SPG21

General Information

Gene Name       : SPG21
Gene ID             : ENSG00000090487.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SPG21)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SPG21ENSG00000090487.1065.1657.6961.42ENCSR000AEF
HepG2SPG21ENSG00000090487.1035.2253.3644.29ENCSR985KAT
K562SPG21ENSG00000090487.1056.8966.4661.67ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SPG21 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SPG21 RNA is bound by 14 proteins.  







eCLIP assay for SPG21 is not avaliable on ENCORE database.





14 proteins are bound to SPG21 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr156527586065275978-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.920718.96729HepG2BUD13
chr156525605765256075-3'-UTR,CDS,intron-Distal4.385065.84664K562PUM2
chr156525560665255671-3'-UTR,intron-Distal5.139464.77410HepG2SUB1
chr156525553865255582-3'-UTR,intron-Distal,intron-Proximal4.307225.10483K562IGF2BP1
chr156525577965255906-3'-UTR,intron-Distal3.014195.79469K562IGF2BP2
chr156525538165255419-3'-UTR,intron-Distal,intron-Proximal3.419594.48983K562TIA1
chr156525761265257715-3'-UTR,CDS,intron-Distal,intron-Proximal3.738804.54206HepG2PRPF8
chr156525597365256067-3'-UTR,CDS,intron-Distal3.158214.61266K562IGF2BP1
chr156525587965255938-3'-UTR,intron-Distal4.8076014.39081K562PUM2
chr156525552865255579-3'-UTR,intron-Distal,intron-Proximal6.0402354.68430K562PUM2
chr156525545565255513-3'-UTR,intron-Distal,intron-Proximal3.334624.23616K562TIA1
chr156525551365255596-3'-UTR,intron-Distal,intron-Proximal4.4265016.59982K562TIA1
chr156527584465275923-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.103736.39699K562DDX3X
chr156525554165255632-3'-UTR,intron-Distal,intron-Proximal4.188583.41738HepG2PTBP1
chr156525771865257799-3'-UTR,CDS,intron-Distal3.238966.13091K562YBX3
chr156528200265282058-5'-UTR,intron-Distal,intron-Proximal4.676656.30252K562DDX3X
chr156528205865282138-5'-UTR,intron-Distal,intron-Proximal3.914943.45994HepG2NCBP2
chr156527332565273364-5'-UTR,CDS,intron-Distal,intron-Proximal3.338213.70637K562DDX3X
chr156528167765281765-5'-UTR,intron-Distal,intron-Proximal4.7722115.80192K562EIF4G2
chr156528205265282155-5'-UTR,intron-Distal,intron-Proximal4.0203116.10838HepG2DDX3X
chr156528200065282052-5'-UTR,intron-Distal,intron-Proximal4.696145.48791HepG2DDX3X
chr156528178365281830-5'-UTR,intron-Distal,intron-Proximal4.752978.13013K562EIF4G2
chr156528205965282145-5'-UTR,intron-Distal,intron-Proximal3.512516.26812HepG2EFTUD2
chr156528175165281844-5'-UTR,intron-Distal,intron-Proximal4.675196.71516K562TARDBP
chr156528205865282166-5'-UTR,intron-Distal,intron-Proximal3.697146.60215K562DDX3X
chr156528215565282242-5'-UTR,intron-Distal,intron-Proximal4.927208.90399HepG2DDX3X
chr156527934165279457-intron-Distal,intron-Proximal4.109588.43456K562TARDBP
chr156528184465281938-intron-Distal,intron-Proximal4.3896110.28022K562TARDBP
chr156528185465281898-intron-Distal,intron-Proximal5.072256.84138K562EIF4G2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SPG21 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SPG21 is not available on ENCORE database.

  • 78 RBPs can affect the levels of SPG21.  








The Knockdown/knockout RNA-Seq assay for SPG21 is not available on ENCORE database.





78 RBPs can affect the gene expression of SPG21 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SPG21ENSG00000090487.6573.00890902.46150-0.655306.411804.96940HepG2ADAR
SPG21ENSG00000090487.6714.14870898.58040-0.331403.187002.37040HepG2AKAP8L
SPG21ENSG00000090487.61019.368201436.56170-0.494904.247603.28340HepG2ASCC1
SPG21ENSG00000090487.61353.32500911.758100.569703.236302.40350HepG2CNOT7
SPG21ENSG00000090487.6819.076901428.85170-0.802808.539007.51210HepG2DDX6
SPG21ENSG00000090487.6673.39960855.64830-0.345603.167302.45020HepG2DKC1
SPG21ENSG00000090487.6793.331701373.38580-0.791709.274308.22810HepG2EIF2S1
SPG21ENSG00000090487.6419.97620650.24990-0.630704.516703.38320HepG2EIF3D
SPG21ENSG00000090487.6826.973801517.65400-0.8759010.163108.95570HepG2EIF4A3
SPG21ENSG00000090487.6764.989301477.83760-0.950009.379308.15130HepG2EIF4B
SPG21ENSG00000090487.61364.452601666.48950-0.288503.692403.01470HepG2ETF1
SPG21ENSG00000090487.61167.740601531.54800-0.391302.925502.21270HepG2FXR1
SPG21ENSG00000090487.6932.045201420.57820-0.608005.631504.69570HepG2G3BP1
SPG21ENSG00000090487.61145.566101508.33120-0.396902.999802.07170HepG2G3BP2
SPG21ENSG00000090487.6583.40270917.44130-0.653106.806905.86020HepG2HNRNPA1
SPG21ENSG00000090487.6714.179901020.48360-0.514904.706603.81850HepG2HNRNPC
SPG21ENSG00000090487.6782.43170979.78740-0.324503.234202.46410HepG2HNRNPF
SPG21ENSG00000090487.6882.569501438.83090-0.705108.671907.48840HepG2HNRNPK
SPG21ENSG00000090487.6896.926201282.99630-0.516509.586408.40490HepG2HNRNPL
SPG21ENSG00000090487.6568.42350736.78390-0.374302.179901.61470HepG2HNRNPLL
SPG21ENSG00000090487.6792.440101013.73680-0.355303.938203.22590HepG2HNRNPU
SPG21ENSG00000090487.6836.091201443.93080-0.788309.601008.42910HepG2IGF2BP2
SPG21ENSG00000090487.6800.722801355.29190-0.759203.098702.05520HepG2IGF2BP3
SPG21ENSG00000090487.6877.513301035.49860-0.238802.222901.55800HepG2ILF2
SPG21ENSG00000090487.61050.752801452.45220-0.467102.936101.89900HepG2KHSRP
SPG21ENSG00000090487.6789.736001532.08400-0.9561013.3491011.95370HepG2MAGOH
SPG21ENSG00000090487.6974.482201540.61030-0.660806.248105.33010HepG2MATR3
SPG21ENSG00000090487.6529.75940751.41430-0.504302.419401.51940HepG2MTPAP
SPG21ENSG00000090487.61071.636701576.86080-0.557205.043104.19930HepG2NCBP2
SPG21ENSG00000090487.6943.143001343.19140-0.510108.313207.35510HepG2PCBP1
SPG21ENSG00000090487.61038.613101366.77180-0.396103.559802.95640HepG2PTBP1
SPG21ENSG00000090487.61204.575901415.22710-0.232502.738002.14740HepG2PUM1
SPG21ENSG00000090487.6965.417201414.19780-0.550807.481206.40080HepG2PUM2
SPG21ENSG00000090487.6727.39090910.94390-0.324603.349502.68720HepG2PUS1
SPG21ENSG00000090487.6944.978201343.39230-0.507505.722904.78470HepG2RBM25
SPG21ENSG00000090487.6732.61430937.24960-0.355402.583401.62670HepG2RBM27
SPG21ENSG00000090487.6463.64250761.09080-0.715106.663505.01470HepG2RCC2
SPG21ENSG00000090487.6926.421101521.06550-0.7153014.9189013.85030HepG2NELFE
SPG21ENSG00000090487.6921.904901416.70250-0.6198011.5860010.45570HepG2RECQL
SPG21ENSG00000090487.6500.32230632.74440-0.338802.147501.59950HepG2RPS19
SPG21ENSG00000090487.61047.866001422.94220-0.441406.248505.41970HepG2SF3B4
SPG21ENSG00000090487.61028.737901278.30140-0.313403.986503.16750HepG2SLBP
SPG21ENSG00000090487.6860.941001052.79150-0.290203.358702.66120HepG2SMN1
SPG21ENSG00000090487.61043.255301573.17440-0.5926012.6211011.75690HepG2SRFBP1
SPG21ENSG00000090487.61206.193101485.26140-0.300303.602303.08000HepG2SRSF1
SPG21ENSG00000090487.61103.025501316.31700-0.255002.603801.99220HepG2SRSF5
SPG21ENSG00000090487.6892.398101208.35460-0.437306.353905.57870HepG2SRSF9
SPG21ENSG00000090487.61151.669901365.85720-0.246102.568102.06870HepG2SSB
SPG21ENSG00000090487.61156.536501497.02240-0.372305.784304.94490HepG2SUCLG1
SPG21ENSG00000090487.6415.21870679.12790-0.709807.523606.02860HepG2SUPT6H
SPG21ENSG00000090487.6524.09820890.78580-0.765206.281105.32270HepG2SUPV3L1
SPG21ENSG00000090487.61707.387201335.060300.354804.416203.73290HepG2TAF15
SPG21ENSG00000090487.6646.85150985.03570-0.606707.791807.03050HepG2TIAL1
SPG21ENSG00000090487.6812.45090993.84020-0.290702.761402.19760HepG2TRIM56
SPG21ENSG00000090487.6982.228801302.45310-0.407103.919802.85670HepG2TUFM
SPG21ENSG00000090487.61033.07120774.880300.414805.409504.48420HepG2UPF1
SPG21ENSG00000090487.6419.25970756.72480-0.8519015.2449013.87380HepG2ZC3H8
SPG21ENSG00000090487.61929.936801333.716200.5330010.527809.51440K562AGGF1
SPG21ENSG00000090487.61827.348801387.779000.396903.745802.98300K562AKAP8L
SPG21ENSG00000090487.61617.086602177.17180-0.429104.463703.75140K562AQR
SPG21ENSG00000090487.61770.648801456.089500.282102.865001.93720K562ATP5C1
SPG21ENSG00000090487.61006.952101322.96160-0.393804.734802.93810K562BCCIP
SPG21ENSG00000090487.6822.807501018.84820-0.308302.272701.55550K562CPSF6
SPG21ENSG00000090487.61837.526901493.431800.299003.380102.39900K562DKC1
SPG21ENSG00000090487.6874.753901114.21460-0.349102.295001.46270K562EFTUD2
SPG21ENSG00000090487.61316.191001608.21450-0.289103.135902.37690K562EIF2S2
SPG21ENSG00000090487.6777.207901193.11770-0.618404.982203.54440K562EIF3D
SPG21ENSG00000090487.6745.029101080.32400-0.536105.374504.23290K562EIF4A3
SPG21ENSG00000090487.6751.91080972.89450-0.371703.603402.25470K562EIF4B
SPG21ENSG00000090487.62036.747002433.31690-0.256702.977502.00540K562EIF4G2
SPG21ENSG00000090487.6544.284401036.63240-0.9295012.5589010.65670K562FMR1
SPG21ENSG00000090487.6565.78290878.63020-0.635005.517704.17250K562FTO
SPG21ENSG00000090487.6786.55150972.75810-0.306502.032301.34810K562GPKOW
SPG21ENSG00000090487.6827.617601241.88240-0.585506.922106.01820K562HNRNPC
SPG21ENSG00000090487.61304.509901652.60120-0.341203.843602.78840K562HNRNPU
SPG21ENSG00000090487.6839.971001259.49770-0.584405.612603.38920K562LIN28B
SPG21ENSG00000090487.61053.666601358.44060-0.366504.756903.71930K562MTPAP
SPG21ENSG00000090487.61564.159901156.478200.435602.678701.81280K562NAA15
SPG21ENSG00000090487.61312.711201509.34060-0.201402.327501.63700K562NSUN2
SPG21ENSG00000090487.6977.973201314.91160-0.427103.241302.34030K562PCBP3
SPG21ENSG00000090487.6796.962801008.58180-0.339702.760701.95990K562POLR2G
SPG21ENSG00000090487.6738.256001113.47060-0.592906.316304.86160K562PSIP1
SPG21ENSG00000090487.61604.865201319.903000.281902.407801.78100K562PTBP1
SPG21ENSG00000090487.62276.543402766.86560-0.281403.571002.48040K562PUM2
SPG21ENSG00000090487.62016.394301376.389900.550806.202105.42840K562PUS1
SPG21ENSG00000090487.61889.852801341.006800.494907.457406.51480K562RBM15
SPG21ENSG00000090487.6442.751101015.86380-1.1981022.5089019.75660K562RCC2
SPG21ENSG00000090487.6752.710501049.96430-0.480203.337302.21180K562SUPV3L1
SPG21ENSG00000090487.6842.536401070.97660-0.346102.116201.30900K562TIAL1
SPG21ENSG00000090487.6812.104601111.17260-0.452303.412502.27420K562UCHL5
SPG21ENSG00000090487.61382.023201600.38650-0.211602.232001.58260K562UPF1
SPG21ENSG00000090487.61074.488801369.39910-0.349903.139602.21020K562WDR3
SPG21ENSG00000090487.6865.208201131.34980-0.386902.641601.46710K562XRN2
SPG21ENSG00000090487.62006.805402452.67480-0.289502.450901.64710K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SPG21 is not available on ENCORE database.





14 RBPs can affect the splicing of SPG21 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESPG21ENSG00000090487.6chr15-652688126526889365266939652670856527320165273363-0.057000.001180.02403excludedK562SRSF1
SESPG21ENSG00000090487.6chr15-652758446527593165273201652733636528200265282249-0.168000.000930.01971excludedK562SF3B4
SESPG21ENSG00000090487.6chr15-652758446527593165273201652733636528200265282249-0.148000.000060.00351excludedK562AKAP8L
SESPG21ENSG00000090487.6chr15-652758446527593165273201652733636528200265282249-0.130000.000350.01105excludedHepG2HNRNPK
SESPG21ENSG00000090487.6chr15-652615916526169965257660652578016526693965267113-0.051000.000000.00004excludedK562AQR
SESPG21ENSG00000090487.6chr15-652624516526257765261591652616996526693965267085-0.053000.000270.00572excludedK562PUS1
SESPG21ENSG00000090487.6chr15-652758446527593165273201652733636528200265282249-0.205000.000000.00002excludedK562PUS1
SESPG21ENSG00000090487.6chr15-652624516526256065257660652578016526693965267085-0.080000.000910.04756excludedK562EFTUD2
SESPG21ENSG00000090487.6chr15-652688126526889365266939652670856527320165273363-0.074000.000390.01192excludedHepG2SRSF1
SESPG21ENSG00000090487.6chr15-652758446527593165273201652733636528200265282249-0.153000.004130.09674excludedK562UTP18
SESPG21ENSG00000090487.6chr15-652616066526169965257660652578016526245165262560-0.075000.002690.07963excludedK562TARDBP
SESPG21ENSG00000090487.6chr15-652758446527593165273201652733636528200265282249-0.148000.000100.00440excludedK562RBM15
SESPG21ENSG00000090487.6chr15-652624516526259965261591652616996526693965267085-0.052000.000440.01437excludedK562AGGF1
SESPG21ENSG00000090487.6chr15-652758446527593165273201652733636528200265282249-0.197000.000000.00004excludedK562AGGF1
A3SSSPG21ENSG00000090487.6chr15-6526245165262599652624516526256065266939652670850.134000.000000.00000longerK562AQR
A3SSSPG21ENSG00000090487.6chr15-6526696765267201652669676526708565268812652688930.072000.000000.00000longerK562AQR
MXESPG21ENSG00000090487.6chr15-6526693965267085652688126526889365262451652625606527320165273363-0.118000.002730.045972includedHepG2U2AF1
MXESPG21ENSG00000090487.6chr15-6526245165262560652669396526708565257660652578016526881265268893-0.061000.000090.003342includedHepG2SRSF1
MXESPG21ENSG00000090487.6chr15-65261591652616996526245165262599652576606525780165266939652670850.076000.000000.000001includedK562AQR
MXESPG21ENSG00000090487.6chr15-6526693965267085652758646527593165257660652578016528200265282249-0.162000.000010.000192includedK562AQR
MXESPG21ENSG00000090487.6chr15-6526693965267085652732016527336365257660652578016527584465275931-0.087000.000000.000002includedK562AQR
MXESPG21ENSG00000090487.6chr15-6526245165262560652669396526708565257660652578016526881265268893-0.056000.001800.042182includedK562TARDBP
MXESPG21ENSG00000090487.6chr15-65261591652616996526245165262560652576606525780165266939652670850.296000.000000.000001includedHepG2U2AF2
MXESPG21ENSG00000090487.6chr15-65266939652670856526881265268893652624516526256065273201652733630.067000.005310.085611includedK562FXR2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SPG21 is not avaliable on ENCORE database.