TAF15

General Information

Gene Name : TAF15
Gene ID : ENSG00000270647.5
Essential Gene : Yes

Functions

RNA stability & decay
P-body / stress granules

Localization(RBPImage: TAF15)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Speckles
Nuclear release mitosis

Domains (AlphaFold: TAF15)

RRM

Antibody Validation

View validation images for all TAF15 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	TAF15	ENSG00000270647.5	209.14	176.42	192.78	ENCSR000AEF
HepG2	TAF15	ENSG00000270647.5	143.62	156.10	149.86	ENCSR985KAT
K562	TAF15	ENSG00000270647.5	192.69	182.80	187.75	ENCSR000AEO

Assays

6 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 339	ENCSR568DZW	TAF15	K562	Released	ENCAB249IHJ	ENCSR653CNZ
eCLIP	eCLIP: 388	ENCSR841EQA	TAF15	HepG2	Released	ENCAB249IHJ	ENCSR708TCY
knockdown followed by RNA-seq	TAF15-BGKLV08-K562	ENCSR611ZAL	TAF15	K562	Released		ENCSR344XID	shRNA	KD% = 74.7,66.8
knockdown followed by RNA-seq	TAF15-BGHLV12-HepG2	ENCSR998RZI	TAF15	HepG2	Released		ENCSR603TCV	shRNA	KD% = 99.6,99.9
knockdown followed by RNA-seq	TAF15-BGRSLV02-RS293		TAF15	Ribo-STAMP-293T	Released			shRNA	KD% = ,
RNA Bind-n-Seq	RBNS: TAF15	ENCSR827QYL	TAF15	cell-free sample	Released		ENCSR876NDK

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
TAF15	339	K562	ENCSR568DZW	ENCSR653CNZ	ENCAB249IHJ	A300-308A	1	Released	ENCODE3
TAF15	388	HepG2	ENCSR841EQA	ENCSR708TCY	ENCAB249IHJ	A300-308A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
TAF15	ENCAB249IHJ	A300-308A	1	Released, ENCODE3	Released, ENCODE3	BGHLV12-81, Released, ENCODE3	BGKLV08_57, Released, ENCODE3
TAF15	ENCAB228JAJ	ab134916	YJ030723S	Released, ENCODE3	Released, ENCODE3		BGKLV08-57, Released, ENCODE3
TAF15	ENCAB936CXL	MA3-078	SA242977	Released, ENCODE3	Released, ENCODE4		BGKLV08-57, Released, ENCODE4
TAF15		28409S	1	Released, ENCODE3	Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
TAF15	K562	shRNA	ENCSR611ZAL	ENCSR344XID	TAF15-LV08-57,TAF15-LV08-58	Nontarget-LV08-1_00003531,nontarget-LV08-2_00003531	74.7,66.8	Released	ENCODE3
TAF15	HepG2	shRNA	ENCSR998RZI	ENCSR603TCV	TAF15-BGHLV12-81,TAF15-BGHLV12-82	NT-BGHLV12-93,NT-BGHLV12-94	99.6,99.9	Released	ENCODE3
TAF15	Ribo-STAMP-293T	shRNA			BGRSLV01-17,BGRSLV01-18	BGRSLV01-1,BGRSLV01-2		NotSatisfied	ENCORE2
TAF15	Ribo-STAMP-293T	shRNA			TAF15-BGRSLV02-9,TAF15-BGRSLV02-10	NT-BGRSLV02-1,NT-BGRSLV02-2	,	Released	ENCORE2

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
TAF15	TAF15		Released	ENCODE3

Localization Image in HepG2

TAF15: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Speckles

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
TAF15	Product_ID: A300-308A Lot_ID: 1 Source: Bethyl Labs Target Name: TAF15-human
TAF15	Product_ID: MA3-078 Lot_ID: SA242977 Source: Thermo Fisher Target Name: TAF15-human
TAF15	Product_ID: ab134916 Lot_ID: YJ030723S Source: Abcam Target Name: TAF15-human
TAF15	Product_ID: 28409S Lot_ID: 1 Source: Cell Signaling Technology Target Name: TAF15-human

RNA Targets

TAF15 protein binds to 1,229 RNA regions.

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The binding motifs of TAF15

Proteins bound to RNA

TAF15 RNA is bound by 63 proteins.

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TAF15 protein has 1,229 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 1,229 entries.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
TAF15	chr16	31198367	31198455	+	4.70457	58.90420	K562	FUS	intron-Distal
TAF15	chr16	31199198	31199249	+	4.09226	44.56679	HepG2	FUS	intron-Distal
TAF15	chr16	31198583	31198628	+	3.94475	36.13672	HepG2	FUS	intron-Distal
TAF15	chr16	31198926	31198979	+	3.62414	32.65363	HepG2	FUS	intron-Distal
TAF15	chr16	31199326	31199364	+	3.39196	31.63345	HepG2	FUS	intron-Distal
TAF15	chr16	31198793	31198846	+	3.65656	28.97527	HepG2	FUS	intron-Distal
TAF15	chr1	17067026	17067037	+	6.38184	25.57836	HepG2	CROCC	intron-Distal
TAF15	chr16	31199461	31199502	+	3.61651	19.17671	K562	FUS	intron-Distal
TAF15	chrX	13329195	13329241	+	3.62251	12.79553	K562	GS1-600G8.3	intron-Proximal
TAF15	chr21	47560635	47560687	-	3.17172	10.25327	HepG2	FTCD	intron-Distal

Showing 1 to 10 of 100 entries

63 proteins are bound to TAF15 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr17	34171775	34171950	+	CDS,intron-Distal,intron-Proximal	5.70282	85.34425	K562	UCHL5
chr17	34161555	34161608	+	3'-UTR,CDS,intron-Proximal	5.39889	65.28186	HepG2	U2AF2
chr17	34161572	34161616	+	3'-UTR,CDS,intron-Proximal	5.91467	64.02235	K562	U2AF2
chr17	34171950	34172040	+	CDS	5.45151	50.74848	K562	UCHL5
chr17	34174102	34174218	+	3'-UTR,CDS,intron-Distal	3.25649	49.39107	K562	PUM2
chr17	34171624	34171788	+	CDS,intron-Distal,intron-Proximal	4.18180	47.71679	K562	GTF2F1
chr17	34161558	34161572	+	CDS,intron-Proximal	5.42823	43.61436	K562	U2AF2
chr17	34171511	34171665	+	CDS,intron-Proximal	4.67817	42.86902	K562	UCHL5
chr17	34136515	34136581	+	5'-UTR,CDS,intron-Proximal	4.06635	42.65667	K562	DDX3X
chr17	34171677	34171775	+	CDS,intron-Distal,intron-Proximal	5.97665	42.17581	K562	UCHL5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 231 entries

No autoregularoty interactions between protein TAF15 and its RNA.

Diffrential Expression

8,895 differentially expressed genes after Knockdown/Knockout TAF15 protein.

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113 RBPs can affect the levels of TAF15.

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8,895 differentially expressed genes after Knockdown/Knockout TAF15 protein :

Only display 100 entries as example. Please click "View All" button to see all 8,895 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
LASP1	ENSG00000002834.13	2767.83760	7022.37870	-1.34320	73.97070	71.57660	HepG2	TAF15
CX3CL1	ENSG00000006210.6	1285.55060	3610.68640	-1.48990	73.07760	70.70980	HepG2	TAF15
CYP51A1	ENSG00000001630.11	5321.72940	12227.18580	-1.20010	58.94380	56.77690	HepG2	TAF15
PLEKHG6	ENSG00000008323.11	208.35680	726.25580	-1.80140	41.90220	40.05990	HepG2	TAF15
RBM6	ENSG00000004534.10	5694.96560	2785.86980	1.03150	31.16400	29.54730	HepG2	TAF15
SLC7A2	ENSG00000003989.12	7186.90200	12455.22950	-0.79330	30.63760	29.04230	HepG2	TAF15
RPS20	ENSG00000008988.5	7134.31290	12281.74490	-0.78370	28.97500	27.40820	HepG2	TAF15
LUC7L	ENSG00000007392.12	1755.72030	882.09820	0.99300	27.24240	25.71910	HepG2	TAF15
UPF1	ENSG00000005007.8	1373.57960	2570.86650	-0.90430	25.81130	24.33030	HepG2	TAF15
ADIPOR2	ENSG00000006831.9	3623.89000	6196.98630	-0.77400	25.57430	24.10160	HepG2	TAF15
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

113 RBPs can affect the gene expression of TAF15 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TAF15	ENSG00000172660.7	1576.47640	3017.83220	-0.93680	46.08230	44.14980	HepG2	CKAP4
TAF15	ENSG00000172660.7	4260.95380	6703.18260	-0.65370	42.58530	40.27070	K562	NSUN2
TAF15	ENSG00000172660.7	3601.93380	6614.18300	-0.87680	34.58430	32.11680	K562	SF3A3
TAF15	ENSG00000172660.7	4144.51440	8590.53690	-1.05150	32.47880	29.81970	K562	GRSF1
TAF15	ENSG00000172660.7	4554.62680	10106.79230	-1.14990	31.30100	29.51870	K562	AQR
TAF15	ENSG00000172660.7	4163.34780	2020.47350	1.04300	25.49840	23.97200	HepG2	PCBP1
TAF15	ENSG00000172660.7	1452.84230	3451.30480	-1.24830	22.46840	20.94850	HepG2	HNRNPLL
TAF15	ENSG00000172660.7	2911.45880	5523.74550	-0.92390	20.94490	18.63520	K562	GPKOW
TAF15	ENSG00000172660.7	4085.98720	6032.89070	-0.56220	19.50900	17.65000	K562	MTPAP
TAF15	ENSG00000172660.7	1068.74590	1920.80810	-0.84580	16.76350	15.17670	HepG2	DNAJC21
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 136 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

1,535 alternative splicing events after Knockdown/Knockout TAF15 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	RNASEK-C17orf49	ENSG00000161939.14	chr17	+	6916637	6916835	6915953	6916080	6916984	6917061	0.27100	0.00000	included	K562	TAF15
SE	MORF4L2	ENSG00000123562.12	chrX	-	102939608	102939657	102933426	102933528	102940098	102940188	0.15900	0.00067	included	K562	TAF15
SE	RNPS1	ENSG00000205937.7	chr16	-	2314573	2314761	2314176	2314332	2318055	2318413	0.14100	0.00375	included	K562	TAF15
SE	PSMD1	ENSG00000173692.8	chr2	+	232017430	232017525	232010953	232011070	232018277	232018380	0.07300	0.00650	included	K562	TAF15
SE	HNRNPR	ENSG00000125944.14	chr1	-	23667344	23667510	23664982	23665101	23670703	23670803	0.18700	0.00032	included	K562	TAF15
SE	BPNT1	ENSG00000162813.13	chr1	-	220253068	220253196	220247308	220247413	220263027	220263191	0.11000	0.00065	included	K562	TAF15
SE	GAPVD1	ENSG00000165219.17	chr9	+	128097450	128097531	128094788	128094908	128099296	128099374	0.33900	0.00014	included	K562	TAF15
SE	SRSF11	ENSG00000116754.9	chr1	+	70697541	70697658	70694104	70694238	70697950	70698058	0.14600	0.00032	included	K562	TAF15
SE	TROVE2	ENSG00000116747.8	chr1	+	193029003	193029352	193028788	193028906	193038163	193038309	0.42600	0.00650	included	K562	TAF15
SE	PIGF	ENSG00000151665.8	chr2	-	46818941	46819064	46808423	46808730	46819613	46819722	0.21800	0.00680	included	K562	TAF15

Showing 1 to 10 of 100 entries

29 RBPs can affect the splicing of TAF15 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	TAF15	ENSG00000172660.7	chr17	+	34147167	34147252	34147027	34147079	34147335	34147441	-0.14300	0.00000	excluded	K562	SRSF1
SE	TAF15	ENSG00000172660.7	chr17	+	34171813	34172042	34171283	34171372	34173909	34174238	-0.07700	0.00024	excluded	K562	PRPF8
SE	TAF15	ENSG00000172660.7	chr17	+	34160910	34160945	34151081	34151202	34161569	34161602	-0.15300	0.00000	excluded	HepG2	U2AF1
SE	TAF15	ENSG00000172660.7	chr17	+	34147167	34147252	34147027	34147079	34147335	34147441	-0.19700	0.00000	excluded	HepG2	U2AF2
SE	TAF15	ENSG00000172660.7	chr17	+	34160910	34160945	34151081	34151202	34161569	34161602	-0.41900	0.00000	excluded	HepG2	U2AF2
SE	TAF15	ENSG00000172660.7	chr17	+	34160761	34160945	34151081	34151202	34161569	34161602	-0.07000	0.00000	excluded	K562	AQR
SE	TAF15	ENSG00000172660.7	chr17	+	34147167	34147252	34147027	34147079	34147335	34147441	-0.12000	0.00000	excluded	K562	AQR
SE	TAF15	ENSG00000172660.7	chr17	+	34136975	34137067	34136487	34136580	34161569	34161602	-0.79800	0.00006	excluded	K562	PUS1
SE	TAF15	ENSG00000172660.7	chr17	+	34136975	34137067	34136487	34136580	34144719	34144759	0.05800	0.00106	included	HepG2	DDX6
SE	TAF15	ENSG00000172660.7	chr17	+	34160910	34160945	34151081	34151202	34161569	34161602	-0.17100	0.00000	excluded	HepG2	SF3A3

Showing 1 to 10 of 55 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

TAF15

General Information

Functions

Localization(RBPImage: TAF15)

Domains (AlphaFold: TAF15)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

TAF15 protein has 1,229 RNA targets:

63 proteins are bound to TAF15 RNA:

No autoregularoty interactions between protein TAF15 and its RNA.

Diffrential Expression

8,895 differentially expressed genes after Knockdown/Knockout TAF15 protein :

113 RBPs can affect the gene expression of TAF15 :

1,535 alternative splicing events after Knockdown/Knockout TAF15 protein :

29 RBPs can affect the splicing of TAF15 :

No autoregularoty alternative splicing events between protein TAF15 and its RNA.