GATA1

General Information

Gene Name       : GATA1
Gene ID             : ENSG00000102145.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: GATA1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878GATA1ENSG00000102145.130.000.000.00ENCSR000AEF
HepG2GATA1ENSG00000102145.130.050.050.05ENCSR985KAT
K562GATA1ENSG00000102145.13205.09183.32194.20ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
GATA1ENCAB334NIY710049RI243501Released, ENCODE4


  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
GATA1Product_ID: 710049
Lot_ID: RI243501
Source: Thermo Fisher
Target Name: GATA1-human		 ThermoFisher_710049_RI243501_GATA1.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the GATA1 specific antibody, 710049. Lane 1 is 2.5% of five million whole cell lysate input. Lanes 2 and 3 are 50% of IP enrichment from five million whole cell lysate using normal IgG antibody and the GATA1-specific antibody, 710049. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.








RNA Targets

  • eCLIP assay for GATA1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • GATA1 RNA is bound by 26 proteins.  







eCLIP assay for GATA1 is not avaliable on ENCORE database.





26 proteins are bound to GATA1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chrX4865262548652711+3'-UTR,CDS4.3133637.64087K562PUM2
chrX4865254148652595+3'-UTR,CDS3.150737.83020K562PABPC4
chrX4865254648652572+3'-UTR,CDS3.272678.96960K562DDX55
chrX4865263348652672+3'-UTR,CDS3.3288012.87834K562PABPC4
chrX4864949748649565+3'-UTR,CDS,intron-Proximal3.8425310.49508K562DDX3X
chrX4864951048649557+3'-UTR,CDS4.5562216.97960K562PCBP1
chrX4865259548652633+3'-UTR,CDS3.532284.59348K562PABPC4
chrX4864500048645052+5'-UTR3.013465.85620K562DDX3X
chrX4864962848649654+CDS4.9797611.62664K562RPS3
chrX4865219448652221+CDS,intron-Distal,intron-Proximal3.483396.63359K562BUD13
chrX4865072948650733+CDS,intron-Proximal4.054345.75237K562PCBP1
chrX4865045048650494+CDS4.6812611.11968K562PCBP1
chrX4865234248652397+CDS,intron-Distal3.703767.43070K562DDX24
chrX4865233748652405+CDS,intron-Distal3.8562214.19868K562LSM11
chrX4865215448652224+CDS,intron-Distal,intron-Proximal5.4788423.95513K562AQR
chrX4865233448652399+CDS,intron-Distal4.0898910.91138K562NIPBL
chrX4865246048652505+CDS,intron-Proximal4.1687514.65557K562PCBP1
chrX4865234948652403+CDS,intron-Distal3.9422625.89548K562RPS3
chrX4865232948652404+CDS,intron-Distal3.1715016.61954K562DDX6
chrX4865058848650627+CDS4.3911414.65557K562PCBP1
chrX4865233748652397+CDS,intron-Distal3.179997.36733K562DROSHA
chrX4865038148650408+CDS3.213373.78871K562IGF2BP1
chrX4865234448652384+CDS,intron-Distal3.623446.74131K562GEMIN5
chrX4864962348649660+CDS3.265235.36775K562DDX6
chrX4865170248651733+CDS,intron-Proximal3.9562330.45466K562AQR
chrX4865194748651993+intron-Distal4.5121220.10947K562PTBP1
chrX4865185948651962+intron-Distal4.4544342.11623K562PCBP1
chrX4864874448648792+intron-Distal3.935665.50026K562DDX52
chrX4865211148652196+intron-Distal,intron-Proximal5.320009.72234K562HNRNPK
chrX4864849048648605+intron-Distal4.196113.04054K562GTF2F1
chrX4865182348651922+intron-Distal4.0284512.62760K562HNRNPK
chrX4864848548648588+intron-Distal6.5763713.15364K562DDX52
chrX4865210748652175+intron-Distal,intron-Proximal3.7771112.53493K562CSTF2T
chrX4864544448645576+intron-Distal6.6855619.78370K562PTBP1
chrX4865202448652085+intron-Distal3.568747.88956K562CSTF2T
chrX4865182448652015+intron-Distal4.2841047.77640K562ILF3
chrX4865181548651947+intron-Distal4.90169400.00000K562PTBP1
chrX4865209648652147+intron-Distal,intron-Proximal3.924065.79938K562LIN28B
chrX4865201548652080+intron-Distal4.0747713.75515K562ILF3
chrX4864849648648556+intron-Distal4.114803.54264K562SAFB2
chrX4864816548648202+intron-Distal3.409423.84192K562DDX52
chrX4864631548646366+intron-Distal4.116943.80946K562DDX52
chrX4864851448648604+intron-Distal4.013517.96984K562DHX30
chrX4864853848648569+intron-Distal4.806463.27332K562DDX6
chrX4864530548645347+intron-Distal4.193545.63677K562PTBP1
chrX4865210048652188+intron-Distal,intron-Proximal3.3518018.11775K562ILF3
chrX4864851548648600+intron-Distal4.9192912.14695K562EFTUD2
chrX4865192248652035+intron-Distal5.4533830.24693K562HNRNPK
chrX4864974548649812+intron-Proximal4.642028.91093K562PRPF8
chrX4864973648649739+intron-Proximal6.4551114.50093K562AQR
chrX4864973948649796+intron-Proximal7.0197522.27579K562AQR
chrX4865174848651789+intron-Proximal3.3701513.65012K562AQR
chrX4865173348651748+intron-Proximal4.7952838.04379K562AQR
chrX4864505348645094+intron-Proximal4.214967.08156K562PRPF8
chrX4864505348645095+intron-Proximal3.682399.53666K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for GATA1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for GATA1 is not available on ENCORE database.

  • 56 RBPs can affect the levels of GATA1.  








The Knockdown/knockout RNA-Seq assay for GATA1 is not available on ENCORE database.





56 RBPs can affect the gene expression of GATA1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
GATA1ENSG00000102145.918.863804.803401.973402.178401.70950HepG2SSB
GATA1ENSG00000102145.912.350300.0000099999.999903.278902.11810HepG2TBRG4
GATA1ENSG00000102145.95043.775004072.829600.308405.754204.98390K562AGGF1
GATA1ENSG00000102145.95813.513404237.923600.456005.863504.88980K562AKAP8L
GATA1ENSG00000102145.94272.208504966.70690-0.217301.796501.30340K562AQR
GATA1ENSG00000102145.93573.662603079.642400.214502.788001.82410K562BCLAF1
GATA1ENSG00000102145.91904.053302567.05560-0.431004.175502.82300K562CCAR1
GATA1ENSG00000102145.94812.683803934.673800.290503.572202.30840K562CPEB4
GATA1ENSG00000102145.91934.607501580.827100.291302.426801.68810K562CPSF6
GATA1ENSG00000102145.93114.744102336.367900.414706.638004.89640K562CSTF2
GATA1ENSG00000102145.99242.323707191.010300.362003.665602.53880K562CELF1
GATA1ENSG00000102145.95575.089804647.623600.262403.800002.37400K562DDX21
GATA1ENSG00000102145.94800.050804071.876500.237303.513602.79140K562DDX47
GATA1ENSG00000102145.91986.200202760.49320-0.474905.358703.48040K562DNAJC21
GATA1ENSG00000102145.94207.864502725.482000.626502.851001.55150K562EEF2
GATA1ENSG00000102145.93557.795204386.23460-0.302004.675203.77170K562EIF2S2
GATA1ENSG00000102145.91783.419602611.17910-0.550103.516602.37040K562EIF3A
GATA1ENSG00000102145.92075.924801364.144300.6057011.406309.76810K562EIF3G
GATA1ENSG00000102145.93718.466702573.397000.530905.917304.11820K562EIF4B
GATA1ENSG00000102145.93426.447302494.375100.457907.718805.32550K562EWSR1
GATA1ENSG00000102145.93911.104402508.481400.6407010.116808.38270K562FIP1L1
GATA1ENSG00000102145.91607.582702494.21990-0.633707.362005.37600K562FKBP4
GATA1ENSG00000102145.9242.287201055.08770-2.1226010.880109.29180K562G3BP2
GATA1ENSG00000102145.91945.047101509.230800.365903.467802.58190K562GPKOW
GATA1ENSG00000102145.94790.400903679.744600.380404.685103.26970K562HNRNPL
GATA1ENSG00000102145.93281.607201949.774000.751003.678002.43110K562IGF2BP2
GATA1ENSG00000102145.93527.383902781.804500.342503.322601.76630K562LARP7
GATA1ENSG00000102145.92676.353802043.338000.389203.111802.12950K562MATR3
GATA1ENSG00000102145.92006.770501473.207300.445804.976803.78180K562METAP2
GATA1ENSG00000102145.95397.633704025.898400.4229014.7704013.23690K562NSUN2
GATA1ENSG00000102145.93518.467802105.328800.740803.774802.56800K562PABPN1
GATA1ENSG00000102145.93683.947405005.41150-0.442204.182503.15870K562PCBP3
GATA1ENSG00000102145.93032.956503839.28380-0.340104.247703.25210K562POLR2G
GATA1ENSG00000102145.94182.365802847.920100.554307.478505.98850K562PPIG
GATA1ENSG00000102145.92710.963501989.584300.446203.029102.33770K562PTBP1
GATA1ENSG00000102145.94991.374606380.02420-0.354104.014603.03630K562PUF60
GATA1ENSG00000102145.94943.143004095.093300.271403.423202.77550K562RBM15
GATA1ENSG00000102145.92959.781701906.994400.634104.018502.98770K562RBM22
GATA1ENSG00000102145.92750.281701859.552200.564503.182501.65830K562RBM34
GATA1ENSG00000102145.93042.806902349.692400.372804.633103.34540K562RCC2
GATA1ENSG00000102145.92995.280702006.988800.577604.272002.87750K562NELFE
GATA1ENSG00000102145.95118.379003972.517900.365506.414905.21530K562SF3A3
GATA1ENSG00000102145.91788.029901096.009300.706007.924606.43250K562SF3B4
GATA1ENSG00000102145.92693.659102227.408200.274102.200001.30610K562SRFBP1
GATA1ENSG00000102145.93296.876901950.616100.757105.781104.76680K562SRSF1
GATA1ENSG00000102145.92203.727301681.812400.389803.844002.57430K562SRSF4
GATA1ENSG00000102145.92641.464001842.606300.519505.665704.05920K562SRSF5
GATA1ENSG00000102145.95336.238404147.534300.363506.631904.80870K562SRSF7
GATA1ENSG00000102145.9482.229401035.60120-1.102702.901801.39010K562TAF15
GATA1ENSG00000102145.93955.677001973.805601.0028010.691909.14920K562TARDBP
GATA1ENSG00000102145.93367.420301904.049100.8225017.8716015.64050K562TIA1
GATA1ENSG00000102145.93397.203002476.651500.455904.371903.17700K562TIAL1
GATA1ENSG00000102145.93504.608501869.255400.9067010.370807.84140K562TRA2A
GATA1ENSG00000102145.93228.566702631.525100.294902.528201.63020K562TRIM56
GATA1ENSG00000102145.9692.846001055.38020-0.607202.932702.10560K562U2AF2
GATA1ENSG00000102145.93465.220904268.74460-0.300905.678404.69020K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for GATA1 is not available on ENCORE database.





10 RBPs can affect the splicing of GATA1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEGATA1ENSG00000102145.9chrX+486494974864973648644961486450534865025048650628-0.193000.000000.00000excludedK562SRSF1
SEGATA1ENSG00000102145.9chrX+486494974864973648644961486450534865025048650628-0.082000.001140.08459excludedK562XRCC6
SEGATA1ENSG00000102145.9chrX+486494974864973648644961486450534865025048650628-0.101000.000010.00064excludedK562FXR1
SEGATA1ENSG00000102145.9chrX+486494974864973648644980486450534865025048650628-0.171000.002300.04429excludedK562U2AF1
SEGATA1ENSG00000102145.9chrX+486494974864973648644980486450534865025048650628-0.127000.000030.00231excludedK562TARDBP
SEGATA1ENSG00000102145.9chrX+486494974864973648644961486450534865025048650628-0.160000.000000.00000excludedK562HNRNPU
SEGATA1ENSG00000102145.9chrX+4864949748649736486449804864505348650250486506280.086000.000570.02919includedK562HNRNPK
SEGATA1ENSG00000102145.9chrX+486494974864973648644961486450534865025048650628-0.150000.000000.00013excludedK562PTBP1
SEGATA1ENSG00000102145.9chrX+486494974864973648644961486450534865025048650628-0.228000.000000.00000excludedK562HNRNPC
MXEGATA1ENSG00000102145.9chrX+48649497486497364865038748650628486449804864505348650729486508750.068000.001580.095351includedK562HNRNPL
MXEGATA1ENSG00000102145.9chrX+4864949748649736486503874865062848644980486450534865072948650875-0.094000.004030.075922includedK562TARDBP
MXEGATA1ENSG00000102145.9chrX+4864949748649736486502504865062848644980486450534865072948650875-0.115000.000220.008032includedK562TARDBP
MXEGATA1ENSG00000102145.9chrX+4864949748649736486502504865030948644961486450534865038748650628-0.135000.000000.000012includedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for GATA1 is not avaliable on ENCORE database.