SHANK3

General Information

Gene Name       : SHANK3
Gene ID             : ENSG00000251322.7
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SHANK3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SHANK3ENSG00000251322.70.000.000.00ENCSR000AEF
HepG2SHANK3ENSG00000251322.75.431.203.31ENCSR985KAT
K562SHANK3ENSG00000251322.70.010.010.01ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SHANK3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SHANK3 RNA is bound by 42 proteins.  







eCLIP assay for SHANK3 is not avaliable on ENCORE database.





42 proteins are bound to SHANK3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr225117128451171377+3'-UTR3.909523.34998HepG2IGF2BP3
chr225117129551171323+3'-UTR3.479644.69540HepG2IGF2BP1
chr225117009451170110+3'-UTR3.828275.78025HepG2RBFOX2
chr225117067051170710+3'-UTR4.299743.97409HepG2LSM11
chr225117124051171295+3'-UTR4.429875.40422HepG2IGF2BP1
chr225116255851162648+CDS,intron-Distal,intron-Proximal3.381969.36967HepG2MATR3
chr225115317651153269+CDS,intron-Distal,intron-Proximal3.477346.90022HepG2RBFOX2
chr225114322251143274+CDS3.466169.94493HepG2PPIG
chr225115975951159816+CDS3.788543.57687HepG2EIF3H
chr225116255051162606+CDS,intron-Distal,intron-Proximal4.535279.66158HepG2SUGP2
chr225116955651169648+CDS3.437444.71371HepG2GRWD1
chr225114235551142449+CDS,intron-Proximal4.792584.77477HepG2RBFOX2
chr225114345651143528+CDS,intron-Proximal3.287836.24463HepG2GRWD1
chr225114346251143527+CDS,intron-Proximal4.2055312.18291HepG2PPIG
chr225115317251153334+CDS,intron-Distal,intron-Proximal4.0885112.20375HepG2PRPF4
chr225115976251159813+CDS3.239304.77136HepG2PPIG
chr225114338951143454+CDS,intron-Proximal3.099338.74848HepG2PPIG
chr225115319951153324+CDS,intron-Distal,intron-Proximal5.034477.81647HepG2FAM120A
chr225115860951158659+CDS,intron-Proximal4.046486.65791HepG2BUD13
chr225114233451142359+CDS4.430964.84481HepG2PPIG
chr225113704351137178+CDS,intron-Proximal5.052086.74224HepG2AQR
chr225114327451143290+CDS3.006974.88012HepG2PPIG
chr225113711451137178+CDS,intron-Proximal3.135556.12136HepG2BUD13
chr225114339251143456+CDS3.050735.12345HepG2GRWD1
chr225115318751153321+CDS,intron-Distal,intron-Proximal4.074123.30705HepG2GTF2F1
chr225116189551161965+intron-Distal3.068598.83112HepG2SUGP2
chr225114373951143833+intron-Distal3.9423014.76764HepG2DDX59
chr225114432051144383+intron-Distal4.587533.15681HepG2RBM15
chr225116777251167823+intron-Distal4.531994.23131HepG2IGF2BP1
chr225114363451143708+intron-Distal3.859447.69664HepG2DDX59
chr225114370051143776+intron-Distal4.2737912.33860HepG2HNRNPK
chr225116801651168081+intron-Distal6.0210733.96009HepG2RBFOX2
chr225114959551149704+intron-Distal3.647385.12035HepG2DROSHA
chr225115035351150397+intron-Distal3.038404.02266HepG2CSTF2T
chr225116813951168280+intron-Distal4.122806.69714HepG2DROSHA
chr225116827651168339+intron-Distal4.537124.70962HepG2GTF2F1
chr225114946951149500+intron-Distal5.212724.28084HepG2DKC1
chr225112203751122123+intron-Distal4.232964.57620HepG2PRPF4
chr225113840451138463+intron-Distal3.005263.18654HepG2NKRF
chr225116833551168375+intron-Distal4.423888.40143HepG2CSTF2T
chr225116425451164282+intron-Distal3.035964.86332HepG2SUGP2
chr225112262651122726+intron-Distal4.243296.90648HepG2FAM120A
chr225114950251149572+intron-Distal3.766103.31824HepG2TIAL1
chr225114956751149624+intron-Distal5.2600219.69650HepG2RBFOX2
chr225114969851149740+intron-Distal4.7690512.38345HepG2RBFOX2
chr225116844951168472+intron-Distal6.4554116.23042HepG2RBFOX2
chr225113810551138224+intron-Distal4.183993.69388HepG2XPO5
chr225113863551138726+intron-Distal5.069768.29600HepG2CSTF2T
chr225116776451167839+intron-Distal4.2003022.74340HepG2RBFOX2
chr225113904251139107+intron-Distal3.337146.30718HepG2RBFOX2
chr225116827051168335+intron-Distal3.8341012.38761HepG2CSTF2T
chr225116747851167586+intron-Distal3.2789511.00842HepG2CSTF2T
chr225114935451149409+intron-Distal4.663505.34770HepG2IGF2BP1
chr225114943251149459+intron-Distal4.6930511.29890HepG2RBFOX2
chr225116384451163891+intron-Distal3.056165.66264HepG2SUGP2
chr225116873951168803+intron-Distal4.231978.79635HepG2NKRF
chr225114472351144871+intron-Distal4.4407316.10450HepG2PRPF4
chr225116808151168156+intron-Distal5.2540834.13075HepG2RBFOX2
chr225112206351122147+intron-Distal4.7001310.72554HepG2FAM120A
chr225116703851167070+intron-Distal3.516056.71496HepG2CSTF2T
chr225114460851144737+intron-Distal,intron-Proximal3.153966.79234HepG2RBFOX2
chr225112252951122664+intron-Distal4.973275.33542HepG2FASTKD2
chr225113840451138448+intron-Distal3.919603.40087HepG2RBFOX2
chr225114935351149411+intron-Distal5.0698526.46801HepG2RBFOX2
chr225116833151168402+intron-Distal4.2200517.64237HepG2RBFOX2
chr225116825951168331+intron-Distal5.2815829.69931HepG2RBFOX2
chr225113839851138463+intron-Distal3.642484.33898HepG2FAM120A
chr225116298551163022+intron-Distal3.922343.03891HepG2PTBP1
chr225116303151163125+intron-Distal3.379819.28863HepG2SUGP2
chr225116762151167670+intron-Distal5.158838.83237HepG2CSTF2T
chr225115459251154670+intron-Distal4.4237612.10975HepG2DDX59
chr225114952151149567+intron-Distal4.8302213.82570HepG2RBFOX2
chr225116778751167839+intron-Distal4.113096.74777HepG2CDC40
chr225116640751166464+intron-Distal4.158557.81031HepG2NKRF
chr225113954551139621+intron-Distal4.085953.90256HepG2PRPF4
chr225116260651162663+intron-Distal,intron-Proximal3.9676310.28524HepG2SUGP2
chr225116881951168848+intron-Distal3.075084.88713HepG2CSTF2T
chr225113815551138198+intron-Distal3.799603.40229HepG2CSTF2T
chr225116748551167555+intron-Distal3.573234.95334HepG2FKBP4
chr225113618051136302+intron-Distal,intron-Proximal3.406717.93742HepG2NKRF
chr225116189151161957+intron-Distal3.611677.81620HepG2MATR3
chr225115478451154846+intron-Distal3.701698.40525HepG2DDX59
chr225116673251166793+intron-Distal3.789713.19512HepG2FKBP4
chr225116278651162830+intron-Distal5.029928.19013HepG2MATR3
chr225116852751168634+intron-Distal3.930667.75227HepG2DDX6
chr225116153451161630+intron-Distal4.8291914.39851HepG2HNRNPK
chr225115809051158158+intron-Distal4.969575.80475HepG2XPO5
chr225116652351166576+intron-Distal3.355335.44187HepG2CSTF2T
chr225116614751166208+intron-Distal3.533417.30591HepG2CSTF2T
chr225116777051167870+intron-Distal3.9227718.56002HepG2CSTF2T
chr225114475351144851+intron-Distal5.195696.92491HepG2FAM120A
chr225114778151147899+intron-Distal3.454774.29582HepG2HLTF
chr225114935951149469+intron-Distal6.0273913.72187HepG2DKC1
chr225116287751162971+intron-Distal4.0571916.16864HepG2SUGP2
chr225116778151167826+intron-Distal4.268173.56107HepG2RBM5
chr225116720851167324+intron-Distal3.787576.58297HepG2HNRNPK
chr225112249651122576+intron-Distal4.885196.74166HepG2FAM120A
chr225116302551163085+intron-Distal3.683894.84557HepG2CSTF2T
chr225114963251149728+intron-Distal3.577864.25556HepG2TIAL1
chr225114925351149333+intron-Distal5.252196.53245HepG2DKC1
chr225116804251168106+intron-Distal3.254864.00954HepG2DGCR8
chr225116125651161323+intron-Distal3.120988.21817HepG2MATR3
chr225114477151144875+intron-Distal4.621485.82840HepG2GTF2F1
chr225116854051168677+intron-Distal5.3241556.34366HepG2RBFOX2
chr225115525851155300+intron-Distal4.219718.92104HepG2HNRNPK
chr225114935751149459+intron-Distal3.455153.45199HepG2SRSF7
chr225112165551121700+intron-Distal,intron-Proximal3.790555.39685HepG2CSTF2T
chr225116762951167655+intron-Distal3.472705.63456HepG2RBFOX2
chr225116853551168592+intron-Distal3.522389.07843HepG2CSTF2T
chr225115264151152703+intron-Distal4.290704.86307HepG2PRPF4
chr225114973851149801+intron-Distal3.526194.91480HepG2IGF2BP1
chr225116851451168540+intron-Distal4.4131024.03269HepG2RBFOX2
chr225114377651143841+intron-Distal5.5800511.68724HepG2HNRNPK
chr225115019551150290+intron-Distal3.445626.05986HepG2CSTF2T
chr225114473751144864+intron-Distal4.9659814.53487HepG2RBFOX2
chr225112286351122903+intron-Distal4.891418.19768HepG2CSTF2T
chr225114963851149686+intron-Distal3.430073.57574HepG2SRSF7
chr225112194051122014+intron-Distal,intron-Proximal3.904978.04077HepG2CSTF2T
chr225112242851122479+intron-Distal5.116957.65828HepG2CSTF2T
chr225116399651164066+intron-Distal3.072794.04108HepG2XPO5
chr225114366451143704+intron-Distal3.245523.80010HepG2XRN2
chr225116412951164193+intron-Distal3.765744.36087HepG2MATR3
chr225116529651165393+intron-Distal3.007703.82227HepG2FUS
chr225116708751167146+intron-Distal4.156964.57620HepG2PRPF4
chr225114057751140625+intron-Distal4.110223.50841HepG2PCBP2
chr225113617551136288+intron-Distal,intron-Proximal4.0631010.26986HepG2PRPF8
chr225113837651138464+intron-Distal4.286533.84437HepG2PRPF4
chr225115035251150461+intron-Distal3.4283113.43510HepG2RBFOX2
chr225114995851150010+intron-Distal,intron-Proximal3.401894.14880HepG2CSTF2T
chr225116777651167839+intron-Distal3.674945.01332HepG2GTF2F1
chr225116614751166200+intron-Distal3.965543.83024HepG2IGF2BP1
chr225115042251150475+intron-Distal3.115175.21772HepG2CSTF2T
chr225112248851122541+intron-Distal5.077957.44133HepG2CSTF2T
chr225116137751161465+intron-Distal3.6352910.38326HepG2SUGP2
chr225114436151144421+intron-Distal,intron-Proximal3.080313.40321HepG2GRWD1
chr225116292451162948+intron-Distal4.459255.15027HepG2MATR3
chr225112226151122334+intron-Distal6.0696013.17963HepG2FAM120A
chr225116815651168258+intron-Distal4.8632540.83206HepG2RBFOX2
chr225115849751158590+intron-Distal,intron-Proximal4.980539.60820HepG2SLTM
chr225115022651150265+intron-Distal5.024338.60555HepG2RBFOX2
chr225113840651138458+intron-Distal3.524394.60046HepG2CSTF2T
chr225116636351166392+intron-Distal3.253033.48042HepG2NKRF
chr225112260251122677+intron-Distal4.7578213.78704HepG2CSTF2T
chr225116534051165392+intron-Distal3.911333.28544HepG2DGCR8
chr225116092451160984+intron-Distal,intron-Proximal3.532014.23548HepG2RBM15
chr225112228951122348+intron-Distal5.4585610.23793HepG2CSTF2T
chr225115034951150477+intron-Distal3.534616.59813HepG2FAM120A
chr225113956551139617+intron-Distal4.163674.43799HepG2CSTF2T
chr225114974051149810+intron-Distal4.3296110.67734HepG2RBFOX2
chr225116635751166410+intron-Distal3.016574.36876HepG2FAM120A
chr225114940951149462+intron-Distal3.739325.85178HepG2IGF2BP1
chr225112268751122724+intron-Distal3.617605.56645HepG2CSTF2T
chr225115470751154767+intron-Distal5.346457.04496HepG2DDX59
chr225112254151122602+intron-Distal4.151517.82628HepG2CSTF2T
chr225114962451149698+intron-Distal6.1524435.62791HepG2RBFOX2
chr225113929351139362+intron-Distal4.797606.05659HepG2CSTF2T
chr225116848351168514+intron-Distal4.1750815.91991HepG2RBFOX2
chr225116783951167891+intron-Distal4.0867915.17408HepG2RBFOX2
chr225114358551143631+intron-Distal,intron-Proximal3.637965.59440HepG2HNRNPK
chr225116748351167666+intron-Distal3.112104.71346HepG2NCBP2
chr225112204451122143+intron-Distal6.0367214.87993HepG2CSTF2T
chr225114948951149553+intron-Distal3.382353.97248HepG2DROSHA
chr225115521551155258+intron-Distal5.158959.36897HepG2HNRNPK
chr225116842151168449+intron-Distal4.7763014.56640HepG2RBFOX2
chr225116779151167883+intron-Distal3.910666.51675HepG2SUGP2
chr225116722251167343+intron-Distal3.7115418.71516HepG2CSTF2T
chr225115438251154454+intron-Distal5.3063010.63855HepG2HNRNPK
chr225116155851161619+intron-Distal3.9972210.76881HepG2PCBP2
chr225114957851149676+intron-Distal3.249277.44361HepG2IGF2BP1
chr225116850051168598+intron-Distal3.560644.35431HepG2PRPF4
chr225114188651141962+intron-Distal4.478705.84190HepG2HNRNPL
chr225114880551148847+intron-Distal3.260013.07152HepG2HLTF
chr225116873051168784+intron-Distal4.3892320.26813HepG2RBFOX2
chr225114995551150023+intron-Distal,intron-Proximal3.240003.18654HepG2NKRF
chr225114994951150026+intron-Distal,intron-Proximal4.470968.91455HepG2PRPF4
chr225116299251163034+intron-Distal3.054283.24944HepG2MATR3
chr225116793051167997+intron-Distal4.9855118.28058HepG2RBFOX2
chr225116776451167857+intron-Distal3.9187410.88971HepG2PRPF4
chr225114997051150017+intron-Distal,intron-Proximal3.345063.23106HepG2CDC40
chr225113625451136297+intron-Distal6.039136.68817HepG2EFTUD2
chr225114357651143634+intron-Distal,intron-Proximal3.404529.13490HepG2DDX59
chr225116873751168810+intron-Distal3.572936.21701HepG2FASTKD2
chr225116531051165389+intron-Distal3.634409.31244HepG2CSTF2T
chr225115457651154661+intron-Distal3.677618.88915HepG2HNRNPK
chr225115419551154291+intron-Distal,intron-Proximal4.4927818.33344HepG2RBFOX2
chr225116169351161733+intron-Distal3.079775.10681HepG2SUGP2
chr225114967651149738+intron-Distal3.958396.75303HepG2IGF2BP1
chr225116180651161871+intron-Distal4.425698.36737HepG2MATR3
chr225114945951149521+intron-Distal5.1848628.13621HepG2RBFOX2
chr225113938951139471+intron-Distal5.7480417.82686HepG2XPO5
chr225114771851147834+intron-Distal3.083593.42154HepG2SAFB
chr225113703051137099+intron-Proximal4.208514.57620HepG2PRPF4
chr225116906251169135+intron-Proximal3.1769910.23158HepG2CSTF2T
chr225113617751136231+intron-Proximal4.260668.44359HepG2EFTUD2
chr225113702651137092+intron-Proximal4.573876.05659HepG2CSTF2T
chr225113618151136240+intron-Proximal4.305575.16036HepG2CSTF2T
chr225112172551121764+intron-Proximal3.486854.21158HepG2CSTF2T
chr225115325751153328+intron-Proximal3.308213.59805HepG2SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SHANK3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SHANK3 is not available on ENCORE database.

  • 57 RBPs can affect the levels of SHANK3.  








The Knockdown/knockout RNA-Seq assay for SHANK3 is not available on ENCORE database.





57 RBPs can affect the gene expression of SHANK3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SHANK3ENSG00000251322.3681.49640954.31540-0.485806.843605.97370HepG2ACO1
SHANK3ENSG00000251322.3237.40470843.77640-1.8295010.226609.26920HepG2AKAP1
SHANK3ENSG00000251322.3324.27840521.94680-0.686706.066804.97990HepG2CALR
SHANK3ENSG00000251322.3400.48810663.25150-0.727803.202202.37260HepG2CIRBP
SHANK3ENSG00000251322.3181.60440385.29000-1.085102.179601.50540HepG2CNOT7
SHANK3ENSG00000251322.3382.61050262.448800.543703.872002.66170HepG2YBX3
SHANK3ENSG00000251322.3599.68070476.369500.332002.664701.93450HepG2DAZAP1
SHANK3ENSG00000251322.3448.87300257.688000.800604.251203.39570HepG2DNAJC21
SHANK3ENSG00000251322.3416.20450255.437300.704204.267903.49090HepG2DNAJC2
SHANK3ENSG00000251322.3259.33390417.69580-0.687602.099601.30360HepG2EIF3D
SHANK3ENSG00000251322.3765.28970450.194700.765407.979506.62640HepG2EIF4G2
SHANK3ENSG00000251322.3993.996601218.21370-0.293502.982402.36170HepG2ETF1
SHANK3ENSG00000251322.3489.70210716.60920-0.549304.901203.87090HepG2FUBP3
SHANK3ENSG00000251322.3837.44160510.580000.713802.394301.79490HepG2GPKOW
SHANK3ENSG00000251322.3531.72380326.387300.704002.728501.37190HepG2HNRNPA0
SHANK3ENSG00000251322.3829.92230458.562100.8558014.8592013.36800HepG2HNRNPF
SHANK3ENSG00000251322.3590.62230433.938100.444604.182703.36680HepG2HNRNPL
SHANK3ENSG00000251322.3421.15250684.47530-0.700707.721506.25440HepG2HNRNPM
SHANK3ENSG00000251322.3470.61690287.470900.711007.564006.60020HepG2HNRNPU
SHANK3ENSG00000251322.3766.29670451.551200.762909.598008.32520HepG2IGF2BP1
SHANK3ENSG00000251322.3525.79030674.20740-0.358702.671401.47690HepG2NAA15
SHANK3ENSG00000251322.3544.68630290.859600.905004.183302.42440HepG2NOLC1
SHANK3ENSG00000251322.3844.62780346.618101.284907.610905.78710HepG2NONO
SHANK3ENSG00000251322.3683.09320432.123100.660502.859802.09810HepG2NSUN2
SHANK3ENSG00000251322.3699.96700352.339500.990206.192604.83010HepG2PABPC1
SHANK3ENSG00000251322.3579.03670256.399601.1752019.1524017.34750HepG2PPIL4
SHANK3ENSG00000251322.31013.76040450.913501.1687012.2523011.11690HepG2PUF60
SHANK3ENSG00000251322.3691.89840478.662500.531506.852806.00540HepG2PUM1
SHANK3ENSG00000251322.3818.10030478.314100.774202.760802.09080HepG2PUM2
SHANK3ENSG00000251322.3584.316601018.19310-0.8012013.2758012.30960HepG2RBM22
SHANK3ENSG00000251322.3665.76000817.94540-0.297001.808901.35160HepG2NELFE
SHANK3ENSG00000251322.3709.26970387.454900.872204.396803.38730HepG2RPS3A
SHANK3ENSG00000251322.3525.09640256.000701.0363015.7606014.41130HepG2SAFB2
SHANK3ENSG00000251322.3620.96000364.840600.767103.157501.76360HepG2SART3
SHANK3ENSG00000251322.3849.394201262.75500-0.572104.264203.41710HepG2SF3A3
SHANK3ENSG00000251322.3772.80540482.240200.680303.488802.70580HepG2SF3B1
SHANK3ENSG00000251322.3930.96760765.129600.282902.081101.55740HepG2SF3B4
SHANK3ENSG00000251322.3965.88670432.351401.1595031.2731029.43180HepG2SLBP
SHANK3ENSG00000251322.3474.58480249.487900.927602.623301.35970HepG2SNRNP200
SHANK3ENSG00000251322.3228.40800536.59670-1.232202.964602.15440HepG2SNRNP70
SHANK3ENSG00000251322.3299.48490798.67560-1.4151020.2604019.22850HepG2SRSF1
SHANK3ENSG00000251322.3847.41340445.208900.9285017.5014016.11950HepG2SRSF5
SHANK3ENSG00000251322.3698.80670450.527400.633204.028403.21350HepG2SRSF7
SHANK3ENSG00000251322.3845.79730669.814200.336502.136801.30450HepG2SUPT6H
SHANK3ENSG00000251322.3391.53220718.00820-0.874904.783104.07890HepG2TAF15
SHANK3ENSG00000251322.3763.52240475.187200.684103.557102.74770HepG2TARDBP
SHANK3ENSG00000251322.3560.38520279.300801.004507.029406.29940HepG2TIAL1
SHANK3ENSG00000251322.3522.94280281.830700.8917010.210309.23190HepG2TRIM56
SHANK3ENSG00000251322.3832.71570440.519900.918505.940504.59460HepG2TUFM
SHANK3ENSG00000251322.3551.62780848.69880-0.621602.689502.06880HepG2U2AF1
SHANK3ENSG00000251322.3984.30220466.281101.077805.522304.31470HepG2UBE2L3
SHANK3ENSG00000251322.3461.14090221.688601.056605.601004.51360HepG2UCHL5
SHANK3ENSG00000251322.31291.513001119.871800.205601.963501.35850HepG2UPF1
SHANK3ENSG00000251322.3631.537901081.19040-0.7757014.7885013.56810HepG2UTP3
SHANK3ENSG00000251322.3570.83230347.075700.717702.557401.51090HepG2XPO5
SHANK3ENSG00000251322.3902.741201231.64290-0.448207.667606.87460HepG2ZNF622
SHANK3ENSG00000251322.39.037400.0000099999.999902.403001.56650K562PSIP1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SHANK3 is not available on ENCORE database.






No RBPs affect the alternative splcing events of SHANK3 on ENCORE database.





The Knockdown/knockout RNA-Seq assay for SHANK3 is not avaliable on ENCORE database.