FBXW7

General Information

Gene Name       : FBXW7
Gene ID             : ENSG00000109670.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: FBXW7)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FBXW7ENSG00000109670.1451.7737.9644.87ENCSR000AEF
HepG2FBXW7ENSG00000109670.1410.7814.2212.50ENCSR985KAT
K562FBXW7ENSG00000109670.149.489.659.57ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for FBXW7 is not avaliable on ENCORE database.



Proteins bound to RNA
  • FBXW7 RNA is bound by 22 proteins.  







eCLIP assay for FBXW7 is not avaliable on ENCORE database.





22 proteins are bound to FBXW7 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr4153332955153333010-3'-UTR,5'-UTR,intron-Distal3.255563.31745K562ZNF622
chr4153247108153247169-CDS,intron-Distal,intron-Proximal3.704434.93376K562PRPF8
chr4153332650153332704-CDS,intron-Distal3.498564.22460K562RBM15
chr4153332721153332781-CDS,intron-Distal3.916745.08388K562UCHL5
chr4153251870153251918-CDS,intron-Distal,intron-Proximal4.026883.02457HepG2BCLAF1
chr4153332464153332514-CDS,intron-Distal,intron-Proximal3.387073.36945K562ZNF622
chr4153332586153332648-CDS,intron-Distal4.347077.87612K562UCHL5
chr4153268051153268125-CDS,intron-Distal,intron-Proximal3.940995.05356HepG2PRPF8
chr4153332649153332691-CDS,intron-Distal4.463084.10264K562ZNF622
chr4153332605153332726-CDS,intron-Distal4.344367.09561HepG2BCLAF1
chr4153332479153332586-CDS,intron-Distal,intron-Proximal3.9112811.51254K562UCHL5
chr4153332648153332701-CDS,intron-Distal3.388995.76403K562UCHL5
chr4153332638153332701-CDS,intron-Distal3.952333.22063K562TRA2A
chr4153332572153332690-CDS,intron-Distal3.381204.77136HepG2PPIG
chr4153268185153268241-CDS,intron-Distal,intron-Proximal4.770094.20763HepG2U2AF2
chr4153249394153249485-CDS,intron-Distal3.983403.43980K562ZNF622
chr4153332473153332605-CDS,intron-Distal,intron-Proximal3.602546.60490HepG2BCLAF1
chr4153332526153332580-CDS,intron-Distal3.713114.49887K562ZNF622
chr4153392484153392606-intron-Distal6.7358727.75544HepG2PCBP2
chr4153414643153414709-intron-Distal4.664735.84463HepG2SUGP2
chr4153379570153379631-intron-Distal4.098413.34609K562TARDBP
chr4153386505153386606-intron-Distal3.128873.73266K562KHSRP
chr4153421085153421133-intron-Distal3.796253.04224HepG2SUGP2
chr4153408435153408552-intron-Distal4.8561416.41401K562KHSRP
chr4153409978153410040-intron-Distal4.817097.83372K562KHSRP
chr4153415305153415379-intron-Distal3.659983.10961HepG2MATR3
chr4153385420153385509-intron-Distal4.542924.31720HepG2MATR3
chr4153396193153396256-intron-Distal3.201053.61097K562ILF3
chr4153408485153408633-intron-Distal3.995604.77518HepG2U2AF2
chr4153380460153380532-intron-Distal3.508644.28420HepG2HNRNPM
chr4153380080153380132-intron-Distal4.495654.64592HepG2HNRNPM
chr4153406534153406599-intron-Distal4.352544.51735HepG2QKI
chr4153414826153414877-intron-Distal3.611274.57452HepG2SUGP2
chr4153408360153408435-intron-Distal3.482085.14864K562KHSRP
chr4153392675153392744-intron-Distal4.183567.54289HepG2PTBP1
chr4153349775153349839-intron-Distal3.995403.26999K562KHSRP
chr4153392506153392600-intron-Distal5.237505.82558K562PCBP1
chr4153451375153451567-intron-Distal,intron-Proximal,polyA_site4.956006.73862HepG2SFPQ
chr4153419156153419259-intron-Distal4.854397.27974HepG2QKI
chr4153401709153401763-intron-Distal4.173694.28663HepG2SUGP2
chr4153408394153408509-intron-Distal4.730686.68793HepG2KHSRP
chr4153392497153392569-intron-Distal3.969093.59342K562CSTF2T
chr4153392606153392647-intron-Distal5.309245.14122HepG2PCBP2
chr4153408710153408789-intron-Distal4.631334.17759HepG2QKI
chr4153416827153416886-intron-Distal3.809023.16028HepG2SUGP2
chr4153339222153339306-intron-Distal3.953663.34609K562TARDBP
chr4153387182153387245-intron-Distal3.805263.42844K562KHSRP
chr4153392689153392747-intron-Distal3.988075.02233K562PTBP1
chr4153414749153414826-intron-Distal4.7446711.37109HepG2SUGP2
chr4153415053153415124-intron-Distal4.083304.03269HepG2PTBP1
chr4153392491153392607-intron-Distal4.5411112.32174K562PTBP1
chr4153387264153387324-intron-Distal4.253854.31512K562KHSRP
chr4153410040153410110-intron-Distal3.252834.52210K562KHSRP
chr4153403378153403476-intron-Distal4.044974.37030K562KHSRP
chr4153397236153397316-intron-Distal4.428625.68841K562KHSRP
chr4153379665153379761-intron-Distal5.3006110.51914K562TARDBP
chr4153317216153317289-intron-Distal4.885097.43163HepG2QKI
chr4153377947153378056-intron-Distal3.924803.22972K562TARDBP
chr4153386606153386715-intron-Distal4.342005.46313K562KHSRP
chr4153396166153396257-intron-Distal4.216584.58424HepG2ILF3
chr4153448511153448596-intron-Distal3.468033.98726HepG2RBFOX2
chr4153408552153408626-intron-Distal4.623977.17304K562KHSRP
chr4153392413153392467-intron-Distal4.173744.14103K562KHSRP
chr4153392494153392569-intron-Distal3.561216.41195HepG2PTBP1
chr4153449852153449960-intron-Distal3.071683.36386HepG2SFPQ
chr4153455552153455630-intron-Distal4.494566.96007HepG2XPO5
chr4153370108153370199-intron-Distal3.801123.66782HepG2HNRNPM
chr4153392487153392559-intron-Distal5.064186.66835K562ILF3
chr4153423943153424120-intron-Distal3.547558.67954K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for FBXW7 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for FBXW7 is not available on ENCORE database.

  • 77 RBPs can affect the levels of FBXW7.  








The Knockdown/knockout RNA-Seq assay for FBXW7 is not available on ENCORE database.





77 RBPs can affect the gene expression of FBXW7 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FBXW7ENSG00000109670.9479.29330327.202600.550605.195604.41500HepG2ACO1
FBXW7ENSG00000109670.91006.84440346.135801.5403022.0569020.71040HepG2AKAP1
FBXW7ENSG00000109670.9467.49420328.699800.508104.245203.31020HepG2AKAP8L
FBXW7ENSG00000109670.9390.99550286.399700.449002.157201.46030HepG2ASCC1
FBXW7ENSG00000109670.91060.75440434.404601.2879023.5828022.10700HepG2BOP1
FBXW7ENSG00000109670.9653.07780356.043500.8751010.732009.36530HepG2CALR
FBXW7ENSG00000109670.9382.11890272.099000.489802.473301.73780HepG2CIRBP
FBXW7ENSG00000109670.9468.35200327.083300.517804.696603.87400HepG2CKAP4
FBXW7ENSG00000109670.9392.00940186.448901.072009.048907.28580HepG2CSTF2
FBXW7ENSG00000109670.9468.88190293.573600.675405.037304.15040HepG2DDX21
FBXW7ENSG00000109670.9762.14010452.879500.750804.053502.88340HepG2DDX59
FBXW7ENSG00000109670.9575.45700284.822601.014508.947007.90120HepG2DDX6
FBXW7ENSG00000109670.9387.63690234.980900.722104.728403.57110HepG2EIF3D
FBXW7ENSG00000109670.9851.42010302.600001.4924021.2093019.47600HepG2EIF4A3
FBXW7ENSG00000109670.9902.54400294.617101.615109.715808.46580HepG2EIF4B
FBXW7ENSG00000109670.9642.64520451.100800.510504.929803.86410HepG2EIF4G1
FBXW7ENSG00000109670.91103.07490660.452900.7399013.6038012.43540HepG2ETF1
FBXW7ENSG00000109670.9500.73180319.692600.647305.454404.28010HepG2EWSR1
FBXW7ENSG00000109670.9611.48550398.517600.617603.917603.01430HepG2FIP1L1
FBXW7ENSG00000109670.9239.58690154.783900.630203.038202.21650HepG2FUBP3
FBXW7ENSG00000109670.9528.16180351.617800.586903.103701.92130HepG2FUS
FBXW7ENSG00000109670.9411.00890305.300400.428802.058201.45770HepG2FXR1
FBXW7ENSG00000109670.9394.54740283.216300.478202.372101.75310HepG2G3BP1
FBXW7ENSG00000109670.9443.69380312.355600.506304.262503.06800HepG2HDGF
FBXW7ENSG00000109670.9610.55110320.579100.929308.583907.41600HepG2HNRNPC
FBXW7ENSG00000109670.9451.50180286.769500.654704.370003.50860HepG2HNRNPK
FBXW7ENSG00000109670.9520.30240287.885100.853807.224406.18530HepG2IGF2BP2
FBXW7ENSG00000109670.9738.79620270.160001.451307.507605.94370HepG2IGF2BP3
FBXW7ENSG00000109670.9802.00890586.505300.451402.502801.71440HepG2LARP4
FBXW7ENSG00000109670.9743.12770305.406901.2828011.3160010.02210HepG2MAGOH
FBXW7ENSG00000109670.9714.16140307.117901.2174010.450909.28540HepG2MATR3
FBXW7ENSG00000109670.9454.93130314.353600.533202.975902.32040HepG2NCBP2
FBXW7ENSG00000109670.9605.46250453.423300.417103.166902.35320HepG2NOL12
FBXW7ENSG00000109670.9456.14300279.958700.704204.838403.89450HepG2PABPC4
FBXW7ENSG00000109670.9575.00290332.864800.788505.112303.73730HepG2PCBP2
FBXW7ENSG00000109670.9472.22610228.966801.044209.702208.29890HepG2PRPF8
FBXW7ENSG00000109670.9474.22290285.435600.732307.538506.72410HepG2PTBP1
FBXW7ENSG00000109670.9332.37880432.82550-0.381002.067001.54050HepG2PUF60
FBXW7ENSG00000109670.9688.92290459.124800.585405.628604.68560HepG2PUM2
FBXW7ENSG00000109670.9471.01920333.270000.499004.298103.56130HepG2PUS1
FBXW7ENSG00000109670.9659.58400309.120201.0933015.9883014.66550HepG2QKI
FBXW7ENSG00000109670.9570.42310421.325000.437003.233502.31400HepG2RBM15
FBXW7ENSG00000109670.91154.36670552.014601.0642023.4630022.25120HepG2RBM22
FBXW7ENSG00000109670.9408.65660280.551600.542503.524602.77060HepG2RBM25
FBXW7ENSG00000109670.9567.99670317.657100.838309.913209.00560HepG2NELFE
FBXW7ENSG00000109670.9489.56660295.864100.726507.318506.38750HepG2RECQL
FBXW7ENSG00000109670.9722.55750478.396400.594805.629804.70670HepG2RPLP0
FBXW7ENSG00000109670.9449.47840228.634700.975109.649108.58510HepG2RPS19
FBXW7ENSG00000109670.9635.09290323.106200.9749010.270508.81360HepG2RPS2
FBXW7ENSG00000109670.9474.45240226.506501.066609.320307.99920HepG2RRP9
FBXW7ENSG00000109670.9357.02910500.93130-0.488602.602401.33280HepG2SART3
FBXW7ENSG00000109670.9807.91740441.950300.870207.227906.10190HepG2SF3A3
FBXW7ENSG00000109670.9577.33730427.057200.434902.703902.00590HepG2SF3B1
FBXW7ENSG00000109670.9515.64780297.163900.795008.731607.77210HepG2SF3B4
FBXW7ENSG00000109670.9703.61180475.172700.566202.874602.07780HepG2SNRNP70
FBXW7ENSG00000109670.9871.30910623.477000.482705.995705.33610HepG2SRFBP1
FBXW7ENSG00000109670.9813.29840310.179401.3906030.7898029.58710HepG2SRSF1
FBXW7ENSG00000109670.9749.04280427.342800.8096012.6074011.40260HepG2SRSF5
FBXW7ENSG00000109670.9399.97140252.351500.664406.121805.35750HepG2SRSF9
FBXW7ENSG00000109670.9744.53030486.014500.615208.231807.25460HepG2SUCLG1
FBXW7ENSG00000109670.9591.85710295.360901.002709.216508.10190HepG2SUPV3L1
FBXW7ENSG00000109670.9638.73690278.814301.1958020.0873018.77240HepG2TAF15
FBXW7ENSG00000109670.9401.97700256.178600.649903.354402.43820HepG2TIA1
FBXW7ENSG00000109670.9700.45180309.461901.1784019.6775018.56640HepG2TIAL1
FBXW7ENSG00000109670.9754.32470340.972201.1454014.8763013.37760HepG2U2AF1
FBXW7ENSG00000109670.9520.02570353.262300.557702.866401.79010HepG2XRCC6
FBXW7ENSG00000109670.9682.80410335.128401.0267014.8493013.49360HepG2ZC3H8
FBXW7ENSG00000109670.9598.72680431.061400.473905.046204.36210HepG2ZNF622
FBXW7ENSG00000109670.9716.91090916.44300-0.354302.519601.89540K562AKAP8L
FBXW7ENSG00000109670.92007.92770933.495201.1049021.1647019.71510K562AQR
FBXW7ENSG00000109670.9763.88370608.786400.327302.609801.90660K562EIF2S2
FBXW7ENSG00000109670.9725.92130505.287300.522604.494703.44850K562EIF4A3
FBXW7ENSG00000109670.9447.09150595.94140-0.414602.660601.82780K562FIP1L1
FBXW7ENSG00000109670.9680.72040390.234000.802608.855007.83780K562HNRNPC
FBXW7ENSG00000109670.9666.61980842.65630-0.338102.428901.44650K562HNRNPL
FBXW7ENSG00000109670.9469.76460612.50060-0.382802.948102.02610K562HNRNPU
FBXW7ENSG00000109670.9590.94970749.71940-0.343303.357802.54240K562NSUN2
FBXW7ENSG00000109670.91466.179701184.348300.307902.035001.33480K562PUF60
FBXW7ENSG00000109670.9712.38790458.257500.636403.269501.70810K562RAVER1
FBXW7ENSG00000109670.9739.35450885.55550-0.260301.852001.34920K562RBM15
FBXW7ENSG00000109670.9518.31860739.83150-0.513405.245904.14850K562SF3A3
FBXW7ENSG00000109670.91029.62010781.942700.396902.826101.45040K562SSRP1
FBXW7ENSG00000109670.9427.04240645.16730-0.595304.801003.85840K562TARDBP
FBXW7ENSG00000109670.9654.93490794.94600-0.279502.168501.52730K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for FBXW7 is not available on ENCORE database.





4 RBPs can affect the splicing of FBXW7 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEFBXW7ENSG00000109670.9chr4-153333631153333681153332454153333024153456092153456153-0.489000.002000.03645excludedK562SRSF1
SEFBXW7ENSG00000109670.9chr4-153251883153252020153250823153250937153253747153253871-0.139000.002810.02900excludedK562AQR
SEFBXW7ENSG00000109670.9chr4-1533033401533035181532711931532712761533324541533330300.113000.007830.08727includedK562PUS1
A3SSFBXW7ENSG00000109670.9chr4-1532493591532496081532493591532495411532508231532509370.425000.000000.00000longerK562AQR
A3SSFBXW7ENSG00000109670.9chr4-1532518831532520501532518831532520201532537471532538710.102000.001510.01001longerK562AQR
MXEFBXW7ENSG00000109670.9chr4-1532711931532712761533324541533330241532680811532682231534560921534572530.182000.003060.051551includedHepG2FTO

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for FBXW7 is not avaliable on ENCORE database.