EDC3

General Information

Gene Name       : EDC3
Gene ID             : ENSG00000179151.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: EDC3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878EDC3ENSG00000179151.1227.2331.1929.21ENCSR000AEF
HepG2EDC3ENSG00000179151.1240.9231.4936.20ENCSR985KAT
K562EDC3ENSG00000179151.1235.3034.4234.86ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
EDC3A303-986A1BGKcLV40-11, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
EDC3K562CRISPRBGKcLV38-27,BGKcLV38-28BGKcLV38-1,BGKcLV38-240.8,40.8NotSatisfiedENCORE2
EDC3K562CRISPREDC3-BGKcLV40-11,EDC3-BGKcLV40-12NT-BGKcLV40-1,NT-BGKcLV40-276.6,66.0SubmittingENCORE2
EDC3HepG2CRISPRBGHcLV39-35,BGHcLV39-36BGHcLV39-1,BGHcLV39-20.0,0.0NotSatisfiedENCORE2
EDC3HepG2CRISPRBGHcLV41-19,BGHcLV41-20BGHcLV41-1,BGHcLV41-2no clear band on the psition,NotSatisfiedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
EDC3Product_ID: A303-986A
Lot_ID: 1
Source: Bethyl Labs
Target Name: EDC3-human		 EDC3-K562-CRISPR-A303-986A.png<br>Caption: Western blot following CRISPR against EDC3 in K562 whole cell lysate using EDC3 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against EDC3. EDC3 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for EDC3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • EDC3 RNA is bound by 18 proteins.  







eCLIP assay for EDC3 is not avaliable on ENCORE database.





18 proteins are bound to EDC3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr157494806674948200-3'-UTR,CDS,intron-Distal,intron-Proximal4.644585.86954K562UCHL5
chr157492319874923278-3'-UTR,intron-Distal5.0453712.56575K562UPF1
chr157492417574924255-3'-UTR,intron-Distal4.1702414.26407K562UPF1
chr157494815174948292-3'-UTR,CDS,intron-Distal,intron-Proximal3.360809.07205HepG2BCLAF1
chr157492406974924135-3'-UTR,intron-Distal3.081255.39816K562LIN28B
chr157492394674924032-3'-UTR,intron-Distal5.637866.97910HepG2PCBP2
chr157494818574948307-3'-UTR,CDS,intron-Distal,intron-Proximal4.337594.93465K562RBM15
chr157493282374932912-3'-UTR,CDS,intron-Distal,intron-Proximal3.268754.51003HepG2PPIG
chr157492394874924060-3'-UTR,intron-Distal5.821007.75552K562PCBP1
chr157492393074923964-3'-UTR,intron-Distal4.448333.78860K562AKAP1
chr157493274874932844-3'-UTR,CDS,intron-Distal,intron-Proximal4.9112314.11848HepG2PRPF8
chr157494819074948263-3'-UTR,CDS,intron-Distal,intron-Proximal3.957163.28461K562BUD13
chr157492335574923397-3'-UTR,intron-Distal4.9151411.38624K562UPF1
chr157492409874924134-3'-UTR,intron-Distal5.6807010.54419K562UPF1
chr157492305174923131-3'-UTR,intron-Distal6.2003017.37470K562UPF1
chr157492297474923051-3'-UTR,intron-Distal4.1496715.20799K562UPF1
chr157492339774923543-3'-UTR,intron-Distal6.1733934.31163K562UPF1
chr157492428874924347-3'-UTR,intron-Distal4.5679215.13329K562UPF1
chr157492297374923059-3'-UTR,intron-Distal3.647523.92010K562DDX55
chr157492382874923896-3'-UTR,intron-Distal4.9919118.65988K562UPF1
chr157492392574924055-3'-UTR,intron-Distal3.263733.93724HepG2HNRNPK
chr157492791574927981-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.166684.23351K562BUD13
chr157492354374923645-3'-UTR,intron-Distal4.6791112.80730K562UPF1
chr157492795074928017-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.845474.90235K562SF3B4
chr157492389674924023-3'-UTR,intron-Distal4.9428922.37472K562UPF1
chr157493274374932814-3'-UTR,CDS,intron-Distal,intron-Proximal4.508394.21433K562PRPF8
chr157498821774988266-5'-UTR,intron-Distal3.948995.47892K562DDX3X
chr157496384274963983-CDS,intron-Distal,intron-Proximal3.205633.21309HepG2GRWD1
chr157496399574964114-CDS,intron-Distal,intron-Proximal3.560024.34695HepG2BCLAF1
chr157495973974959791-intron-Distal5.107405.36996HepG2PCBP2
chr157496857374968689-intron-Distal4.245033.50357HepG2QKI
chr157494616574946274-intron-Distal4.521605.20135HepG2QKI
chr157497180474971917-intron-Distal3.021323.28806K562KHSRP
chr157493259574932644-intron-Distal4.176913.02181K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for EDC3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for EDC3 is not available on ENCORE database.

  • 63 RBPs can affect the levels of EDC3.  








The Knockdown/knockout RNA-Seq assay for EDC3 is not available on ENCORE database.





63 RBPs can affect the gene expression of EDC3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
EDC3ENSG00000179151.71025.48460756.136400.439503.618702.94470HepG2BOP1
EDC3ENSG00000179151.71066.18230686.299500.635403.756002.85850HepG2CNOT7
EDC3ENSG00000179151.7793.078301182.58770-0.5764010.499709.20020HepG2DAZAP1
EDC3ENSG00000179151.7454.77230686.82700-0.594805.332004.00010HepG2DHX30
EDC3ENSG00000179151.7498.90100712.10720-0.513305.266604.32430HepG2DNAJC21
EDC3ENSG00000179151.7469.16370664.45740-0.502102.894501.76000HepG2AGO1
EDC3ENSG00000179151.7650.954401061.82940-0.705906.868005.96200HepG2EIF2S1
EDC3ENSG00000179151.7578.65430743.45310-0.361502.524701.41070HepG2EIF2S2
EDC3ENSG00000179151.7842.548801117.73830-0.407802.975502.13260HepG2EIF4G2
EDC3ENSG00000179151.71275.395801492.38980-0.226702.116901.57630HepG2ETF1
EDC3ENSG00000179151.7468.26510674.69210-0.526903.125801.77730HepG2FKBP4
EDC3ENSG00000179151.7777.226601098.29730-0.498903.717402.94950HepG2G3BP1
EDC3ENSG00000179151.7882.569501112.15850-0.333602.222601.59200HepG2HNRNPK
EDC3ENSG00000179151.7634.94470794.38920-0.323203.002302.37310HepG2HNRNPU
EDC3ENSG00000179151.7583.66870762.86880-0.386303.003501.94550HepG2KIF1C
EDC3ENSG00000179151.7520.50960665.85910-0.355301.944401.31200HepG2NSUN2
EDC3ENSG00000179151.7744.211901085.64110-0.544804.476603.57080HepG2PABPC4
EDC3ENSG00000179151.7879.653101119.45660-0.347802.533601.96030HepG2PUF60
EDC3ENSG00000179151.7738.131601188.41010-0.6871014.6902013.55060HepG2PUM1
EDC3ENSG00000179151.7997.11120850.110100.230002.020001.47440HepG2PUS1
EDC3ENSG00000179151.7993.151701201.21530-0.274402.562602.03900HepG2NELFE
EDC3ENSG00000179151.7592.40290707.43860-0.256001.949501.39270HepG2SAFB2
EDC3ENSG00000179151.7561.80490743.27170-0.403802.656001.96500HepG2SF3B1
EDC3ENSG00000179151.71750.325601408.860600.313004.365503.77770HepG2SRFBP1
EDC3ENSG00000179151.7912.661101223.23670-0.422605.928305.23160HepG2SSB
EDC3ENSG00000179151.7516.82160806.92490-0.642804.976804.11130HepG2SUPV3L1
EDC3ENSG00000179151.7685.169301054.30670-0.621809.176708.25120HepG2TAF15
EDC3ENSG00000179151.7357.95740540.83930-0.595404.066402.88650HepG2TFIP11
EDC3ENSG00000179151.7686.52880968.74340-0.496805.122203.99660HepG2TIA1
EDC3ENSG00000179151.7858.230701157.78470-0.431902.542601.74060HepG2UBE2L3
EDC3ENSG00000179151.71022.82590825.659600.308802.972102.35530HepG2UTP3
EDC3ENSG00000179151.7392.64430853.75630-1.1206026.4864024.79880HepG2ZC3H8
EDC3ENSG00000179151.71312.214802012.66770-0.617107.656405.65230K562ABCF1
EDC3ENSG00000179151.72548.288902110.892000.271602.379401.47860K562AKAP8
EDC3ENSG00000179151.72614.365702097.289000.317804.346303.17290K562ATP5C1
EDC3ENSG00000179151.72141.043901836.945400.220902.444401.82660K562DDX47
EDC3ENSG00000179151.71525.948101235.899400.304003.271801.82120K562DDX6
EDC3ENSG00000179151.7544.19360995.64690-0.8715010.694807.92260K562DHX30
EDC3ENSG00000179151.7705.49760956.40050-0.439003.479801.96030K562DNAJC21
EDC3ENSG00000179151.71277.217601652.17370-0.371404.820603.90600K562EIF2S2
EDC3ENSG00000179151.71558.098201273.553400.290802.211801.47480K562EIF4A3
EDC3ENSG00000179151.72132.836302499.09750-0.228602.523601.62260K562EIF4G2
EDC3ENSG00000179151.7683.579001017.99530-0.574603.991703.10450K562G3BP2
EDC3ENSG00000179151.71423.987001069.900200.412403.796602.87260K562GPKOW
EDC3ENSG00000179151.71410.482001140.936400.305902.510101.93880K562HNRNPC
EDC3ENSG00000179151.71558.162401221.813400.350702.492201.32520K562HNRNPK
EDC3ENSG00000179151.71655.220101224.403400.434803.068801.96820K562IGF2BP2
EDC3ENSG00000179151.71446.330301104.668400.388703.493801.88830K562LARP7
EDC3ENSG00000179151.72451.093502030.539200.271502.358301.39260K562MAK16
EDC3ENSG00000179151.71831.884301463.023500.324304.526403.51400K562MTPAP
EDC3ENSG00000179151.71888.799601250.596500.594802.473401.55090K562PABPN1
EDC3ENSG00000179151.71698.751401257.402400.433903.378301.88420K562PCBP1
EDC3ENSG00000179151.71550.975101200.173800.369802.713701.97090K562PRPF8
EDC3ENSG00000179151.72172.632902900.57270-0.416905.994204.36820K562PUM1
EDC3ENSG00000179151.72581.110401931.403900.418206.642105.74910K562RBM15
EDC3ENSG00000179151.71284.27680964.927800.412403.874302.25860K562RBM25
EDC3ENSG00000179151.71703.056901222.323400.478403.666802.72430K562RPS19
EDC3ENSG00000179151.71754.488301406.222800.319102.752201.67320K562SAFB
EDC3ENSG00000179151.72425.855801143.576601.084805.366503.51700K562SF1
EDC3ENSG00000179151.72003.619401604.010100.320803.994703.02340K562SF3A3
EDC3ENSG00000179151.71401.097501057.925100.405204.401603.31230K562SF3B4
EDC3ENSG00000179151.72270.751901393.963700.703902.942001.57880K562SFPQ
EDC3ENSG00000179151.72061.185701313.523400.649902.580001.41110K562SNRNP200
EDC3ENSG00000179151.71157.50330884.685000.387703.189102.06910K562SRFBP1
EDC3ENSG00000179151.71777.849301224.950900.537306.615905.53140K562SRSF1
EDC3ENSG00000179151.71481.645401157.116000.356602.760601.71350K562SRSF5
EDC3ENSG00000179151.71498.924801045.195100.520105.749004.27150K562TRIM56
EDC3ENSG00000179151.71261.252901018.632100.308102.637201.85200K562U2AF2
EDC3ENSG00000179151.72232.566901723.592600.373206.419605.37780K562UPF1
EDC3ENSG00000179151.72916.187502009.822600.536902.715801.43900K562UTP18
EDC3ENSG00000179151.7940.828701920.42830-1.0294015.5947013.12570K562UTP3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for EDC3 is not available on ENCORE database.





13 RBPs can affect the splicing of EDC3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEEDC3ENSG00000179151.7chr15-749794317497952074967371749674837498822074988348-0.117000.001610.03062excludedK562SRSF1
SEEDC3ENSG00000179151.7chr15-749794317497952074967371749674837498822074988348-0.173000.000150.00808excludedK562PRPF8
SEEDC3ENSG00000179151.7chr15-749794317497952074967371749674837498822074988348-0.098000.001210.06934excludedHepG2RBM22
SEEDC3ENSG00000179151.7chr15-749692817496936374967301749674837498822074988328-0.118000.000150.06176excludedK562XRN2
SEEDC3ENSG00000179151.7chr15-749794317497952074967371749674837498822074988348-0.158000.000950.07692excludedHepG2PRPF8
SEEDC3ENSG00000179151.7chr15-749794317497952074969281749693637498822074988348-0.327000.008990.07463excludedK562AQR
SEEDC3ENSG00000179151.7chr15-749794317497952074967371749674837498822074988348-0.087000.001790.02740excludedK562PUS1
SEEDC3ENSG00000179151.7chr15-749692817496936374967301749674837498822074988328-0.131000.000030.01754excludedK562UCHL5
SEEDC3ENSG00000179151.7chr15-749794317497952074967371749674837498822074988348-0.212000.000000.00002excludedK562EFTUD2
SEEDC3ENSG00000179151.7chr15-7496928174969363749673017496748374988220749883280.089000.000720.03358includedHepG2MATR3
SEEDC3ENSG00000179151.7chr15-749794317497952074967371749674837498822074988348-0.148000.000710.06461excludedHepG2SUPV3L1
SEEDC3ENSG00000179151.7chr15-749794317497952074967371749674837498822074988348-0.106000.000160.00663excludedK562AGGF1
SEEDC3ENSG00000179151.7chr15-749692817496936374967301749674837498822074988328-0.087000.000100.02662excludedHepG2DDX55
SEEDC3ENSG00000179151.7chr15-7497943174979520749673717496748374988220749883410.325000.000010.00057includedHepG2HNRNPC
A3SSEDC3ENSG00000179151.7chr15-7493280674932995749328067493296074948073749484090.234000.000000.00000longerK562AQR
A3SSEDC3ENSG00000179151.7chr15-7492790274928093749279027492796774932806749329950.110000.000000.00000longerK562AQR
A3SSEDC3ENSG00000179151.7chr15-7492507374925319749250737492528774927749749279970.189000.000000.00000longerK562AQR
MXEEDC3ENSG00000179151.7chr15-74948073749484097496397874964115749328067493296074967301749674830.137000.005750.040461includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for EDC3 is not avaliable on ENCORE database.