TBK1

General Information

Gene Name       : TBK1
Gene ID             : ENSG00000183735.9
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TBK1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TBK1ENSG00000183735.930.2726.6928.48ENCSR000AEF
HepG2TBK1ENSG00000183735.98.0517.0712.56ENCSR985KAT
K562TBK1ENSG00000183735.920.0921.7420.91ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TBK1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TBK1 RNA is bound by 11 proteins.  







eCLIP assay for TBK1 is not avaliable on ENCORE database.





11 proteins are bound to TBK1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr126489524864895308+3'-UTR5.8230423.51840K562PUM2
chr126489532364895368+3'-UTR4.413369.14508K562PUM2
chr126489576664895830+3'-UTR3.779033.42844K562KHSRP
chr126489555464895580+3'-UTR3.885065.35091K562PUM2
chr126484590364845977+5'-UTR,intron-Proximal4.068276.62281HepG2NCBP2
chr126484969764849726+5'-UTR,CDS4.054103.38968HepG2BCLAF1
chr126484963164849729+5'-UTR,CDS,intron-Proximal3.099083.68829K562YBX3
chr126486800764868073+CDS,intron-Proximal3.033784.24005HepG2BCLAF1
chr126489147264891511+CDS3.498593.27569HepG2BCLAF1
chr126486800764868061+CDS,intron-Proximal3.950085.96588K562ZNF622
chr126487562864875712+CDS5.054107.39496HepG2BCLAF1
chr126488384364883936+CDS,intron-Proximal5.631176.69228HepG2PRPF8
chr126488910664889221+intron-Distal,intron-Proximal3.725298.67954K562KHSRP
chr126487119064871253+intron-Distal5.715299.35180K562EXOSC5
chr126487703364877129+intron-Distal4.191584.50052K562HNRNPL
chr126486921164869265+intron-Distal3.258273.43875K562EXOSC5
chr126487159264871628+intron-Distal4.583025.76606K562EXOSC5
chr126487677264876877+intron-Distal4.498325.41654K562KHSRP
chr126488393264884035+intron-Distal,intron-Proximal3.919626.15234K562PRPF8
chr126487666764876770+intron-Distal3.765813.25414K562RBFOX2
chr126487127764871312+intron-Distal4.696275.12432K562EXOSC5
chr126487074364870794+intron-Distal3.841035.50856K562EXOSC5
chr126484977964849872+intron-Distal,intron-Proximal4.860796.73684K562KHSRP
chr126488898564889102+intron-Distal4.7214412.89363K562KHSRP
chr126487047964870539+intron-Distal4.428799.10527K562EXOSC5
chr126486911764869167+intron-Distal3.957253.01456K562EXOSC5
chr126484974764849779+intron-Proximal4.120294.10688K562KHSRP
chr126487965264879703+intron-Proximal5.038504.40745K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TBK1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TBK1 is not available on ENCORE database.

  • 60 RBPs can affect the levels of TBK1.  








The Knockdown/knockout RNA-Seq assay for TBK1 is not available on ENCORE database.





60 RBPs can affect the gene expression of TBK1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TBK1ENSG00000183735.5423.83160572.08920-0.432702.631001.65700HepG2ADAR
TBK1ENSG00000183735.51472.27940763.400500.9474011.0340010.04030HepG2AKAP1
TBK1ENSG00000183735.5968.97490812.122000.254701.981401.38350HepG2AUH
TBK1ENSG00000183735.5992.65390755.823500.393103.571602.71160HepG2CALR
TBK1ENSG00000183735.5830.10190600.123700.467903.354602.50840HepG2CIRBP
TBK1ENSG00000183735.5417.07400859.98620-1.0440013.3849012.00250HepG2CPSF6
TBK1ENSG00000183735.5681.76810845.34290-0.310303.376602.57250HepG2DAZAP1
TBK1ENSG00000183735.5634.92100488.052200.379402.329801.70050HepG2DDX21
TBK1ENSG00000183735.51018.25350731.324100.477403.476802.78510HepG2DDX3X
TBK1ENSG00000183735.5422.05410576.10620-0.448903.766902.95480HepG2DNAJC21
TBK1ENSG00000183735.5428.69150570.92730-0.413402.474001.85130HepG2DNAJC2
TBK1ENSG00000183735.5377.97880603.92880-0.676104.990204.20690HepG2EIF2S1
TBK1ENSG00000183735.5494.63410673.29030-0.444902.720102.03510HepG2FXR1
TBK1ENSG00000183735.5733.08030974.90020-0.411302.530901.91620HepG2GPKOW
TBK1ENSG00000183735.5536.69580730.21410-0.444203.897603.06050HepG2HNRNPF
TBK1ENSG00000183735.5482.78810632.33410-0.389302.233101.60070HepG2HNRNPK
TBK1ENSG00000183735.5718.89110930.36170-0.372002.317901.73610HepG2HNRNPLL
TBK1ENSG00000183735.5454.46790642.64440-0.499804.710503.93680HepG2HNRNPU
TBK1ENSG00000183735.5534.26840656.44520-0.297102.064301.41990HepG2ILF2
TBK1ENSG00000183735.5435.49250589.17730-0.436104.304803.04360HepG2KIF1C
TBK1ENSG00000183735.5233.68940362.43900-0.633104.394402.84280HepG2PKM
TBK1ENSG00000183735.5409.98950573.19280-0.483403.664602.82850HepG2PPIL4
TBK1ENSG00000183735.5710.75390467.811200.603304.804803.77250HepG2PRPF8
TBK1ENSG00000183735.5540.13600656.50360-0.281502.188301.62520HepG2PUS1
TBK1ENSG00000183735.51786.45940584.705201.6112018.4882016.82350HepG2RAVER1
TBK1ENSG00000183735.51073.38210779.341800.461705.223804.56780HepG2RBM22
TBK1ENSG00000183735.5930.41610604.299200.622506.912205.88650HepG2RBM25
TBK1ENSG00000183735.5643.26970462.772400.475002.926502.12070HepG2RRP9
TBK1ENSG00000183735.51367.83020812.844900.750706.206605.17290HepG2SF3A3
TBK1ENSG00000183735.51240.88340920.896700.430203.624202.82590HepG2SF3B1
TBK1ENSG00000183735.5834.66330640.093100.382803.569002.90990HepG2SF3B4
TBK1ENSG00000183735.5810.46360595.642400.444202.342701.46990HepG2SMNDC1
TBK1ENSG00000183735.51643.46730880.233600.9007026.3251025.19120HepG2SRFBP1
TBK1ENSG00000183735.5990.74470668.114400.568307.962907.25700HepG2SRSF1
TBK1ENSG00000183735.5681.11080543.543000.325402.695902.14980HepG2SRSF9
TBK1ENSG00000183735.5913.56450764.243700.257402.158701.69140HepG2SSB
TBK1ENSG00000183735.5769.62140600.515500.357802.879402.30810HepG2TAF15
TBK1ENSG00000183735.51289.72830633.155501.026307.379906.36060HepG2U2AF1
TBK1ENSG00000183735.5386.77540594.16360-0.619403.898403.04660HepG2XRN2
TBK1ENSG00000183735.5676.54520473.977600.513306.020005.08920HepG2ZC3H8
TBK1ENSG00000183735.51028.85120792.818100.375905.029004.34620HepG2ZNF622
TBK1ENSG00000183735.51142.260501459.96420-0.354002.859902.26330K562AQR
TBK1ENSG00000183735.51182.842201516.86740-0.358802.933401.79140K562CPEB4
TBK1ENSG00000183735.5700.550601250.23890-0.8356014.0450012.25530K562CPSF6
TBK1ENSG00000183735.5956.30330681.756400.488104.208303.06510K562EFTUD2
TBK1ENSG00000183735.5629.03370786.76960-0.322802.622301.84600K562EIF3G
TBK1ENSG00000183735.5970.27430738.495000.393702.596201.51060K562FKBP4
TBK1ENSG00000183735.5970.80990770.291100.333703.037702.40730K562FXR1
TBK1ENSG00000183735.51208.26130869.162200.475103.034002.28760K562G3BP2
TBK1ENSG00000183735.5630.97440850.80460-0.431203.426702.77280K562HNRNPC
TBK1ENSG00000183735.5492.37170759.72460-0.625705.949904.19430K562HNRNPF
TBK1ENSG00000183735.51221.14160914.409000.417202.311701.52220K562NAA15
TBK1ENSG00000183735.5738.868801159.22880-0.649802.787601.79390K562PABPN1
TBK1ENSG00000183735.51384.15900922.120300.585906.831405.27330K562PCBP2
TBK1ENSG00000183735.51358.25850663.424601.0337016.3833014.53880K562PRPF8
TBK1ENSG00000183735.5584.79160762.82290-0.383402.213101.41200K562PSIP1
TBK1ENSG00000183735.52643.784802052.727700.365003.390202.48620K562PUF60
TBK1ENSG00000183735.51499.784801088.330500.462503.799803.17740K562PUS1
TBK1ENSG00000183735.51244.06350829.419100.584803.174601.63780K562RAVER1
TBK1ENSG00000183735.5757.81450965.59330-0.349602.507501.71080K562RBM22
TBK1ENSG00000183735.5548.03710695.91680-0.344602.343301.43450K562RCC2
TBK1ENSG00000183735.5728.127401293.06490-0.828503.905402.24550K562SFPQ
TBK1ENSG00000183735.5950.80070632.743900.587407.031405.70530K562SYNCRIP
TBK1ENSG00000183735.5749.80480963.59760-0.361902.959002.10910K562TIA1
TBK1ENSG00000183735.5590.63990779.41040-0.400102.803001.84910K562TRIM56
TBK1ENSG00000183735.51185.65450870.600900.445503.433702.54090K562U2AF2
TBK1ENSG00000183735.51065.713901272.43870-0.255802.715702.00290K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TBK1 is not available on ENCORE database.





15 RBPs can affect the splicing of TBK1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETBK1ENSG00000183735.5chr12+6488976164889869648894786488955564890146648901860.085000.000030.00133includedHepG2HNRNPK
SETBK1ENSG00000183735.5chr12+648897616488986964889478648895556489014664890186-0.073000.000370.04023excludedHepG2DDX59
SETBK1ENSG00000183735.5chr12+648897616488986964889478648895556489014664890186-0.112000.000000.00000excludedHepG2U2AF2
SETBK1ENSG00000183735.5chr12+648894786488955564889262648893846489014664890186-0.062000.000340.00489excludedK562AQR
SETBK1ENSG00000183735.5chr12+648539686485410964849619648497376485811364858179-0.141000.000550.01047excludedK562PUS1
SETBK1ENSG00000183735.5chr12+648894786488955564889277648893846489014664890186-0.054000.003120.04323excludedK562PUS1
SETBK1ENSG00000183735.5chr12+648897616488986964889478648895556489014664890186-0.090000.002910.09722excludedHepG2SFPQ
SETBK1ENSG00000183735.5chr12+6488976164889869648894786488955564890146648901860.053000.001410.05446includedHepG2MATR3
SETBK1ENSG00000183735.5chr12+6488976164889869648894786488955564890146648901860.156000.000020.00302includedHepG2IGF2BP3
SETBK1ENSG00000183735.5chr12+6488976164889869648894606488955564890146648901860.054000.000470.06161includedK562RBM22
SETBK1ENSG00000183735.5chr12+648539686485410964849619648497376485811364858179-0.197000.000400.00937excludedK562U2AF2
SETBK1ENSG00000183735.5chr12+6488976164889869648894786488955564890146648901860.052000.000490.02183includedK562TARDBP
SETBK1ENSG00000183735.5chr12+648539686485410964849619648497376485811364858179-0.240000.000010.00046excludedK562AGGF1
SETBK1ENSG00000183735.5chr12+6488976164889869648894786488955564890146648901860.139000.000600.02880includedHepG2HNRNPU
A3SSTBK1ENSG00000183735.5chr12+6487805664878279648780826487827964875621648758010.069000.004050.02400longerK562AQR
A3SSTBK1ENSG00000183735.5chr12+6484959564849737648496196484973764845659648459670.070000.010670.05586longerK562AQR
A3SSTBK1ENSG00000183735.5chr12+6489012464890186648901466489018664889478648895550.066000.000160.00137longerK562AQR
RITBK1ENSG00000183735.5chr12+6487923464879797648792346487929364879705648797970.079000.001340.00966includedK562PUS1
RITBK1ENSG00000183735.5chr12+648792346487979764879234648792936487970564879797-0.053000.003430.03969excludedK562PRPF8
RITBK1ENSG00000183735.5chr12+6487923464879797648792346487929364879705648797970.068000.002720.02619includedK562AKAP8L
MXETBK1ENSG00000183735.5chr12+64882266648823686488382064883899648797056487979764889262648893840.161000.000010.000641includedHepG2FTO
MXETBK1ENSG00000183735.5chr12+64890124648901866489072864890830648894786488955564890942648910390.146000.000140.001641includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TBK1 is not avaliable on ENCORE database.