PSIP1

General Information

Gene Name : PSIP1
Gene ID : ENSG00000164985.14
Essential Gene : No

Functions

Splicing regulation
Viral RNA regulation

Localization(RBPImage: PSIP1)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Cytoplasm
Cytoskeleton
Microtubule
Mitotic-Apparatus (Spindle; Centrosomes)

Domains (AlphaFold: PSIP1)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A300-848A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	PSIP1	ENSG00000164985.14	279.07	200.92	240.00	ENCSR000AEF
HepG2	PSIP1	ENSG00000164985.14	32.09	57.09	44.59	ENCSR985KAT
K562	PSIP1	ENSG00000164985.14	69.70	80.34	75.02	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	PSIP1-BGKLV21-K562	ENCSR611LQB	PSIP1	K562	Released		ENCSR572FFX	shRNA	KD% = 94.3,89.7
knockdown followed by RNA-seq	PSIP1-BGHLV18-HepG2	ENCSR744YVR	PSIP1	HepG2	Released		ENCSR674KEK	shRNA	KD% = 99.9,99.6

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
PSIP1	ENCAB004FAZ	A300-848A	1		Released, ENCODE3	Released, ENCODE3	BGHLV18-43, Released, ENCODE3	BGKLV21-45, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
PSIP1	K562	shRNA	ENCSR611LQB	ENCSR572FFX	PSIP1_BGKLV21_45_17582,PSIP1_BGKLV21_46_17583	non-target_BGKLV21_1,non-target_BGKLV21_2	94.3,89.7	Released	ENCODE3
PSIP1	HepG2	shRNA	ENCSR744YVR	ENCSR674KEK	PSIP1_BGHLV18_43,PSIP1_BGHLV18_44	NT_BGHLV18_1,NT_BGHLV18_2	99.9,99.6	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

PSIP1: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Cytoplasm

Cytoskeleton

Microtubule

Mitotic-Apparatus (Spindle; Centrosomes)

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
PSIP1	Product_ID: A300-848A Lot_ID: 1 Source: Bethyl Labs Target Name: PSIP1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for PSIP1 is not avaliable on ENCORE database.

Proteins bound to RNA

PSIP1 RNA is bound by 16 proteins.

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eCLIP assay for PSIP1 is not avaliable on ENCORE database.

16 proteins are bound to PSIP1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr9	15472628	15472749	-	CDS,intron-Distal,intron-Proximal	5.34038	39.05035	K562	UCHL5
chr9	15474005	15474099	-	CDS,intron-Distal,intron-Proximal	5.82774	28.12248	K562	UCHL5
chr9	15469934	15469990	-	CDS,intron-Distal,intron-Proximal	4.93327	18.46254	K562	ZNF622
chr9	15469934	15469989	-	CDS,intron-Distal,intron-Proximal	4.40578	17.18054	K562	UCHL5
chr9	15472647	15472709	-	CDS,intron-Distal	3.69232	16.95148	K562	ZNF622
chr9	15474099	15474194	-	CDS,intron-Distal	4.30052	14.93923	K562	UCHL5
chr9	15469284	15469326	-	CDS,intron-Distal	4.44002	14.76032	K562	UCHL5
chr9	15479611	15479683	-	CDS,intron-Distal	4.15371	14.65767	K562	UCHL5
chr9	15469294	15469335	-	CDS,intron-Distal,intron-Proximal	5.96789	13.41267	K562	ZNF622
chr9	15486003	15486047	-	CDS,intron-Distal,intron-Proximal	4.01581	13.27302	K562	UCHL5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 55 entries

eCLIP assay for PSIP1 is not avaliable on ENCORE database.

Diffrential Expression

4,171 differentially expressed genes after Knockdown/Knockout PSIP1 protein.

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136 RBPs can affect the levels of PSIP1.

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4,171 differentially expressed genes after Knockdown/Knockout PSIP1 protein :

Only display 100 entries as example. Please click "View All" button to see all 4,171 entries.

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PLP1	ENSG00000123560.9	667.56860	115.26010	2.53390	24.70840	20.92720	HepG2	PSIP1
TNS1	ENSG00000079308.12	931.76480	2752.84930	-1.56290	16.39970	12.79460	HepG2	PSIP1
DKK1	ENSG00000107984.5	3630.32740	1286.20910	1.49690	14.90440	11.36620	HepG2	PSIP1
EGR1	ENSG00000120738.7	643.57860	188.90160	1.76840	14.66080	11.18070	HepG2	PSIP1
QPCT	ENSG00000115828.11	283.58910	69.25330	2.03370	12.64640	9.26320	HepG2	PSIP1
PFKFB4	ENSG00000114268.7	1106.28960	2844.50770	-1.36240	12.57000	9.22820	HepG2	PSIP1
IGFBP5	ENSG00000115461.4	91.07460	8.66430	3.39380	11.35570	8.08640	HepG2	PSIP1
VCAN	ENSG00000038427.11	7154.64210	3421.39610	1.06420	8.78180	5.76030	HepG2	PSIP1
HEXB	ENSG00000049860.9	755.76470	1587.48660	-1.07070	7.81180	4.93370	HepG2	PSIP1
SPARC	ENSG00000113140.6	3895.21150	1875.30710	1.05450	7.68770	4.83590	HepG2	PSIP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

136 RBPs can affect the gene expression of PSIP1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PSIP1	ENSG00000164985.10	372.29670	1979.20690	-2.41040	177.46240	175.06790	HepG2	ZNF622
PSIP1	ENSG00000164985.10	796.42180	3290.22830	-2.04660	78.79940	76.61460	HepG2	BOP1
PSIP1	ENSG00000164985.10	793.93380	1927.84240	-1.27990	44.15900	42.56360	HepG2	RBM22
PSIP1	ENSG00000164985.10	1224.84190	3185.06450	-1.37870	37.36350	35.28000	HepG2	TARDBP
PSIP1	ENSG00000164985.10	566.76140	1222.91150	-1.10950	35.46590	33.70080	HepG2	CKAP4
PSIP1	ENSG00000164985.10	1153.47380	2177.41800	-0.91660	33.22430	31.98990	HepG2	SRFBP1
PSIP1	ENSG00000164985.10	412.04850	2245.16660	-2.44590	34.93260	31.27100	K562	PSIP1
PSIP1	ENSG00000164985.10	1249.65320	3424.00540	-1.45420	32.29590	30.39710	HepG2	GPKOW
PSIP1	ENSG00000164985.10	780.38180	1854.83350	-1.24900	30.80470	29.10190	HepG2	PUF60
PSIP1	ENSG00000164985.10	1088.84920	1959.57550	-0.84770	30.52660	28.56760	HepG2	DAZAP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 177 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for PSIP1 is not available on ENCORE database.

19 RBPs can affect the splicing of PSIP1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	PSIP1	ENSG00000164985.10	chr9	-	15470992	15471229	15469935	15469991	15472629	15472748	0.07700	0.00000	0.00007	included	K562	AKAP8L
SE	PSIP1	ENSG00000164985.10	chr9	-	15479588	15479685	15478474	15478550	15486003	15486066	-0.07300	0.00000	0.00000	excluded	K562	AQR
SE	PSIP1	ENSG00000164985.10	chr9	-	15489983	15490122	15486824	15486929	15506558	15506635	-0.09800	0.00000	0.00000	excluded	K562	PUS1
SE	PSIP1	ENSG00000164985.10	chr9	-	15479588	15479685	15478474	15478550	15486003	15486066	-0.07400	0.00000	0.00000	excluded	K562	PUS1
A3SS	PSIP1	ENSG00000164985.10	chr9	-	15470987	15471207	15470987	15471174	15472629	15472748	0.27500	0.00000	0.00013	longer	K562	AGGF1
A3SS	PSIP1	ENSG00000164985.10	chr9	-	15470633	15471309	15470633	15471229	15472629	15472748	0.39400	0.00000	0.00000	longer	K562	U2AF2
A3SS	PSIP1	ENSG00000164985.10	chr9	-	15470973	15471207	15470973	15471174	15472629	15472835	0.28600	0.00000	0.00001	longer	K562	PUS1
A3SS	PSIP1	ENSG00000164985.10	chr9	-	15470633	15471309	15470633	15471229	15472629	15472748	0.53100	0.00000	0.00000	longer	HepG2	U2AF1
A3SS	PSIP1	ENSG00000164985.10	chr9	-	15470633	15471309	15470633	15471229	15472629	15472748	0.45600	0.00000	0.00000	longer	K562	U2AF1
SE	PSIP1	ENSG00000164985.10	chr9	-	15470973	15471174	15469935	15469991	15472629	15472835	-0.05800	0.00001	0.00064	excluded	K562	HNRNPU

Showing 1 to 10 of 25 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

PSIP1

General Information

Functions

Localization(RBPImage: PSIP1)

Domains (AlphaFold: PSIP1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for PSIP1 is not avaliable on ENCORE database.

16 proteins are bound to PSIP1 RNA:

eCLIP assay for PSIP1 is not avaliable on ENCORE database.

Diffrential Expression

4,171 differentially expressed genes after Knockdown/Knockout PSIP1 protein :

136 RBPs can affect the gene expression of PSIP1 :

The Knockdown/knockout RNA-Seq assay for PSIP1 is not available on ENCORE database.

19 RBPs can affect the splicing of PSIP1 :

The Knockdown/knockout RNA-Seq assay for PSIP1 is not avaliable on ENCORE database.