MTPAP

General Information

Gene Name : MTPAP
Gene ID : ENSG00000107951.14
Essential Gene : Yes

Functions

3' end processing
tRNA regulation
mitochondrial RNA regulation

Localization(RBPImage: MTPAP)

Cytoplasm
Compartment/Organelle
Mitochondria

Domains (AlphaFold: MTPAP)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A303-904A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	MTPAP	ENSG00000107951.14	16.47	13.47	14.97	ENCSR000AEF
HepG2	MTPAP	ENSG00000107951.14	9.29	15.13	12.21	ENCSR985KAT
K562	MTPAP	ENSG00000107951.14	20.85	18.10	19.48	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 470	ENCSR200DKE	MTPAP	K562	Released	ENCAB235DTM	ENCSR927XDB
knockdown followed by RNA-seq	MTPAP-BGKLV34-K562	ENCSR631RFX	MTPAP	K562	Released		ENCSR174OYC	shRNA	KD% = 76.4,77.3
knockdown followed by RNA-seq	MTPAP-BGHLV35-HepG2	ENCSR701GSV	MTPAP	HepG2	Released		ENCSR264TUE	shRNA	KD% = 52.9,51.5

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
MTPAP	470	K562	ENCSR200DKE	ENCSR927XDB	ENCAB235DTM	A303-904A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
MTPAP	ENCAB235DTM	A303-904A	1			Released, ENCODE3	BGHLV35-27, Released, ENCODE3	BGKLV34-23, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
MTPAP	K562	shRNA	ENCSR631RFX	ENCSR174OYC	MTPAP_BGKLV34-23,MTPAP_BGKLV34-24	NT_BGKLV34-1,NT_BGKLV34-2	76.4,77.3	Released	ENCODE3
MTPAP	HepG2	shRNA			BGHLV33-19,BGHLV33-20	BGHLV33-1,BGHLV33-2	47.1,28.0	NotSatisfied	ENCODE3
MTPAP	HepG2	shRNA	ENCSR701GSV	ENCSR264TUE	MTPAP_BGHLV35-27,MTPAP_BGHLV35-28	NT_BGHLV35-1,NT_BGHLV35-2	52.9,51.5	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

MTPAP: Click to RBP Image Database

Cytoplasm

Compartment/Organelle

Mitochondria

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
MTPAP	Product_ID: A303-904A Lot_ID: 1 Source: Bethyl Labs Target Name: MTPAP-human

RNA Targets

MTPAP protein binds to 991 RNA regions.

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Proteins bound to RNA

MTPAP RNA is bound by 11 proteins.

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MTPAP protein has 991 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
MTPAP	chr7	1055601	1055723	-	8.00375	69.15446	K562	C7orf50	intron-Distal
MTPAP	chrX	152954585	152954611	+	3.11830	28.64470	K562	SLC6A8	intron-Distal
MTPAP	chrX	152954496	152954547	+	3.53517	25.90406	K562	SLC6A8	intron-Distal
MTPAP	chr7	1057666	1057716	-	6.11482	18.82833	K562	C7orf50	intron-Distal
MTPAP	chr7	1058373	1058415	-	4.51521	15.93276	K562	C7orf50	intron-Distal
MTPAP	chrX	152953589	152953615	+	3.00845	15.32264	K562	SLC6A8	5'-UTR
MTPAP	chrX	152955132	152955154	+	3.18281	14.74985	K562	SLC6A8	intron-Distal,intron-Proximal
MTPAP	chr22	20111020	20111093	+	3.48222	14.15571	K562	RANBP1	intron-Distal
MTPAP	chr2	3243322	3243390	-	5.42353	11.12741	K562	TSSC1	intron-Distal
MTPAP	chr2	198281496	198281590	-	4.04609	10.51724	K562	SF3B1	CDS,intron-Distal,intron-Proximal

Showing 1 to 10 of 100 entries

11 proteins are bound to MTPAP RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr10	30610204	30610248	-	intron-Distal	5.96041	17.72428	K562	TROVE2
chr10	30625563	30625645	-	intron-Distal,intron-Proximal	5.67331	11.14062	K562	KHSRP
chr10	30625488	30625563	-	intron-Distal	4.52914	10.04635	K562	KHSRP
chr10	30604961	30605060	-	CDS,intron-Distal,intron-Proximal	4.96906	9.79042	K562	EFTUD2
chr10	30638130	30638209	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.46659	7.61934	HepG2	U2AF2
chr10	30625890	30625984	-	CDS,intron-Distal,intron-Proximal	3.38440	7.61934	HepG2	U2AF2
chr10	30628733	30628892	-	intron-Distal,intron-Proximal	3.10590	6.88025	HepG2	KHSRP
chr10	30628755	30628841	-	intron-Distal,intron-Proximal	4.47761	6.44495	HepG2	U2AF2
chr10	30637542	30637688	-	intron-Distal	3.69518	5.32884	K562	KHSRP
chr10	30625904	30625986	-	CDS,intron-Distal,intron-Proximal	3.42540	5.05651	K562	U2AF2
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 21 entries

No autoregularoty interactions between protein MTPAP and its RNA.

Diffrential Expression

8,502 differentially expressed genes after Knockdown/Knockout MTPAP protein.

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63 RBPs can affect the levels of MTPAP.

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8,502 differentially expressed genes after Knockdown/Knockout MTPAP protein :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ASB4	ENSG00000005981.8	39.23720	275.77240	-2.81320	21.00640	18.47840	HepG2	MTPAP
HSD17B6	ENSG00000025423.7	161.03400	11.64980	3.78890	15.34050	13.07740	HepG2	MTPAP
ITGAL	ENSG00000005844.13	203.74820	37.59050	2.43820	15.10270	12.85970	HepG2	MTPAP
UHRF1	ENSG00000034063.9	907.82780	2113.49850	-1.21910	14.32210	12.13130	HepG2	MTPAP
C8B	ENSG00000021852.8	385.97720	94.48590	2.03020	13.69080	11.53340	HepG2	MTPAP
MLXIPL	ENSG00000009950.11	9229.16620	4308.03820	1.09910	13.38940	11.26310	HepG2	MTPAP
HMGB3	ENSG00000029993.10	709.16430	1506.61610	-1.08710	11.35810	9.39270	HepG2	MTPAP
CALCOCO1	ENSG00000012822.11	1540.63590	713.27620	1.11090	11.24990	9.29120	HepG2	MTPAP
FKBP4	ENSG00000004478.5	753.90320	1587.96000	-1.07470	10.79660	8.87070	HepG2	MTPAP
ZFX	ENSG00000005889.11	1725.81810	642.20630	1.42610	9.60970	7.76790	HepG2	MTPAP
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

63 RBPs can affect the gene expression of MTPAP :

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
MTPAP	ENSG00000107951.8	385.87880	797.89010	-1.04800	20.57330	18.66610	K562	MTPAP
MTPAP	ENSG00000107951.8	1216.53880	748.19880	0.70120	7.83950	6.97210	K562	PUS1
MTPAP	ENSG00000107951.8	1074.19270	729.04080	0.55910	7.41590	6.47650	K562	RBM15
MTPAP	ENSG00000107951.8	388.19150	644.11520	-0.73050	7.25310	6.33060	K562	HNRNPC
MTPAP	ENSG00000107951.8	305.45440	535.30510	-0.80940	6.56220	5.67240	HepG2	EIF2S1
MTPAP	ENSG00000107951.8	388.81980	622.33100	-0.67860	6.67300	5.44830	K562	CPSF6
MTPAP	ENSG00000107951.8	878.13740	1308.28700	-0.57520	6.45250	5.29070	K562	GRSF1
MTPAP	ENSG00000107951.8	199.78450	365.63810	-0.87200	6.28300	5.27670	HepG2	CPSF6
MTPAP	ENSG00000107951.8	990.92350	725.07820	0.45050	5.62900	4.86460	K562	AGGF1
MTPAP	ENSG00000107951.8	267.91130	423.43410	-0.66040	5.49590	4.83980	HepG2	TIAL1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 72 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

314 alternative splicing events after Knockdown/Knockout MTPAP protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	SNRNP70	ENSG00000104852.10	chr19	+	49605370	49606844	49604646	49604728	49607890	49607992	0.07300	0.00000	included	K562	MTPAP
SE	NSUN6	ENSG00000241058.1	chr10	-	18932497	18932569	18931404	18931484	18937418	18937574	0.10200	0.00012	included	K562	MTPAP
SE	ZFAS1	ENSG00000177410.8	chr20	+	47897439	47897501	47895640	47895745	47905581	47905797	0.19600	0.00064	included	K562	MTPAP
SE	MBNL1	ENSG00000152601.13	chr3	+	152173330	152173366	152165408	152165562	152174055	152174150	0.06600	0.00215	included	K562	MTPAP
SE	NQO2	ENSG00000124588.15	chr6	+	3004728	3004885	3000222	3000319	3006701	3006793	0.09900	0.00010	included	K562	MTPAP
SE	SREK1	ENSG00000153914.11	chr5	+	65451892	65454760	65449290	65449424	65455046	65455162	0.24700	0.00000	included	K562	MTPAP
SE	SEC31A	ENSG00000138674.12	chr4	-	83782783	83782861	83778841	83778917	83784470	83784545	0.12000	0.00225	included	K562	MTPAP
SE	ISCU	ENSG00000136003.11	chr12	+	108957835	108957931	108956381	108956512	108958054	108958168	0.18900	0.00180	included	K562	MTPAP
SE	FNBP4	ENSG00000109920.8	chr11	-	47747288	47747388	47746023	47746330	47752925	47753113	0.13200	0.00001	included	K562	MTPAP
SE	ZFX	ENSG00000005889.11	chrX	+	24179831	24179959	24170836	24170947	24190831	24190917	0.60300	0.00116	included	K562	MTPAP

Showing 1 to 10 of 100 entries

1 RBPs can affect the splicing of MTPAP :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP	Bound by RBP
SE	MTPAP	ENSG00000107951.8	chr10	-	30604891	30604965			30598729	30602900	30605046	30605187	-0.07900	0.00004	0.00078	excluded	K562	AQR

Showing 1 to 1 of 1 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

MTPAP

General Information

Functions

Localization(RBPImage: MTPAP)

Domains (AlphaFold: MTPAP)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

MTPAP protein has 991 RNA targets:

11 proteins are bound to MTPAP RNA:

No autoregularoty interactions between protein MTPAP and its RNA.

Diffrential Expression

8,502 differentially expressed genes after Knockdown/Knockout MTPAP protein :

63 RBPs can affect the gene expression of MTPAP :

314 alternative splicing events after Knockdown/Knockout MTPAP protein :

1 RBPs can affect the splicing of MTPAP :

No autoregularoty alternative splicing events between protein MTPAP and its RNA.