DDX52
chr191057212910572200+intron-Proximal4.752915.33214K562PRPF8
chr191056161710561660+intron-Proximal3.973855.47926K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PDE4A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PDE4A is not available on ENCORE database.

  • 68 RBPs can affect the levels of PDE4A.  








The Knockdown/knockout RNA-Seq assay for PDE4A is not available on ENCORE database.





68 RBPs can affect the gene expression of PDE4A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PDE4AENSG00000065989.11138.17410208.73450-0.595202.476501.45930HepG2AATF
PDE4AENSG00000065989.11336.79270474.33660-0.494102.444501.55910HepG2ABCF1
PDE4AENSG00000065989.11147.76730289.49830-0.970206.600605.72280HepG2BOP1
PDE4AENSG00000065989.11284.71020431.98260-0.601503.085802.05280HepG2CCAR1
PDE4AENSG00000065989.11207.28580337.36040-0.702703.146102.32680HepG2CNOT7
PDE4AENSG00000065989.1153.86260129.99140-1.271106.018504.52940HepG2CSTF2
PDE4AENSG00000065989.11359.32520274.882900.386402.538101.73640HepG2DDX19B
PDE4AENSG00000065989.11136.53690230.19650-0.753603.918903.12600HepG2DDX21
PDE4AENSG00000065989.11581.05280302.870700.939907.865906.87620HepG2DDX6
PDE4AENSG00000065989.11664.94620291.020201.1920013.8309012.57160HepG2EIF2S1
PDE4AENSG00000065989.11205.93190375.15310-0.865304.457802.16950HepG2EIF3H
PDE4AENSG00000065989.11457.13380301.032900.602603.618902.86200HepG2G3BP1
PDE4AENSG00000065989.11351.07770248.187500.500303.008402.26290HepG2HNRNPF
PDE4AENSG00000065989.11309.87810242.047200.356301.919401.40570HepG2HNRNPU
PDE4AENSG00000065989.11224.10000324.74020-0.535102.190501.60490HepG2MAGOH
PDE4AENSG00000065989.11236.89070334.19020-0.496402.241301.66810HepG2NCBP2
PDE4AENSG00000065989.11470.22940308.361700.608602.658301.79210HepG2PABPC1
PDE4AENSG00000065989.11294.84730215.885200.449602.473501.77250HepG2PPIL4
PDE4AENSG00000065989.11169.44300272.55490-0.685704.626803.65390HepG2PRPF4
PDE4AENSG00000065989.11248.57160323.26990-0.379102.000501.52170HepG2PTBP1
PDE4AENSG00000065989.11399.65690328.721300.281801.852201.34610HepG2PUM1
PDE4AENSG00000065989.11502.28970328.470500.612705.359504.43990HepG2PUM2
PDE4AENSG00000065989.11148.32910248.19260-0.742702.618201.93170HepG2RAVER1
PDE4AENSG00000065989.11285.29100193.551800.559602.792602.17490HepG2RPS19
PDE4AENSG00000065989.11278.71380405.94020-0.542502.278101.66540HepG2SF3A3
PDE4AENSG00000065989.11478.13310284.576100.748505.950904.94870HepG2SF3B1
PDE4AENSG00000065989.11372.91780170.143201.132003.565602.04000HepG2SNRNP200
PDE4AENSG00000065989.11318.42280404.88000-0.346602.068101.61510HepG2SRFBP1
PDE4AENSG00000065989.11176.19480351.31220-0.995609.233308.48220HepG2SRSF1
PDE4AENSG00000065989.11207.99640306.21030-0.558002.228001.34160HepG2SRSF3
PDE4AENSG00000065989.11222.38700351.54590-0.660603.201502.65920HepG2SSB
PDE4AENSG00000065989.11118.93500206.05380-0.792803.715802.94850HepG2SUPV3L1
PDE4AENSG00000065989.11241.16670315.75450-0.388801.910901.43000HepG2TAF15
PDE4AENSG00000065989.11335.23290237.298700.498403.433702.82050HepG2TRIM56
PDE4AENSG00000065989.11425.69570197.996601.104203.166002.10990HepG2U2AF2
PDE4AENSG00000065989.11267.53580360.00570-0.428302.727902.03240HepG2UPF1
PDE4AENSG00000065989.11155.45150347.57310-1.1609011.8386010.73460HepG2UTP3
PDE4AENSG00000065989.11184.08520273.01490-0.568602.278901.32030HepG2XRCC6
PDE4AENSG00000065989.11287.92280395.93900-0.459603.503702.90860HepG2ZNF622
PDE4AENSG00000065989.11965.51950665.480200.536804.991803.48060K562CCAR1
PDE4AENSG00000065989.111915.566101198.530600.676402.966201.86010K562CNOT7
PDE4AENSG00000065989.11712.65210556.668300.356302.843901.51070K562DDX6
PDE4AENSG00000065989.11976.24740745.054300.389802.788801.45590K562DHX30
PDE4AENSG00000065989.111232.75540880.477000.485406.795905.32310K562DKC1
PDE4AENSG00000065989.11820.71310597.163800.458702.626301.73980K562EFTUD2
PDE4AENSG00000065989.11750.97310603.061600.316402.626101.45620K562EIF2S1
PDE4AENSG00000065989.11416.61490311.505000.419402.716101.92620K562EIF3G
PDE4AENSG00000065989.11757.01190573.621200.400102.869402.03330K562EIF4A3
PDE4AENSG00000065989.11675.95750516.564200.387903.233601.96680K562EIF4B
PDE4AENSG00000065989.11795.57960596.539600.415303.902503.20230K562FXR1
PDE4AENSG00000065989.11151.00280292.61590-0.954405.648404.55640K562G3BP2
PDE4AENSG00000065989.11829.86340655.725100.339702.302201.75090K562HNRNPC
PDE4AENSG00000065989.11845.60420585.651200.529804.802703.24900K562HNRNPF
PDE4AENSG00000065989.111053.639101452.55220-0.463204.394203.39830K562HSPD1
PDE4AENSG00000065989.11622.52710441.341800.496102.811101.77610K562IGF2BP2
PDE4AENSG00000065989.11622.29300448.848800.471303.603902.20320K562IGF2BP3
PDE4AENSG00000065989.11913.05360665.241200.456703.186501.59280K562LIN28B
PDE4AENSG00000065989.11672.44130463.695400.536104.713303.60880K562MAGOH
PDE4AENSG00000065989.11607.32250462.733800.392202.750501.82990K562MATR3
PDE4AENSG00000065989.111355.09560972.778500.478105.658704.26840K562MBNL1
PDE4AENSG00000065989.11623.25640412.549000.595203.385702.30530K562PCBP2
PDE4AENSG00000065989.11804.293101018.16960-0.340202.872402.05610K562POLR2G
PDE4AENSG00000065989.11959.986901216.18650-0.341302.491201.71710K562PPIG
PDE4AENSG00000065989.11754.44000450.519400.743709.307308.13780K562PTBP1
PDE4AENSG00000065989.111865.648101603.465300.218402.405801.50930K562PUM2
PDE4AENSG00000065989.11991.90230811.459300.289601.968401.49550K562PUS1
PDE4AENSG00000065989.111126.38440790.658100.510506.409205.53260K562RBM15
PDE4AENSG00000065989.11577.15740431.919200.418102.748101.91110K562RBM22
PDE4AENSG00000065989.11638.45010457.880100.479502.740101.74110K562RPS3
PDE4AENSG00000065989.11503.26740304.215300.726107.309905.87880K562SF3B4
PDE4AENSG00000065989.111074.67310630.289500.769703.161701.73250K562SFPQ
PDE4AENSG00000065989.11806.02210508.619600.664106.595904.81550K562SRFBP1
PDE4AENSG00000065989.11638.28630441.674600.531104.410003.52250K562SRSF1
PDE4AENSG00000065989.11629.37330441.984200.509803.772002.51350K562SRSF4
PDE4AENSG00000065989.11720.53660446.970300.688806.494005.36800K562TARDBP
PDE4AENSG00000065989.11621.01260431.162000.526304.491703.41080K562TIA1
PDE4AENSG00000065989.11806.75450565.495900.512503.049602.06200K562TIAL1
PDE4AENSG00000065989.11563.21290423.177000.412302.584101.53380K562TRA2A
PDE4AENSG00000065989.11977.68550600.897700.702207.876706.08860K562TRIM56
PDE4AENSG00000065989.11213.64970292.89560-0.455102.367601.62460K562U2AF2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PDE4A is not available on ENCORE database.





6 RBPs can affect the splicing of PDE4A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPDE4AENSG00000065989.11chr19+1056832510568456105655041056559810568554105687780.217000.000000.00000includedHepG2U2AF1
SEPDE4AENSG00000065989.11chr19+1056832510568456105655041056559810568554105687780.154000.000000.00000includedHepG2U2AF2
SEPDE4AENSG00000065989.11chr19+1056832510568456105655041056559810568554105687780.137000.000030.00062includedK562AQR
SEPDE4AENSG00000065989.11chr19+1056832510568456105655041056559810568554105687780.099000.004010.05263includedK562PUS1
SEPDE4AENSG00000065989.11chr19+1056832510568456105655041056559810568554105687780.065000.000190.02071includedK562HNRNPUL1
SEPDE4AENSG00000065989.11chr19+1056832510568456105655041056559810568554105687780.150000.000120.07331includedK562HLTF
A3SSPDE4AENSG00000065989.11chr19+105595061055962910559592105596291055689310557085-0.089000.000150.05585shorterHepG2HNRNPUL1
A3SSPDE4AENSG00000065989.11chr19+105595061055962910559592105596291055689310557085-0.089000.000100.00383shorterHepG2U2AF2
A5SSPDE4AENSG00000065989.11chr19+1057255210572732105725521057267510574468105746510.066000.000550.01121longerK562AQR
RIPDE4AENSG00000065989.11chr19+1057220110572675105722011057235610572552105726750.141000.016120.08457includedK562PUS1
RIPDE4AENSG00000065989.11chr19+1057220110572675105722011057235610572552105726750.108000.017990.08993includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PDE4A is not avaliable on ENCORE database.