PSMC2

General Information

Gene Name       : PSMC2
Gene ID             : ENSG00000161057.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PSMC2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PSMC2ENSG00000161057.11186.07162.12174.09ENCSR000AEF
HepG2PSMC2ENSG00000161057.11125.16172.59148.88ENCSR985KAT
K562PSMC2ENSG00000161057.11367.96381.55374.75ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PSMC2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PSMC2 RNA is bound by 17 proteins.  







eCLIP assay for PSMC2 is not avaliable on ENCORE database.





17 proteins are bound to PSMC2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr7103002423103002527+3'-UTR,CDS4.059435.41973HepG2G3BP1
chr7103002472103002545+3'-UTR,CDS,intron-Proximal4.698864.78529HepG2BCLAF1
chr7102995264102995346+5'-UTR,CDS,intron-Proximal4.003516.39986K562SF3B4
chr7102988176102988237+5'-UTR,CDS,intron-Proximal3.3652012.13488K562AQR
chr7102988169102988217+5'-UTR,CDS3.126903.24162HepG2G3BP1
chr7102988210102988275+5'-UTR,CDS,intron-Proximal3.151457.70737HepG2PRPF8
chr7102988149102988218+5'-UTR,CDS3.624074.17155HepG2BCLAF1
chr7102988125102988230+5'-UTR,CDS,intron-Proximal3.7063310.72017K562GRWD1
chr7102988131102988232+5'-UTR,CDS,intron-Proximal3.1486514.37271K562UCHL5
chr7102995315102995398+5'-UTR,CDS,intron-Proximal4.147893.31827HepG2GRWD1
chr7103004603103004706+CDS3.8400810.69038K562SND1
chr7103003149103003202+CDS3.359823.57857HepG2BCLAF1
chr7103008032103008064+CDS,intron-Proximal4.652216.29942HepG2G3BP1
chr7103004635103004679+CDS5.5609111.69058K562RPS3
chr7103004744103004755+CDS,intron-Proximal5.8668032.27742K562PUM2
chr7103003788103003839+CDS,intron-Proximal4.160453.96931HepG2G3BP1
chr7103006522103006550+CDS,intron-Proximal5.0622426.42481K562PUM2
chr7103008395103008447+CDS3.833429.54348K562PUM2
chr7103004595103004695+CDS4.308187.67223HepG2G3BP1
chr7103008284103008345+CDS,intron-Proximal5.654166.90654K562SF3B4
chr7103004605103004662+CDS3.381363.27569HepG2BCLAF1
chr7102996148102996186+CDS,intron-Distal4.064133.39686HepG2G3BP1
chr7103003156103003197+CDS3.416624.91258K562YBX3
chr7103008159103008189+CDS,intron-Proximal4.531804.83675HepG2G3BP1
chr7103006607103006654+CDS,intron-Proximal5.243367.23718K562AQR
chr7103004581103004662+CDS,intron-Proximal3.740687.44037K562BUD13
chr7103004689103004744+CDS5.6418449.33373K562PUM2
chr7103004589103004643+CDS,intron-Proximal3.320244.89070K562UCHL5
chr7103007973103008032+CDS3.613904.86632HepG2G3BP1
chr7103003171103003206+CDS,intron-Proximal3.958383.39686HepG2G3BP1
chr7102998013102998079+intron-Distal3.315004.24981K562MATR3
chr7103002577103002661+intron-Distal,intron-Proximal3.088785.01170K562KHSRP
chr7103002777103002856+intron-Distal3.125065.57010K562KHSRP
chr7103002895103002983+intron-Distal3.123055.40698K562KHSRP
chr7102988295102988363+intron-Distal,intron-Proximal3.683426.32052K562AQR
chr7102989541102989691+intron-Distal3.255555.68494K562MATR3
chr7102991484102991551+intron-Distal3.613234.72029K562MATR3
chr7102992346102992446+intron-Distal3.365497.89420K562MATR3
chr7103003001103003117+intron-Distal,intron-Proximal3.535327.82071K562KHSRP
chr7102991385102991496+intron-Distal3.333595.81842K562PTBP1
chr7102989589102989679+intron-Distal4.7237211.65716K562PTBP1
chr7102998851102998891+intron-Distal4.713094.90095K562PTBP1
chr7103002565103002624+intron-Proximal4.864586.13333K562RBM22
chr7103003257103003295+intron-Proximal3.223463.20886K562PRPF8
chr7102988237102988279+intron-Proximal5.0196315.45935K562AQR
chr7103003255103003300+intron-Proximal4.336883.78820K562GPKOW
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PSMC2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PSMC2 is not available on ENCORE database.

  • 79 RBPs can affect the levels of PSMC2.  








The Knockdown/knockout RNA-Seq assay for PSMC2 is not available on ENCORE database.





79 RBPs can affect the gene expression of PSMC2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PSMC2ENSG00000161057.61394.623101159.432000.266403.101802.46360HepG2ACO1
PSMC2ENSG00000161057.62949.708301683.002800.809409.858808.92170HepG2AKAP1
PSMC2ENSG00000161057.61359.361001164.928500.222602.060201.38510HepG2AKAP8L
PSMC2ENSG00000161057.61588.514501331.356000.254702.048701.37790HepG2CALR
PSMC2ENSG00000161057.62023.434101323.042100.612807.027505.83540HepG2CIRBP
PSMC2ENSG00000161057.61141.770301544.73270-0.436103.904603.10080HepG2CPSF6
PSMC2ENSG00000161057.62349.856101793.293100.389905.178404.34860HepG2CELF1
PSMC2ENSG00000161057.6807.516801114.74280-0.465103.064501.59390HepG2DDX28
PSMC2ENSG00000161057.61969.685001612.291600.288801.851101.32860HepG2DDX3X
PSMC2ENSG00000161057.6906.221601384.75110-0.611705.143604.32540HepG2DDX6
PSMC2ENSG00000161057.6943.724001218.38660-0.368505.433004.56510HepG2DNAJC2
PSMC2ENSG00000161057.61278.12460978.695200.385002.807101.87980HepG2EEF2
PSMC2ENSG00000161057.61054.28740815.906200.369702.567601.49600HepG2EFTUD2
PSMC2ENSG00000161057.6853.848501822.20990-1.0936014.5031012.74830HepG2EIF4G2
PSMC2ENSG00000161057.61412.576101133.024700.318002.695101.87030HepG2EWSR1
PSMC2ENSG00000161057.61282.390501848.68990-0.5277010.462009.18400HepG2HNRNPF
PSMC2ENSG00000161057.61437.217801756.07820-0.289103.556902.79950HepG2HNRNPL
PSMC2ENSG00000161057.61223.48390995.053100.298002.467501.56660HepG2HNRNPM
PSMC2ENSG00000161057.61190.521901371.25160-0.203901.873101.36500HepG2HNRNPU
PSMC2ENSG00000161057.61322.319001820.42670-0.461206.035905.00790HepG2IGF2BP1
PSMC2ENSG00000161057.61780.170901399.883500.346602.565701.91340HepG2IGF2BP2
PSMC2ENSG00000161057.61000.399301400.68640-0.485609.896608.59600HepG2ILF2
PSMC2ENSG00000161057.61834.014601484.855200.304601.986101.42610HepG2MAGOH
PSMC2ENSG00000161057.62025.193801493.222600.439502.766002.13520HepG2MATR3
PSMC2ENSG00000161057.61137.544701704.35140-0.583303.916602.75170HepG2MTPAP
PSMC2ENSG00000161057.61372.17120958.284100.517803.271901.70670HepG2NKRF
PSMC2ENSG00000161057.61113.80100754.927100.561002.808601.91280HepG2PABPC1
PSMC2ENSG00000161057.6824.760901223.04510-0.568408.180106.96100HepG2PPIL4
PSMC2ENSG00000161057.62241.847701824.999600.296702.726202.13380HepG2PUF60
PSMC2ENSG00000161057.61284.060801510.88870-0.234701.902401.36940HepG2QKI
PSMC2ENSG00000161057.61886.013901236.233300.609303.396702.61760HepG2RAVER1
PSMC2ENSG00000161057.6803.400001126.08040-0.487103.415401.49000HepG2RBM14
PSMC2ENSG00000161057.62330.164001898.642400.295402.677402.16550HepG2RBM22
PSMC2ENSG00000161057.61181.132101446.07920-0.292003.197102.54070HepG2RECQL
PSMC2ENSG00000161057.61565.240201991.56780-0.347503.197202.47050HepG2RPLP0
PSMC2ENSG00000161057.6977.52140773.069400.338402.507201.91940HepG2RPS19
PSMC2ENSG00000161057.6738.837901221.15420-0.7249015.9883014.63250HepG2SAFB2
PSMC2ENSG00000161057.61061.02570775.907000.451403.715602.62300HepG2SERBP1
PSMC2ENSG00000161057.62245.796501421.108600.660105.869904.86270HepG2SF3A3
PSMC2ENSG00000161057.61298.711701750.10510-0.430405.371004.44800HepG2SLBP
PSMC2ENSG00000161057.62550.064202144.488700.249803.946503.37920HepG2SRFBP1
PSMC2ENSG00000161057.62760.217901516.059600.8644031.3505030.13860HepG2SRSF1
PSMC2ENSG00000161057.61394.118001802.04680-0.370304.397803.64200HepG2SRSF5
PSMC2ENSG00000161057.61373.493401816.29430-0.403106.505405.51080HepG2SRSF7
PSMC2ENSG00000161057.62182.171001861.997200.228802.659502.15350HepG2SSB
PSMC2ENSG00000161057.61055.227201628.87720-0.626307.477706.36200HepG2TARDBP
PSMC2ENSG00000161057.61562.948901332.388900.230201.806701.38470HepG2TIAL1
PSMC2ENSG00000161057.6955.711801344.34060-0.492308.052407.16910HepG2TRIM56
PSMC2ENSG00000161057.62063.477201233.665600.7420010.469309.22780HepG2U2AF1
PSMC2ENSG00000161057.61502.885701216.777200.304603.733803.05430HepG2UTP3
PSMC2ENSG00000161057.61383.051501171.422400.239502.732302.06430HepG2ZC3H8
PSMC2ENSG00000161057.62514.140301386.096100.8589037.6983036.28200HepG2ZNF622
PSMC2ENSG00000161057.6887.098901234.98120-0.477302.953001.60890HepG2ZRANB2
PSMC2ENSG00000161057.68149.763306963.799800.226801.810501.31580K562AQR
PSMC2ENSG00000161057.63418.897004384.50750-0.358906.140404.06390K562BCCIP
PSMC2ENSG00000161057.63318.781104236.87840-0.352307.243905.66650K562BCLAF1
PSMC2ENSG00000161057.63634.229304695.11790-0.369503.046901.54230K562BUD13
PSMC2ENSG00000161057.64679.644305806.68370-0.311305.182403.63440K562CPEB4
PSMC2ENSG00000161057.62429.502003214.30330-0.403806.265404.58360K562CSTF2
PSMC2ENSG00000161057.63888.339904609.78970-0.245503.558502.18240K562DDX21
PSMC2ENSG00000161057.64600.057605580.45360-0.278704.131003.27810K562EIF2S2
PSMC2ENSG00000161057.62875.402003667.49710-0.351002.241701.32000K562EIF3D
PSMC2ENSG00000161057.66238.494508184.70540-0.391707.512805.97750K562EIF4G2
PSMC2ENSG00000161057.63328.121704180.85270-0.329103.759702.24990K562EXOSC5
PSMC2ENSG00000161057.64906.831302923.955400.7468024.9028023.20700K562FXR1
PSMC2ENSG00000161057.62802.226803778.90740-0.431403.243302.60460K562HNRNPC
PSMC2ENSG00000161057.65642.010503873.631500.542406.471104.51940K562HNRNPK
PSMC2ENSG00000161057.65871.876103985.409200.559006.161704.69830K562HNRNPM
PSMC2ENSG00000161057.62479.841503615.33790-0.543902.682101.76630K562KRR1
PSMC2ENSG00000161057.63953.750004575.04820-0.210603.274202.39750K562MTPAP
PSMC2ENSG00000161057.64240.996805083.54420-0.261404.467603.54490K562NSUN2
PSMC2ENSG00000161057.65137.586903332.775300.624309.476008.08490K562PRPF8
PSMC2ENSG00000161057.62677.916603388.01800-0.339302.358201.52950K562PSIP1
PSMC2ENSG00000161057.65011.011403960.033100.339504.112003.31770K562PTBP1
PSMC2ENSG00000161057.611263.087808930.268800.334703.138902.27220K562PUF60
PSMC2ENSG00000161057.67543.747109306.92630-0.303004.710503.44670K562PUM2
PSMC2ENSG00000161057.64365.828105015.78180-0.200202.458501.68700K562SF3A3
PSMC2ENSG00000161057.64334.472905138.74260-0.245605.087403.86480K562SRPK2
PSMC2ENSG00000161057.64665.370503882.105400.265102.672401.97610K562SRSF1
PSMC2ENSG00000161057.63576.802404113.87410-0.201802.394201.30930K562SRSF7
PSMC2ENSG00000161057.62407.049003227.50040-0.423203.382202.24760K562SUPV3L1
PSMC2ENSG00000161057.65391.441904091.440700.398006.012504.79360K562SYNCRIP
PSMC2ENSG00000161057.62593.386903258.80500-0.329502.298501.45190K562TIAL1
PSMC2ENSG00000161057.64483.071003248.114200.464807.670406.32630K562U2AF2
PSMC2ENSG00000161057.64481.441605390.16960-0.266404.144703.28320K562UPF1
PSMC2ENSG00000161057.63936.901004858.95380-0.303603.212701.38960K562UPF2
PSMC2ENSG00000161057.63684.517104612.23080-0.324003.728002.71130K562WDR3
PSMC2ENSG00000161057.66145.683907845.76380-0.352302.993302.09110K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PSMC2 is not available on ENCORE database.





3 RBPs can affect the splicing of PSMC2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPSMC2ENSG00000161057.6chr7+102995314102995396102987956102988228103002403103002535-0.290000.004100.06361excludedK562SF3B4
SEPSMC2ENSG00000161057.6chr7+102994367102994405102988109102988228103002403103002535-0.170000.000000.00000excludedK562AQR
A3SSPSMC2ENSG00000161057.6chr7+103003132103003205103003141103003205103002403103002535-0.118000.000000.00000shorterK562SF3B4
A3SSPSMC2ENSG00000161057.6chr7+103003132103003205103003141103003205103002403103002535-0.059000.001250.08040shorterHepG2SF3B4
MXEPSMC2ENSG00000161057.6chr7+103002403103002455103003141103003205102996029102996240103003790103003886-0.077000.009030.058272includedK562AQR
MXEPSMC2ENSG00000161057.6chr7+103002403103002535103003141103003205102996029102996240103003790103003886-0.073000.009680.061672includedK562AQR
MXEPSMC2ENSG00000161057.6chr7+102996140102996240103002403103002535102995314102995396103003790103003886-0.063000.000000.000002includedK562AQR
MXEPSMC2ENSG00000161057.6chr7+102996140102996240103002403103002497102995314102995396103003790103003886-0.054000.000000.000002includedK562AQR
MXEPSMC2ENSG00000161057.6chr7+103002403103002497103003141103003205102996029102996240103003790103003886-0.079000.006000.041952includedK562AQR
MXEPSMC2ENSG00000161057.6chr7+1029961401029962401030024031030025351029953141029953961030031321030032050.172000.000030.001521includedHepG2DDX55

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PSMC2 is not avaliable on ENCORE database.