HNRNPA2B1

General Information

Gene Name : HNRNPA2B1
Gene ID : ENSG00000122566.21
Essential Gene : No

Functions

Splicing regulation
RNA modification
RNA stability & decay
microRNA processing
RNA localization
RNA export
Translation regulation
Viral RNA regulation

Localization

Not Available

Domains (AlphaFold: HNRNPA2B1)

RRM

Antibody Validation

View validation images for all HNRNPA2B1 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	HNRNPA2B1	ENSG00000122566.21	1085.45	923.31	1004.38	ENCSR000AEF
HepG2	HNRNPA2B1	ENSG00000122566.21	729.92	1008.26	869.09	ENCSR985KAT
K562	HNRNPA2B1	ENSG00000122566.21	1067.54	1001.61	1034.58	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Controls	Method	Note
knockdown followed by RNA-seq	HNRNPA2B1-BGKLV28-K562	ENCSR794NUE	HNRNPA2B1	K562	Released	ENCSR164MUK	shRNA	KD% = 59.5,71.1
knockdown followed by RNA-seq	HNRNPA2B1-BGHLV23-HepG2	ENCSR769GES	HNRNPA2B1	HepG2	Released	ENCSR042QTH	shRNA	KD% = 41.3,51.1
RNA Bind-n-Seq	RBNS: HNRNPA2B1	ENCSR890PDQ	HNRNPA2B1	cell-free sample	Released

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
HNRNPA2B1	ENCAB791DTS	GTX127928	41094	Released, ENCODE3	Released, ENCODE3	BGHLV23-19, Released, ENCODE3	BGKLV28-19, Released, ENCODE3
HNRNPA2B1	ENCAB421UFR	GTX127928	40135	Released, ENCODE3	NotSatisfied, ENCODE3	BGHLV23-19, Released, ENCODE3
HNRNPA2B1	ENCAB615ENI	sc-32316	A1912	Released, ENCODE3	Released, ENCODE3
HNRNPA2B1	ENCAB000AVB	ARP41035_P050	QC21057	Released, ENCODE3	Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
HNRNPA2B1	K562	shRNA			BGKLV25-23,BGKLV25-24	BGKLV25-1,BGKLV25-2	37.9,48.5	NotSatisfied	ENCODE3
HNRNPA2B1	K562	shRNA	ENCSR794NUE	ENCSR164MUK	HNRNPA2B1_BGKLV28-19,HNRNPA2B1_BGKLV28-20	non-target_BGKLV28-1,non-target_BGKLV28-2	59.5,71.1	Released	ENCODE3
HNRNPA2B1	HepG2	shRNA	ENCSR769GES	ENCSR042QTH	HNRNPA2B1-BGHLV23-19,HNRNPA2B1-BGHLV23-20	non-target-BGHLV23-1,non-target-BGHLV23-2	41.3,51.1	Released	ENCODE3

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
HNRNPA2B1	HNRNPA2B1		Released	ENCODE3

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
HNRNPA2B1	Product_ID: GTX127928 Lot_ID: 41094 Source: GeneTex Target Name: HNRNPA2B1-human
HNRNPA2B1	Product_ID: sc-32316 Lot_ID: A1912 Source: Santa Cruz Biotech Target Name: HNRNPA2B1-human
HNRNPA2B1	Product_ID: ARP41035_P050 Lot_ID: QC21057 Source: Aviva Target Name: HNRNPA2B1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for HNRNPA2B1 is not avaliable on ENCORE database.

The binding motifs of HNRNPA2B1

Proteins bound to RNA

HNRNPA2B1 RNA is bound by 58 proteins.

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eCLIP assay for HNRNPA2B1 is not avaliable on ENCORE database.

58 proteins are bound to HNRNPA2B1 RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr7	26231673	26231679	-	3'-UTR,intron-Distal	6.42863	400.00000	HepG2	SUB1
chr7	26231608	26231647	-	3'-UTR,intron-Distal	6.63632	400.00000	HepG2	SUB1
chr7	26231593	26231608	-	3'-UTR,intron-Distal	6.09746	400.00000	HepG2	SUB1
chr7	26231955	26231958	-	3'-UTR,intron-Distal	5.71234	400.00000	K562	PUM2
chr7	26230053	26230088	-	3'-UTR,intron-Distal	4.20915	400.00000	HepG2	U2AF2
chr7	26231915	26231919	-	3'-UTR,intron-Distal	5.32932	400.00000	K562	PUM2
chr7	26231933	26231942	-	3'-UTR,intron-Distal	5.57989	400.00000	K562	PUM2
chr7	26231942	26231951	-	3'-UTR,intron-Distal	5.70132	400.00000	K562	PUM2
chr7	26230773	26230787	-	3'-UTR,intron-Distal,intron-Proximal	4.53302	400.00000	HepG2	U2AF2
chr7	26231481	26231533	-	3'-UTR,intron-Distal	4.71728	400.00000	K562	PUM2
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 435 entries

eCLIP assay for HNRNPA2B1 is not avaliable on ENCORE database.

Diffrential Expression

5,374 differentially expressed genes after Knockdown/Knockout HNRNPA2B1 protein.

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137 RBPs can affect the levels of HNRNPA2B1.

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5,374 differentially expressed genes after Knockdown/Knockout HNRNPA2B1 protein :

Only display 100 entries as example. Please click "View All" button to see all 5,374 entries.

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TFPI	ENSG00000003436.10	19372.61480	9983.04920	0.95640	44.09570	41.25900	HepG2	HNRNPA2B1
BAZ1B	ENSG00000009954.6	1855.79500	3566.37960	-0.94240	36.48410	33.87420	HepG2	HNRNPA2B1
ANLN	ENSG00000011426.6	1815.57630	3368.09500	-0.89150	33.69300	31.19300	HepG2	HNRNPA2B1
NCAPD2	ENSG00000010292.8	3242.83750	5567.47030	-0.77980	21.93910	19.83010	HepG2	HNRNPA2B1
POLDIP2	ENSG00000004142.7	1423.65990	2374.28960	-0.73790	19.93500	17.88460	HepG2	HNRNPA2B1
IL32	ENSG00000008517.12	3843.82750	2507.66470	0.61610	17.70430	15.74510	HepG2	HNRNPA2B1
BRCA1	ENSG00000012048.15	722.38350	1257.62300	-0.79990	16.70420	14.80190	HepG2	HNRNPA2B1
ASB4	ENSG00000005981.8	412.09410	166.79040	1.30480	16.56470	14.67380	HepG2	HNRNPA2B1
DBNDD1	ENSG00000003249.9	1226.39030	766.27100	0.67840	12.16720	10.46950	HepG2	HNRNPA2B1
TACC3	ENSG00000013810.14	930.63370	1587.67510	-0.77060	11.64390	9.96890	HepG2	HNRNPA2B1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

137 RBPs can affect the gene expression of HNRNPA2B1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
HNRNPA2B1	ENSG00000122566.16	30435.78900	45970.67130	-0.59490	56.63380	53.97680	K562	NSUN2
HNRNPA2B1	ENSG00000122566.16	14874.78550	24375.92560	-0.71260	55.19800	53.56360	HepG2	ZNF622
HNRNPA2B1	ENSG00000122566.16	13172.56790	32573.16120	-1.30610	52.08940	49.91630	HepG2	PUF60
HNRNPA2B1	ENSG00000122566.16	9337.55600	23920.28960	-1.35710	48.75470	46.85810	HepG2	BOP1
HNRNPA2B1	ENSG00000122566.16	19332.44390	31345.14120	-0.69720	43.87900	41.60270	HepG2	HNRNPL
HNRNPA2B1	ENSG00000122566.16	21962.52690	34411.07510	-0.64780	42.27430	40.04410	HepG2	DAZAP1
HNRNPA2B1	ENSG00000122566.16	19200.94380	31625.90000	-0.71990	33.62300	31.13430	HepG2	HNRNPA2B1
HNRNPA2B1	ENSG00000122566.16	11235.43710	23156.10170	-1.04330	28.30360	26.45300	HepG2	TARDBP
HNRNPA2B1	ENSG00000122566.16	7650.91420	14473.04850	-0.91970	27.43470	25.83140	HepG2	RPS19
HNRNPA2B1	ENSG00000122566.16	14279.10200	24138.50820	-0.75740	26.79410	25.24180	HepG2	PUS1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 171 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for HNRNPA2B1 is not available on ENCORE database.

44 RBPs can affect the splicing of HNRNPA2B1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26237450	26237486	26237241	26237352	26240191	26240366	-0.12000	0.00000	excluded	K562	SRSF1
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26237450	26237486	26237241	26237352	26240191	26240366	-0.06500	0.00001	excluded	K562	SF3B4
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26233194	26233218	26232870	26232993	26235466	26235529	-0.06000	0.00000	excluded	K562	SF3B4
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26230612	26230748	26229744	26230080	26232114	26232197	-0.24200	0.00028	excluded	K562	PRPF8
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26233194	26233218	26232870	26232993	26235466	26235529	-0.07700	0.00000	excluded	HepG2	U2AF1
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26231041	26231270	26230612	26230748	26232114	26232197	0.29300	0.00008	included	HepG2	DKC1
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26237450	26237486	26237241	26237352	26240191	26240366	0.07200	0.00001	included	HepG2	TBRG4
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26231041	26231270	26230612	26230748	26232114	26232197	0.46700	0.00000	included	HepG2	TBRG4
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26231920	26231958	26231041	26231270	26232114	26232197	-0.22200	0.00000	excluded	HepG2	TBRG4
SE	HNRNPA2B1	ENSG00000122566.16	chr7	-	26231920	26231958	26230612	26230748	26232114	26232229	-0.20200	0.00000	excluded	K562	AQR

Showing 1 to 10 of 113 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

HNRNPA2B1

General Information

Functions

Localization

Domains (AlphaFold: HNRNPA2B1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for HNRNPA2B1 is not avaliable on ENCORE database.

58 proteins are bound to HNRNPA2B1 RNA:

eCLIP assay for HNRNPA2B1 is not avaliable on ENCORE database.

Diffrential Expression

5,374 differentially expressed genes after Knockdown/Knockout HNRNPA2B1 protein :

137 RBPs can affect the gene expression of HNRNPA2B1 :

The Knockdown/knockout RNA-Seq assay for HNRNPA2B1 is not available on ENCORE database.

44 RBPs can affect the splicing of HNRNPA2B1 :

The Knockdown/knockout RNA-Seq assay for HNRNPA2B1 is not avaliable on ENCORE database.