FAM120A

General Information

Gene Name : FAM120A
Gene ID : ENSG00000048828.16
Essential Gene : No

Functions

Novel RBP

Localization(RBPImage: FAM120A)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Cytoplasm
Cytosolic

Domains (AlphaFold: FAM120A)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A303-889A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	FAM120A	ENSG00000048828.16	34.95	44.66	39.80	ENCSR000AEF
HepG2	FAM120A	ENSG00000048828.16	50.72	35.88	43.30	ENCSR985KAT
K562	FAM120A	ENSG00000048828.16	43.57	46.78	45.17	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 279	ENCSR006OEQ	FAM120A	K562	Released	ENCAB468JSB	ENCSR811FFO
eCLIP	eCLIP: 297	ENCSR987NYS	FAM120A	HepG2	Released	ENCAB468JSB	ENCSR839KAX
knockdown followed by RNA-seq	FAM120A-BGKLV19-K562	ENCSR492BKM	FAM120A	K562	Released		ENCSR661HEL	shRNA	KD% = 59.0,47.8
knockdown followed by RNA-seq	FAM120A-BGHLV16-HepG2	ENCSR047VPW	FAM120A	HepG2	Released		ENCSR689PHN	shRNA	KD% = 67.8,71.5

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
FAM120A	279	K562	ENCSR006OEQ	ENCSR811FFO	ENCAB468JSB	A303-889A	1	Released	ENCODE3
FAM120A	297	HepG2	ENCSR987NYS	ENCSR839KAX	ENCAB468JSB	A303-889A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
FAM120A	ENCAB468JSB	A303-889A	1		Released, ENCODE3	Released, ENCODE3	BGHLV16-25, Released, ENCODE3	BGKLV19-27, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
FAM120A	K562	shRNA	ENCSR492BKM	ENCSR661HEL	FAM120A_BGKLV19_27B,FAM120A_BGKLV19_28B	NT_BGKLV19_1B,NT_BGKLV19_2B	59.0,47.8	Released	ENCODE3
FAM120A	HepG2	shRNA	ENCSR047VPW	ENCSR689PHN	FAM120A_BGHLV16_25,FAM120A_BGHLV16_26	NT_BGHLV16_1,NT_BGHLV16_2	67.8,71.5	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

FAM120A: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Cytoplasm

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
FAM120A	Product_ID: A303-889A Lot_ID: 1 Source: Bethyl Labs Target Name: FAM120A-human

RNA Targets

FAM120A protein binds to 13,679 RNA regions.

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Proteins bound to RNA

FAM120A RNA is bound by 37 proteins.

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FAM120A protein has 13,679 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
FAM120A	chr17	36955783	36955852	-	5.74268	56.23471	HepG2	PIP4K2B	5'-UTR,intron-Distal,intron-Proximal
FAM120A	chr19	6413985	6414061	-	3.99378	52.22194	K562	KHSRP	3'-UTR,intron-Distal
FAM120A	chr11	75283432	75283494	+	4.17481	50.26767	K562	SERPINH1	3'-UTR,5'-UTR,intron-Proximal
FAM120A	chr2	242447656	242447734	-	4.25787	38.22693	HepG2	STK25	5'-UTR,intron-Distal
FAM120A	chr16	68262149	68262251	+	4.50160	37.62805	K562	NFATC3	3'-UTR
FAM120A	chr13	113763548	113763654	+	5.27222	36.61914	HepG2	F7	intron-Distal
FAM120A	chr12	50157838	50157927	+	3.19999	35.95117	K562	TMBIM6	3'-UTR
FAM120A	chr14	105339780	105339863	+	6.44392	30.59067	HepG2	CEP170B	intron-Distal
FAM120A	chr2	65497084	65497101	+	4.24083	29.81753	K562	ACTR2	3'-UTR
FAM120A	chr17	45772100	45772195	+	5.88176	29.66138	HepG2	TBKBP1	intron-Distal,intron-Proximal

Showing 1 to 10 of 100 entries

37 proteins are bound to FAM120A RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr9	96313053	96313163	+	intron-Distal,intron-Proximal	7.64387	83.37895	K562	QKI
chr9	96313050	96313164	+	intron-Distal,intron-Proximal	7.01160	45.99060	HepG2	QKI
chr9	96321000	96321087	+	intron-Distal,intron-Proximal	5.88889	31.38880	K562	AQR
chr9	96327026	96327082	+	3'-UTR	5.70767	27.36379	K562	PABPC4
chr9	96323339	96323430	+	CDS,intron-Proximal	5.65174	23.36607	K562	AQR
chr9	96320994	96321052	+	CDS,intron-Distal,intron-Proximal	4.96259	22.62936	HepG2	PRPF8
chr9	96303385	96303519	+	intron-Distal	5.11274	19.33404	K562	TARDBP
chr9	96214641	96214716	+	CDS,intron-Proximal	3.84008	16.96409	HepG2	PRPF8
chr9	96320995	96321000	+	CDS,intron-Distal	5.65577	15.88168	K562	AQR
chr9	96316377	96316443	+	intron-Distal	5.60453	14.94144	HepG2	HNRNPL
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 136 entries

The FAM120A protein binds to its own RNA.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
FAM120A	chr9	96328224	96328284	+	3.45609	8.12495	K562	FAM120A	3'-UTR

Showing 1 to 1 of 1 entries

Diffrential Expression

2,146 differentially expressed genes after Knockdown/Knockout FAM120A protein.

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78 RBPs can affect the levels of FAM120A.

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2,146 differentially expressed genes after Knockdown/Knockout FAM120A protein :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
NR1H4	ENSG00000012504.9	206.16100	488.06900	-1.24330	17.14540	14.31820	HepG2	FAM120A
HMGB3	ENSG00000029993.10	344.73620	680.44430	-0.98100	14.13780	11.55920	HepG2	FAM120A
WDR54	ENSG00000005448.12	377.37910	157.66180	1.25910	13.88330	11.33310	HepG2	FAM120A
ST3GAL1	ENSG00000008513.10	565.37290	1008.44450	-0.83490	13.54190	11.01840	HepG2	FAM120A
MGST1	ENSG00000008394.8	661.76960	1127.71840	-0.76900	12.31670	9.87020	HepG2	FAM120A
FOXN3	ENSG00000053254.11	2019.24790	3087.48290	-0.61260	11.63580	9.26400	HepG2	FAM120A
FAM120A	ENSG00000048828.12	766.36270	1260.72350	-0.71820	11.50030	9.14650	HepG2	FAM120A
TMSB10	ENSG00000034510.4	4237.33020	2859.07170	0.56750	10.80810	8.51920	HepG2	FAM120A
PNPLA6	ENSG00000032444.11	581.58890	313.80630	0.89000	10.33920	8.07960	HepG2	FAM120A
PRSS8	ENSG00000052344.11	321.04880	148.43440	1.11290	10.21230	7.97000	HepG2	FAM120A
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

78 RBPs can affect the gene expression of FAM120A :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
FAM120A	ENSG00000048828.12	2775.24550	1467.14460	0.91950	34.54810	32.81500	HepG2	PCBP1
FAM120A	ENSG00000048828.12	2576.29870	4311.83540	-0.74300	34.61060	32.06640	K562	SRPK2
FAM120A	ENSG00000048828.12	1245.07320	2182.98590	-0.81010	27.52060	25.95120	HepG2	PUS1
FAM120A	ENSG00000048828.12	2243.98060	1319.87410	0.76560	24.51570	23.17740	HepG2	SRSF9
FAM120A	ENSG00000048828.12	2168.60980	3417.65820	-0.65620	22.60860	21.53580	HepG2	SRFBP1
FAM120A	ENSG00000048828.12	1027.83710	1724.02330	-0.74620	19.47010	17.97510	HepG2	HNRNPU
FAM120A	ENSG00000048828.12	2548.70020	1622.32440	0.65160	18.38400	17.39050	HepG2	SRSF1
FAM120A	ENSG00000048828.12	2597.83730	1467.36180	0.82400	17.13660	15.55040	HepG2	RBM25
FAM120A	ENSG00000048828.12	3016.63900	1537.30590	0.97240	16.69750	15.20660	HepG2	IGF2BP2
FAM120A	ENSG00000048828.12	2801.75050	1532.25300	0.87060	15.32450	13.82040	HepG2	HNRNPK
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 87 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

73 alternative splicing events after Knockdown/Knockout FAM120A protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	APOC1	ENSG00000130208.5	chr19	+	45417928	45417990	45417503	45417746	45418128	45418206	0.12400	0.00010	included	HepG2	FAM120A
SE	EPB41	ENSG00000159023.14	chr1	+	29385100	29385157	29379615	29379824	29386933	29386996	0.40100	0.00498	included	HepG2	FAM120A
SE	WSB1	ENSG00000109046.10	chr17	+	25634769	25634945	25633807	25633908	25636125	25636298	0.24700	0.00075	included	HepG2	FAM120A
SE	TFPI	ENSG00000003436.10	chr2	-	188378342	188378373	188368374	188368497	188418926	188419219	0.14600	0.00222	included	HepG2	FAM120A
SE	CD46	ENSG00000117335.14	chr1	+	207940951	207940996	207940357	207940540	207941123	207941168	0.05400	0.00062	included	HepG2	FAM120A
SE	C8orf59	ENSG00000176731.7	chr8	-	86131464	86131592	86129614	86129731	86132534	86132613	0.17700	0.00059	included	HepG2	FAM120A
SE	EVA1A	ENSG00000115363.9	chr2	-	75747319	75747394	75745183	75745334	75749490	75749613	0.40700	0.00062	included	HepG2	FAM120A
SE	PDK1	ENSG00000152256.9	chr2	+	173433468	173433545	173431583	173431661	173435453	173435552	0.15800	0.00029	included	HepG2	FAM120A
SE	SETD5	ENSG00000168137.11	chr3	+	9476273	9476314	9476017	9476169	9476507	9476566	0.34300	0.00281	included	HepG2	FAM120A
SE	RSRC2	ENSG00000111011.13	chr12	-	122998313	122998421	122995655	122995735	122999651	122999774	0.11200	0.00005	included	HepG2	FAM120A

Showing 1 to 10 of 73 entries

10 RBPs can affect the splicing of FAM120A :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	FAM120A	ENSG00000048828.12	chr9	+	96285561	96285645			96278264	96278551	96289436	96289524	0.08700	0.00000	0.00034	included	HepG2	HNRNPM
SE	FAM120A	ENSG00000048828.12	chr9	+	96261071	96261168			96259752	96259881	96277948	96278049	-0.11500	0.00000	0.00000	excluded	K562	PUS1
SE	FAM120A	ENSG00000048828.12	chr9	+	96261071	96261168			96259752	96259881	96277948	96278049	-0.06400	0.00000	0.00011	excluded	K562	AGGF1
SE	FAM120A	ENSG00000048828.12	chr9	+	96314388	96314443			96312858	96312973	96318663	96318873	0.09400	0.00000	0.00038	included	K562	PTBP1
A3SS	FAM120A	ENSG00000048828.12	chr9	+	96323360	96323532			96323390	96323532	96320862	96321000	0.09700	0.00000	0.00005	longer	K562	AQR
SE	FAM120A	ENSG00000048828.12	chr9	+	96285561	96285645			96278264	96278551	96289436	96289524	0.11300	0.00001	0.00253	included	K562	HNRNPM
SE	FAM120A	ENSG00000048828.12	chr9	+	96285561	96285645			96278264	96278551	96289436	96289524	0.08800	0.00003	0.00140	included	HepG2	SRSF1
MXE	FAM120A	ENSG00000048828.12	chr9	+	96320862	96321000	96323390	96323532	96320108	96320292	96324489	96324586	0.21100	0.00005	0.00358	1included	K562	UCHL5
MXE	FAM120A	ENSG00000048828.12	chr9	+	96320862	96320997	96323390	96323532	96320108	96320292	96324489	96324586	0.22500	0.00006	0.00518	1included	K562	IGF2BP2
SE	FAM120A	ENSG00000048828.12	chr9	+	96314388	96314443			96312858	96312973	96318663	96318873	0.06300	0.00020	0.03539	included	K562	MATR3

Showing 1 to 10 of 12 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

FAM120A

General Information

Functions

Localization(RBPImage: FAM120A)

Domains (AlphaFold: FAM120A)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

FAM120A protein has 13,679 RNA targets:

37 proteins are bound to FAM120A RNA:

The FAM120A protein binds to its own RNA.

Diffrential Expression

2,146 differentially expressed genes after Knockdown/Knockout FAM120A protein :

78 RBPs can affect the gene expression of FAM120A :

73 alternative splicing events after Knockdown/Knockout FAM120A protein :

10 RBPs can affect the splicing of FAM120A :

No autoregularoty alternative splicing events between protein FAM120A and its RNA.