VHL

General Information

Gene Name       : VHL
Gene ID             : ENSG00000134086.7
Essential Gene : No

Functions

Localization

Domains (AlphaFold: VHL)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878VHLENSG00000134086.734.0131.9132.96ENCSR000AEF
HepG2VHLENSG00000134086.731.5845.8638.72ENCSR985KAT
K562VHLENSG00000134086.753.1256.5954.86ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for VHL is not avaliable on ENCORE database.



Proteins bound to RNA
  • VHL RNA is bound by 20 proteins.  







eCLIP assay for VHL is not avaliable on ENCORE database.





20 proteins are bound to VHL RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr31019154910191682+3'-UTR,CDS3.171868.82533K562GRWD1
chr31019231110192346+3'-UTR4.0453740.56575K562UPF1
chr31019269710192733+3'-UTR5.7182829.12258HepG2AKAP1
chr31019331910193334+3'-UTR3.8606322.05664K562UPF1
chr31019239210192434+3'-UTR3.898854.34279HepG2FUBP3
chr31019234610192374+3'-UTR3.5438526.61330K562UPF1
chr31019324110193295+3'-UTR3.7277528.30662K562UPF1
chr31019346010193505+3'-UTR3.8501333.07186K562UPF1
chr31019287510192890+3'-UTR4.5223429.50769K562UPF1
chr31019359510193676+3'-UTR3.3775826.04501K562AKAP1
chr31019279210192874+3'-UTR4.9894375.98561K562AKAP1
chr31019282610192875+3'-UTR4.6889527.77157K562UPF1
chr31019338610193496+3'-UTR3.8995227.92559K562FAM120A
chr31019249210192565+3'-UTR4.0498245.42111K562PUM2
chr31019340610193458+3'-UTR4.0917418.89798HepG2AKAP1
chr31019287110192921+3'-UTR3.324143.34225HepG2STAU2
chr31019289010192957+3'-UTR4.9266245.15206K562UPF1
chr31019339510193510+3'-UTR4.8160730.26922HepG2UPF1
chr31019308310193099+3'-UTR3.598874.51064HepG2AKAP1
chr31019287510192899+3'-UTR4.9319413.63746HepG2UPF1
chr31019297910193048+3'-UTR4.4208028.88928K562UPF1
chr31019359510193732+3'-UTR3.0546914.54679K562ILF3
chr31019187010191936+3'-UTR4.9260912.05221HepG2LIN28B
chr31019229110192370+3'-UTR4.4670318.98401K562FAM120A
chr31019359710193692+3'-UTR4.6386719.01650HepG2AKAP1
chr31019364610193729+3'-UTR5.5007863.29751K562UPF1
chr31019345810193502+3'-UTR4.0235414.66442HepG2AKAP1
chr31019223210192296+3'-UTR3.1136313.10371K562DDX6
chr31019222310192273+3'-UTR4.660285.48435HepG2TIA1
chr31019248610192518+3'-UTR5.601059.27187HepG2FUBP3
chr31019158510191737+3'-UTR,CDS3.035794.81051K562SRSF1
chr31019287410192920+3'-UTR5.7212237.82224K562AKAP1
chr31019272010192735+3'-UTR5.0875927.74228K562UPF1
chr31019231410192360+3'-UTR3.962263.31824HepG2TIAL1
chr31019333610193374+3'-UTR3.4205925.82830K562UPF1
chr31019154410191664+3'-UTR,CDS3.474268.80587HepG2GRWD1
chr31019222810192280+3'-UTR3.227463.86174K562DDX55
chr31019359610193646+3'-UTR4.7476756.07815K562UPF1
chr31019332910193386+3'-UTR3.8423814.20154K562FAM120A
chr31019230910192371+3'-UTR4.974929.53754HepG2FUBP3
chr31019251810192577+3'-UTR4.330288.10367HepG2FUBP3
chr31019340810193437+3'-UTR3.6571846.02382K562UPF1
chr31019266910192685+3'-UTR4.0284823.08365K562AKAP1
chr31019361410193696+3'-UTR4.0643815.47908K562FAM120A
chr31019289910192926+3'-UTR5.8673613.62665HepG2UPF1
chr31019263910192655+3'-UTR5.6169924.82259HepG2UPF1
chr31019266710192697+3'-UTR6.6643228.74895HepG2AKAP1
chr31019268510192738+3'-UTR4.2272931.02407K562AKAP1
chr31019222610192295+3'-UTR3.0656929.32254K562PUM2
chr31019276510192869+3'-UTR4.8667724.28569HepG2UPF1
chr31019190710191939+3'-UTR4.5822919.81279K562LIN28B
chr31019343710193460+3'-UTR4.0610346.92581K562UPF1
chr31019228910192311+3'-UTR4.6341423.21013K562UPF1
chr31019231910192372+3'-UTR4.2449119.97482K562TIA1
chr31019287210192918+3'-UTR4.6987118.57875HepG2AKAP1
chr31019339010193408+3'-UTR3.2568219.25267K562UPF1
chr31019365810193701+3'-UTR3.109245.45716HepG2STAU2
chr31019279410192872+3'-UTR5.3938631.29190HepG2AKAP1
chr31019359710193617+3'-UTR4.6193611.55409HepG2UPF1
chr31019223910192289+3'-UTR4.0649025.97667K562UPF1
chr31019352110193538+3'-UTR5.2823414.14667K562UPF1
chr31019237010192402+3'-UTR3.353735.19341K562FAM120A
chr31019320810193241+3'-UTR4.2801524.68162K562UPF1
chr31019251910192548+3'-UTR3.967366.62084HepG2AKAP1
chr31019306310193120+3'-UTR3.2550532.95323K562UPF1
chr31019230910192355+3'-UTR4.376147.31670HepG2UPF1
chr31019361710193652+3'-UTR5.0930517.73545HepG2UPF1
chr31019184810191907+3'-UTR5.5369349.88885K562LIN28B
chr31019257610192639+3'-UTR5.7156136.47140HepG2UPF1
chr31019312010193137+3'-UTR3.3733916.59875K562UPF1
chr31019265710192742+3'-UTR7.7032650.49178HepG2UPF1
chr31019231510192357+3'-UTR4.5908511.17016HepG2AKAP1
chr31019267010192720+3'-UTR4.7887550.49699K562UPF1
chr31019365210193723+3'-UTR4.2982511.49403HepG2UPF1
chr31018350810183603+5'-UTR,CDS3.397208.81470HepG2GRWD1
chr31018349010183611+5'-UTR,CDS5.2224425.16796K562DDX3X
chr31018347910183599+5'-UTR,CDS4.8738433.14191HepG2DDX3X
chr31018352210183608+5'-UTR,CDS3.966159.52225K562UCHL5
chr31018360810183671+CDS4.220587.51551K562UCHL5
chr31019153410191585+CDS4.272283.53067K562SRSF1
chr31018831710188320+CDS,intron-Distal3.792709.76876K562YBX3
chr31018365610183737+CDS3.244135.80517HepG2GRWD1
chr31018830310188317+CDS,intron-Distal3.316157.76680K562YBX3
chr31019142110191532+CDS,intron-Proximal3.561645.67192K562SF3B4
chr31018376610183802+CDS4.219596.85451K562YBX3
chr31019147210191486+CDS3.305339.39295K562YBX3
chr31018359910183661+CDS3.994078.75653HepG2DDX3X
chr31018384910183908+CDS,intron-Proximal4.367473.59236HepG2AQR
chr31019139710191512+CDS,intron-Proximal4.182493.93614HepG2AQR
chr31018812110188179+intron-Distal,intron-Proximal4.995458.11845HepG2SF3A3
chr31018387110183917+intron-Proximal3.407154.41130K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for VHL is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for VHL is not available on ENCORE database.

  • 76 RBPs can affect the levels of VHL.  








The Knockdown/knockout RNA-Seq assay for VHL is not available on ENCORE database.





76 RBPs can affect the gene expression of VHL :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
VHLENSG00000134086.71063.243401483.23170-0.480308.737407.78100HepG2ACO1
VHLENSG00000134086.71616.268202419.33770-0.581903.161502.59780HepG2AKAP1
VHLENSG00000134086.71067.820401413.58440-0.404702.661301.64260HepG2AKAP8
VHLENSG00000134086.7672.831101207.59810-0.8438011.612109.02310HepG2ATP5C1
VHLENSG00000134086.71786.040402274.17880-0.348605.659804.73760HepG2AUH
VHLENSG00000134086.72552.005901901.909400.424103.763602.87110HepG2CIRBP
VHLENSG00000134086.71068.553501483.07400-0.472907.823806.81400HepG2CKAP4
VHLENSG00000134086.71319.494401654.27950-0.326203.854303.11780HepG2CELF1
VHLENSG00000134086.71353.064801095.082100.305102.481101.61930HepG2DDX24
VHLENSG00000134086.71723.555002317.75730-0.427302.183801.62100HepG2DDX3X
VHLENSG00000134086.7779.027701133.83850-0.541502.178601.48420HepG2DDX55
VHLENSG00000134086.7791.269401083.39330-0.453305.484804.52500HepG2DNAJC21
VHLENSG00000134086.7848.030501073.82920-0.340604.236003.46150HepG2DNAJC2
VHLENSG00000134086.7787.853601043.41480-0.405302.692601.78120HepG2EEF2
VHLENSG00000134086.71202.310801914.01370-0.670804.331903.59950HepG2EIF2S1
VHLENSG00000134086.72219.867902611.13340-0.234202.639402.04950HepG2ETF1
VHLENSG00000134086.71397.047801979.67710-0.502902.863702.18720HepG2G3BP1
VHLENSG00000134086.7757.290601286.27380-0.764308.498306.71740HepG2GNB2L1
VHLENSG00000134086.7711.60590968.80380-0.445102.502301.89050HepG2GPKOW
VHLENSG00000134086.7841.910801093.77250-0.377602.992702.32300HepG2HNRNPA1
VHLENSG00000134086.7935.642401208.57700-0.369304.719003.94480HepG2HNRNPU
VHLENSG00000134086.71067.612101234.52120-0.209602.024901.38620HepG2ILF2
VHLENSG00000134086.71151.985001355.96220-0.235202.684401.67810HepG2KIF1C
VHLENSG00000134086.71366.951702134.41030-0.642903.817703.04730HepG2MAGOH
VHLENSG00000134086.7789.840301067.10630-0.434103.298401.54090HepG2MARK2
VHLENSG00000134086.71469.844702197.13450-0.580003.556002.84190HepG2NCBP2
VHLENSG00000134086.71617.131401868.96690-0.208802.211501.65780HepG2PCBP1
VHLENSG00000134086.71351.476201073.726700.331804.026803.11180HepG2PRPF4
VHLENSG00000134086.71156.857301901.71630-0.7171017.7853016.62670HepG2PTBP1
VHLENSG00000134086.71386.716801683.70250-0.280002.187001.64870HepG2PUF60
VHLENSG00000134086.72020.491601787.329600.176802.134601.60030HepG2PUM1
VHLENSG00000134086.71254.502201510.79180-0.268203.255002.59970HepG2PUS1
VHLENSG00000134086.71761.731002059.66420-0.225402.064001.51270HepG2QKI
VHLENSG00000134086.7898.735201304.98200-0.538102.581401.89970HepG2RAVER1
VHLENSG00000134086.71679.441102182.40940-0.377905.209804.55460HepG2RBM22
VHLENSG00000134086.71417.911602116.45050-0.5779012.4980011.50270HepG2NELFE
VHLENSG00000134086.71502.62610915.066400.715409.208507.99450HepG2SF3B1
VHLENSG00000134086.7998.848801255.13600-0.329504.684603.88410HepG2SMN1
VHLENSG00000134086.7942.233901330.00030-0.497303.180102.14630HepG2SMNDC1
VHLENSG00000134086.71412.201401857.53140-0.395403.384402.77380HepG2TAF15
VHLENSG00000134086.7581.73710901.44400-0.631903.809502.97390HepG2TARDBP
VHLENSG00000134086.7990.885601184.85650-0.257902.560602.01370HepG2TRIM56
VHLENSG00000134086.7825.124101644.91420-0.9953020.5330018.00910HepG2TUFM
VHLENSG00000134086.7884.495601155.73030-0.385902.517401.91630HepG2U2AF1
VHLENSG00000134086.7644.439401225.65620-0.927402.683801.71100HepG2U2AF2
VHLENSG00000134086.7470.97990666.93570-0.501902.134101.46780HepG2UCHL5
VHLENSG00000134086.74719.578407023.86260-0.5736014.3103013.12270K562AGGF1
VHLENSG00000134086.74195.769807308.64130-0.8007015.8505014.06100K562AKAP8L
VHLENSG00000134086.74193.866007668.51260-0.8707031.4078028.15670K562ATP5C1
VHLENSG00000134086.71985.728202391.30800-0.268103.808202.67080K562BCLAF1
VHLENSG00000134086.76269.059308393.92080-0.421105.871504.12050K562CCDC124
VHLENSG00000134086.76364.716708240.91300-0.372703.797602.06800K562DDX19B
VHLENSG00000134086.71727.366902096.69480-0.279503.572402.04560K562DDX27
VHLENSG00000134086.71753.908602137.37990-0.285302.634801.61880K562DDX3X
VHLENSG00000134086.72692.885903243.07660-0.268203.778603.03380K562DDX47
VHLENSG00000134086.71422.004102087.67410-0.554002.939001.61660K562EEF2
VHLENSG00000134086.73471.306202798.113900.310904.589203.69200K562EIF2S2
VHLENSG00000134086.71859.758902431.96320-0.387004.755603.72690K562EIF3G
VHLENSG00000134086.73105.595902333.769800.412102.735502.03390K562G3BP2
VHLENSG00000134086.71981.566802346.15170-0.243702.477801.40290K562GLRX3
VHLENSG00000134086.7975.034901455.82930-0.578306.899305.64410K562GPKOW
VHLENSG00000134086.73142.286503728.82870-0.246902.131801.46270K562GRSF1
VHLENSG00000134086.71561.287201909.48650-0.290402.406701.84460K562HNRNPC
VHLENSG00000134086.71263.178301704.92990-0.432703.344402.08120K562HNRNPF
VHLENSG00000134086.74592.447902979.676100.624009.381807.93670K562HSPD1
VHLENSG00000134086.75449.725607756.31640-0.509204.286603.22870K562KIF1C
VHLENSG00000134086.7927.449101243.12250-0.422602.472701.59410K562KRR1
VHLENSG00000134086.71495.531001936.13520-0.372502.941701.43830K562LIN28B
VHLENSG00000134086.76120.301808689.03050-0.505608.450706.67950K562MBNL1
VHLENSG00000134086.74517.927906090.37930-0.430903.143202.19280K562NAA15
VHLENSG00000134086.72410.685502740.63920-0.185102.842302.08660K562NSUN2
VHLENSG00000134086.71432.384202049.37580-0.516804.834903.73810K562PCBP3
VHLENSG00000134086.71477.482901864.06410-0.335302.728601.32000K562PHF6
VHLENSG00000134086.71170.574301571.96930-0.425404.783603.72940K562POLR2G
VHLENSG00000134086.76372.482204884.917100.383405.595004.03360K562PUM1
VHLENSG00000134086.73196.435107248.21080-1.1812032.4877030.60050K562PUS1
VHLENSG00000134086.73380.139507062.25300-1.0630044.4958042.01870K562RBM15
VHLENSG00000134086.71108.889701561.63910-0.493906.034104.56790K562RCC2
VHLENSG00000134086.72863.216702233.203900.358403.522701.68680K562SND1
VHLENSG00000134086.71000.049801480.42600-0.565906.312404.59000K562SRFBP1
VHLENSG00000134086.72266.103202847.07490-0.329302.714302.01310K562TARDBP
VHLENSG00000134086.71245.264101646.68460-0.403103.036402.05200K562TIAL1
VHLENSG00000134086.71210.482401749.02450-0.531004.281903.04940K562TRIM56
VHLENSG00000134086.71871.888502337.33490-0.320403.394302.50700K562U2AF2
VHLENSG00000134086.73095.219902476.517900.321603.292001.44900K562UPF2
VHLENSG00000134086.72020.976402486.53210-0.299102.863501.97190K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for VHL is not available on ENCORE database.





13 RBPs can affect the splicing of VHL :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEVHLENSG00000134086.7chr3+101846441018470510182691101838711018819710188360-0.285000.000000.00001excludedK562SRSF1
SEVHLENSG00000134086.7chr3+101846441018470510182691101838711018819710188320-0.229000.000120.02467excludedK562MATR3
SEVHLENSG00000134086.7chr3+1018464410184705101826911018387110188197101883200.133000.000010.00049includedK562AKAP8L
SEVHLENSG00000134086.7chr3+101882161018832010184229101847051019147010191829-0.053000.001360.04004excludedK562AKAP8L
SEVHLENSG00000134086.7chr3+1018464410184705101826911018387110188197101883200.180000.000960.01181includedK562AQR
SEVHLENSG00000134086.7chr3+101881971018832010184229101847051019147010191829-0.077000.000020.00043excludedK562AQR
SEVHLENSG00000134086.7chr3+1018464410184705101826911018387110188197101883200.327000.000000.00000includedK562PUS1
SEVHLENSG00000134086.7chr3+101881971018832010184229101847051019147010191829-0.102000.000000.00000excludedK562PUS1
SEVHLENSG00000134086.7chr3+1018464410184705101826911018387110188197101883200.200000.002360.09482includedK562EFTUD2
SEVHLENSG00000134086.7chr3+1018464410184705101826911018387110188197101883200.159000.000120.09014includedK562ZRANB2
SEVHLENSG00000134086.7chr3+101846441018470510182691101838711018819710188320-0.181000.000000.00001excludedK562EIF4G2
SEVHLENSG00000134086.7chr3+101881971018832010184229101847051019147010191829-0.078000.000370.01752excludedK562HNRNPU
SEVHLENSG00000134086.7chr3+1018464410184705101826911018387110188197101883200.155000.000000.00012includedK562RBM15
SEVHLENSG00000134086.7chr3+1018464410184705101826911018387110188197101883200.217000.000000.00000includedK562AGGF1
SEVHLENSG00000134086.7chr3+1018464410184705101826911018387110188197101883200.326000.000040.00334includedK562HNRNPK
SEVHLENSG00000134086.7chr3+101846441018470510182691101838711018819710188320-0.196000.000870.03619excludedK562PTBP1
MXEVHLENSG00000134086.7chr3+10184644101847051018819710188360101826911018387110191470101918290.146000.000110.001351includedK562AQR
MXEVHLENSG00000134086.7chr3+10184644101847051018829210188320101826911018387110191470101918290.124000.000700.006671includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for VHL is not avaliable on ENCORE database.