MAP2K3

General Information

Gene Name       : MAP2K3
Gene ID             : ENSG00000034152.18
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: MAP2K3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MAP2K3ENSG00000034152.183.9814.029.00ENCSR000AEF
HepG2MAP2K3ENSG00000034152.1856.9031.2144.05ENCSR985KAT
K562MAP2K3ENSG00000034152.189.016.917.96ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MAP2K3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MAP2K3 RNA is bound by 25 proteins.  







eCLIP assay for MAP2K3 is not avaliable on ENCORE database.





25 proteins are bound to MAP2K3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr172120542721205483+3'-UTR,CDS,intron-Proximal3.158045.54603HepG2AQR
chr172120765221207743+3'-UTR,CDS,intron-Proximal3.481254.76523HepG2SF3B4
chr172120386821203970+3'-UTR,CDS3.614136.82013HepG2PPIG
chr172120556621205627+3'-UTR,CDS,intron-Proximal5.5690610.32702HepG2AQR
chr172120654021206624+3'-UTR,CDS,intron-Distal,intron-Proximal4.061749.91476HepG2PRPF8
chr172121535121215459+3'-UTR,CDS,intron-Distal,intron-Proximal3.659638.68003HepG2SF3B4
chr172120641621206503+3'-UTR,CDS,intron-Distal,intron-Proximal5.048757.81134HepG2AQR
chr172120430221204348+3'-UTR,CDS,intron-Proximal4.192246.81564HepG2PRPF8
chr172121680621216884+3'-UTR,CDS,intron-Proximal3.323457.13280HepG2PRPF8
chr172121794721218008+3'-UTR3.921246.19596HepG2UPF1
chr172120223421202284+3'-UTR,5'-UTR,CDS,intron-Proximal4.767909.10443HepG2PRPF8
chr172121820321218309+3'-UTR4.191397.92952HepG2TIA1
chr172121818621218291+3'-UTR4.5999512.84412HepG2TIAL1
chr172121820121218298+3'-UTR3.215445.78757K562UPF1
chr172121824321218324+3'-UTR3.721625.62040K562TIA1
chr172121558821215632+3'-UTR,CDS,intron-Proximal4.478664.28193HepG2AQR
chr172121820021218320+3'-UTR4.4404532.10275HepG2UPF1
chr172121791321218000+3'-UTR3.217704.75109K562UPF1
chr172121762921217661+3'-UTR4.272024.44583HepG2UPF1
chr172121820121218288+3'-UTR3.5579511.91930HepG2DDX6
chr172121540921215455+3'-UTR,CDS,intron-Proximal3.931239.87553HepG2SF3A3
chr172121819821218243+3'-UTR4.146093.77503K562TIA1
chr172120779121207868+3'-UTR,CDS,intron-Proximal3.694953.21539HepG2SRSF1
chr172120556921205583+3'-UTR,CDS,intron-Proximal4.0097410.01959HepG2PRPF8
chr172121793421218016+3'-UTR4.162238.49053HepG2AKAP1
chr172120171621201813+3'-UTR,5'-UTR,CDS,intron-Proximal3.427264.77916HepG2AQR
chr172120393221204014+3'-UTR,CDS,intron-Proximal4.3851913.80141HepG2PRPF8
chr172121819721218304+3'-UTR3.3839016.06894HepG2AKAP1
chr172121783221217887+3'-UTR4.232274.66439HepG2AKAP1
chr172121773521217832+3'-UTR4.7064012.57965HepG2UPF1
chr172121559221215647+3'-UTR,CDS,intron-Proximal3.996516.65114HepG2PRPF8
chr172121739221217537+3'-UTR,CDS,intron-Proximal4.425218.29703HepG2AQR
chr172121805321218114+3'-UTR4.832176.52213HepG2UPF1
chr172121822421218303+3'-UTR4.5089335.36510HepG2DDX55
chr172121825021218289+3'-UTR3.691329.97931HepG2LARP4
chr172121788721217998+3'-UTR5.546039.07598K562PUM2
chr172121820021218224+3'-UTR3.9404011.41999HepG2DDX55
chr172120843221208447+3'-UTR,CDS,intron-Proximal3.361647.76525HepG2PRPF8
chr172120220921202270+3'-UTR,5'-UTR,CDS,intron-Proximal3.183324.82455HepG2BUD13
chr172121783221217884+3'-UTR5.065996.71037HepG2UPF1
chr172120765021207755+3'-UTR,CDS,intron-Proximal5.218576.38747HepG2AQR
chr172121555221215588+3'-UTR,CDS3.977123.11282HepG2G3BP1
chr172120377721203858+3'-UTR,CDS,intron-Proximal4.547245.28859HepG2SF3B4
chr172120828921208377+3'-UTR,CDS,intron-Proximal3.835719.23873HepG2SF3A3
chr172121819021218249+3'-UTR3.6553813.27063HepG2LARP4
chr172120843621208588+3'-UTR,CDS,intron-Distal,intron-Proximal4.176913.12843K562PRPF8
chr172120648821206525+3'-UTR,CDS,intron-Distal,intron-Proximal3.187556.22359HepG2BUD13
chr172121685021216956+CDS,intron-Distal,intron-Proximal5.060865.17615K562AQR
chr172121689721216973+CDS,intron-Distal,intron-Proximal5.064158.42614HepG2EFTUD2
chr172118827021188323+CDS,intron-Proximal3.913958.96944HepG2PRPF8
chr172119869521198726+intron-Distal3.968113.40229HepG2CSTF2T
chr172119463521194762+intron-Distal,intron-Proximal4.468274.71638K562HNRNPL
chr172120471221204775+intron-Distal3.741923.15816HepG2PRPF4
chr172119351721193607+intron-Distal3.978694.33898HepG2FAM120A
chr172120883521208905+intron-Distal3.750776.25245HepG2PRPF4
chr172119321321193283+intron-Distal3.223575.21772HepG2CSTF2T
chr172120657021206623+intron-Distal,intron-Proximal3.702924.76597HepG2EFTUD2
chr172119274821192849+intron-Distal3.045015.05679HepG2FAM120A
chr172119274721192847+intron-Distal3.325237.65259HepG2NKRF
chr172120231321202407+intron-Distal,intron-Proximal4.9297111.64439HepG2EFTUD2
chr172119816121198249+intron-Distal3.317365.59719HepG2CSTF2T
chr172119692021196981+intron-Distal4.251044.92128HepG2CSTF2T
chr172119275221192846+intron-Distal3.575579.05327HepG2CSTF2T
chr172119461621194699+intron-Distal,intron-Proximal3.946049.42847HepG2HNRNPL
chr172119174321191807+intron-Distal3.835759.58042HepG2CSTF2T
chr172120534721205435+intron-Distal,intron-Proximal4.211237.70374HepG2FAM120A
chr172120643221206482+intron-Distal,intron-Proximal4.424995.01214HepG2BUD13
chr172121446121214622+intron-Distal3.110585.58948HepG2HNRNPM
chr172120657521206619+intron-Distal,intron-Proximal5.385517.21923HepG2BUD13
chr172120883921208901+intron-Distal3.904963.35727HepG2FUS
chr172120827921208357+intron-Proximal4.808215.86025HepG2SF3B4
chr172120224021202274+intron-Proximal3.495404.23256HepG2EFTUD2
chr172120846421208515+intron-Proximal3.589655.17182HepG2RBM22
chr172121673121216788+intron-Proximal4.632764.50924HepG2SF3B4
chr172120538121205427+intron-Proximal3.422563.81059HepG2AQR
chr172120558321205642+intron-Proximal4.5168117.15802HepG2PRPF8
chr172120536221205422+intron-Proximal4.230704.55101HepG2PRPF4
chr172120180521201852+intron-Proximal3.844675.34978HepG2PRPF8
chr172121674521216797+intron-Proximal4.594054.62947HepG2AQR
chr172120537621205441+intron-Proximal5.626926.82887HepG2EFTUD2
chr172120844721208526+intron-Proximal3.7611911.69715HepG2PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MAP2K3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MAP2K3 is not available on ENCORE database.

  • 85 RBPs can affect the levels of MAP2K3.  








The Knockdown/knockout RNA-Seq assay for MAP2K3 is not available on ENCORE database.





85 RBPs can affect the gene expression of MAP2K3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MAP2K3ENSG00000034152.14521.27440693.79480-0.412502.769301.69580HepG2AATF
MAP2K3ENSG00000034152.141077.839501288.53990-0.257602.562401.82090HepG2AKAP8L
MAP2K3ENSG00000034152.141591.26530834.163200.9317015.6801014.42240HepG2BOP1
MAP2K3ENSG00000034152.141650.806201282.222800.364406.128005.20940HepG2CKAP4
MAP2K3ENSG00000034152.14514.57100765.78830-0.573604.792603.90870HepG2CPSF6
MAP2K3ENSG00000034152.141352.60450968.551700.481704.768903.34370HepG2CPSF7
MAP2K3ENSG00000034152.14925.97060578.440300.678709.777607.92190HepG2YBX3
MAP2K3ENSG00000034152.141811.792201214.808200.5766010.692209.59020HepG2CELF1
MAP2K3ENSG00000034152.141763.757301306.348800.433007.008505.90770HepG2DAZAP1
MAP2K3ENSG00000034152.141500.721401186.164600.339305.103604.01830HepG2DDX19B
MAP2K3ENSG00000034152.14855.32430579.270200.562106.507504.82130HepG2DDX1
MAP2K3ENSG00000034152.142398.264501556.434800.623605.959105.08140HepG2DDX6
MAP2K3ENSG00000034152.14740.94060547.841300.435503.297202.23080HepG2DHX30
MAP2K3ENSG00000034152.14745.76610568.017400.392703.500302.71620HepG2DNAJC21
MAP2K3ENSG00000034152.141015.64880562.954600.8512020.3451018.72940HepG2DNAJC2
MAP2K3ENSG00000034152.14639.61950892.23080-0.480204.711503.20790HepG2EIF2S2
MAP2K3ENSG00000034152.14547.05130722.75770-0.401803.104901.96410HepG2EIF3G
MAP2K3ENSG00000034152.141634.339901234.493200.404703.356602.46470HepG2EIF4G2
MAP2K3ENSG00000034152.14720.178901018.93180-0.500604.147502.83440HepG2ESF1
MAP2K3ENSG00000034152.141309.755601903.38260-0.5393011.1297010.05500HepG2ETF1
MAP2K3ENSG00000034152.141832.869101253.239800.548307.334605.97800HepG2EWSR1
MAP2K3ENSG00000034152.14919.013201187.89330-0.370202.064201.39450HepG2FIP1L1
MAP2K3ENSG00000034152.141031.522301546.99170-0.584702.692002.03490HepG2G3BP1
MAP2K3ENSG00000034152.14807.02520573.458600.492802.714702.07410HepG2HNRNPA1
MAP2K3ENSG00000034152.14824.10290637.851100.369502.470701.81240HepG2HNRNPC
MAP2K3ENSG00000034152.141350.107201116.829300.273602.815102.09100HepG2HNRNPF
MAP2K3ENSG00000034152.141455.516001190.023800.290403.610002.84620HepG2HNRNPL
MAP2K3ENSG00000034152.141432.216701099.756300.381003.965103.11210HepG2IGF2BP1
MAP2K3ENSG00000034152.142102.810301572.291200.419402.790802.11340HepG2IGF2BP2
MAP2K3ENSG00000034152.14472.59290647.24000-0.453705.221904.24160HepG2ILF2
MAP2K3ENSG00000034152.141013.887101581.81550-0.641703.297202.19090HepG2KHSRP
MAP2K3ENSG00000034152.141617.282501031.679600.648505.423704.24670HepG2LARP4
MAP2K3ENSG00000034152.14604.21490844.95420-0.483802.265301.39370HepG2MTPAP
MAP2K3ENSG00000034152.141698.231301295.365800.390603.917103.00960HepG2NOL12
MAP2K3ENSG00000034152.14805.71160528.187500.609103.384301.78650HepG2NOLC1
MAP2K3ENSG00000034152.141884.28320777.212301.2775012.6212010.68920HepG2PABPC1
MAP2K3ENSG00000034152.14509.76620627.20980-0.299102.148501.39460HepG2PARN
MAP2K3ENSG00000034152.142056.816801613.390600.350204.416203.67920HepG2PCBP1
MAP2K3ENSG00000034152.14351.02350537.80060-0.615503.538102.14500HepG2PKM
MAP2K3ENSG00000034152.14861.09490565.154600.607406.161605.09490HepG2PPIL4
MAP2K3ENSG00000034152.14502.08850767.56020-0.612307.933006.70950HepG2PRPF4
MAP2K3ENSG00000034152.141424.482501641.74900-0.204801.811101.35030HepG2PTBP1
MAP2K3ENSG00000034152.141768.100501236.503400.515805.990405.15740HepG2PUF60
MAP2K3ENSG00000034152.141655.408301312.560100.334705.284004.51810HepG2PUM1
MAP2K3ENSG00000034152.141437.35750686.665901.065603.158102.40850HepG2RAVER1
MAP2K3ENSG00000034152.141368.259201109.473400.302402.295501.50620HepG2RBM15
MAP2K3ENSG00000034152.141136.23500753.152300.593103.418902.23930HepG2RCC2
MAP2K3ENSG00000034152.141100.695801827.05600-0.7311017.0932015.96850HepG2NELFE
MAP2K3ENSG00000034152.141110.630901701.75060-0.615609.383108.34820HepG2RECQL
MAP2K3ENSG00000034152.141552.993901203.124800.368203.191802.46580HepG2RPLP0
MAP2K3ENSG00000034152.14909.98420564.289300.689304.835004.02330HepG2SAFB2
MAP2K3ENSG00000034152.141329.60620819.902900.697408.552607.37550HepG2SF3B1
MAP2K3ENSG00000034152.141496.451101185.526000.335904.693703.81710HepG2SLBP
MAP2K3ENSG00000034152.14922.33940658.072200.487007.090906.13480HepG2SMN1
MAP2K3ENSG00000034152.141194.44240702.796200.765102.622601.69220HepG2SMNDC1
MAP2K3ENSG00000034152.14532.16590912.29650-0.777605.270304.18260HepG2SNRNP70
MAP2K3ENSG00000034152.142670.263801796.803300.5714015.2226014.29630HepG2SRFBP1
MAP2K3ENSG00000034152.141506.184801784.03790-0.244202.637502.17260HepG2SRSF1
MAP2K3ENSG00000034152.141583.232101220.815600.374905.065004.25800HepG2SRSF5
MAP2K3ENSG00000034152.141346.894001097.253900.295603.153402.41600HepG2SRSF7
MAP2K3ENSG00000034152.141153.953901560.01630-0.435007.242306.48810HepG2SSB
MAP2K3ENSG00000034152.141827.983301388.447700.396706.735305.84010HepG2SUCLG1
MAP2K3ENSG00000034152.14422.68870801.88670-0.9238013.7975011.82020HepG2SUPT6H
MAP2K3ENSG00000034152.14487.85460991.17540-1.022703.068002.36010HepG2SUPV3L1
MAP2K3ENSG00000034152.14485.970101603.69240-1.7225064.2235061.96110HepG2TAF15
MAP2K3ENSG00000034152.141229.207401473.43730-0.261502.103501.37240HepG2TIA1
MAP2K3ENSG00000034152.14807.98550615.753500.391903.233202.69940HepG2TIAL1
MAP2K3ENSG00000034152.14998.85870621.195000.6851012.3879011.31920HepG2TRIM56
MAP2K3ENSG00000034152.141549.108701016.009000.608406.234405.30800HepG2U2AF1
MAP2K3ENSG00000034152.141952.508901278.541000.610705.853104.60430HepG2UBE2L3
MAP2K3ENSG00000034152.141434.087301045.358200.456007.612606.54860HepG2UPF1
MAP2K3ENSG00000034152.141357.130801009.246700.427205.647904.84150HepG2UTP3
MAP2K3ENSG00000034152.141640.569301149.688800.5129011.7098010.77700HepG2ZNF622
MAP2K3ENSG00000034152.14233.99420146.452900.675903.843203.19360K562AGGF1
MAP2K3ENSG00000034152.14454.82090314.238800.533303.163902.54430K562AQR
MAP2K3ENSG00000034152.14162.67160250.75290-0.624303.694202.88450K562EIF2S2
MAP2K3ENSG00000034152.14232.70910151.969100.614603.161401.80090K562EXOSC5
MAP2K3ENSG00000034152.14268.16040189.620100.499902.508701.92640K562FXR1
MAP2K3ENSG00000034152.1422.6766074.01840-1.706705.227904.18560K562G3BP2
MAP2K3ENSG00000034152.14456.43660334.098700.450002.382901.67980K562GRSF1
MAP2K3ENSG00000034152.14275.29320178.224800.627203.545202.33070K562HNRNPL
MAP2K3ENSG00000034152.14186.81610121.833500.616602.681601.85460K562MAGOH
MAP2K3ENSG00000034152.14261.63810159.793700.711303.439301.97020K562NONO
MAP2K3ENSG00000034152.14300.59670230.684600.381801.983301.33820K562NSUN2
MAP2K3ENSG00000034152.14227.01590338.86180-0.577903.192101.50890K562PKM
MAP2K3ENSG00000034152.14247.30070156.910600.656203.416402.48870K562PPIG
MAP2K3ENSG00000034152.14245.53380147.253100.737502.362301.80710K562RBM15
MAP2K3ENSG00000034152.14214.91090113.522000.920705.549604.31010K562RBM22
MAP2K3ENSG00000034152.14188.29570116.033000.698403.131802.38340K562SRSF1
MAP2K3ENSG00000034152.14178.78640111.141400.685702.756601.66800K562TRA2A
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MAP2K3 is not available on ENCORE database.





9 RBPs can affect the splicing of MAP2K3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMAP2K3ENSG00000034152.14chr17+211993972119952221187983211882812120172421201791-0.107000.000030.00152excludedHepG2HNRNPK
SEMAP2K3ENSG00000034152.14chr17+211993972119952221187983211882812120172421201791-0.098000.000000.00047excludedHepG2AKAP1
SEMAP2K3ENSG00000034152.14chr17+2119939721199522211879832118828121201724212017910.080000.004000.05247includedK562PUS1
SEMAP2K3ENSG00000034152.14chr17+211993972119952221187983211882812120172421201791-0.100000.000000.00036excludedHepG2MATR3
SEMAP2K3ENSG00000034152.14chr17+2119939721199522211879832118828121201724212017910.107000.000480.07332includedK562EIF4G2
SEMAP2K3ENSG00000034152.14chr17+2119939721199522211879832118828121201724212017910.164000.000000.00006includedHepG2HNRNPC
SEMAP2K3ENSG00000034152.14chr17+2119939721199522211879832118828121201724212017910.057000.000440.08327includedHepG2PRPF4
A3SSMAP2K3ENSG00000034152.14chr17+2120644821206546212064942120654621205454212055710.053000.007110.03935longerK562AQR
MXEMAP2K3ENSG00000034152.14chr17+2120649421206546212077372120786521205454212055712120836221208440-0.223000.001670.063372includedK562SAFB

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MAP2K3 is not avaliable on ENCORE database.