ADAR

General Information

Gene Name : ADAR
Gene ID : ENSG00000160710.16
Essential Gene : No

Functions

Splicing regulation
RNA modification

Localization(RBPImage: ADAR)

Nuclei
Nucleoplasm
Nucleolus
Cytoplasm
Compartment/Organelle
Mitochondria

Domains (AlphaFold: ADAR)

dRBM

Antibody Validation

View validation images for all ADAR antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	ADAR	ENSG00000160710.16	148.23	145.22	146.72	ENCSR000AEF
HepG2	ADAR	ENSG00000160710.16	52.15	64.66	58.41	ENCSR985KAT
K562	ADAR	ENSG00000160710.16	48.38	51.05	49.72	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 4137	ENCSR202LKI	ADAR	K562	Released	ENCAB667NOE	ENCSR873NGI
knockdown followed by RNA-seq	ADAR-BGKLV24-K562	ENCSR164TLB	ADAR	K562	Released		ENCSR667PLJ	shRNA	KD% = 81.0,71.7
knockdown followed by RNA-seq	ADAR-BGHLV20-HepG2	ENCSR104OLN	ADAR	HepG2	Released		ENCSR305XWT	shRNA	KD% = 77.0,68.8

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
ADAR	4137	K562	ENCSR202LKI	ENCSR873NGI	ENCAB667NOE	14175S	1	Released	ENCODE4

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
ADAR	ENCAB202TNA	A303-883A	1	Released, ENCODE3	BGHLV20-3, Released, ENCODE3	BGKLV24-3, Released, ENCODE3
ADAR	ENCAB047LUR	A303-883A	3	Released, ENCODE4	BGHLV20-3, Released, ENCODE3	BGKLV24-3, Released, ENCODE4
ADAR		81284S	1	Submitted, ENCORE2	BGHLV20-3, Released, ENCODE3	BGKLV24-3, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
ADAR	K562	shRNA	ENCSR164TLB	ENCSR667PLJ	ADAR_BGKLV24_3_17596,ADAR_BGKLV24_4_17597	non-target_BGKLV24_1_17594,non-target_BGKLV24_2_17595	81.0,71.7	Released	ENCODE3
ADAR	HepG2	shRNA	ENCSR104OLN	ENCSR305XWT	ADAR-BGHLV20-3_17708,ADAR-BGHLV20-4_17709	non-target-BGHLV20-1_17706,non-target-BGHLV20-2_17707	77.0,68.8	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

ADAR: Click to RBP Image Database

Nuclei

Nucleoplasm

Nucleolus

Cytoplasm

Compartment/Organelle

Mitochondria

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
ADAR	Product_ID: A303-883A Lot_ID: 1 Source: Bethyl Labs Target Name: ADAR-human
ADAR	Product_ID: 81284S Lot_ID: 1 Source: Cell Signaling Technology Target Name: ADAR-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for ADAR is not avaliable on ENCORE database.

Proteins bound to RNA

ADAR RNA is bound by 40 proteins.

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eCLIP assay for ADAR is not avaliable on ENCORE database.

40 proteins are bound to ADAR RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	154554654	154554709	-	3'-UTR,intron-Distal	5.06687	32.09757	K562	LIN28B
chr1	154600329	154600406	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.15424	31.56996	HepG2	DDX3X
chr1	154600324	154600400	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.89889	31.18315	HepG2	NCBP2
chr1	154554776	154554835	-	3'-UTR,intron-Distal	3.72215	25.84103	K562	PABPC4
chr1	154554773	154554835	-	3'-UTR,intron-Distal	3.83349	23.67191	K562	UPF1
chr1	154554709	154554738	-	3'-UTR,intron-Distal	5.51903	23.41534	K562	LIN28B
chr1	154573915	154573996	-	CDS,intron-Distal	4.56144	21.46572	K562	PUM2
chr1	154555333	154555428	-	3'-UTR,intron-Distal	3.99530	19.37461	K562	UPF1
chr1	154556737	154556812	-	3'-UTR,intron-Distal	4.32631	18.68027	K562	UPF1
chr1	154556040	154556099	-	3'-UTR,intron-Distal	3.52603	15.96245	K562	UPF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 153 entries

eCLIP assay for ADAR is not avaliable on ENCORE database.

Diffrential Expression

3,273 differentially expressed genes after Knockdown/Knockout ADAR protein.

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69 RBPs can affect the levels of ADAR.

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3,273 differentially expressed genes after Knockdown/Knockout ADAR protein :

Only display 100 entries as example. Please click "View All" button to see all 3,273 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CYP24A1	ENSG00000019186.5	139.53380	692.28740	-2.31080	45.88430	42.80470	HepG2	ADAR
GAS7	ENSG00000007237.14	320.34670	61.49440	2.38100	28.23340	25.71390	HepG2	ADAR
ACSM3	ENSG00000005187.7	1307.21280	595.55600	1.13410	19.31660	17.10130	HepG2	ADAR
NR1H4	ENSG00000012504.9	1264.94630	613.15370	1.04470	16.45510	14.35680	HepG2	ADAR
TFPI	ENSG00000003436.10	3762.34450	6858.34930	-0.86620	16.44050	14.34460	HepG2	ADAR
ZFX	ENSG00000005889.11	1424.08390	502.34630	1.50320	15.92000	13.84490	HepG2	ADAR
SH3YL1	ENSG00000035115.17	234.97310	565.54760	-1.26720	15.80440	13.73610	HepG2	ADAR
MAP4K3	ENSG00000011566.10	1176.29860	2241.52950	-0.93020	15.79210	13.72820	HepG2	ADAR
ITGA3	ENSG00000005884.13	16.03130	111.70730	-2.80080	14.86620	12.84230	HepG2	ADAR
ASB4	ENSG00000005981.8	49.74720	192.25810	-1.95040	14.64540	12.63340	HepG2	ADAR
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

69 RBPs can affect the gene expression of ADAR :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ADAR	ENSG00000160710.11	1052.21790	3637.50910	-1.78950	56.68870	53.44430	HepG2	ADAR
ADAR	ENSG00000160710.11	3445.36250	5554.10220	-0.68890	20.51480	19.18490	HepG2	TAF15
ADAR	ENSG00000160710.11	776.81500	2853.68540	-1.87720	17.05230	13.39550	K562	ADAR
ADAR	ENSG00000160710.11	3155.60980	5699.15810	-0.85280	14.29620	12.64240	HepG2	ASCC1
ADAR	ENSG00000160710.11	3394.53860	6111.69010	-0.84840	12.30460	11.04070	HepG2	MATR3
ADAR	ENSG00000160710.11	4736.65120	6600.67220	-0.47870	11.08150	10.19550	HepG2	RBM22
ADAR	ENSG00000160710.11	4260.04400	5550.49180	-0.38170	11.08140	9.75350	HepG2	DAZAP1
ADAR	ENSG00000160710.11	2904.10370	4634.90920	-0.67440	10.94940	9.64880	HepG2	TARDBP
ADAR	ENSG00000160710.11	4261.98080	5588.05700	-0.39080	9.15220	8.15280	HepG2	PCBP1
ADAR	ENSG00000160710.11	3616.79060	4551.05890	-0.33150	8.18810	7.13570	HepG2	ZC3H8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 74 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for ADAR is not available on ENCORE database.

14 RBPs can affect the splicing of ADAR :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	ADAR	ENSG00000160710.11	chr1	-	154597538	154597629			154574571	154575102	154600330	154600474	0.06500	0.00000	0.00355	included	K562	APOBEC3C
A3SS	ADAR	ENSG00000160710.11	chr1	-	154561835	154562018			154561835	154561938	154562232	154562404	0.09000	0.00000	0.00000	longer	K562	AQR
A5SS	ADAR	ENSG00000160710.11	chr1	-	154562659	154562885			154562737	154562885	154562232	154562404	-0.24800	0.00000	0.00000	shorter	HepG2	RBM22
A5SS	ADAR	ENSG00000160710.11	chr1	-	154562659	154562885			154562737	154562885	154562232	154562404	0.11600	0.00000	0.00052	longer	HepG2	HNRNPK
A5SS	ADAR	ENSG00000160710.11	chr1	-	154562659	154562885			154562737	154562885	154562232	154562404	0.07000	0.00003	0.00441	longer	K562	RBM15
A3SS	ADAR	ENSG00000160710.11	chr1	-	154560600	154560776			154560600	154560734	154561026	154561149	0.06400	0.00006	0.00058	longer	K562	AQR
A5SS	ADAR	ENSG00000160710.11	chr1	-	154562659	154562871			154562737	154562871	154562232	154562404	0.09200	0.00007	0.01038	longer	K562	SF3B4
A5SS	ADAR	ENSG00000160710.11	chr1	-	154562659	154562885			154562737	154562885	154562232	154562404	-0.16200	0.00009	0.01442	shorter	HepG2	SRSF9
MXE	ADAR	ENSG00000160710.11	chr1	-	154561026	154561149	154561844	154561938	154560600	154560734	154562232	154562404	-0.19200	0.00009	0.00564	2included	K562	XRN2
A5SS	ADAR	ENSG00000160710.11	chr1	-	154562659	154562885			154562737	154562885	154562232	154562404	-0.17000	0.00026	0.03210	shorter	K562	PRPF8

Showing 1 to 10 of 16 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

ADAR

General Information

Functions

Localization(RBPImage: ADAR)

Domains (AlphaFold: ADAR)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for ADAR is not avaliable on ENCORE database.

40 proteins are bound to ADAR RNA:

eCLIP assay for ADAR is not avaliable on ENCORE database.

Diffrential Expression

3,273 differentially expressed genes after Knockdown/Knockout ADAR protein :

69 RBPs can affect the gene expression of ADAR :

The Knockdown/knockout RNA-Seq assay for ADAR is not available on ENCORE database.

14 RBPs can affect the splicing of ADAR :

The Knockdown/knockout RNA-Seq assay for ADAR is not avaliable on ENCORE database.