ATXN2

General Information

Gene Name : ATXN2
Gene ID : ENSG00000204842.15
Essential Gene : No

Functions

Translation regulation
P-body / stress granules

Localization(RBPImage: ATXN2)

Nuclei
Nucleoplasm
Cytoplasm
Cytosolic

Domains (AlphaFold: ATXN2)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A301-118A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	ATXN2	ENSG00000204842.15	22.90	17.88	20.39	ENCSR000AEF
HepG2	ATXN2	ENSG00000204842.15	35.23	28.07	31.65	ENCSR985KAT
K562	ATXN2	ENSG00000204842.15	35.16	44.21	39.69	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
ATXN2	ENCAB360GKL	A301-118A	2			Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Sample_reps	Control_reps	KD%	Status	Project
ATXN2	HepG2	shRNA	BGHLV23-3,BGHLV23-4	BGHLV23-1,BGHLV23-2	redo transfection,redo transfection	NotSatisfied	ENCODE3
ATXN2	HepG2	shRNA	BGHLV31-13,BGHLV31-14	BGHLV31-1,BGHLV31-2	No band show on the position,No band show on the position	NotSatisfied	ENCODE3
ATXN2	K562	CRISPR	BGKcLV11-11,BGKcLV11-12	BGKcLV11-1,BGKcLV11-2	,no clear band on the position	NotSatisfied	ENCODE4
ATXN2	K562	CRISPR	BGKcLV11-13,BGKcLV11-14	BGKcLV11-1,BGKcLV11-2	,no clear band on the position	NotSatisfied	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

ATXN2: Click to RBP Image Database

Nuclei

Nucleoplasm

Cytoplasm

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
ATXN2	Product_ID: A301-118A Lot_ID: 2 Source: Bethyl Labs Target Name: ATXN2-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for ATXN2 is not avaliable on ENCORE database.

Proteins bound to RNA

ATXN2 RNA is bound by 58 proteins.

CanvasJS.com

eCLIP assay for ATXN2 is not avaliable on ENCORE database.

58 proteins are bound to ATXN2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr12	112018393	112018475	-	intron-Distal	5.91819	37.51693	HepG2	PCBP2
chr12	112036005	112036070	-	intron-Distal	5.46858	23.87104	K562	NONO
chr12	112035373	112035447	-	intron-Distal	4.83516	22.56973	K562	CSTF2T
chr12	112035753	112035842	-	intron-Distal	5.39508	21.65425	K562	NONO
chr12	112036205	112036303	-	intron-Distal	5.34542	20.86485	K562	NONO
chr12	112035344	112035464	-	intron-Distal	4.52840	20.70730	K562	NONO
chr12	112031552	112031649	-	intron-Distal	5.53501	18.16415	HepG2	QKI
chr12	111962838	111962931	-	intron-Distal,intron-Proximal	4.18136	16.23757	K562	KHSRP
chr12	112033972	112034033	-	intron-Distal	5.82096	15.65161	K562	TARDBP
chr12	111958682	111958737	-	CDS,intron-Distal,intron-Proximal	6.04866	15.35511	HepG2	BCLAF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 275 entries

eCLIP assay for ATXN2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for ATXN2 is not available on ENCORE database.
68 RBPs can affect the levels of ATXN2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for ATXN2 is not available on ENCORE database.

68 RBPs can affect the gene expression of ATXN2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ATXN2	ENSG00000204842.10	352.82000	970.90600	-1.46040	20.31450	19.01040	HepG2	AKAP1
ATXN2	ENSG00000204842.10	747.48770	1441.93510	-0.94790	14.33540	12.61720	K562	PRPF8
ATXN2	ENSG00000204842.10	1502.39980	927.55430	0.69570	12.15540	10.98110	HepG2	QKI
ATXN2	ENSG00000204842.10	606.73650	903.17180	-0.57390	9.53880	8.17010	HepG2	DDX19B
ATXN2	ENSG00000204842.10	2900.17160	4309.99160	-0.57150	9.13980	7.64010	K562	PUF60
ATXN2	ENSG00000204842.10	1314.78560	841.84210	0.64310	8.74370	7.59440	HepG2	RBM25
ATXN2	ENSG00000204842.10	1272.83730	891.68150	0.51330	7.94550	7.02520	HepG2	SF3B4
ATXN2	ENSG00000204842.10	1758.89600	2594.22830	-0.56060	8.32380	7.00030	K562	GRSF1
ATXN2	ENSG00000204842.10	519.42590	846.16720	-0.70400	9.08020	6.93750	HepG2	FAM120A
ATXN2	ENSG00000204842.10	1292.87250	930.74680	0.47400	7.09380	6.41950	HepG2	SRSF1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 79 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for ATXN2 is not available on ENCORE database.

37 RBPs can affect the splicing of ATXN2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	ATXN2	ENSG00000204842.10	chr12	-	111902465	111902519	111895017	111895163	111907911	111908044	0.23300	0.00000	included	K562	FMR1
SE	ATXN2	ENSG00000204842.10	chr12	-	111990709	111990781	111990083	111990234	111991961	111992021	-0.74300	0.00000	excluded	HepG2	U2AF2
SE	ATXN2	ENSG00000204842.10	chr12	-	111916873	111916906	111908361	111908546	111923068	111923135	0.19900	0.00000	included	HepG2	LARP4
SE	ATXN2	ENSG00000204842.10	chr12	-	111891480	111891649	111890071	111890644	111893832	111894060	-0.15900	0.00117	excluded	HepG2	LARP4
SE	ATXN2	ENSG00000204842.10	chr12	-	111902465	111902519	111895017	111895163	111907911	111908044	-0.13800	0.00022	excluded	K562	RBM15
SE	ATXN2	ENSG00000204842.10	chr12	-	111891480	111891649	111890071	111890644	111893832	111894060	-0.19600	0.00003	excluded	K562	RBM15
SE	ATXN2	ENSG00000204842.10	chr12	-	111902465	111902519	111895017	111895163	111907911	111908044	-0.13900	0.00013	excluded	K562	AGGF1
SE	ATXN2	ENSG00000204842.10	chr12	-	111902465	111902519	111895017	111895163	111907911	111908044	0.17500	0.00037	included	K562	CPSF6
SE	ATXN2	ENSG00000204842.10	chr12	-	111891480	111891649	111890071	111890644	111893832	111894060	0.30300	0.00004	included	K562	ZC3H8
SE	ATXN2	ENSG00000204842.10	chr12	-	111916873	111916906	111908361	111908546	111923068	111923135	0.18900	0.00015	included	K562	HNRNPC

Showing 1 to 10 of 82 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

ATXN2

General Information

Functions

Localization(RBPImage: ATXN2)

Domains (AlphaFold: ATXN2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for ATXN2 is not avaliable on ENCORE database.

58 proteins are bound to ATXN2 RNA:

eCLIP assay for ATXN2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for ATXN2 is not available on ENCORE database.

68 RBPs can affect the gene expression of ATXN2 :

The Knockdown/knockout RNA-Seq assay for ATXN2 is not available on ENCORE database.

37 RBPs can affect the splicing of ATXN2 :

The Knockdown/knockout RNA-Seq assay for ATXN2 is not avaliable on ENCORE database.