THEM4

General Information

Gene Name       : THEM4
Gene ID             : ENSG00000159445.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: THEM4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878THEM4ENSG00000159445.1216.9217.7217.32ENCSR000AEF
HepG2THEM4ENSG00000159445.1211.9815.6913.84ENCSR985KAT
K562THEM4ENSG00000159445.1233.0232.4832.75ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for THEM4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • THEM4 RNA is bound by 12 proteins.  







eCLIP assay for THEM4 is not avaliable on ENCORE database.





12 proteins are bound to THEM4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1151867397151867497-3'-UTR,CDS,intron-Distal,intron-Proximal6.7442923.05208K562PRPF8
chr1151861683151861824-3'-UTR,CDS,intron-Distal,intron-Proximal4.636094.34038HepG2BCLAF1
chr1151847262151847364-3'-UTR,intron-Distal3.033663.50044K562YBX3
chr1151846758151846821-3'-UTR,intron-Distal,intron-Proximal4.312045.43239K562YBX3
chr1151861807151861882-3'-UTR,CDS,intron-Distal,intron-Proximal3.520053.32861HepG2U2AF2
chr1151861682151861737-3'-UTR,CDS,intron-Distal,intron-Proximal3.205793.31745K562ZNF622
chr1151881829151881878-CDS,intron-Distal4.709795.07098K562DDX3X
chr1151867439151867587-CDS,intron-Distal,intron-Proximal3.927553.56019HepG2GRWD1
chr1151866166151866236-intron-Distal5.9275617.58839K562PTBP1
chr1151866170151866231-intron-Distal3.232183.10961HepG2MATR3
chr1151866168151866236-intron-Distal4.316758.55014HepG2PTBP1
chr1151861852151861914-intron-Distal,intron-Proximal5.089945.90023K562SF3B4
chr1151864916151864960-intron-Distal3.848023.39864HepG2SUGP2
chr1151871479151871525-intron-Distal4.325614.27460K562HNRNPM
chr1151864313151864400-intron-Distal3.950823.76275K562PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for THEM4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for THEM4 is not available on ENCORE database.

  • 73 RBPs can affect the levels of THEM4.  








The Knockdown/knockout RNA-Seq assay for THEM4 is not available on ENCORE database.





73 RBPs can affect the gene expression of THEM4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
THEM4ENSG00000159445.8304.24020204.138800.575603.919103.21920HepG2ACO1
THEM4ENSG00000159445.8545.59480247.489901.140409.898508.95880HepG2AKAP1
THEM4ENSG00000159445.8269.64270204.089700.401702.067801.48110HepG2CKAP4
THEM4ENSG00000159445.8250.60940380.31550-0.601804.782303.84790HepG2DAZAP1
THEM4ENSG00000159445.8392.77940237.072300.728304.485803.70390HepG2DDX3X
THEM4ENSG00000159445.8177.66290279.40900-0.653202.295401.40760HepG2DDX59
THEM4ENSG00000159445.8352.31460195.304300.851007.427306.41860HepG2DKC1
THEM4ENSG00000159445.8252.55260160.026200.658202.981402.04800HepG2EIF3D
THEM4ENSG00000159445.8344.75360216.347700.672103.695102.95990HepG2EIF4A3
THEM4ENSG00000159445.8252.15920359.45650-0.511502.601601.81040HepG2EIF4G2
THEM4ENSG00000159445.8194.29160298.29510-0.618502.591701.84480HepG2FIP1L1
THEM4ENSG00000159445.8279.69650202.498000.465901.906601.34950HepG2G3BP1
THEM4ENSG00000159445.8305.07390214.987600.504802.279001.47470HepG2G3BP2
THEM4ENSG00000159445.8209.54250142.480100.556402.146701.36310HepG2GEMIN5
THEM4ENSG00000159445.8316.33420187.793400.752204.497003.69960HepG2HNRNPA1
THEM4ENSG00000159445.8336.75250208.891700.688804.019603.19490HepG2HNRNPC
THEM4ENSG00000159445.8243.52310357.21070-0.552704.305603.43180HepG2HNRNPF
THEM4ENSG00000159445.8311.12970207.510100.584204.033203.31240HepG2HNRNPU
THEM4ENSG00000159445.8231.23670351.74620-0.605204.468103.56670HepG2IGF2BP1
THEM4ENSG00000159445.8331.37880218.376700.601603.023202.33800HepG2MAGOH
THEM4ENSG00000159445.8334.46930224.767400.573302.784802.15020HepG2NCBP2
THEM4ENSG00000159445.8282.69300205.391700.460802.469701.66500HepG2PARN
THEM4ENSG00000159445.8332.53380212.584800.645404.812104.04660HepG2PCBP1
THEM4ENSG00000159445.8380.80900251.214800.600002.693101.48870HepG2PRPF6
THEM4ENSG00000159445.8320.66550216.317800.567803.908103.28280HepG2PTBP1
THEM4ENSG00000159445.8544.92100382.184300.511705.609004.82710HepG2PUM1
THEM4ENSG00000159445.8267.84260381.89480-0.511802.998202.29940HepG2PUM2
THEM4ENSG00000159445.8341.82790207.927900.717106.121605.26970HepG2PUS1
THEM4ENSG00000159445.8366.32460234.267200.644904.421603.65810HepG2QKI
THEM4ENSG00000159445.8396.45040254.724000.638103.735802.57400HepG2RBM27
THEM4ENSG00000159445.8396.58720240.736900.720105.805805.06770HepG2NELFE
THEM4ENSG00000159445.8297.42850224.221000.407501.934801.40660HepG2RECQL
THEM4ENSG00000159445.8296.49640384.86820-0.376302.055401.45610HepG2RPLP0
THEM4ENSG00000159445.8257.51250155.721600.725603.882303.16510HepG2RPS19
THEM4ENSG00000159445.8253.35540134.314100.915504.694503.65280HepG2RPS3A
THEM4ENSG00000159445.8241.22590156.276500.626202.871901.91410HepG2SERBP1
THEM4ENSG00000159445.8381.23200263.502500.532802.984502.25200HepG2SF3B1
THEM4ENSG00000159445.8311.37520225.206000.467302.510401.94310HepG2SF3B4
THEM4ENSG00000159445.8266.68450345.22880-0.372401.980201.36880HepG2SLBP
THEM4ENSG00000159445.8387.39900235.069900.720605.915505.28920HepG2SRSF1
THEM4ENSG00000159445.8480.51170343.934900.482304.078803.48210HepG2SSB
THEM4ENSG00000159445.8329.36760211.299900.640304.363703.68400HepG2TAF15
THEM4ENSG00000159445.8307.99960201.611400.611303.877303.30640HepG2TIAL1
THEM4ENSG00000159445.8557.38980279.811000.9941014.3638013.16030HepG2UTP3
THEM4ENSG00000159445.8323.73420818.22910-1.3377026.3976024.75580K562AGGF1
THEM4ENSG00000159445.8645.15130899.02970-0.478704.372403.07350K562AKAP8
THEM4ENSG00000159445.8429.43860851.38470-0.9874014.0399012.39160K562AKAP8L
THEM4ENSG00000159445.81761.014901342.312600.391603.642302.19530K562APOBEC3C
THEM4ENSG00000159445.8703.046001223.60590-0.799405.115504.36030K562AQR
THEM4ENSG00000159445.8662.76280893.27010-0.430604.585103.37520K562ATP5C1
THEM4ENSG00000159445.8506.76110704.90960-0.476103.192702.25480K562BOP1
THEM4ENSG00000159445.8566.99530916.27490-0.6924010.727308.77060K562DKC1
THEM4ENSG00000159445.8422.44790647.75860-0.616702.596801.71570K562EFTUD2
THEM4ENSG00000159445.8645.778101112.84060-0.7851010.286908.53140K562FIP1L1
THEM4ENSG00000159445.8752.63500437.715400.781908.732607.73030K562FXR1
THEM4ENSG00000159445.8397.59610550.39220-0.469203.316701.71620K562G3BP1
THEM4ENSG00000159445.8514.10800715.59370-0.477103.650602.74350K562GPKOW
THEM4ENSG00000159445.8385.08150625.07600-0.698902.913401.65820K562HNRNPA2B1
THEM4ENSG00000159445.8343.66580575.48030-0.743805.428403.78360K562IGF2BP2
THEM4ENSG00000159445.8579.05610415.420000.479002.999201.44220K562ILF3
THEM4ENSG00000159445.8560.00600903.60130-0.690206.251504.89630K562KIF1C
THEM4ENSG00000159445.8568.12150864.91250-0.606404.820103.28090K562MAK16
THEM4ENSG00000159445.8637.794701012.25200-0.666408.172406.44280K562MBNL1
THEM4ENSG00000159445.8615.91580896.49890-0.541607.299106.03880K562MTPAP
THEM4ENSG00000159445.8416.64830709.50920-0.768005.647604.22850K562NAA15
THEM4ENSG00000159445.8333.82290546.75420-0.711802.865101.85200K562PABPN1
THEM4ENSG00000159445.8414.66240591.31360-0.512004.286302.57670K562PCBP1
THEM4ENSG00000159445.8848.13310587.814400.528805.501504.59250K562PTBP1
THEM4ENSG00000159445.8276.04590844.48150-1.6132028.0405026.29330K562PUS1
THEM4ENSG00000159445.8378.59390822.70270-1.1197012.7671011.49350K562RBM15
THEM4ENSG00000159445.8279.92410404.79400-0.532203.310801.84210K562RBM25
THEM4ENSG00000159445.8528.30580337.043200.648304.113002.86420K562RPS3
THEM4ENSG00000159445.8246.80190500.01460-1.018604.501402.85090K562SF1
THEM4ENSG00000159445.8758.00420982.87270-0.374803.883802.92650K562SF3A3
THEM4ENSG00000159445.8354.56570574.24560-0.695602.635401.44850K562SNRNP200
THEM4ENSG00000159445.8868.58340642.017800.436003.987002.99840K562SYNCRIP
THEM4ENSG00000159445.8266.63420413.69240-0.633703.742502.42930K562U2AF1
THEM4ENSG00000159445.81293.853401056.204900.292703.215802.44410K562UPF1
THEM4ENSG00000159445.8515.87400856.07310-0.730703.618702.07910K562UTP18
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for THEM4 is not available on ENCORE database.





9 RBPs can affect the splicing of THEM4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETHEM4ENSG00000159445.8chr1-151862458151862690151861689151861849151867483151867670-0.342000.000000.00000excludedK562SRSF1
SETHEM4ENSG00000159445.8chr1-151862458151862690151861689151861849151867483151867670-0.401000.000000.00000excludedK562PRPF8
SETHEM4ENSG00000159445.8chr1-1518624581518626901518616891518618491518674831518676700.353000.000230.05476includedK562WDR3
SETHEM4ENSG00000159445.8chr1-151862458151862690151861689151861849151867483151867670-0.350000.000000.00010excludedK562XRCC6
SETHEM4ENSG00000159445.8chr1-1518624581518626901518616891518618491518674831518676700.179000.005740.05210includedK562AQR
SETHEM4ENSG00000159445.8chr1-151862458151862690151861689151861849151867483151867670-0.446000.000000.00000excludedK562FXR1
SETHEM4ENSG00000159445.8chr1-151862458151862690151861689151861849151867483151867670-0.415000.000340.02615excludedHepG2NCBP2
SETHEM4ENSG00000159445.8chr1-151862458151862690151861689151861849151867483151867670-0.430000.000000.00000excludedHepG2SRSF1
SETHEM4ENSG00000159445.8chr1-1518624581518626901518616891518618491518674831518676700.285000.000020.00166includedK562HNRNPU
SETHEM4ENSG00000159445.8chr1-151862458151862690151861689151861849151867483151867670-0.234000.000030.00243excludedK562PTBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for THEM4 is not avaliable on ENCORE database.