DEF6

General Information

Gene Name       : DEF6
Gene ID             : ENSG00000023892.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: DEF6)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DEF6ENSG00000023892.105.8514.6810.27ENCSR000AEF
HepG2DEF6ENSG00000023892.108.123.325.72ENCSR985KAT
K562DEF6ENSG00000023892.1015.8910.6913.29ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for DEF6 is not avaliable on ENCORE database.



Proteins bound to RNA
  • DEF6 RNA is bound by 9 proteins.  







eCLIP assay for DEF6 is not avaliable on ENCORE database.





9 proteins are bound to DEF6 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr63528935235289437+3'-UTR3.775903.02850K562YBX3
chr63526562635265730+5'-UTR,CDS,intron-Proximal3.736443.70637K562DDX3X
chr63528563835285701+CDS,intron-Proximal3.407393.99908K562BUD13
chr63528609035286178+CDS3.896243.16390K562SRSF1
chr63528563535285685+CDS,intron-Proximal3.924419.10472K562AQR
chr63528054335280600+CDS,intron-Distal,intron-Proximal4.127475.34978HepG2PRPF8
chr63528761335287697+CDS4.193017.79539K562UCHL5
chr63527772235277827+intron-Distal3.458383.86715K562HNRNPK
chr63528054935280591+intron-Distal,intron-Proximal3.955114.98250K562AQR
chr63527805635278117+intron-Distal3.324933.54718K562PRPF8
chr63527789135277966+intron-Distal4.078063.58835K562HNRNPK
chr63528088535280985+intron-Distal4.763635.96444HepG2PCBP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for DEF6 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for DEF6 is not available on ENCORE database.

  • 80 RBPs can affect the levels of DEF6.  








The Knockdown/knockout RNA-Seq assay for DEF6 is not available on ENCORE database.





80 RBPs can affect the gene expression of DEF6 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
DEF6ENSG00000023892.9275.48820189.968200.536103.241102.59070HepG2ACO1
DEF6ENSG00000023892.9305.27000192.761300.663202.946502.39970HepG2AKAP1
DEF6ENSG00000023892.9253.93870148.518300.773702.773301.83440HepG2BCCIP
DEF6ENSG00000023892.9275.16110189.941600.534603.271702.55910HepG2CKAP4
DEF6ENSG00000023892.9264.35290175.700100.589203.969602.99250HepG2DDX19B
DEF6ENSG00000023892.9190.64630133.339400.515701.871901.30260HepG2DDX21
DEF6ENSG00000023892.962.00410130.49420-1.073504.470903.29860HepG2DDX24
DEF6ENSG00000023892.9272.80180184.633200.563102.420301.83130HepG2DDX3X
DEF6ENSG00000023892.9260.29690158.645200.714303.258202.59360HepG2DDX6
DEF6ENSG00000023892.9209.40070119.180700.813005.298604.44070HepG2DNAJC2
DEF6ENSG00000023892.9265.33200152.468300.799204.202303.47970HepG2EIF2S1
DEF6ENSG00000023892.9325.50330185.645900.810005.908904.69040HepG2EWSR1
DEF6ENSG00000023892.9259.69060170.044900.610802.715102.03050HepG2FXR1
DEF6ENSG00000023892.9164.77140104.110700.662202.592201.73000HepG2GEMIN5
DEF6ENSG00000023892.9321.38140194.838800.721903.842003.09870HepG2GPKOW
DEF6ENSG00000023892.9233.49380135.036300.789903.873703.06400HepG2HNRNPC
DEF6ENSG00000023892.9278.17320214.127300.377402.023701.43550HepG2HNRNPL
DEF6ENSG00000023892.9121.97960185.93890-0.608202.163201.60010HepG2HNRNPLL
DEF6ENSG00000023892.9268.06580134.143700.998708.518007.49690HepG2HNRNPU
DEF6ENSG00000023892.9246.91050170.104600.537502.155501.57440HepG2MAGOH
DEF6ENSG00000023892.9305.11490171.046800.834904.481503.69580HepG2MATR3
DEF6ENSG00000023892.9269.88240189.065800.513302.199401.47280HepG2MSI2
DEF6ENSG00000023892.9260.67090181.643300.521002.811302.20130HepG2PCBP1
DEF6ENSG00000023892.9382.52340222.529100.781506.223105.37670HepG2PUF60
DEF6ENSG00000023892.9321.68280236.236200.445303.017702.40430HepG2PUM1
DEF6ENSG00000023892.9261.52470193.497100.434502.260301.69050HepG2PUS1
DEF6ENSG00000023892.9255.27130113.793201.165507.935506.95790HepG2RPS19
DEF6ENSG00000023892.9257.62400152.806500.753503.283702.41200HepG2RPS2
DEF6ENSG00000023892.9202.83200119.462800.763604.369003.59200HepG2SAFB2
DEF6ENSG00000023892.9193.14390139.316900.471202.027901.46420HepG2SMN1
DEF6ENSG00000023892.9112.15700198.03800-0.820303.154802.07620HepG2SRSF3
DEF6ENSG00000023892.9212.03750293.78140-0.470402.666502.15970HepG2SSB
DEF6ENSG00000023892.9382.65820249.880500.614705.332804.51960HepG2SUCLG1
DEF6ENSG00000023892.9343.61280130.357401.3982015.3770014.36800HepG2TIAL1
DEF6ENSG00000023892.9269.71250131.510101.036109.152808.21860HepG2TRIM56
DEF6ENSG00000023892.9311.07450213.251800.544603.601502.82030HepG2UPF1
DEF6ENSG00000023892.9321.41380219.188000.552203.630502.44660HepG2UTP18
DEF6ENSG00000023892.9101.97420166.98320-0.711503.300702.57760HepG2ZC3H8
DEF6ENSG00000023892.9777.447801084.50280-0.480202.581801.38550K562APOBEC3C
DEF6ENSG00000023892.9441.34400839.36660-0.9274010.579309.54280K562AQR
DEF6ENSG00000023892.91309.768501060.391300.304603.032102.07670K562ATP5C1
DEF6ENSG00000023892.9204.29560305.17430-0.579002.835101.95170K562BOP1
DEF6ENSG00000023892.9618.71270910.95620-0.558102.801001.73030K562CNOT7
DEF6ENSG00000023892.9429.81070324.508400.405302.302401.58040K562CPSF6
DEF6ENSG00000023892.9462.06040335.341700.462303.028901.92040K562CSTF2
DEF6ENSG00000023892.91036.565301511.45670-0.544107.588005.99840K562CELF1
DEF6ENSG00000023892.9713.08620872.78440-0.291502.452501.83380K562DDX47
DEF6ENSG00000023892.9287.84080414.81920-0.527202.785901.50270K562EEF2
DEF6ENSG00000023892.91063.67120543.317100.9691013.2609011.86890K562EIF2S2
DEF6ENSG00000023892.9274.54900428.98200-0.643903.614102.41560K562EIF3D
DEF6ENSG00000023892.9879.912101229.09590-0.482206.766705.31920K562EIF4G2
DEF6ENSG00000023892.9245.29800376.81100-0.619303.864602.85180K562FIP1L1
DEF6ENSG00000023892.9402.44390588.91100-0.549305.271904.47420K562FXR1
DEF6ENSG00000023892.968.21630291.45010-2.0951011.9560010.28210K562G3BP2
DEF6ENSG00000023892.9505.42080732.45050-0.535205.520703.93360K562GLRX3
DEF6ENSG00000023892.9631.30770825.40010-0.386802.565601.53000K562HNRNPA1
DEF6ENSG00000023892.9328.05240511.85190-0.641805.141904.35120K562HNRNPC
DEF6ENSG00000023892.91018.86080788.817300.369103.044701.93040K562HNRNPL
DEF6ENSG00000023892.9613.39140412.732500.571502.560001.58590K562IGF2BP2
DEF6ENSG00000023892.9171.72250264.52330-0.623302.514701.62750K562KRR1
DEF6ENSG00000023892.9608.53460433.291900.489902.307801.53640K562MAGOH
DEF6ENSG00000023892.91699.081201201.499700.499806.320904.83890K562MBNL1
DEF6ENSG00000023892.9935.203201310.06280-0.486304.970403.46070K562MSI2
DEF6ENSG00000023892.9995.544601344.49680-0.433504.061602.23710K562NOL12
DEF6ENSG00000023892.9230.42480618.17560-1.4237017.9899015.94220K562PCBP3
DEF6ENSG00000023892.9177.67690474.14830-1.4161019.5699017.55120K562POLR2G
DEF6ENSG00000023892.9625.30310458.960000.446102.742601.84240K562PSIP1
DEF6ENSG00000023892.9853.260601341.01130-0.652307.787606.41200K562PUF60
DEF6ENSG00000023892.9475.43300812.40100-0.772904.859602.70520K562RPS3A
DEF6ENSG00000023892.9278.87430436.81770-0.647404.537402.66310K562SDAD1
DEF6ENSG00000023892.9210.03500333.64580-0.667702.964801.33800K562SERBP1
DEF6ENSG00000023892.9609.09480844.33460-0.471104.997803.92940K562SF3A3
DEF6ENSG00000023892.9222.55030302.79410-0.444202.317201.53630K562SF3B4
DEF6ENSG00000023892.9584.27530865.04910-0.566107.991406.49670K562SRPK2
DEF6ENSG00000023892.9564.94010412.779000.452601.913001.31250K562SRSF1
DEF6ENSG00000023892.9453.36960311.359700.542002.880401.80070K562SRSF4
DEF6ENSG00000023892.9601.66860389.970300.625502.700201.66710K562SRSF5
DEF6ENSG00000023892.9319.63320452.13090-0.500302.659201.43940K562STAU1
DEF6ENSG00000023892.9353.65070475.60170-0.427402.808401.98230K562SYNCRIP
DEF6ENSG00000023892.9702.24700417.644700.749605.438904.43050K562TARDBP
DEF6ENSG00000023892.9643.98830402.895600.676504.128503.09910K562TIA1
DEF6ENSG00000023892.9608.02840395.631700.619902.893601.77070K562TRA2A
DEF6ENSG00000023892.9147.00930282.21440-0.940904.644403.15320K562U2AF1
DEF6ENSG00000023892.9125.34410291.56270-1.217908.449007.03190K562U2AF2
DEF6ENSG00000023892.9498.48490807.25990-0.695508.233906.84830K562WDR43
DEF6ENSG00000023892.9780.09070994.58310-0.350402.677901.41470K562WRN
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for DEF6 is not available on ENCORE database.





1 RBPs can affect the splicing of DEF6 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSDEF6ENSG00000023892.9chr6+3527999035280123352800783528012335278193352784210.195000.000070.00063longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for DEF6 is not avaliable on ENCORE database.