RPLP0

General Information

Gene Name : RPLP0
Gene ID : ENSG00000089157.15
Essential Gene : Yes

Functions

Ribosome & basic translation

Localization(RBPImage: RPLP0)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Speckles
Cytoplasm
Compartment/Organelle
Cytosolic
Nuclear release mitosis

Domains (AlphaFold: RPLP0)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A302-882A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	RPLP0	ENSG00000089157.15	2730.84	4259.08	3494.96	ENCSR000AEF
HepG2	RPLP0	ENSG00000089157.15	3155.74	2486.65	2821.19	ENCSR985KAT
K562	RPLP0	ENSG00000089157.15	3880.85	3706.36	3793.61	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Controls	Method	Note
knockdown followed by RNA-seq	RPLP0-BGHLV18-HepG2	ENCSR082YGI	RPLP0	HepG2	Released	ENCSR674KEK	shRNA	KD% = 37.5,47.6
knockdown followed by RNA-seq	RPLP0-BGKcLV11-K562	ENCSR928MEW	RPLP0	K562	Released	ENCSR292PXV	CRISPR	KD% = 57.3,67.6
knockdown followed by RNA-seq	RPLP0-BGHcLV03-HepG2	ENCSR000SKS	RPLP0	HepG2	Released	ENCSR105NML	CRISPR	KD% = 57.4,41.4

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
RPLP0	ENCAB053FZB	A302-882A	1		Released, ENCODE3	Released, ENCODE3	BGHLV18-53, Released, ENCODE3	BGKcLV11-89, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
RPLP0	K562	shRNA			BGKLV21-53,BGKLV21-54	BGKLV21-1,BGKLV21-2	2.2,18.9	NotSatisfied	ENCODE3
RPLP0	K562	shRNA			BGKLV38-79,BGKLV38-80	BGKLV38-1,BGKLV38-2	33.1,32.7	NotSatisfied	ENCODE3
RPLP0	K562	shRNA			BGKLV38-81,BGKLV38-82	BGKLV38-1,BGKLV38-2	0.9,0.0	NotSatisfied	ENCODE3
RPLP0	K562	shRNA			BGKLV38-83,BGKLV38-84	BGKLV38-1,BGKLV38-2	22.8,16.9	NotSatisfied	ENCODE3
RPLP0	K562	shRNA			BGKLV38-85,BGKLV38-86	BGKLV38-1,BGKLV38-2	0,1.7	NotSatisfied	ENCODE3
RPLP0	HepG2	shRNA	ENCSR082YGI	ENCSR674KEK	RPLP0_BGHLV18_53,RPLP0_BGHLV18_54	NT_BGHLV18_1,NT_BGHLV18_2	37.5,47.6	Released	ENCODE3
RPLP0	K562	CRISPR			BGKcLV02-21,BGKcLV02-22	BGKcLV02-1,BGKcLV02-2	0.0,0.0	NotSatisfied	ENCODE3
RPLP0	K562	CRISPR			BGKcLV02-21-D12,BGKcLV02-22-D12	BGKcLV02-1,BGKcLV02-2	35.6,44.0	NotSatisfied	ENCODE3
RPLP0	K562	CRISPR			BGKcLV02-22-D12,BGKcLV02-21-D22	BGKcLV02-1,BGKcLV02-2	44.0,54.8	NotSatisfied	ENCODE3
RPLP0	K562	CRISPR			BGKcLV02-21-D22,BGKcLV02-22-D22	BGKcLV02-1,BGKcLV02-2	54.8,52.4	NotSatisfied	ENCODE3
RPLP0	K562	CRISPR			BGKcLV02-22-D22,BGKcLV02-21-D30	BGKcLV02-1,BGKcLV02-2	52.4,	NotSatisfied	ENCODE3
RPLP0	K562	CRISPR			BGKcLV02-21-D30,BGKcLV02-22-D30	BGKcLV02-1,BGKcLV02-2		NotSatisfied	ENCODE3
RPLP0	K562	CRISPR			BGKcLV02-22-D30,BGKcLV11-89	BGKcLV02-1,BGKcLV02-2	,57.3	NotSatisfied	ENCODE3
RPLP0	K562	CRISPR	ENCSR928MEW	ENCSR292PXV	RPLP0-BGKcLV11-89,RPLP0-BGKcLV11-90	NT-BGKcLV11-1,NT-BGKcLV11-2	57.3,67.6	Released	ENCODE4
RPLP0	HepG2	CRISPR	ENCSR000SKS	ENCSR105NML	RPLP0_BGHcLV03-17,RPLP0_BGHcLV03-18	NT_BGHcLV03-1,NT_BGHcLV03-2	57.4,41.4	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

RPLP0: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Speckles

Cytoplasm

Compartment/Organelle

Cytosolic

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
RPLP0	Product_ID: A302-882A Lot_ID: 1 Source: Bethyl Labs Target Name: RPLP0-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for RPLP0 is not avaliable on ENCORE database.

Proteins bound to RNA

RPLP0 RNA is bound by 26 proteins.

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eCLIP assay for RPLP0 is not avaliable on ENCORE database.

26 proteins are bound to RPLP0 RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr12	120635126	120635196	-	3'-UTR,CDS,intron-Distal,intron-Proximal	5.41642	400.00000	K562	METAP2
chr12	120635136	120635157	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.43837	400.00000	K562	YBX3
chr12	120635124	120635128	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.08488	400.00000	HepG2	YBX3
chr12	120635240	120635265	-	3'-UTR,CDS,intron-Distal	3.20481	400.00000	K562	YBX3
chr12	120635186	120635196	-	3'-UTR,CDS,intron-Distal	3.61356	400.00000	K562	YBX3
chr12	120636424	120636434	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.30090	400.00000	K562	YBX3
chr12	120636385	120636397	-	3'-UTR,CDS,intron-Distal	3.18727	400.00000	K562	YBX3
chr12	120636376	120636385	-	3'-UTR,CDS,intron-Distal	3.37734	400.00000	K562	YBX3
chr12	120636444	120636461	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.61065	400.00000	K562	YBX3
chr12	120636461	120636478	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.20948	400.00000	K562	YBX3
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 217 entries

eCLIP assay for RPLP0 is not avaliable on ENCORE database.

Diffrential Expression

6,547 differentially expressed genes after Knockdown/Knockout RPLP0 protein.

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142 RBPs can affect the levels of RPLP0.

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6,547 differentially expressed genes after Knockdown/Knockout RPLP0 protein :

Only display 100 entries as example. Please click "View All" button to see all 6,547 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CRLF1	ENSG00000006016.6	613.43720	4704.89620	-2.93920	161.30030	158.02350	HepG2	RPLP0
E2F2	ENSG00000007968.6	23.57230	242.29670	-3.36160	34.08830	32.30190	HepG2	RPLP0
DBF4	ENSG00000006634.3	222.95980	685.80600	-1.62100	26.88970	25.23220	HepG2	RPLP0
NCAPD2	ENSG00000010292.8	1525.51890	3515.07370	-1.20430	25.21590	23.58720	HepG2	RPLP0
KDM1A	ENSG00000004487.11	1985.43470	4017.44990	-1.01680	24.48230	22.87620	HepG2	RPLP0
DBNDD1	ENSG00000003249.9	3044.86960	1478.36870	1.04230	23.76800	22.18010	HepG2	RPLP0
SYT7	ENSG00000011347.5	533.63740	169.49790	1.65450	22.74120	21.17210	HepG2	RPLP0
IL32	ENSG00000008517.12	5669.96380	2952.11480	0.94150	21.78290	20.23540	HepG2	RPLP0
DHX33	ENSG00000005100.8	934.12460	1908.11660	-1.03050	20.75990	19.23840	HepG2	RPLP0
RECQL	ENSG00000004700.11	382.85460	895.02730	-1.22510	20.20040	18.69960	HepG2	RPLP0
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

142 RBPs can affect the gene expression of RPLP0 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
RPLP0	ENSG00000089157.11	4964.70900	26942.76050	-2.44010	147.64390	144.50850	HepG2	RPLP0
RPLP0	ENSG00000089157.11	17475.25850	56226.07170	-1.68590	134.85360	132.54390	HepG2	PTBP1
RPLP0	ENSG00000089157.11	20849.59230	61103.40290	-1.55120	117.20000	115.24640	HepG2	SRSF1
RPLP0	ENSG00000089157.11	22428.21620	60897.55260	-1.44110	94.71610	91.98030	HepG2	QKI
RPLP0	ENSG00000089157.11	24322.52190	58541.39870	-1.26720	86.07290	83.67740	HepG2	SF3B4
RPLP0	ENSG00000089157.11	21168.05660	49709.88840	-1.23160	81.39890	79.27970	HepG2	SRSF9
RPLP0	ENSG00000089157.11	15904.72090	58931.17380	-1.88960	64.15710	61.38000	HepG2	NCBP2
RPLP0	ENSG00000089157.11	25353.45670	62575.51720	-1.30340	57.62680	55.91610	HepG2	NELFE
RPLP0	ENSG00000089157.11	22329.66350	55267.18540	-1.30750	57.15750	54.41420	HepG2	RBM25
RPLP0	ENSG00000089157.11	28166.50750	47748.04630	-0.76150	52.07030	50.61370	HepG2	SRFBP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 175 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for RPLP0 is not available on ENCORE database.

34 RBPs can affect the splicing of RPLP0 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	RPLP0	ENSG00000089157.11	chr12	-	120636356	120636542	120635124	120635265	120636656	120636803	-0.06700	0.00000	excluded	K562	PRPF8
SE	RPLP0	ENSG00000089157.11	chr12	-	120636656	120636704	120635124	120635265	120636920	120637008	0.09400	0.00007	included	K562	WRN
SE	RPLP0	ENSG00000089157.11	chr12	-	120636356	120636573	120635124	120635265	120636656	120636803	-0.06700	0.00000	excluded	HepG2	PRPF8
SE	RPLP0	ENSG00000089157.11	chr12	-	120636356	120636573	120635124	120635265	120636656	120636803	-0.09600	0.00000	excluded	K562	EFTUD2
SE	RPLP0	ENSG00000089157.11	chr12	-	120636356	120636573	120635124	120635265	120636656	120636803	-0.05600	0.00000	excluded	HepG2	PCBP2
SE	RPLP0	ENSG00000089157.11	chr12	-	120636356	120636573	120635124	120635265	120636656	120636869	-0.06300	0.00000	excluded	HepG2	SF3A3
SE	RPLP0	ENSG00000089157.11	chr12	-	120636434	120636573	120635124	120635265	120636656	120636803	0.14800	0.03018	included	HepG2	LSM11
SE	RPLP0	ENSG00000089157.11	chr12	-	120636656	120636704	120635124	120635265	120636920	120637008	0.09500	0.00000	included	K562	ZC3H8
A3SS	RPLP0	ENSG00000089157.11	chr12	-	120638532	120638694	120638532	120638634	120638885	120639014	-0.09400	0.00000	shorter	HepG2	HNRNPUL1
A3SS	RPLP0	ENSG00000089157.11	chr12	-	120638532	120638694	120638532	120638634	120638885	120639014	0.11100	0.00000	longer	HepG2	DROSHA

Showing 1 to 10 of 64 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

RPLP0

General Information

Functions

Localization(RBPImage: RPLP0)

Domains (AlphaFold: RPLP0)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for RPLP0 is not avaliable on ENCORE database.

26 proteins are bound to RPLP0 RNA:

eCLIP assay for RPLP0 is not avaliable on ENCORE database.

Diffrential Expression

6,547 differentially expressed genes after Knockdown/Knockout RPLP0 protein :

142 RBPs can affect the gene expression of RPLP0 :

The Knockdown/knockout RNA-Seq assay for RPLP0 is not available on ENCORE database.

34 RBPs can affect the splicing of RPLP0 :

The Knockdown/knockout RNA-Seq assay for RPLP0 is not avaliable on ENCORE database.