HSPD1

General Information

Gene Name : HSPD1
Gene ID : ENSG00000144381.16
Essential Gene : Yes

Functions

Novel RBP

Localization(RBPImage: HSPD1)

Cytoplasm
Compartment/Organelle
Mitochondria

Domains (AlphaFold: HSPD1)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A302-845A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	HSPD1	ENSG00000144381.16	626.12	552.47	589.30	ENCSR000AEF
HepG2	HSPD1	ENSG00000144381.16	1234.14	2074.35	1654.24	ENCSR985KAT
K562	HSPD1	ENSG00000144381.16	472.71	494.96	483.83	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	HSPD1-BGKLV29-K562	ENCSR222ABK	HSPD1	K562	Released		ENCSR032YMP	shRNA	KD% = 61.7,66.3
knockdown followed by RNA-seq	HSPD1-BGHLV27-HepG2	ENCSR243IGA	HSPD1	HepG2	Released		ENCSR246RRQ	shRNA	KD% = 44.3,47.6

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
HSPD1	ENCAB679PIU	A302-845A	1		Released, ENCODE3	Released, ENCODE3	BGHLV27-25, Released, ENCODE3	BGKLV29-41, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
HSPD1	K562	shRNA	ENCSR222ABK	ENCSR032YMP	HSPD1_BGKLV29-41,HSPD1_BGKLV29-42	NT_BGKLV29-1,NT_BGKLV29-2	61.7,66.3	Released	ENCODE3
HSPD1	HepG2	shRNA	ENCSR243IGA	ENCSR246RRQ	HSPD1_BGHLV27-25,HSPD1_BGHLV27-26	non-target_BGHLV27-1,non-target_BGHLV27-2	44.3,47.6	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

HSPD1: Click to RBP Image Database

Cytoplasm

Compartment/Organelle

Mitochondria

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
HSPD1	Product_ID: A302-845A Lot_ID: 1 Source: Bethyl Labs Target Name: HSPD1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for HSPD1 is not avaliable on ENCORE database.

Proteins bound to RNA

HSPD1 RNA is bound by 35 proteins.

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eCLIP assay for HSPD1 is not avaliable on ENCORE database.

35 proteins are bound to HSPD1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr2	198351478	198351508	-	3'-UTR,intron-Distal	5.50783	400.00000	K562	PUM2
chr2	198351508	198351539	-	3'-UTR,intron-Distal	5.57681	400.00000	K562	PUM2
chr2	198351658	198351736	-	3'-UTR,intron-Distal	6.79594	70.14936	HepG2	SUB1
chr2	198352581	198352648	-	CDS,intron-Distal,intron-Proximal	4.81467	63.16622	K562	PUM2
chr2	198351335	198351379	-	3'-UTR,intron-Distal	4.45530	61.73537	K562	PUM2
chr2	198359343	198359417	-	3'-UTR,CDS,intron-Distal,intron-Proximal	6.38561	51.25948	HepG2	PRPF8
chr2	198353162	198353215	-	CDS,intron-Distal	3.54213	46.37931	HepG2	BCLAF1
chr2	198353043	198353127	-	CDS,intron-Distal	3.04303	43.97306	HepG2	BCLAF1
chr2	198351487	198351541	-	3'-UTR,intron-Distal	6.42858	42.87489	HepG2	SUB1
chr2	198359412	198359436	-	3'-UTR,CDS,intron-Distal	3.16548	41.95063	HepG2	BCLAF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 152 entries

eCLIP assay for HSPD1 is not avaliable on ENCORE database.

Diffrential Expression

6,936 differentially expressed genes after Knockdown/Knockout HSPD1 protein.

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163 RBPs can affect the levels of HSPD1.

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6,936 differentially expressed genes after Knockdown/Knockout HSPD1 protein :

Only display 100 entries as example. Please click "View All" button to see all 6,936 entries.

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SLC7A2	ENSG00000003989.12	5242.99610	11651.65510	-1.15210	19.18520	16.29340	HepG2	HSPD1
MAPK8IP2	ENSG00000008735.10	249.01400	67.94530	1.87370	13.68720	11.10330	HepG2	HSPD1
GCLM	ENSG00000023909.5	1093.82830	510.72790	1.09870	12.79950	10.26750	HepG2	HSPD1
NUCB2	ENSG00000070081.11	1301.48860	619.48420	1.07090	12.73620	10.21640	HepG2	HSPD1
FNIP2	ENSG00000052795.8	1853.51880	3598.08770	-0.95700	12.41730	9.92060	HepG2	HSPD1
KPNA6	ENSG00000025800.9	1206.27580	2338.28850	-0.95490	12.00980	9.57590	HepG2	HSPD1
MTHFD2	ENSG00000065911.7	2151.38300	4059.50510	-0.91600	11.93250	9.50360	HepG2	HSPD1
RNASET2	ENSG00000026297.11	4221.31070	7759.71800	-0.87830	11.40490	9.00850	HepG2	HSPD1
GPC1	ENSG00000063660.4	374.46030	107.31620	1.80280	10.15070	7.89780	HepG2	HSPD1
CDH1	ENSG00000039068.14	488.27230	952.04130	-0.96330	9.71810	7.49620	HepG2	HSPD1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

163 RBPs can affect the gene expression of HSPD1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
HSPD1	ENSG00000144381.12	3742.25730	25538.41410	-2.77070	169.21680	165.11990	K562	HSPD1
HSPD1	ENSG00000144381.12	22512.95160	50959.61690	-1.17860	153.64700	150.21100	HepG2	HNRNPL
HSPD1	ENSG00000144381.12	25149.45420	59974.32560	-1.25380	102.71070	100.59630	HepG2	PTBP1
HSPD1	ENSG00000144381.12	18182.27470	38314.92800	-1.07540	94.26870	91.79750	HepG2	PUS1
HSPD1	ENSG00000144381.12	12482.63490	34209.25280	-1.45450	82.79820	80.77450	HepG2	TIAL1
HSPD1	ENSG00000144381.12	34306.08600	66744.26510	-0.96020	65.95620	64.17000	HepG2	NELFE
HSPD1	ENSG00000144381.12	28207.25790	64950.08180	-1.20330	66.40960	64.16070	HepG2	QKI
HSPD1	ENSG00000144381.12	11460.30790	21815.10200	-0.92870	63.04440	60.32690	K562	UPF1
HSPD1	ENSG00000144381.12	12048.48840	31862.01090	-1.40300	58.69130	56.52520	HepG2	HNRNPA1
HSPD1	ENSG00000144381.12	25479.41940	40599.36780	-0.67210	51.84460	50.24640	HepG2	ZNF622
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 215 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for HSPD1 is not available on ENCORE database.

13 RBPs can affect the splicing of HSPD1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	HSPD1	ENSG00000144381.12	chr2	-	198359380	198359476			198358880	198358974	198360017	198360100	-0.06100	0.00000	0.00000	excluded	K562	SF3B4
SE	HSPD1	ENSG00000144381.12	chr2	-	198359380	198359495			198358917	198358974	198360017	198360100	-0.05500	0.00000	0.00000	excluded	K562	PRPF8
SE	HSPD1	ENSG00000144381.12	chr2	-	198359376	198359476			198358880	198358974	198360017	198360100	-0.06000	0.00000	0.00000	excluded	K562	AQR
SE	HSPD1	ENSG00000144381.12	chr2	-	198359380	198359495			198358880	198358974	198360017	198360100	-0.05100	0.00000	0.00000	excluded	HepG2	SF3A3
SE	HSPD1	ENSG00000144381.12	chr2	-	198359386	198359476			198358871	198358974	198360017	198360088	-0.06600	0.00000	0.00000	excluded	HepG2	SF3B4
SE	HSPD1	ENSG00000144381.12	chr2	-	198359380	198359516			198358917	198358974	198360017	198360088	-0.07000	0.00000	0.00000	excluded	K562	SF3B1
MXE	HSPD1	ENSG00000144381.12	chr2	-	198359386	198359476	198360017	198360088	198358871	198358974	198361863	198362116	0.65000	0.00000	0.00000	1included	HepG2	SF3B4
SE	HSPD1	ENSG00000144381.12	chr2	-	198359386	198359495			198358871	198358974	198360017	198360100	-0.39400	0.00001	0.00020	excluded	HepG2	U2AF2
SE	HSPD1	ENSG00000144381.12	chr2	-	198359386	198359495			198358871	198358974	198360017	198360100	0.34600	0.00002	0.00334	included	HepG2	SUPV3L1
MXE	HSPD1	ENSG00000144381.12	chr2	-	198359386	198359476	198360017	198360088	198358871	198358974	198361863	198362116	0.34700	0.00007	0.00221	1included	HepG2	U2AF1

Showing 1 to 10 of 25 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

HSPD1

General Information

Functions

Localization(RBPImage: HSPD1)

Domains (AlphaFold: HSPD1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for HSPD1 is not avaliable on ENCORE database.

35 proteins are bound to HSPD1 RNA:

eCLIP assay for HSPD1 is not avaliable on ENCORE database.

Diffrential Expression

6,936 differentially expressed genes after Knockdown/Knockout HSPD1 protein :

163 RBPs can affect the gene expression of HSPD1 :

The Knockdown/knockout RNA-Seq assay for HSPD1 is not available on ENCORE database.

13 RBPs can affect the splicing of HSPD1 :

The Knockdown/knockout RNA-Seq assay for HSPD1 is not avaliable on ENCORE database.