AP2S1

General Information

Gene Name       : AP2S1
Gene ID             : ENSG00000042753.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: AP2S1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878AP2S1ENSG00000042753.1118.5134.3426.43ENCSR000AEF
HepG2AP2S1ENSG00000042753.1183.5041.9662.73ENCSR985KAT
K562AP2S1ENSG00000042753.11124.0379.70101.87ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for AP2S1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • AP2S1 RNA is bound by 14 proteins.  







eCLIP assay for AP2S1 is not avaliable on ENCORE database.





14 proteins are bound to AP2S1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr194734154647341668-3'-UTR,intron-Distal,intron-Proximal5.1825110.09956HepG2DDX55
chr194734148447341536-3'-UTR,intron-Distal6.0990466.06905K562PABPC4
chr194734148247341595-3'-UTR,intron-Distal4.565004.93188HepG2UPF1
chr194734150147341708-3'-UTR,CDS,intron-Distal,intron-Proximal3.527874.74299HepG2AKAP1
chr194734153647341594-3'-UTR,intron-Distal6.4519683.29681K562PABPC4
chr194734167447341735-3'-UTR,CDS,intron-Distal,intron-Proximal4.921299.74340HepG2LARP4
chr194734160147341674-3'-UTR,intron-Distal,intron-Proximal6.4570413.26729HepG2LARP4
chr194734159947341652-3'-UTR,intron-Distal,intron-Proximal5.0685665.02744K562PABPC4
chr194734143347341535-3'-UTR,intron-Distal3.540146.03035K562NOLC1
chr194734144347341484-3'-UTR,intron-Distal5.1558643.59132K562PABPC4
chr194734145147341517-3'-UTR,intron-Distal5.418587.26512HepG2LARP4
chr194734168547341720-3'-UTR,CDS,intron-Distal,intron-Proximal4.7208216.45220K562PABPC4
chr194734146347341721-3'-UTR,CDS,intron-Distal,intron-Proximal3.0064512.01603K562DDX6
chr194734154947341724-3'-UTR,CDS,intron-Distal,intron-Proximal5.6554017.52177K562PCBP1
chr194734159547341690-3'-UTR,intron-Distal,intron-Proximal3.699833.48322HepG2UPF1
chr194734142247341526-3'-UTR,intron-Distal,intron-Proximal6.4150252.72658HepG2SUB1
chr194735402047354096-5'-UTR,CDS,intron-Distal,intron-Proximal4.8977511.11007HepG2DDX3X
chr194734926047349395-5'-UTR,CDS,intron-Distal3.454058.58659K562LIN28B
chr194734935047349400-5'-UTR,CDS,intron-Distal,intron-Proximal4.467713.53770HepG2DDX3X
chr194735401947354094-5'-UTR,CDS,intron-Distal,intron-Proximal3.521989.58776K562DDX3X
chr194734932747349400-5'-UTR,CDS,intron-Distal,intron-Proximal4.1059426.31825K562DDX3X
chr194734934547349398-5'-UTR,CDS,intron-Distal4.5525320.82721K562PABPC4
chr194735402247354051-5'-UTR,CDS,intron-Distal,intron-Proximal3.228547.94485K562PABPC4
chr194734924947349265-CDS,intron-Distal,intron-Proximal3.6124613.51526K562YBX3
chr194734199647342034-CDS,intron-Distal,intron-Proximal3.3131711.97741K562YBX3
chr194734920647349275-CDS,intron-Distal,intron-Proximal3.987553.86479HepG2PRPF8
chr194734175847341796-CDS,intron-Distal3.789503.81620HepG2LARP4
chr194734273047342760-CDS,intron-Distal5.1018118.23831K562YBX3
chr194734178247341794-CDS,intron-Distal3.0520112.07802K562YBX3
chr194734282547342835-CDS,intron-Distal4.0888115.66718K562YBX3
chr194734277947342835-CDS,intron-Distal4.180495.92795K562METAP2
chr194734172847341796-CDS,intron-Distal4.059513.04123K562LIN28B
chr194734272247342730-CDS,intron-Distal4.254319.87532K562YBX3
chr194734277347342825-CDS,intron-Distal4.6157749.62714K562YBX3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for AP2S1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for AP2S1 is not available on ENCORE database.

  • 82 RBPs can affect the levels of AP2S1.  








The Knockdown/knockout RNA-Seq assay for AP2S1 is not available on ENCORE database.





82 RBPs can affect the gene expression of AP2S1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
AP2S1ENSG00000042753.7817.88860515.564700.6657010.459709.43600HepG2ACO1
AP2S1ENSG00000042753.71760.92120774.970601.1840017.1234015.91530HepG2AKAP1
AP2S1ENSG00000042753.7428.27420269.153700.670004.718903.96340HepG2BOP1
AP2S1ENSG00000042753.7589.59330249.025101.243309.844708.43480HepG2CNOT7
AP2S1ENSG00000042753.7632.85710476.794200.408404.134803.13830HepG2DDX19B
AP2S1ENSG00000042753.71232.00980742.346400.730707.634906.64340HepG2DDX3X
AP2S1ENSG00000042753.7735.40420455.693600.690404.375103.42580HepG2DDX55
AP2S1ENSG00000042753.7227.81050340.50390-0.579802.636701.49900HepG2EIF2S2
AP2S1ENSG00000042753.7258.74100373.63720-0.530103.354602.18100HepG2EIF3G
AP2S1ENSG00000042753.7434.80960684.50060-0.654706.636005.44050HepG2EIF4G1
AP2S1ENSG00000042753.7707.767401000.33620-0.499106.386405.53490HepG2ETF1
AP2S1ENSG00000042753.7643.40860503.742200.352902.318501.55470HepG2EWSR1
AP2S1ENSG00000042753.7251.90330339.07740-0.428702.060901.37430HepG2FUBP3
AP2S1ENSG00000042753.7962.11870683.573500.493003.731802.93810HepG2FXR1
AP2S1ENSG00000042753.7418.19160553.22250-0.403703.527202.72490HepG2HNRNPF
AP2S1ENSG00000042753.7391.08060642.13850-0.715406.167605.15560HepG2HNRNPK
AP2S1ENSG00000042753.7199.21740361.24210-0.858608.781507.54820HepG2ILF2
AP2S1ENSG00000042753.7493.96480366.757200.429502.034201.33570HepG2MSI2
AP2S1ENSG00000042753.7124.84050237.01840-0.924904.794703.81970HepG2NSUN2
AP2S1ENSG00000042753.7498.46870630.15050-0.338202.729202.12550HepG2PCBP1
AP2S1ENSG00000042753.7260.45080340.32430-0.385902.170601.47860HepG2PRPF4
AP2S1ENSG00000042753.7829.88970697.138000.251402.171101.63280HepG2PUM1
AP2S1ENSG00000042753.7643.26110525.126800.292602.257001.68770HepG2PUS1
AP2S1ENSG00000042753.7440.45510694.45560-0.656907.203706.26600HepG2QKI
AP2S1ENSG00000042753.71370.90120836.098100.7133013.3183012.35150HepG2RBM22
AP2S1ENSG00000042753.7500.96900630.24900-0.331202.084501.49400HepG2RBM25
AP2S1ENSG00000042753.7531.86690366.404600.537502.918201.82830HepG2RCC2
AP2S1ENSG00000042753.7598.06640713.59100-0.254801.767201.31430HepG2NELFE
AP2S1ENSG00000042753.7465.14850664.58660-0.514805.274004.45660HepG2RECQL
AP2S1ENSG00000042753.7411.41000596.02300-0.534804.087803.28350HepG2RPLP0
AP2S1ENSG00000042753.7702.49680400.990000.808803.044302.33660HepG2SF3A3
AP2S1ENSG00000042753.7466.38000367.300900.344402.439101.82970HepG2SMN1
AP2S1ENSG00000042753.71137.38900944.346000.268202.715002.21600HepG2SRFBP1
AP2S1ENSG00000042753.7413.43610543.53830-0.394703.329802.57620HepG2SRSF7
AP2S1ENSG00000042753.7315.51610566.87560-0.8453011.8352010.83480HepG2SRSF9
AP2S1ENSG00000042753.7667.09500819.92270-0.297602.559502.06100HepG2SSB
AP2S1ENSG00000042753.7262.63590453.58940-0.788305.683304.76780HepG2SUPV3L1
AP2S1ENSG00000042753.7334.62010626.27850-0.9043012.2063011.15680HepG2TAF15
AP2S1ENSG00000042753.7345.70280575.50230-0.735307.762406.37600HepG2TIA1
AP2S1ENSG00000042753.7469.74280641.62540-0.449902.447701.62910HepG2TUFM
AP2S1ENSG00000042753.7191.89960355.61730-0.890008.828307.70040HepG2UPF1
AP2S1ENSG00000042753.7515.30180343.333800.585705.656504.84960HepG2UTP3
AP2S1ENSG00000042753.7248.41400335.85400-0.435102.668802.00830HepG2ZC3H8
AP2S1ENSG00000042753.7514.84860391.110300.396503.363602.77750HepG2ZNF622
AP2S1ENSG00000042753.72005.375301311.167500.6129014.1804012.99840K562AGGF1
AP2S1ENSG00000042753.71881.882601440.791300.385203.790002.59950K562AKAP8
AP2S1ENSG00000042753.72284.032001364.333200.743308.125806.94700K562AKAP8L
AP2S1ENSG00000042753.7392.43850531.75820-0.438302.770501.71710K562CCAR1
AP2S1ENSG00000042753.71952.471001566.903900.317303.332202.02280K562CCDC124
AP2S1ENSG00000042753.71482.115301157.981800.355902.907101.59160K562CIRBP
AP2S1ENSG00000042753.71273.993201049.338500.279802.235701.30750K562DDX3X
AP2S1ENSG00000042753.7969.755401321.20870-0.446206.192105.27160K562DDX47
AP2S1ENSG00000042753.71739.146201468.094900.244302.515201.68390K562DKC1
AP2S1ENSG00000042753.71148.16600786.076400.546504.835203.61350K562EFTUD2
AP2S1ENSG00000042753.7268.73570540.89910-1.009206.625705.01480K562EIF3A
AP2S1ENSG00000042753.71275.37690777.432400.714008.194706.65180K562FIP1L1
AP2S1ENSG00000042753.7372.30110728.44240-0.968308.758807.35310K562G3BP2
AP2S1ENSG00000042753.72585.926101936.985300.416804.694403.71100K562GRSF1
AP2S1ENSG00000042753.71366.406401824.96240-0.417504.736403.34350K562HNRNPA1
AP2S1ENSG00000042753.7503.15200755.15430-0.585803.865903.17510K562HNRNPC
AP2S1ENSG00000042753.7904.18340639.527600.499503.636102.55660K562HNRNPM
AP2S1ENSG00000042753.71673.320202021.11110-0.272402.824601.92170K562HNRNPU
AP2S1ENSG00000042753.71664.693101053.923300.659408.489107.11120K562HSPD1
AP2S1ENSG00000042753.71583.053301080.433100.551004.462703.03290K562IGF2BP2
AP2S1ENSG00000042753.7452.83450712.24630-0.653403.153601.62130K562ILF2
AP2S1ENSG00000042753.71828.853701447.884400.336902.835501.99870K562KIF1C
AP2S1ENSG00000042753.71858.701701385.993100.423304.476003.01490K562MAK16
AP2S1ENSG00000042753.71578.091301136.904500.473003.149302.19690K562NAA15
AP2S1ENSG00000042753.71078.15170774.883700.476403.016601.64780K562NONO
AP2S1ENSG00000042753.71390.81110713.353600.963105.451603.93310K562PABPN1
AP2S1ENSG00000042753.71354.485601010.321200.422803.842602.68820K562PCBP2
AP2S1ENSG00000042753.7723.75580897.57820-0.310502.126301.42500K562POLR2G
AP2S1ENSG00000042753.71628.09100882.652500.8832014.0462011.74550K562PPIG
AP2S1ENSG00000042753.71341.41040764.946400.8102010.239708.79040K562PRPF8
AP2S1ENSG00000042753.71544.206801103.213900.485105.963105.02070K562PTBP1
AP2S1ENSG00000042753.72170.290102571.52290-0.244702.319101.34930K562PUM1
AP2S1ENSG00000042753.72884.063801353.015301.0918016.7081015.41380K562PUS1
AP2S1ENSG00000042753.71808.333801318.333500.455805.602204.78440K562RBM15
AP2S1ENSG00000042753.7627.41770799.78250-0.350202.379401.37950K562SAFB
AP2S1ENSG00000042753.7615.62800826.87400-0.425603.105001.57030K562SDAD1
AP2S1ENSG00000042753.71192.43890652.305800.870203.566402.14610K562SF1
AP2S1ENSG00000042753.71422.473501204.148100.240302.015401.31200K562SF3A3
AP2S1ENSG00000042753.71038.693001233.67230-0.248202.655201.73510K562SRPK2
AP2S1ENSG00000042753.71617.715801081.515900.580807.930306.74050K562SRSF1
AP2S1ENSG00000042753.71402.626101021.406800.457504.339002.97690K562SRSF5
AP2S1ENSG00000042753.7803.399601021.65400-0.346703.150701.52830K562SRSF9
AP2S1ENSG00000042753.71357.624901055.833400.362603.335002.42530K562TIA1
AP2S1ENSG00000042753.7589.15130850.75590-0.530103.438901.44360K562TRNAU1AP
AP2S1ENSG00000042753.7811.023601151.35350-0.505508.430907.03230K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for AP2S1 is not available on ENCORE database.





11 RBPs can affect the splicing of AP2S1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEAP2S1ENSG00000042753.7chr19-473427214734287747341996473420564734924947349399-0.055000.001090.02240excludedK562SRSF1
SEAP2S1ENSG00000042753.7chr19-473492494734939947342721473428354735402047354023-0.068000.000000.00001excludedK562SF3B4
SEAP2S1ENSG00000042753.7chr19-473427214734283547341996473420564734924947349405-0.071000.000600.01331excludedHepG2U2AF1
SEAP2S1ENSG00000042753.7chr19-473493004734939947342721473428354735402047354034-0.075000.000070.09717excludedK562LIN28B
SEAP2S1ENSG00000042753.7chr19-4734272147342877473419964734205647349249473493990.088000.009200.08546includedHepG2U2AF2
SEAP2S1ENSG00000042753.7chr19-473492494734939947342721473428354735402047354023-0.097000.000000.00000excludedK562AQR
SEAP2S1ENSG00000042753.7chr19-4734272147342877473419964734205647349249473493990.067000.000660.03786includedK562EFTUD2
SEAP2S1ENSG00000042753.7chr19-473492494734939947342721473428354735402047354023-0.064000.000020.00158excludedHepG2PCBP1
SEAP2S1ENSG00000042753.7chr19-473492494734939947342721473428354735402047354023-0.052000.000130.00923excludedHepG2SF3B4
SEAP2S1ENSG00000042753.7chr19-4735339047353545473492494734939947354020473540910.060000.000010.00236includedHepG2TAF15
SEAP2S1ENSG00000042753.7chr19-473427214734287747341996473420564734924947349399-0.062000.000430.02393excludedK562HNRNPK
SEAP2S1ENSG00000042753.7chr19-473493004734939947342721473428354735402047354034-0.095000.000060.00166excludedK562HNRNPC
A3SSAP2S1ENSG00000042753.7chr19-4734272147342877473427214734283547349249473493990.086000.000000.00000longerK562U2AF2
A3SSAP2S1ENSG00000042753.7chr19-4734272147342877473427214734283547349249473493990.112000.000000.00003longerHepG2U2AF2
A3SSAP2S1ENSG00000042753.7chr19-4734272147342877473427214734283547349249473493990.077000.000000.00002longerHepG2U2AF1
A3SSAP2S1ENSG00000042753.7chr19-4734272147342877473427214734283547349249473493990.084000.000000.00000longerK562U2AF1
MXEAP2S1ENSG00000042753.7chr19-47341996473420564734272147342835473414144734180547354020473540910.068000.000000.000001includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for AP2S1 is not avaliable on ENCORE database.