NOTCH1

General Information

Gene Name       : NOTCH1
Gene ID             : ENSG00000148400.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: NOTCH1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NOTCH1ENSG00000148400.100.721.841.28ENCSR000AEF
HepG2NOTCH1ENSG00000148400.101.010.120.56ENCSR985KAT
K562NOTCH1ENSG00000148400.104.531.723.12ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NOTCH1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • NOTCH1 RNA is bound by 17 proteins.  







eCLIP assay for NOTCH1 is not avaliable on ENCORE database.





17 proteins are bound to NOTCH1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr9139390222139390349-3'-UTR,intron-Distal3.834176.33374K562TIA1
chr9139389146139389218-3'-UTR,intron-Distal3.589985.24187K562DDX6
chr9139389214139389300-3'-UTR,intron-Distal6.9402813.61817K562PUM2
chr9139405673139405769-CDS,intron-Distal,intron-Proximal4.930433.91589K562SF3B4
chr9139409978139410029-CDS,intron-Distal5.1701510.74913K562YBX3
chr9139412719139412744-CDS,intron-Distal3.745823.46958K562YBX3
chr9139390600139390747-CDS,intron-Distal4.570495.82109K562IGF2BP2
chr9139400300139400361-CDS,intron-Distal,intron-Proximal4.955115.69951K562AQR
chr9139403354139403480-CDS,intron-Distal4.489105.61640K562YBX3
chr9139412995139413044-CDS,intron-Distal,intron-Proximal4.986076.04760K562AQR
chr9139413042139413139-CDS,intron-Distal,intron-Proximal3.796515.57640K562YBX3
chr9139400038139400113-CDS,intron-Distal3.010013.29348K562YBX3
chr9139396907139396975-CDS,intron-Distal,intron-Proximal4.264275.97994K562AQR
chr9139411677139411725-CDS,intron-Distal,intron-Proximal4.618604.48002K562AQR
chr9139394997139395003-intron-Distal,intron-Proximal4.421106.48405K562AQR
chr9139429351139429470-intron-Distal5.019927.22168HepG2FAM120A
chr9139426786139426848-intron-Distal3.786463.15719K562SMNDC1
chr9139438424139438476-intron-Distal,intron-Proximal4.603314.65563K562AQR
chr9139421892139422006-intron-Distal4.394526.64618K562EWSR1
chr9139426276139426335-intron-Distal3.990254.47051K562EWSR1
chr9139427005139427041-intron-Distal4.637516.12846K562EWSR1
chr9139403260139403321-intron-Distal,intron-Proximal5.253897.28294K562AQR
chr9139437688139437759-intron-Distal3.229263.61506K562NONO
chr9139426765139426842-intron-Distal4.557385.62460K562CSTF2T
chr9139435821139435871-intron-Distal3.978753.99137K562NONO
chr9139433269139433352-intron-Distal4.107654.23759K562NONO
chr9139429803139429929-intron-Distal3.612773.29111K562FAM120A
chr9139437262139437299-intron-Distal3.429993.67595K562EWSR1
chr9139429059139429106-intron-Distal4.396434.42197K562EWSR1
chr9139422312139422382-intron-Distal3.893093.59342K562CSTF2T
chr9139434984139435029-intron-Distal3.244003.41462K562EWSR1
chr9139430820139430868-intron-Distal4.229723.58113K562EWSR1
chr9139419591139419678-intron-Distal4.311474.16830K562EWSR1
chr9139425572139425614-intron-Distal4.505995.55667K562EWSR1
chr9139394957139394996-intron-Distal,intron-Proximal4.662638.52787K562AQR
chr9139427917139427969-intron-Distal4.740465.27179K562EWSR1
chr9139432201139432250-intron-Distal4.653724.98766K562EWSR1
chr9139428873139428938-intron-Distal5.116726.99055K562EWSR1
chr9139425215139425257-intron-Distal3.437244.20405K562EWSR1
chr9139421098139421182-intron-Distal5.153727.85700K562EWSR1
chr9139397573139397634-intron-Distal,intron-Proximal5.9136010.48996K562AQR
chr9139426186139426209-intron-Distal4.239273.86024K562EWSR1
chr9139410339139410432-intron-Distal,intron-Proximal5.268385.65342K562AQR
chr9139429240139429300-intron-Distal4.859905.24810K562GTF2F1
chr9139435379139435432-intron-Distal3.922543.17740K562CSTF2T
chr9139429225139429304-intron-Distal4.130053.59342K562CSTF2T
chr9139428390139428427-intron-Distal4.239273.86024K562EWSR1
chr9139425795139425864-intron-Distal5.283019.01779K562EWSR1
chr9139430921139431061-intron-Distal4.297604.68055HepG2CSTF2T
chr9139426934139426964-intron-Distal4.320014.14056K562EWSR1
chr9139429230139429304-intron-Distal5.088765.27179K562EWSR1
chr9139430226139430278-intron-Distal3.842903.11802K562HNRNPK
chr9139405520139405601-intron-Distal,intron-Proximal4.012855.47926K562AQR
chr9139431221139431285-intron-Distal3.872773.17740K562CSTF2T
chr9139428159139428202-intron-Distal4.836786.12846K562EWSR1
chr9139422508139422547-intron-Distal3.239273.15535K562EWSR1
chr9139430102139430155-intron-Distal4.558037.79950K562DROSHA
chr9139426761139426840-intron-Distal3.946798.29689K562EWSR1
chr9139430106139430159-intron-Distal3.777433.37414K562CSTF2T
chr9139432965139433026-intron-Distal4.355204.46290K562EWSR1
chr9139423062139423131-intron-Distal6.2649611.80331K562DROSHA
chr9139428724139428763-intron-Distal4.214893.30242K562FTO
chr9139423356139423419-intron-Distal5.001887.22498K562EWSR1
chr9139423788139423880-intron-Distal5.197149.14979K562EWSR1
chr9139432034139432086-intron-Distal3.468994.51839K562EWSR1
chr9139413852139413857-intron-Distal,intron-Proximal4.559497.50107K562AQR
chr9139436945139436995-intron-Distal3.550495.36345K562EWSR1
chr9139413857139413891-intron-Distal,intron-Proximal3.974536.80869K562AQR
chr9139429232139429297-intron-Distal4.817324.46951K562FAM120A
chr9139400923139400979-intron-Distal,intron-Proximal4.711929.56266K562AQR
chr9139427937139427991-intron-Distal4.106893.19125K562GTF2F1
chr9139410663139410721-intron-Distal3.047453.01994K562BUD13
chr9139428540139428605-intron-Distal4.153726.09610K562EWSR1
chr9139433703139433766-intron-Distal3.898083.17740K562CSTF2T
chr9139426278139426347-intron-Distal4.678364.14689K562FTO
chr9139430515139430630-intron-Distal3.807926.34658K562NONO
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NOTCH1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NOTCH1 is not available on ENCORE database.

  • 86 RBPs can affect the levels of NOTCH1.  








The Knockdown/knockout RNA-Seq assay for NOTCH1 is not available on ENCORE database.





86 RBPs can affect the gene expression of NOTCH1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NOTCH1ENSG00000148400.980.2302013.428002.5788010.381508.62310HepG2ADAR
NOTCH1ENSG00000148400.952.4071013.164501.993003.891003.27610HepG2AKAP1
NOTCH1ENSG00000148400.960.4914023.666201.353803.061901.96920HepG2AKAP8
NOTCH1ENSG00000148400.969.4704024.064001.529404.821003.83290HepG2AKAP8L
NOTCH1ENSG00000148400.984.1460023.947301.812907.313506.32780HepG2CKAP4
NOTCH1ENSG00000148400.958.4212029.037701.008501.994101.39960HepG2CPSF6
NOTCH1ENSG00000148400.970.0913013.841102.340207.958906.29060HepG2CSTF2
NOTCH1ENSG00000148400.974.92400140.80070-0.910203.719902.22660HepG2DDX47
NOTCH1ENSG00000148400.960.0136010.839302.468906.539905.62170HepG2DDX6
NOTCH1ENSG00000148400.952.9399018.346401.528803.578802.37000HepG2EIF3G
NOTCH1ENSG00000148400.944.7824011.617101.946603.774102.97600HepG2FXR1
NOTCH1ENSG00000148400.940.8298016.325201.322402.261701.45920HepG2GEMIN5
NOTCH1ENSG00000148400.9165.9963032.363402.358607.370505.57340HepG2GRSF1
NOTCH1ENSG00000148400.955.8778013.653902.032902.310701.71570HepG2HNRNPA1
NOTCH1ENSG00000148400.979.2929010.922602.859809.875508.62440HepG2HNRNPK
NOTCH1ENSG00000148400.939.3979015.392201.355802.242301.62660HepG2HNRNPL
NOTCH1ENSG00000148400.942.9441015.084901.509303.149802.50650HepG2HNRNPU
NOTCH1ENSG00000148400.947.1611010.281102.197503.066202.02930HepG2IGF2BP3
NOTCH1ENSG00000148400.964.5508021.893801.559804.872903.52560HepG2KIF1C
NOTCH1ENSG00000148400.9157.0628068.265601.202005.097303.95600HepG2LARP4
NOTCH1ENSG00000148400.9191.2621011.683904.0329029.3945027.51410HepG2MATR3
NOTCH1ENSG00000148400.94.1227023.36470-2.502703.247702.37400HepG2MSI2
NOTCH1ENSG00000148400.982.2911020.228202.024305.621104.02960HepG2NONO
NOTCH1ENSG00000148400.948.2785017.603901.455402.745701.70940HepG2PCBP2
NOTCH1ENSG00000148400.927.030909.814901.461501.889201.42040HepG2PTBP1
NOTCH1ENSG00000148400.9152.3204016.953503.167404.043003.23780HepG2PUM2
NOTCH1ENSG00000148400.98.1086024.39190-1.588902.115701.55910HepG2PUS1
NOTCH1ENSG00000148400.942.1400010.920301.948103.757003.14520HepG2NELFE
NOTCH1ENSG00000148400.950.6230010.175702.314603.024402.38350HepG2RECQL
NOTCH1ENSG00000148400.9115.6692017.840602.6967013.8693012.62940HepG2RPS19
NOTCH1ENSG00000148400.976.6686019.221801.995803.954702.26800HepG2SF1
NOTCH1ENSG00000148400.983.5452022.559001.888806.440605.38700HepG2SF3A3
NOTCH1ENSG00000148400.958.7867010.212602.525007.176906.29600HepG2SF3B4
NOTCH1ENSG00000148400.9137.0028018.697402.873208.589605.89310HepG2SFPQ
NOTCH1ENSG00000148400.937.9591015.669901.276302.182201.60000HepG2SMN1
NOTCH1ENSG00000148400.949.2903010.662202.208703.589303.06750HepG2SRSF1
NOTCH1ENSG00000148400.9112.0335015.775802.8280015.9205014.59210HepG2SRSF5
NOTCH1ENSG00000148400.9144.6829025.674202.4944015.4250012.84890HepG2SSRP1
NOTCH1ENSG00000148400.932.248309.590301.749502.994302.41440HepG2TAF15
NOTCH1ENSG00000148400.975.3572025.217901.579203.510302.31350HepG2TBRG4
NOTCH1ENSG00000148400.957.3281014.666501.966602.155101.70270HepG2TIAL1
NOTCH1ENSG00000148400.956.0340015.607401.844004.277303.16240HepG2TUFM
NOTCH1ENSG00000148400.9105.7557020.006402.4021013.2712011.95760HepG2UPF1
NOTCH1ENSG00000148400.944.4530018.681501.250602.313301.34630HepG2XRCC6
NOTCH1ENSG00000148400.9897.86220521.831200.7828013.1293011.99110K562AGGF1
NOTCH1ENSG00000148400.9756.36640573.411400.399402.932001.91150K562AKAP8
NOTCH1ENSG00000148400.9774.14200542.988500.511603.811303.04230K562AKAP8L
NOTCH1ENSG00000148400.9600.74490962.82040-0.680504.751004.01940K562AQR
NOTCH1ENSG00000148400.9798.00690569.724600.486005.129003.84240K562ATP5C1
NOTCH1ENSG00000148400.9629.78710314.594501.001306.954905.40610K562BCLAF1
NOTCH1ENSG00000148400.9694.10230463.474700.582605.116203.58300K562CCAR1
NOTCH1ENSG00000148400.9973.47160623.618800.642408.215306.17270K562CCDC124
NOTCH1ENSG00000148400.9501.45910238.667001.071002.263001.32640K562CSTF2
NOTCH1ENSG00000148400.91047.565601414.58030-0.433304.088602.89380K562CELF1
NOTCH1ENSG00000148400.9418.12940275.726700.600603.656802.11270K562DDX27
NOTCH1ENSG00000148400.9765.80970571.695100.421602.837801.78250K562DDX3X
NOTCH1ENSG00000148400.9815.42600998.00410-0.291502.787002.13290K562DDX47
NOTCH1ENSG00000148400.9796.44550579.616800.458403.672402.11020K562DDX6
NOTCH1ENSG00000148400.9570.25460280.896501.021505.802504.44940K562EFTUD2
NOTCH1ENSG00000148400.91200.37320576.106801.059007.426506.33040K562EIF2S2
NOTCH1ENSG00000148400.9735.78340537.864200.451904.406102.88980K562EIF4B
NOTCH1ENSG00000148400.9481.71590621.13390-0.366702.821102.21100K562FXR1
NOTCH1ENSG00000148400.939.0625095.26010-1.286102.978602.24170K562G3BP2
NOTCH1ENSG00000148400.9834.458901038.45420-0.315502.776801.63470K562GLRX3
NOTCH1ENSG00000148400.9627.86670457.731000.455903.171802.32350K562GPKOW
NOTCH1ENSG00000148400.9278.56490470.87740-0.757305.234603.90660K562HNRNPM
NOTCH1ENSG00000148400.9587.84300195.272901.589802.610601.62370K562IGF2BP2
NOTCH1ENSG00000148400.9358.26500198.554800.851402.948201.70930K562IGF2BP3
NOTCH1ENSG00000148400.9487.09390815.34600-0.743203.501201.87340K562ILF2
NOTCH1ENSG00000148400.9470.60830205.065401.1983014.7916012.73660K562MAGOH
NOTCH1ENSG00000148400.9710.49970551.610000.365102.664501.61430K562MAK16
NOTCH1ENSG00000148400.9373.99570204.625300.869907.764506.11930K562MATR3
NOTCH1ENSG00000148400.9871.31430645.543600.432602.148001.36270K562MBNL1
NOTCH1ENSG00000148400.9723.222001091.80670-0.594209.650208.23640K562MTPAP
NOTCH1ENSG00000148400.91015.864301213.05290-0.255902.987002.21530K562NSUN2
NOTCH1ENSG00000148400.9295.22630200.525700.557903.243301.77900K562PCBP1
NOTCH1ENSG00000148400.9409.47280182.428501.166303.378602.29900K562PCBP2
NOTCH1ENSG00000148400.9496.26770914.22160-0.881402.041101.32730K562PCBP3
NOTCH1ENSG00000148400.9353.69310701.18190-0.987306.249605.05030K562POLR2G
NOTCH1ENSG00000148400.9626.46990199.245801.6526026.7327024.77190K562PTBP1
NOTCH1ENSG00000148400.9921.432501335.10050-0.535006.497804.80000K562PUM1
NOTCH1ENSG00000148400.91610.097801307.846400.299902.689701.74190K562PUM2
NOTCH1ENSG00000148400.9489.11240190.966201.356708.045206.51280K562RBM22
NOTCH1ENSG00000148400.9426.60790186.222001.195807.000504.58780K562RBM34
NOTCH1ENSG00000148400.9372.14170219.660100.760504.362003.06750K562RPS3
NOTCH1ENSG00000148400.9407.01700646.04550-0.666503.191501.63240K562SDAD1
NOTCH1ENSG00000148400.9199.4454099.215301.007306.615105.25690K562SF3B4
NOTCH1ENSG00000148400.9447.54850195.345101.195909.081207.80930K562SRSF1
NOTCH1ENSG00000148400.9450.41030212.044601.0868010.412908.24530K562SRSF4
NOTCH1ENSG00000148400.9414.43790184.532801.167206.975005.19950K562SRSF5
NOTCH1ENSG00000148400.9495.83180751.02610-0.599004.979803.11430K562SSRP1
NOTCH1ENSG00000148400.9252.40330570.45150-1.176404.513001.95600K562SUGP2
NOTCH1ENSG00000148400.9329.97260556.12360-0.753102.702501.30180K562SUPT6H
NOTCH1ENSG00000148400.9394.52820703.38290-0.834203.994703.00400K562SYNCRIP
NOTCH1ENSG00000148400.938.3547093.52260-1.285903.660201.89030K562TAF15
NOTCH1ENSG00000148400.9466.88720197.663601.2399014.0676012.23630K562TARDBP
NOTCH1ENSG00000148400.9519.69500190.678901.4464018.4747016.20060K562TIA1
NOTCH1ENSG00000148400.9401.12320187.203601.099305.249803.64350K562TRA2A
NOTCH1ENSG00000148400.91107.246101286.22900-0.216202.037701.41500K562UPF1
NOTCH1ENSG00000148400.9709.201801100.58010-0.634007.982406.45180K562WDR3
NOTCH1ENSG00000148400.9748.034301144.51330-0.613608.582207.17440K562WDR43
NOTCH1ENSG00000148400.9500.46240285.291800.810702.470401.34890K562XRN2
NOTCH1ENSG00000148400.9283.43530547.15580-0.948904.157402.01470K562YTHDC2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NOTCH1 is not available on ENCORE database.





1 RBPs can affect the splicing of NOTCH1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSNOTCH1ENSG00000148400.9chr9-1394033211394035481394033211394035231394041841394044130.249000.003760.02247longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NOTCH1 is not avaliable on ENCORE database.