KLK1

General Information

Gene Name       : KLK1
Gene ID             : ENSG00000167748.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: KLK1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878KLK1ENSG00000167748.1021.8218.4220.12ENCSR000AEF
HepG2KLK1ENSG00000167748.100.070.000.04ENCSR985KAT
K562KLK1ENSG00000167748.1010.3110.3810.35ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for KLK1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • KLK1 RNA is bound by 10 proteins.  







eCLIP assay for KLK1 is not avaliable on ENCORE database.





10 proteins are bound to KLK1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr195132369351323750-3'-UTR,CDS,intron-Distal,intron-Proximal5.6732122.12948K562PTBP1
chr195132367551323692-3'-UTR,CDS,intron-Distal3.969434.22551K562SF3B4
chr195132364151323750-3'-UTR,CDS,intron-Distal,intron-Proximal5.1607836.41969K562ILF3
chr195132369251323747-3'-UTR,CDS,intron-Distal,intron-Proximal4.3765527.40202K562SF3B4
chr195132359751323775-3'-UTR,CDS,intron-Distal,intron-Proximal3.3216426.23529K562CSTF2T
chr195132364451323764-3'-UTR,CDS,intron-Distal,intron-Proximal4.2777019.84533K562HNRNPK
chr195132368351323745-3'-UTR,CDS,intron-Distal,intron-Proximal5.2153041.77260K562PCBP1
chr195132255751322611-3'-UTR,CDS,intron-Distal5.932838.95391K562PABPC4
chr195132244951322504-3'-UTR,CDS,intron-Distal,intron-Proximal3.492744.02206K562CSTF2T
chr195132356351323635-3'-UTR,CDS,intron-Distal3.773045.95764K562YBX3
chr195132359851323641-3'-UTR,CDS,intron-Distal3.745275.68907K562ILF3
chr195132399451324080-intron-Distal5.0677723.22668K562PTBP1
chr195132380751323921-intron-Distal4.3401125.07484K562MATR3
chr195132384751323916-intron-Distal3.7195110.75863K562TIA1
chr195132380151323841-intron-Distal5.9912818.60841K562PTBP1
chr195132384151323904-intron-Distal6.7884535.63509K562PTBP1
chr195132374551323806-intron-Distal,intron-Proximal3.6883531.56409K562PCBP1
chr195132399351324079-intron-Distal3.7547820.88329K562PCBP1
chr195132389751323993-intron-Distal4.6194026.15875K562PCBP1
chr195132412651324177-intron-Distal,intron-Proximal5.153319.02396K562ILF3
chr195132375051323800-intron-Distal,intron-Proximal4.7070416.03462K562PTBP1
chr195132409651324141-intron-Distal,intron-Proximal6.0943813.04119K562PTBP1
chr195132392151324000-intron-Distal5.0823621.94624K562MATR3
chr195132390451323994-intron-Distal5.8665740.84952K562PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for KLK1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for KLK1 is not available on ENCORE database.

  • 78 RBPs can affect the levels of KLK1.  








The Knockdown/knockout RNA-Seq assay for KLK1 is not available on ENCORE database.





78 RBPs can affect the gene expression of KLK1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
KLK1ENSG00000167748.6178.86450397.20800-1.151005.230703.54320K562AARS
KLK1ENSG00000167748.61169.13840577.754001.016807.187205.24540K562ABCF1
KLK1ENSG00000167748.6724.14370460.626100.652608.417007.50070K562AGGF1
KLK1ENSG00000167748.6667.49420506.173300.399002.833601.83650K562AKAP8
KLK1ENSG00000167748.61267.72730479.306001.403109.472808.17970K562AKAP8L
KLK1ENSG00000167748.6571.48450343.925800.732505.385804.61380K562AQR
KLK1ENSG00000167748.6734.77130502.914300.546906.120304.69340K562ATP5C1
KLK1ENSG00000167748.6428.60470325.013100.399002.692401.74400K562BCLAF1
KLK1ENSG00000167748.61580.76990873.042700.856402.621601.77420K562BOP1
KLK1ENSG00000167748.6799.55040274.876801.540303.477902.26710K562CCAR1
KLK1ENSG00000167748.6802.70550550.461500.544105.806604.07070K562CCDC124
KLK1ENSG00000167748.6933.52400405.167201.2041023.3558019.80190K562CEBPZ
KLK1ENSG00000167748.6949.55070554.819400.775104.410102.52040K562CKAP4
KLK1ENSG00000167748.62885.06200905.816401.671203.401202.19980K562CNOT7
KLK1ENSG00000167748.61662.45630928.306900.8405015.5658013.66910K562CPSF6
KLK1ENSG00000167748.61061.00780636.124100.738005.801604.39150K562CELF1
KLK1ENSG00000167748.6972.66140465.705101.0624021.0565017.97360K562DDX21
KLK1ENSG00000167748.6221.89360631.98670-1.5100031.9872030.02550K562DDX47
KLK1ENSG00000167748.6950.71520307.776701.6270030.5981026.72320K562DHX30
KLK1ENSG00000167748.6574.85680295.564300.959604.756802.97570K562DNAJC21
KLK1ENSG00000167748.6897.91720333.312301.4296018.1271015.23650K562EEF2
KLK1ENSG00000167748.6168.67760259.69240-0.622502.121001.47730K562EIF2S2
KLK1ENSG00000167748.6158.67190344.63980-1.119004.891003.46830K562EIF3D
KLK1ENSG00000167748.699.35950189.52750-0.931703.783002.86250K562EIF3G
KLK1ENSG00000167748.6852.28590507.045500.749102.775901.50930K562EXOSC5
KLK1ENSG00000167748.6655.05050415.193200.657702.706101.86710K562FIP1L1
KLK1ENSG00000167748.61568.92950800.544700.970602.218501.40400K562FTO
KLK1ENSG00000167748.669.17270338.20950-2.2896032.6331030.68570K562FXR1
KLK1ENSG00000167748.6155.77870264.59650-0.764303.767702.91370K562G3BP2
KLK1ENSG00000167748.6630.90790414.302700.606606.273904.59480K562GLRX3
KLK1ENSG00000167748.61863.44630886.314301.072007.687806.35970K562GPKOW
KLK1ENSG00000167748.6550.83450345.996600.670805.034504.01600K562GRSF1
KLK1ENSG00000167748.6405.92030226.774500.839804.007701.63220K562HLTF
KLK1ENSG00000167748.62121.55880813.314001.383104.121701.93400K562HNRNPA0
KLK1ENSG00000167748.6553.33930385.051500.523004.192402.87120K562HNRNPA1
KLK1ENSG00000167748.61023.63550550.412300.895004.680402.96430K562HNRNPA2B1
KLK1ENSG00000167748.61064.92190434.206201.2942014.8588013.56110K562HNRNPC
KLK1ENSG00000167748.6662.16500387.931300.771307.889205.88000K562HNRNPF
KLK1ENSG00000167748.6667.61510426.384300.646807.213005.77100K562HNRNPU
KLK1ENSG00000167748.61147.33720465.926201.3000018.2271014.29560K562IGF2BP1
KLK1ENSG00000167748.6421.20670283.547300.570802.991501.91130K562IGF2BP2
KLK1ENSG00000167748.61590.21950828.140600.941204.402402.58500K562ILF2
KLK1ENSG00000167748.6580.43090287.230501.014805.934903.75700K562ILF3
KLK1ENSG00000167748.6840.62720508.650600.724709.287107.53990K562KIF1C
KLK1ENSG00000167748.6159.97950298.05670-0.897707.246005.85810K562MAGOH
KLK1ENSG00000167748.6648.54180486.914200.413402.592301.56380K562MAK16
KLK1ENSG00000167748.6753.47270569.819000.403003.275402.27210K562MBNL1
KLK1ENSG00000167748.61204.67660865.137600.477502.086701.32540K562METAP2
KLK1ENSG00000167748.61349.11760551.117101.2915023.0798020.28110K562MSI2
KLK1ENSG00000167748.6839.49060435.575500.9465017.7561015.96120K562MTPAP
KLK1ENSG00000167748.6842.68890399.402901.0771010.732808.57800K562NAA15
KLK1ENSG00000167748.61470.81230484.018501.6034075.1097072.17890K562NSUN2
KLK1ENSG00000167748.61822.08850806.551001.175708.067904.92900K562PPIL4
KLK1ENSG00000167748.6113.10650313.32860-1.4700012.7910011.16660K562PRPF8
KLK1ENSG00000167748.6603.10100389.362700.631204.328903.16010K562PSIP1
KLK1ENSG00000167748.6137.25730289.57630-1.077109.439008.26300K562PTBP1
KLK1ENSG00000167748.6377.19140564.14490-0.580802.473601.70380K562PUF60
KLK1ENSG00000167748.6863.31220587.924500.554203.300902.25130K562PUM2
KLK1ENSG00000167748.61093.66940475.313901.202105.152504.43970K562PUS1
KLK1ENSG00000167748.6886.45130463.143400.9365016.0595014.61560K562RBM15
KLK1ENSG00000167748.685.06730319.08370-1.9073016.9896014.94860K562RPS19
KLK1ENSG00000167748.6308.67060963.38350-1.6420018.5925015.90730K562RPS3
KLK1ENSG00000167748.61135.02910477.520901.2490032.0708029.66820K562SF3A3
KLK1ENSG00000167748.6782.62960302.654801.3706018.2694015.39490K562SLBP
KLK1ENSG00000167748.6114.56800283.87460-1.3090011.4368010.01120K562SRSF1
KLK1ENSG00000167748.6937.48410415.625101.1734025.9920022.66820K562SRSF7
KLK1ENSG00000167748.6294.28710195.503200.589903.566802.08100K562SSB
KLK1ENSG00000167748.62332.56230807.808601.529706.463004.02930K562STIP1
KLK1ENSG00000167748.6797.32130492.200800.695804.947603.00900K562SUCLG1
KLK1ENSG00000167748.6114.53030496.22800-2.115304.373903.33540K562SYNCRIP
KLK1ENSG00000167748.6376.62790287.314000.390401.895501.30200K562TARDBP
KLK1ENSG00000167748.6956.95040374.471801.3535020.9115018.15800K562TIAL1
KLK1ENSG00000167748.6357.72600264.740100.434202.447601.69250K562U2AF2
KLK1ENSG00000167748.61225.21940636.309900.945107.461805.26870K562UBE2L3
KLK1ENSG00000167748.6534.84660321.003000.736405.626004.12390K562UCHL5
KLK1ENSG00000167748.61151.21920513.210701.165409.614408.37370K562UPF1
KLK1ENSG00000167748.61159.36870439.145301.4005032.4068029.67260K562WDR3
KLK1ENSG00000167748.61111.42790387.330501.520709.198307.50250K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for KLK1 is not available on ENCORE database.





5 RBPs can affect the splicing of KLK1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
RIKLK1ENSG00000167748.6chr19-513231545132369951323154513232915132340951323699-0.059000.000740.05355excludedK562NONO
RIKLK1ENSG00000167748.6chr19-513231545132369951323154513232915132340951323699-0.139000.000210.01882excludedK562PPIL4
RIKLK1ENSG00000167748.6chr19-513231545132369951323154513232915132340951323699-0.132000.000430.02797excludedK562SBDS
RIKLK1ENSG00000167748.6chr19-5132315451323699513231545132329151323409513236990.052000.001450.00943includedK562AQR
RIKLK1ENSG00000167748.6chr19-5132315451323699513231545132329151323409513236990.096000.002920.04443includedK562FXR1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for KLK1 is not avaliable on ENCORE database.