EIF2AK3

General Information

Gene Name       : EIF2AK3
Gene ID             : ENSG00000172071.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: EIF2AK3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878EIF2AK3ENSG00000172071.1129.6523.6326.64ENCSR000AEF
HepG2EIF2AK3ENSG00000172071.1115.8117.6016.71ENCSR985KAT
K562EIF2AK3ENSG00000172071.115.296.585.94ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for EIF2AK3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • EIF2AK3 RNA is bound by 15 proteins.  







eCLIP assay for EIF2AK3 is not avaliable on ENCORE database.





15 proteins are bound to EIF2AK3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr28885630588856369-3'-UTR,intron-Distal5.2665412.54168K562PUM2
chr28892668988926802-5'-UTR,CDS,intron-Distal3.7390114.65904HepG2DDX3X
chr28892687188926987-5'-UTR,intron-Distal4.437148.90057HepG2NCBP2
chr28892682888926942-5'-UTR,intron-Distal3.8736018.78076HepG2DDX3X
chr28889033888890487-CDS,intron-Distal5.0978414.71257HepG2BCLAF1
chr28892652188926606-CDS,intron-Distal4.7292311.51889HepG2DDX3X
chr28887907588879141-CDS,intron-Distal3.630116.67313HepG2BCLAF1
chr28889278888892848-CDS,intron-Distal,intron-Proximal3.891863.34184HepG2GRWD1
chr28887903288879075-CDS,intron-Distal,intron-Proximal3.261623.71797HepG2BCLAF1
chr28889278988892898-CDS,intron-Distal,intron-Proximal3.539086.25299K562ZNF622
chr28887467388874683-CDS,intron-Distal,intron-Proximal4.054103.38968HepG2BCLAF1
chr28886177888861840-CDS,intron-Distal,intron-Proximal4.090104.54206HepG2PRPF8
chr28887474688874867-CDS,intron-Distal,intron-Proximal3.917838.99990K562RBM15
chr28888290788882985-CDS,intron-Distal,intron-Proximal4.879545.68502HepG2PRPF8
chr28888996088890040-CDS,intron-Distal,intron-Proximal4.770853.77023K562ZNF622
chr28887042388870513-CDS,intron-Distal,intron-Proximal3.422564.02291HepG2GRWD1
chr28889033388890418-CDS,intron-Distal,intron-Proximal3.436164.08943HepG2LIN28B
chr28888832988888415-CDS,intron-Distal4.452038.47938HepG2BCLAF1
chr28888996088890024-CDS,intron-Distal,intron-Proximal3.283794.25541HepG2GRWD1
chr28888996488890015-CDS,intron-Distal4.070616.22576HepG2BCLAF1
chr28889284888892919-CDS,intron-Distal3.124043.39306HepG2GRWD1
chr28888827988888329-CDS,intron-Distal3.580345.76104HepG2BCLAF1
chr28889611488896266-intron-Distal3.508077.67272HepG2QKI
chr28888119188881219-intron-Distal3.753574.23286HepG2QKI
chr28888121988881270-intron-Distal4.863555.54528HepG2QKI
chr28888118688881272-intron-Distal4.518365.19445K562QKI
chr28889548288895548-intron-Distal4.745036.58335HepG2QKI
chr28885900788859125-intron-Distal3.070983.15317HepG2HNRNPL
chr28888236488882463-intron-Distal4.007033.24603K562KHSRP
chr28888435788884442-intron-Distal4.951144.97123HepG2PCBP2
chr28890429788904371-intron-Distal5.228755.54528HepG2QKI
chr28886875488868858-intron-Distal4.004363.38675HepG2ILF3
chr28885901888859099-intron-Distal4.192163.80299K562HNRNPL
chr28888480188884868-intron-Distal3.748563.17235HepG2HNRNPK
chr28890653488906633-intron-Distal4.287396.41553K562KHSRP
chr28888458188884690-intron-Distal4.849386.64534HepG2HNRNPL
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for EIF2AK3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for EIF2AK3 is not available on ENCORE database.

  • 74 RBPs can affect the levels of EIF2AK3.  








The Knockdown/knockout RNA-Seq assay for EIF2AK3 is not available on ENCORE database.





74 RBPs can affect the gene expression of EIF2AK3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
EIF2AK3ENSG00000172071.7887.330001145.28970-0.368202.333701.46660HepG2ABCF1
EIF2AK3ENSG00000172071.7626.59720859.03570-0.455205.711704.89960HepG2ACO1
EIF2AK3ENSG00000172071.7543.03110886.37560-0.706907.259305.74160HepG2ADAR
EIF2AK3ENSG00000172071.71383.856901033.438600.421103.861002.21500HepG2ATP5C1
EIF2AK3ENSG00000172071.71343.285601071.155800.326503.617002.85010HepG2AUH
EIF2AK3ENSG00000172071.7607.842901041.73420-0.777209.685508.65240HepG2BOP1
EIF2AK3ENSG00000172071.7723.84340858.80710-0.246702.167901.56830HepG2CKAP4
EIF2AK3ENSG00000172071.7594.654201037.99810-0.803705.559904.47180HepG2CNOT7
EIF2AK3ENSG00000172071.71211.76240956.354500.341402.352501.71150HepG2CPSF6
EIF2AK3ENSG00000172071.7681.23130943.11900-0.469304.261002.90480HepG2CPSF7
EIF2AK3ENSG00000172071.71580.587901229.022200.362903.011902.24330HepG2DAZAP1
EIF2AK3ENSG00000172071.7463.86590794.46570-0.7763014.5113012.92840HepG2DDX19B
EIF2AK3ENSG00000172071.7646.16110860.85830-0.413903.223302.16850HepG2DHX30
EIF2AK3ENSG00000172071.7627.78640821.85350-0.388603.788703.02010HepG2DKC1
EIF2AK3ENSG00000172071.7468.05610892.55290-0.9313016.8894015.29530HepG2DNAJC21
EIF2AK3ENSG00000172071.7628.91200884.63560-0.492207.250806.26470HepG2DNAJC2
EIF2AK3ENSG00000172071.71285.95300940.414400.451403.437902.78070HepG2EIF2S1
EIF2AK3ENSG00000172071.71814.029201161.394700.643207.757506.42340HepG2EIF4G2
EIF2AK3ENSG00000172071.7919.767901229.87630-0.419205.627504.81990HepG2ETF1
EIF2AK3ENSG00000172071.7816.510801032.63030-0.338802.085601.31920HepG2G3BP2
EIF2AK3ENSG00000172071.7517.654901002.29910-0.9533013.3978011.97960HepG2HNRNPC
EIF2AK3ENSG00000172071.7824.88910965.69640-0.227401.912201.30870HepG2HNRNPF
EIF2AK3ENSG00000172071.7776.71840984.91300-0.342602.217301.58750HepG2HNRNPK
EIF2AK3ENSG00000172071.7609.61530995.67340-0.7078013.0119011.77520HepG2HNRNPU
EIF2AK3ENSG00000172071.71234.22610988.741700.319801.957301.38040HepG2IGF2BP2
EIF2AK3ENSG00000172071.7797.449801017.04940-0.350904.250303.36070HepG2ILF2
EIF2AK3ENSG00000172071.7681.921501011.85320-0.569303.460701.95660HepG2ILF3
EIF2AK3ENSG00000172071.71660.417201138.498200.544303.689502.23790HepG2KRR1
EIF2AK3ENSG00000172071.7440.42940696.46730-0.661105.558003.32990HepG2MARK2
EIF2AK3ENSG00000172071.7762.913601054.79810-0.467403.105102.44030HepG2MATR3
EIF2AK3ENSG00000172071.71311.50590935.910800.486705.081504.01020HepG2MSI2
EIF2AK3ENSG00000172071.71405.23540961.518000.547304.853603.90820HepG2PABPC4
EIF2AK3ENSG00000172071.7564.09460888.06320-0.654709.254707.94950HepG2PPIL4
EIF2AK3ENSG00000172071.7557.04600771.57470-0.470005.191104.16630HepG2PRPF4
EIF2AK3ENSG00000172071.7954.325901234.84050-0.371805.959805.15690HepG2PUM1
EIF2AK3ENSG00000172071.71626.924301233.971200.398704.238903.41960HepG2PUM2
EIF2AK3ENSG00000172071.71004.452101265.94630-0.333802.905902.02850HepG2RBM15
EIF2AK3ENSG00000172071.7866.844501027.93940-0.245902.017001.55630HepG2RBM22
EIF2AK3ENSG00000172071.71266.024101012.256500.322601.950201.37620HepG2RBM25
EIF2AK3ENSG00000172071.7873.375201146.15190-0.392104.299803.65190HepG2NELFE
EIF2AK3ENSG00000172071.7626.277201040.33580-0.732209.229808.09940HepG2RPLP0
EIF2AK3ENSG00000172071.7379.51030668.55830-0.816909.268108.22090HepG2RPS19
EIF2AK3ENSG00000172071.7819.661601034.05170-0.335204.263103.49490HepG2SMN1
EIF2AK3ENSG00000172071.71494.143901161.002700.363805.168604.54320HepG2SRFBP1
EIF2AK3ENSG00000172071.7879.645101148.52520-0.384804.926804.12960HepG2SRSF5
EIF2AK3ENSG00000172071.7771.89520948.77500-0.297702.818802.11620HepG2SRSF7
EIF2AK3ENSG00000172071.71243.456501007.995500.302803.342402.79050HepG2SSB
EIF2AK3ENSG00000172071.7488.76160780.85240-0.675907.563506.06340HepG2SUPT6H
EIF2AK3ENSG00000172071.71376.857001008.464700.449103.978503.12820HepG2TARDBP
EIF2AK3ENSG00000172071.71257.53510924.309700.444104.976003.86450HepG2TIA1
EIF2AK3ENSG00000172071.7723.46320967.52720-0.419403.987103.40980HepG2TIAL1
EIF2AK3ENSG00000172071.71422.36070989.245200.523804.767003.95560HepG2U2AF1
EIF2AK3ENSG00000172071.7331.80800489.42870-0.560702.015601.36720HepG2UCHL5
EIF2AK3ENSG00000172071.71031.430101255.61590-0.283702.803401.75050HepG2UTP18
EIF2AK3ENSG00000172071.7835.621101179.37320-0.497107.268106.37390HepG2UTP3
EIF2AK3ENSG00000172071.71181.28320761.443500.6334012.6589011.39300HepG2ZC3H8
EIF2AK3ENSG00000172071.71628.426301343.486900.277403.989203.36490HepG2ZNF622
EIF2AK3ENSG00000172071.71332.03350605.156601.1381019.0529017.67770K562AQR
EIF2AK3ENSG00000172071.7554.51130400.561400.469103.892703.06180K562EIF2S2
EIF2AK3ENSG00000172071.7433.95650313.381200.469502.424401.46280K562EIF3D
EIF2AK3ENSG00000172071.7759.76220432.598700.812409.562008.02530K562EIF4A3
EIF2AK3ENSG00000172071.7353.06840449.88560-0.349602.071901.53420K562FXR1
EIF2AK3ENSG00000172071.7874.75410455.696000.940708.788107.37990K562G3BP2
EIF2AK3ENSG00000172071.71117.27360809.083000.465503.222702.22830K562MBNL1
EIF2AK3ENSG00000172071.71101.35520843.434700.384802.826601.68200K562MSI2
EIF2AK3ENSG00000172071.7701.21070431.965900.698807.859505.80760K562NCBP2
EIF2AK3ENSG00000172071.71127.93240865.559800.381902.819201.31770K562NOL12
EIF2AK3ENSG00000172071.7404.22730537.89550-0.412202.435801.66910K562PPIG
EIF2AK3ENSG00000172071.7464.55320284.754600.706005.116404.09740K562PRPF8
EIF2AK3ENSG00000172071.7408.12840553.32880-0.439103.253602.53940K562PTBP1
EIF2AK3ENSG00000172071.7814.21260657.625900.308002.501901.93340K562RBM15
EIF2AK3ENSG00000172071.7608.21350432.145100.493003.881102.26350K562RBM25
EIF2AK3ENSG00000172071.7419.31620290.105400.531402.880002.04550K562RPS19
EIF2AK3ENSG00000172071.7614.91240473.763500.376102.750801.89890K562SF3B4
EIF2AK3ENSG00000172071.71029.06360659.973800.640802.688501.48360K562SNRNP200
EIF2AK3ENSG00000172071.7426.81210542.45090-0.345902.039901.42190K562SRSF1
EIF2AK3ENSG00000172071.7640.45200487.010800.395003.300201.90480K562TROVE2
EIF2AK3ENSG00000172071.7772.04740441.627300.805805.647903.96670K562U2AF1
EIF2AK3ENSG00000172071.7793.95230456.134400.7995011.029509.41700K562U2AF2
EIF2AK3ENSG00000172071.7738.60700570.359100.372803.566702.75870K562UPF1
EIF2AK3ENSG00000172071.7871.62790681.636000.354602.613601.77910K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for EIF2AK3 is not available on ENCORE database.





6 RBPs can affect the splicing of EIF2AK3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEEIF2AK3ENSG00000172071.7chr2-888934308889362688892789888929238889498688895181-0.351000.000410.01011excludedK562SF3B4
SEEIF2AK3ENSG00000172071.7chr2-888934308889362688892789888929238889498688895181-0.212000.000280.01116excludedHepG2SF3A3
SEEIF2AK3ENSG00000172071.7chr2-888934308889362688892789888929238889498688895181-0.334000.000550.01226excludedK562U2AF2
SEEIF2AK3ENSG00000172071.7chr2-8889343088893626888927898889292388894986888951810.580000.001940.04512includedK562RBM15
SEEIF2AK3ENSG00000172071.7chr2-8889343088893626888927898889292388894986888951810.506000.000730.02151includedK562AGGF1
A3SSEIF2AK3ENSG00000172071.7chr2-8888996088890146888899608889012388890335888905700.453000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for EIF2AK3 is not avaliable on ENCORE database.