IGF2BP3

General Information

Gene Name : IGF2BP3
Gene ID : ENSG00000136231.13
Essential Gene : No

Functions

RNA stability & decay
RNA localization
Translation regulation
P-body / stress granules

Localization(RBPImage: IGF2BP3)

Cytoplasm
Cytosolic
Cell Cortex

Domains (AlphaFold: IGF2BP3)

RRM
KH

Antibody Validation

View validation images for all IGF2BP3 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	IGF2BP3	ENSG00000136231.13	48.34	41.68	45.01	ENCSR000AEF
HepG2	IGF2BP3	ENSG00000136231.13	24.86	47.76	36.31	ENCSR985KAT
K562	IGF2BP3	ENSG00000136231.13	49.09	59.27	54.18	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 211	ENCSR993OLA	IGF2BP3	HepG2	Released	ENCAB934MDN	ENCSR077KVG
knockdown followed by RNA-seq	IGF2BP3-BGKLV11-K562	ENCSR302JQA	IGF2BP3	K562	Released		ENCSR129RWD	shRNA	KD% = 87.9,86.2
knockdown followed by RNA-seq	IGF2BP3-BGHLV12-HepG2	ENCSR710NWE	IGF2BP3	HepG2	Released		ENCSR237YZT	shRNA	KD% = 78.1,81.6
RNA Bind-n-Seq	RBNS: IGF2BP3	ENCSR164XGH	IGF2BP3	cell-free sample	Released

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
IGF2BP3	211	HepG2	ENCSR993OLA	ENCSR077KVG	ENCAB934MDN	RN009P	2	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
IGF2BP3	ENCAB934MDN	RN009P	2		Released, ENCODE3	Released, ENCODE3	BGHLV12-43, Released, ENCODE3	BGKLV11-19, Released, ENCODE3
IGF2BP3	ENCAB075HVA	200898	CD0123		Released, ENCODE3	Released, ENCODE3		BGKLV11-19, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
IGF2BP3	K562	shRNA	ENCSR302JQA	ENCSR129RWD	IGF2BP3-LV11-19,IGF2BP3-LV11-20	Nontarget-LV11-1,nontarget-LV11-2	87.9,86.2	Released	ENCODE3
IGF2BP3	K562	shRNA			BGKLV40-7,BGKLV40-8	BGKLV40-1,BGKLV40-2	94.0,94.0	Others	ENCODE4
IGF2BP3	HepG2	shRNA	ENCSR710NWE	ENCSR237YZT	IGF2BP3-BGHLV12-43,IGF2BP3-BGHLV12-44	NT-BGHLV12-01,NT-BGHLV12-02	78.1,81.6	Released	ENCODE3
IGF2BP3	HepG2	shRNA			BGHLV39-7,BGHLV39-8	BGHLV39-1,BGHLV39-2	70.0,70.0	Others	ENCODE4

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
IGF2BP3	IGF2BP3		Released	ENCODE4

Localization Image in HepG2

IGF2BP3: Click to RBP Image Database

Cytoplasm

Cytosolic

Cell Cortex

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
IGF2BP3	Product_ID: RN009P Lot_ID: 2 Source: MBLI Target Name: IGF2BP3-human
IGF2BP3	Product_ID: 200898 Lot_ID: CD0123 Source: Zen Bioscience Target Name: IGF2BP3-human

RNA Targets

IGF2BP3 protein binds to 2,210 RNA regions.

CanvasJS.com

The binding motifs of IGF2BP3

Proteins bound to RNA

IGF2BP3 RNA is bound by 61 proteins.

CanvasJS.com

IGF2BP3 protein has 2,210 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 2,210 entries.

Show entries

Search:

RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
IGF2BP3	chr2	21224685	21224696	-	6.75384	137.26131	HepG2	APOB	CDS,intron-Distal
IGF2BP3	chr12	9268370	9268401	-	3.62359	72.62446	HepG2	A2M	CDS,intron-Distal
IGF2BP3	chr2	21231641	21231667	-	3.64160	53.51723	HepG2	APOB	CDS,intron-Distal
IGF2BP3	chr2	216225844	216225874	-	5.44577	45.10393	HepG2	FN1	3'-UTR,intron-Distal,intron-Proximal
IGF2BP3	chr2	21231737	21231782	-	4.92708	35.82533	HepG2	APOB	CDS,intron-Distal
IGF2BP3	chr2	21233950	21233999	-	3.81850	32.74372	HepG2	APOB	CDS,intron-Distal
IGF2BP3	chr2	21229162	21229182	-	3.33109	30.47865	HepG2	APOB	CDS,intron-Distal
IGF2BP3	chr15	66792393	66792416	-	4.78210	29.97581	HepG2	RPL4	CDS,intron-Distal,intron-Proximal
IGF2BP3	chr2	21230731	21230760	-	3.76704	29.14811	HepG2	APOB	CDS,intron-Distal
IGF2BP3	chr1	150938290	150938342	-	5.45848	26.36858	HepG2	CERS2	3'-UTR,intron-Distal

Showing 1 to 10 of 100 entries

61 proteins are bound to IGF2BP3 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr7	23407882	23407951	-	intron-Distal	7.24995	122.69470	HepG2	PTBP1
chr7	23407884	23407967	-	intron-Distal	7.64276	86.88631	K562	PTBP1
chr7	23454630	23454705	-	intron-Distal	5.79074	59.03895	K562	DDX51
chr7	23454708	23454781	-	intron-Distal	4.99826	58.46272	K562	DDX51
chr7	23454447	23454535	-	intron-Distal	5.99786	53.22499	HepG2	AKAP1
chr7	23454705	23454787	-	intron-Distal	4.91746	42.20143	HepG2	AKAP1
chr7	23490266	23490359	-	intron-Distal	7.06500	41.41268	HepG2	LSM11
chr7	23454578	23454630	-	intron-Distal	5.27336	35.95566	K562	DDX51
chr7	23454465	23454534	-	intron-Distal	4.37597	35.38430	K562	DDX51
chr7	23454554	23454696	-	intron-Distal	4.56374	35.14972	K562	SLTM
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 267 entries

The IGF2BP3 protein binds to its own RNA.

Show entries

Search:

RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
IGF2BP3	chr7	23454633	23454705	-	3.39737	8.68476	HepG2	IGF2BP3	intron-Distal
IGF2BP3	chr7	23454711	23454760	-	3.10160	3.44615	HepG2	IGF2BP3	intron-Distal

Showing 1 to 2 of 2 entries

Diffrential Expression

5,140 differentially expressed genes after Knockdown/Knockout IGF2BP3 protein.

CanvasJS.com

90 RBPs can affect the levels of IGF2BP3.

CanvasJS.com

5,140 differentially expressed genes after Knockdown/Knockout IGF2BP3 protein :

Only display 100 entries as example. Please click "View All" button to see all 5,140 entries.

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
VCAN	ENSG00000038427.11	6487.47780	474.63590	3.77270	52.06380	48.47670	HepG2	IGF2BP3
CDH1	ENSG00000039068.14	429.71360	3057.67060	-2.83100	29.44410	26.66990	HepG2	IGF2BP3
PLEKHG6	ENSG00000008323.11	109.80920	693.70140	-2.65930	18.82450	16.53470	HepG2	IGF2BP3
ITGAL	ENSG00000005844.13	19.35080	231.06270	-3.57780	17.23920	15.06140	HepG2	IGF2BP3
PAX6	ENSG00000007372.16	94.50920	1.46210	6.01420	16.44430	14.32210	HepG2	IGF2BP3
C8B	ENSG00000021852.8	108.39290	552.12620	-2.34870	15.99260	13.89920	HepG2	IGF2BP3
ASB4	ENSG00000005981.8	217.59300	29.88540	2.86400	13.83960	11.83790	HepG2	IGF2BP3
ST3GAL1	ENSG00000008513.10	794.81790	2465.71890	-1.63330	11.09050	9.23970	HepG2	IGF2BP3
TSPAN9	ENSG00000011105.7	951.89000	2947.97490	-1.63090	10.75780	8.93030	HepG2	IGF2BP3
DPEP1	ENSG00000015413.5	34.90190	222.16210	-2.67020	9.34440	7.62250	HepG2	IGF2BP3
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

90 RBPs can affect the gene expression of IGF2BP3 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
IGF2BP3	ENSG00000136231.9	497.56560	2492.96430	-2.32490	93.56070	89.49060	K562	IGF2BP3
IGF2BP3	ENSG00000136231.9	1120.11510	2481.64620	-1.14770	44.71560	41.33030	HepG2	UTP18
IGF2BP3	ENSG00000136231.9	897.77170	2185.77260	-1.28370	21.80400	20.19290	HepG2	GPKOW
IGF2BP3	ENSG00000136231.9	1862.50360	2954.32280	-0.66560	20.67890	18.76340	K562	MTPAP
IGF2BP3	ENSG00000136231.9	1395.66950	2656.37460	-0.92850	19.44880	17.23810	K562	GPKOW
IGF2BP3	ENSG00000136231.9	4442.85510	3054.46250	0.54050	18.04960	17.06640	HepG2	SRFBP1
IGF2BP3	ENSG00000136231.9	3204.30380	2135.52410	0.58530	16.61490	15.66270	HepG2	SRSF1
IGF2BP3	ENSG00000136231.9	3362.08160	1668.65400	1.01060	16.05570	14.66100	HepG2	SUPV3L1
IGF2BP3	ENSG00000136231.9	1043.72240	1889.12130	-0.85600	16.83560	14.40550	K562	RCC2
IGF2BP3	ENSG00000136231.9	2201.02020	3785.47320	-0.78230	15.31610	13.56360	K562	AKAP8L
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 107 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

914 alternative splicing events after Knockdown/Knockout IGF2BP3 protein :

Only display 100 entries as example. Please click "View All" button to see all 914 entries.

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	KDM5B	ENSG00000117139.12	chr1	-	202735524	202735632	202733176	202733273	202736053	202736188	0.14400	0.00005	included	HepG2	IGF2BP3
SE	MARK3	ENSG00000075413.13	chr14	+	103964838	103964865	103957875	103958371	103969218	103969589	0.40100	0.00026	included	HepG2	IGF2BP3
SE	DHX9	ENSG00000135829.12	chr1	+	182824711	182824848	182823175	182823313	182825666	182825707	0.07300	0.00056	included	HepG2	IGF2BP3
SE	ZFAS1	ENSG00000177410.8	chr20	+	47897439	47897501	47897021	47897107	47905581	47905797	0.23000	0.00000	included	HepG2	IGF2BP3
SE	S100A16	ENSG00000188643.6	chr1	-	153581374	153581506	153580474	153580653	153581653	153581813	0.16900	0.00012	included	HepG2	IGF2BP3
SE	CIRBP	ENSG00000099622.9	chr19	+	1272425	1272522	1271979	1272050	1274305	1274809	0.13800	0.00000	included	HepG2	IGF2BP3
SE	PLOD2	ENSG00000152952.7	chr3	-	145795648	145795711	145794568	145794682	145796902	145797044	0.26600	0.00000	included	HepG2	IGF2BP3
SE	IL17RB	ENSG00000056736.5	chr3	+	53889320	53889368	53886897	53887024	53890870	53891013	0.26700	0.00000	included	HepG2	IGF2BP3
SE	APOC1	ENSG00000130208.5	chr19	+	45417928	45417990	45417503	45417746	45418128	45418206	0.07600	0.00003	included	HepG2	IGF2BP3
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.19500	0.00000	included	HepG2	IGF2BP3

Showing 1 to 10 of 100 entries

13 RBPs can affect the splicing of IGF2BP3 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	IGF2BP3	ENSG00000136231.9	chr7	-	23383336	23383472	23381682	23381808	23385558	23385681	-0.16300	0.00000	excluded	HepG2	U2AF1
SE	IGF2BP3	ENSG00000136231.9	chr7	-	23381682	23381808	23358756	23358873	23385558	23385681	-0.15800	0.00001	excluded	K562	AQR
SE	IGF2BP3	ENSG00000136231.9	chr7	-	23383336	23383472	23381682	23381808	23385558	23385681	-0.08100	0.00000	excluded	K562	PUS1
SE	IGF2BP3	ENSG00000136231.9	chr7	-	23383336	23383472	23381682	23381808	23385558	23385681	-0.09700	0.00013	excluded	K562	U2AF1
A3SS	IGF2BP3	ENSG00000136231.9	chr7	-	23381682	23381828	23381682	23381808	23383336	23383472	0.12300	0.00000	longer	K562	AQR
A3SS	IGF2BP3	ENSG00000136231.9	chr7	-	23391124	23391305	23391124	23391205	23401152	23401216	0.10100	0.00000	longer	K562	AQR
A3SS	IGF2BP3	ENSG00000136231.9	chr7	-	23387218	23387467	23387218	23387353	23390923	23391205	0.09100	0.00002	longer	K562	AQR
A3SS	IGF2BP3	ENSG00000136231.9	chr7	-	23351991	23352141	23351991	23352079	23352353	23352467	0.07300	0.00000	longer	K562	AQR
A5SS	IGF2BP3	ENSG00000136231.9	chr7	-	23353087	23353272	23353140	23353272	23352353	23352467	0.05800	0.00000	longer	K562	AQR
A5SS	IGF2BP3	ENSG00000136231.9	chr7	-	23353087	23353272	23353140	23353272	23352353	23352467	0.10700	0.00024	longer	HepG2	SF3A3

Showing 1 to 10 of 22 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

IGF2BP3

General Information

Functions

Localization(RBPImage: IGF2BP3)

Domains (AlphaFold: IGF2BP3)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

IGF2BP3 protein has 2,210 RNA targets:

61 proteins are bound to IGF2BP3 RNA:

The IGF2BP3 protein binds to its own RNA.

Diffrential Expression

5,140 differentially expressed genes after Knockdown/Knockout IGF2BP3 protein :

90 RBPs can affect the gene expression of IGF2BP3 :

914 alternative splicing events after Knockdown/Knockout IGF2BP3 protein :

13 RBPs can affect the splicing of IGF2BP3 :

No autoregularoty alternative splicing events between protein IGF2BP3 and its RNA.