CXXC1

General Information

Gene Name : CXXC1
Gene ID : ENSG00000154832.14
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: CXXC1)

Not Available

Antibody Validation

View validation images for all CXXC1 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	CXXC1	ENSG00000154832.14	35.62	47.64	41.63	ENCSR000AEF
HepG2	CXXC1	ENSG00000154832.14	66.06	33.70	49.88	ENCSR985KAT
K562	CXXC1	ENSG00000154832.14	37.00	27.13	32.06	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Controls	Method	Note
knockdown followed by RNA-seq	CXXC1-BGKcLV17-K562	ENCSR416NPL	CXXC1	K562	Released	ENCSR516TLX	CRISPR	KD% = 71.6,67.9
knockdown followed by RNA-seq	CXXC1-BGHcLV18-HepG2	ENCSR666FOS	CXXC1	HepG2	Released	ENCSR670KAS	CRISPR	KD% = 86.8,91.2
knockdown followed by RNA-seq	CXXC1-BGRSLV03-RS293		CXXC1	Ribo-STAMP-293T	Released		shRNA	KD% = ,

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
CXXC1	ENCAB216VRJ	PA5-76829	UC2739251A			NotSatisfied, ENCODE4	BGHcLV18-7, Released, ENCODE4
CXXC1		40672S	1			Submitted, ENCORE2	BGHcLV18-7, Released, ENCODE4	BGKcLV17-7, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
CXXC1	K562	CRISPR	ENCSR416NPL	ENCSR516TLX	CXXC1-BGKcLV17-7,CXXC1-BGKcLV17-8	NT-BGKcLV17-1,NT-BGKcLV17-2	71.6,67.9	Released	ENCODE4
CXXC1	HepG2	CRISPR	ENCSR666FOS	ENCSR670KAS	CXXC1-BGHcLV18-7,CXXC1-BGHcLV18-8	NT-BGHcLV18-1,NT-BGHcLV18-2	86.8,91.2	Released	ENCODE4
CXXC1	Ribo-STAMP-293T	shRNA			CXXC1-BGRSLV03-19,CXXC1-BGRSLV03-20	NT-BGRSLV03-1,NT-BGRSLV03-2	,	Released	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
CXXC1	Product_ID: PA5-76829 Lot_ID: UC2739251A Source: Thermo Fisher Target Name: CXXC1-human
CXXC1	Product_ID: 40672S Lot_ID: 1 Source: Cell Signaling Technology Target Name: CXXC1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for CXXC1 is not avaliable on ENCORE database.

Proteins bound to RNA

CXXC1 RNA is bound by 18 proteins.

CanvasJS.com

eCLIP assay for CXXC1 is not avaliable on ENCORE database.

18 proteins are bound to CXXC1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr18	47813830	47813935	-	5'-UTR,intron-Distal,intron-Proximal	7.18311	47.03426	K562	EFTUD2
chr18	47813847	47813936	-	5'-UTR,intron-Distal,intron-Proximal	5.93263	21.39404	HepG2	EFTUD2
chr18	47809354	47809425	-	CDS,intron-Distal,intron-Proximal	5.96943	20.65991	K562	SF3B4
chr18	47812297	47812356	-	CDS,intron-Distal,intron-Proximal	5.52569	17.49622	K562	EFTUD2
chr18	47812386	47812453	-	CDS,intron-Distal,intron-Proximal	4.50836	17.08595	K562	EFTUD2
chr18	47810791	47810874	-	CDS,intron-Distal,intron-Proximal	6.23066	16.44087	K562	UCHL5
chr18	47809941	47809995	-	intron-Distal,intron-Proximal	5.50643	16.24956	K562	SF3B4
chr18	47810813	47810877	-	CDS,intron-Distal	4.23132	15.82205	K562	ZNF622
chr18	47811770	47811877	-	intron-Distal,intron-Proximal	3.99470	14.00808	HepG2	RBFOX2
chr18	47811726	47811829	-	intron-Distal,intron-Proximal	4.35355	13.97564	K562	RBFOX2
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 112 entries

eCLIP assay for CXXC1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for CXXC1 is not available on ENCORE database.
93 RBPs can affect the levels of CXXC1.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for CXXC1 is not available on ENCORE database.

93 RBPs can affect the gene expression of CXXC1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CXXC1	ENSG00000154832.10	2087.48330	1080.15190	0.95040	32.02100	30.17940	K562	AGGF1
CXXC1	ENSG00000154832.10	2314.60720	1086.05440	1.09160	30.24810	28.20610	K562	RBM15
CXXC1	ENSG00000154832.10	2554.64880	1114.54950	1.19660	25.40140	23.76140	K562	PUS1
CXXC1	ENSG00000154832.10	1013.32250	572.11030	0.82460	19.29180	18.01240	HepG2	PUM1
CXXC1	ENSG00000154832.10	998.90340	532.12850	0.90850	19.19050	17.74770	HepG2	SRSF5
CXXC1	ENSG00000154832.10	99.61960	349.20140	-1.80960	17.26260	15.10930	K562	G3BP2
CXXC1	ENSG00000154832.10	2239.82000	1123.96290	0.99470	12.24710	10.73830	K562	AKAP8L
CXXC1	ENSG00000154832.10	872.80450	439.08790	0.99100	11.65010	10.32790	HepG2	FXR1
CXXC1	ENSG00000154832.10	934.73880	605.16820	0.62710	10.26230	9.19250	HepG2	SUCLG1
CXXC1	ENSG00000154832.10	845.49940	439.24210	0.94470	10.41540	9.16820	HepG2	MAGOH
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 106 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for CXXC1 is not available on ENCORE database.

13 RBPs can affect the splicing of CXXC1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	CXXC1	ENSG00000154832.10	chr18	-	47813792	47813878	47813109	47813228	47813956	47814049	-0.08400	0.00000	0.00049	excluded	K562	HNRNPL
A5SS	CXXC1	ENSG00000154832.10	chr18	-	47811089	47811227	47811101	47811227	47810747	47810932	0.12500	0.00000	0.00004	longer	K562	AQR
RI	CXXC1	ENSG00000154832.10	chr18	-	47812118	47812627	47812118	47812298	47812391	47812627	0.31100	0.00000	0.00008	included	K562	RBM15
RI	CXXC1	ENSG00000154832.10	chr18	-	47812118	47812627	47812118	47812298	47812391	47812627	0.34100	0.00001	0.00446	included	K562	SMNDC1
A3SS	CXXC1	ENSG00000154832.10	chr18	-	47811089	47811236	47811089	47811209	47811371	47811595	0.05300	0.00003	0.00027	longer	K562	AQR
RI	CXXC1	ENSG00000154832.10	chr18	-	47812118	47812627	47812118	47812298	47812391	47812627	0.25700	0.00004	0.00079	included	K562	AGGF1
SE	CXXC1	ENSG00000154832.10	chr18	-	47813792	47813878	47813109	47813228	47813956	47814049	0.40100	0.00007	0.00217	included	K562	U2AF2
RI	CXXC1	ENSG00000154832.10	chr18	-	47812118	47812627	47812118	47812298	47812391	47812627	-0.36500	0.00014	0.00540	excluded	K562	SRSF1
SE	CXXC1	ENSG00000154832.10	chr18	-	47813792	47813878	47813109	47813228	47813956	47814049	-0.13200	0.00015	0.00889	excluded	K562	PTBP1
RI	CXXC1	ENSG00000154832.10	chr18	-	47812118	47812627	47812118	47812298	47812391	47812627	0.23900	0.00016	0.00230	included	K562	AKAP8L

Showing 1 to 10 of 22 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

CXXC1

General Information

Functions

Localization

Domains (AlphaFold: CXXC1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for CXXC1 is not avaliable on ENCORE database.

18 proteins are bound to CXXC1 RNA:

eCLIP assay for CXXC1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for CXXC1 is not available on ENCORE database.

93 RBPs can affect the gene expression of CXXC1 :

The Knockdown/knockout RNA-Seq assay for CXXC1 is not available on ENCORE database.

13 RBPs can affect the splicing of CXXC1 :

The Knockdown/knockout RNA-Seq assay for CXXC1 is not avaliable on ENCORE database.