HNRNPM

General Information

Gene Name : HNRNPM
Gene ID : ENSG00000099783.11
Essential Gene : Yes

Functions

Splicing regulation
mitochondrial RNA regulation
Viral RNA regulation

Localization

Not Available

Domains (AlphaFold: HNRNPM)

RRM

Antibody Validation

Santa Cruz Biotech: sc-20001

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	HNRNPM	ENSG00000099783.11	154.36	158.30	156.33	ENCSR000AEF
HepG2	HNRNPM	ENSG00000099783.11	205.16	222.84	214.00	ENCSR985KAT
K562	HNRNPM	ENSG00000099783.11	190.80	161.84	176.32	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 222	ENCSR267UCX	HNRNPM	HepG2	Released	ENCAB792TQV	ENCSR459ONR
eCLIP	eCLIP: 224	ENCSR412NOW	HNRNPM	K562	Released	ENCAB792TQV	ENCSR212ILN
knockdown followed by RNA-seq	HNRNPM-BGKLV29-K562	ENCSR746NIM	HNRNPM	K562	Released		ENCSR032YMP	shRNA	KD% = 49.9,63.2
knockdown followed by RNA-seq	HNRNPM-BGHLV30-HepG2	ENCSR995JMS	HNRNPM	HepG2	Released		ENCSR067GHD	shRNA	KD% = 70.9,63.8

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
HNRNPM	222	HepG2	ENCSR267UCX	ENCSR459ONR	ENCAB792TQV	SC-20001	D1304	Released	ENCODE3
HNRNPM	224	K562	ENCSR412NOW	ENCSR212ILN	ENCAB792TQV	SC-20001	D1304	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
HNRNPM	ENCAB792TQV	sc-20001	D1304		Released, ENCODE3	Released, ENCODE3	BGHLV30-41, Released, ENCODE3	BGKLV29-39, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
HNRNPM	K562	shRNA			BGKLV25-27,BGKLV25-28	BGKLV25-1,BGKLV25-2	0.0,0.0	NotSatisfied	ENCODE3
HNRNPM	K562	shRNA			BGKLV28-21,BGKLV28-22	BGKLV28-1,BGKLV28-2	0.0,0.0	NotSatisfied	ENCODE3
HNRNPM	K562	shRNA	ENCSR746NIM	ENCSR032YMP	HNRNPM_BGKLV29-39,HNRNPM_BGKLV29-40	NT_BGKLV29-1,NT_BGKLV29-2	49.9,63.2	Released	ENCODE3
HNRNPM	HepG2	shRNA	ENCSR995JMS	ENCSR067GHD	HNRNPM_BGHLV30-41,HNRNPM_BGHLV30-42	NT_BGHLV30-1,NT_BGHLV30-2	70.9,63.8	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
HNRNPM	Product_ID: sc-20001 Lot_ID: D1304 Source: Santa Cruz Biotech Target Name: HNRNPM-human

RNA Targets

HNRNPM protein binds to 19,646 RNA regions.

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Proteins bound to RNA

HNRNPM RNA is bound by 54 proteins.

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HNRNPM protein has 19,646 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
HNRNPM	chr13	113869861	113869942	+	5.56261	38.05028	HepG2	CUL4A	intron-Distal
HNRNPM	chr19	2197047	2197145	+	6.15480	31.55663	HepG2	DOT1L	intron-Distal
HNRNPM	chr15	25311795	25311837	+	6.08659	31.27285	HepG2	SNHG14	intron-Distal
HNRNPM	chr20	30947708	30947756	+	6.64337	26.71810	HepG2	ASXL1	intron-Distal
HNRNPM	chr16	89375468	89375557	-	6.68206	26.17362	HepG2	ANKRD11	intron-Distal
HNRNPM	chr5	1803441	1803532	+	5.83500	25.11901	K562	NDUFS6	intron-Distal
HNRNPM	chr9	134061133	134061196	+	4.38789	19.96433	K562	NUP214	intron-Distal
HNRNPM	chr14	39736696	39736738	+	3.37659	18.68319	HepG2	CTAGE5, RP11-407N17.3	5'-UTR,CDS,intron-Distal,intron-Proximal
HNRNPM	chr7	50857001	50857124	-	5.02013	16.28748	K562	GRB10	intron-Distal
HNRNPM	chr19	8543627	8543649	+	4.38433	16.26321	K562	HNRNPM	intron-Distal

Showing 1 to 10 of 100 entries

54 proteins are bound to HNRNPM RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr19	8553868	8553915	+	3'-UTR	4.70989	400.00000	K562	PABPC4
chr19	8553871	8553926	+	3'-UTR	6.32384	77.48366	HepG2	SUB1
chr19	8546265	8546342	+	intron-Distal	6.93701	65.65564	K562	EXOSC5
chr19	8531151	8531221	+	5'-UTR,CDS,intron-Distal	3.77395	64.63082	K562	UCHL5
chr19	8553926	8553985	+	3'-UTR	8.24084	57.81104	HepG2	SUB1
chr19	8542829	8542897	+	intron-Distal	6.21828	56.35849	K562	EXOSC5
chr19	8543217	8543268	+	intron-Distal	5.58302	49.49452	K562	EXOSC5
chr19	8543589	8543650	+	intron-Distal	6.09826	49.33347	K562	EXOSC5
chr19	8550514	8550571	+	3'-UTR,CDS	4.62575	47.44019	K562	UCHL5
chr19	8528332	8528410	+	CDS,intron-Proximal	5.60165	46.69618	K562	U2AF2
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 412 entries

The HNRNPM protein binds to its own RNA.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
HNRNPM	chr19	8546094	8546164	+	6.71286	38.91958	K562	HNRNPM	intron-Distal
HNRNPM	chr19	8543311	8543370	+	5.85276	35.28153	K562	HNRNPM	intron-Distal
HNRNPM	chr19	8542904	8542957	+	5.80470	31.89748	K562	HNRNPM	intron-Distal
HNRNPM	chr19	8542967	8543016	+	5.89462	31.07255	K562	HNRNPM	intron-Distal
HNRNPM	chr19	8546164	8546212	+	5.34827	26.54182	K562	HNRNPM	intron-Distal
HNRNPM	chr19	8546335	8546395	+	4.96167	26.48952	K562	HNRNPM	intron-Distal
HNRNPM	chr19	8542834	8542888	+	5.12131	26.14663	K562	HNRNPM	intron-Distal
HNRNPM	chr19	8546108	8546204	+	6.65250	24.77536	HepG2	HNRNPM	intron-Distal
HNRNPM	chr19	8543276	8543311	+	5.01880	24.07572	K562	HNRNPM	intron-Distal
HNRNPM	chr19	8546236	8546266	+	5.20483	24.05101	K562	HNRNPM	intron-Distal

Showing 1 to 10 of 65 entries

Diffrential Expression

7,087 differentially expressed genes after Knockdown/Knockout HNRNPM protein.

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143 RBPs can affect the levels of HNRNPM.

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7,087 differentially expressed genes after Knockdown/Knockout HNRNPM protein :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SLC7A2	ENSG00000003989.12	1979.97940	4546.14030	-1.19920	39.88730	37.16220	HepG2	HNRNPM
SPAG9	ENSG00000008294.16	1260.84450	2774.27080	-1.13770	32.34930	29.85590	HepG2	HNRNPM
ITGA3	ENSG00000005884.13	489.57160	74.57370	2.71470	30.93780	28.47230	HepG2	HNRNPM
ASB4	ENSG00000005981.8	308.37680	56.40340	2.45070	29.52400	27.09000	HepG2	HNRNPM
CRLF1	ENSG00000006016.6	7322.41070	3681.64770	0.99190	20.95610	18.79440	HepG2	HNRNPM
WWTR1	ENSG00000018408.10	1227.48950	2272.47310	-0.88860	18.90270	16.80600	HepG2	HNRNPM
HSF2	ENSG00000025156.8	123.34720	366.36510	-1.57060	18.26820	16.19420	HepG2	HNRNPM
ZNF195	ENSG00000005801.12	764.02190	353.95550	1.10990	16.94800	14.93560	HepG2	HNRNPM
IFNGR1	ENSG00000027697.8	1909.85420	1085.79760	0.81460	15.18360	13.26070	HepG2	HNRNPM
CD74	ENSG00000019582.10	3045.18650	1817.92590	0.74410	14.91600	13.00840	HepG2	HNRNPM
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

143 RBPs can affect the gene expression of HNRNPM :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
HNRNPM	ENSG00000099783.7	6930.71910	3401.30430	1.02680	48.03560	45.68620	K562	FXR1
HNRNPM	ENSG00000099783.7	1591.97160	3509.52420	-1.14050	38.98260	37.50730	HepG2	TIAL1
HNRNPM	ENSG00000099783.7	2272.45970	5460.51740	-1.26480	35.70000	33.65930	HepG2	TARDBP
HNRNPM	ENSG00000099783.7	2045.77240	4722.86010	-1.20700	34.57420	32.78010	HepG2	RPLP0
HNRNPM	ENSG00000099783.7	1865.45790	3216.41680	-0.78590	32.12950	30.28250	HepG2	SAFB2
HNRNPM	ENSG00000099783.7	1941.98040	3209.01720	-0.72460	30.35050	28.42570	HepG2	DNAJC2
HNRNPM	ENSG00000099783.7	2520.07460	4307.12350	-0.77330	29.39410	27.60380	HepG2	SRSF7
HNRNPM	ENSG00000099783.7	2437.08200	5602.04640	-1.20080	29.02830	27.34100	HepG2	HNRNPLL
HNRNPM	ENSG00000099783.7	2074.21950	3540.84360	-0.77150	28.73100	27.15220	HepG2	TRIM56
HNRNPM	ENSG00000099783.7	4827.54880	7269.25880	-0.59050	24.41870	23.31560	HepG2	SRFBP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 173 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

650 alternative splicing events after Knockdown/Knockout HNRNPM protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	PNRC1	ENSG00000146278.10	chr6	+	89792264	89792454	89790496	89791153	89793471	89793916	0.13800	0.00062	included	HepG2	HNRNPM
SE	STX2	ENSG00000111450.9	chr12	-	131280539	131280665	131275378	131276522	131283069	131283180	0.41100	0.00046	included	HepG2	HNRNPM
SE	DEPDC1	ENSG00000024526.12	chr1	-	68947728	68948580	68947122	68947295	68949632	68949773	0.45700	0.00000	included	HepG2	HNRNPM
SE	ALDH3A2	ENSG00000072210.14	chr17	+	19558593	19558700	19555859	19555945	19559678	19559887	0.07500	0.00007	included	HepG2	HNRNPM
SE	SYNCRIP	ENSG00000135316.13	chr6	-	86351009	86351169	86350163	86350282	86352514	86352709	0.14000	0.00000	included	HepG2	HNRNPM
SE	MBNL1	ENSG00000152601.13	chr3	+	152173330	152173366	152165513	152165562	152174055	152174150	0.31400	0.00022	included	HepG2	HNRNPM
SE	APOC1	ENSG00000130208.5	chr19	+	45417928	45417990	45417503	45417746	45418128	45418206	0.17100	0.00000	included	HepG2	HNRNPM
SE	SREK1	ENSG00000153914.11	chr5	+	65451892	65454760	65449290	65449424	65455046	65455162	0.23700	0.00054	included	HepG2	HNRNPM
SE	UAP1	ENSG00000117143.9	chr1	+	162532262	162532374	162531511	162531567	162535801	162536138	0.18500	0.00031	included	HepG2	HNRNPM
SE	SEC31A	ENSG00000138674.12	chr4	-	83782783	83782861	83778841	83778917	83784470	83784545	0.24900	0.00000	included	HepG2	HNRNPM

Showing 1 to 10 of 100 entries

47 RBPs can affect the splicing of HNRNPM :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	HNRNPM	ENSG00000099783.7	chr19	+	8538547	8538592	8536209	8536311	8539050	8539128	-0.06400	0.00000	excluded	K562	PRPF8
SE	HNRNPM	ENSG00000099783.7	chr19	+	8527412	8527465	8520288	8520458	8528380	8528388	-0.08100	0.00000	excluded	K562	AKAP8L
SE	HNRNPM	ENSG00000099783.7	chr19	+	8538547	8538592	8536209	8536311	8539050	8539128	-0.05900	0.00001	excluded	K562	AKAP8L
SE	HNRNPM	ENSG00000099783.7	chr19	+	8548041	8548095	8539050	8539128	8550486	8551289	-0.19700	0.00000	excluded	HepG2	U2AF2
SE	HNRNPM	ENSG00000099783.7	chr19	+	8538547	8538592	8536175	8536311	8539050	8539128	-0.21200	0.00000	excluded	K562	AQR
SE	HNRNPM	ENSG00000099783.7	chr19	+	8551860	8551959	8550486	8551289	8553574	8553994	-0.05300	0.00000	excluded	K562	AQR
SE	HNRNPM	ENSG00000099783.7	chr19	+	8539050	8539128	8536209	8536311	8548041	8548095	-0.06000	0.00017	excluded	K562	SUPV3L1
SE	HNRNPM	ENSG00000099783.7	chr19	+	8527412	8527465	8520288	8520458	8528380	8528388	-0.10000	0.00000	excluded	K562	PUS1
SE	HNRNPM	ENSG00000099783.7	chr19	+	8548041	8548095	8539050	8539128	8550486	8551289	-0.12200	0.00001	excluded	K562	PUS1
SE	HNRNPM	ENSG00000099783.7	chr19	+	8538547	8538592	8536209	8536311	8539050	8539128	-0.08500	0.00000	excluded	K562	PUS1

Showing 1 to 10 of 109 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

HNRNPM

General Information

Functions

Localization

Domains (AlphaFold: HNRNPM)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

HNRNPM protein has 19,646 RNA targets:

54 proteins are bound to HNRNPM RNA:

The HNRNPM protein binds to its own RNA.

Diffrential Expression

7,087 differentially expressed genes after Knockdown/Knockout HNRNPM protein :

143 RBPs can affect the gene expression of HNRNPM :

650 alternative splicing events after Knockdown/Knockout HNRNPM protein :

47 RBPs can affect the splicing of HNRNPM :

No autoregularoty alternative splicing events between protein HNRNPM and its RNA.