EIF4H

General Information

Gene Name : EIF4H
Gene ID : ENSG00000106682.14
Essential Gene : No

Functions

Ribosome & basic translation
Translation regulation
Viral RNA regulation

Localization(RBPImage: EIF4H)

Nuclei
Nucleoplasm
Unknown Nuclear Territory
Cytoplasm
Compartment/Organelle
Mitochondria
P bodies

Domains (AlphaFold: EIF4H)

RRM

Antibody Validation

Cell Signaling Technology: 3469S

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	EIF4H	ENSG00000106682.14	102.34	172.39	137.37	ENCSR000AEF
HepG2	EIF4H	ENSG00000106682.14	190.81	158.28	174.55	ENCSR985KAT
K562	EIF4H	ENSG00000106682.14	241.06	214.76	227.91	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	Target label	Biosample	Status	Method	Note
knockdown followed by RNA-seq	EIF4H-BG293LV05-WT293	EIF4H	293T	Released	shRNA	KD% = ,
knockdown followed by RNA-seq	EIF4H-BG293LV06-WT293	EIF4H	293T	Released	shRNA	KD% = ,
RNA Bind-n-Seq	RBNS: EIF4H	EIF4H	cell-free sample	Released

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
EIF4H		3469S	1			Submitted, ENCORE2	BGHcLV43-21, Submitted, ENCORE2	BGKcLV42-35, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Sample_reps	Control_reps	KD%	Status	Project
EIF4H	HepG2	shRNA	BGHLV20-27,BGHLV20-28	BGHLV20-1,BGHLV20-2	redo transfection,redo transfection	NotSatisfied	ENCODE3
EIF4H	K562	CRISPR	EIF4H-BGKcLV42-35,EIF4H-BGKcLV42-36	NT-BGKcLV42-1,NT-BGKcLV42-2	91.3,90.5	Submitting	ENCORE2
EIF4H	HepG2	CRISPR	EIF4H-BGHcLV43-21,EIF4H-BGHcLV43-22	NT-BGHcLV43-1,NT-BGHcLV43-2	94.8,92.4	Submitting	ENCORE2
EIF4H	293T	shRNA	BG293LV04-25,BG293LV04-26	BG293LV04-1,BG293LV04-2		NotSatisfied	ENCORE2
EIF4H	293T	shRNA	BG293LV04-27,BG293LV04-28	BG293LV04-1,BG293LV04-2		NotSatisfied	ENCORE2
EIF4H	293T	shRNA	BG293LV04-29,BG293LV04-30	BG293LV04-1,BG293LV04-2		NotSatisfied	ENCORE2
EIF4H	293T	shRNA	EIF4H-BG293LV05-111,EIF4H-BG293LV05-112	NT-BG293LV05-1,NT-BG293LV05-2	,	Released	ENCORE2
EIF4H	293T	shRNA	EIF4H-BG293LV06-93B,EIF4H-BG293LV06-94B	NT-BG293LV06-1B,NT-BG293LV06-2B	,	Released	ENCORE2

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
EIF4H	EIF4H		Released	ENCODE4

Localization Image in HepG2

EIF4H: Click to RBP Image Database

Nuclei

Nucleoplasm

Unknown Nuclear Territory

Cytoplasm

Compartment/Organelle

Mitochondria

P bodies

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
EIF4H	Product_ID: 3469S Lot_ID: 1 Source: Cell Signaling Technology Target Name: EIF4H-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for EIF4H is not avaliable on ENCORE database.

The binding motifs of EIF4H

Proteins bound to RNA

EIF4H RNA is bound by 32 proteins.

CanvasJS.com

eCLIP assay for EIF4H is not avaliable on ENCORE database.

32 proteins are bound to EIF4H RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr7	73610711	73610808	+	3'-UTR	4.29673	400.00000	K562	UPF1
chr7	73610011	73610061	+	3'-UTR	3.51981	400.00000	K562	UPF1
chr7	73610124	73610131	+	3'-UTR	4.85164	400.00000	K562	UPF1
chr7	73610488	73610541	+	3'-UTR	5.73638	400.00000	K562	UPF1
chr7	73610109	73610124	+	3'-UTR	4.61702	400.00000	K562	UPF1
chr7	73609903	73609950	+	3'-UTR	4.00649	400.00000	K562	PTBP1
chr7	73610131	73610151	+	3'-UTR	4.63654	400.00000	K562	UPF1
chr7	73610061	73610109	+	3'-UTR	4.66007	400.00000	K562	UPF1
chr7	73609862	73609902	+	3'-UTR	3.31287	87.02229	K562	UPF1
chr7	73610151	73610175	+	3'-UTR	4.79217	86.70408	K562	UPF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 112 entries

eCLIP assay for EIF4H is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for EIF4H is not available on ENCORE database.
85 RBPs can affect the levels of EIF4H.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for EIF4H is not available on ENCORE database.

85 RBPs can affect the gene expression of EIF4H :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
EIF4H	ENSG00000106682.10	5096.85970	9394.88070	-0.88230	37.06380	35.59140	HepG2	RBM22
EIF4H	ENSG00000106682.10	22106.28400	15141.52640	0.54580	22.27540	20.77310	K562	AGGF1
EIF4H	ENSG00000106682.10	3190.34590	4979.38470	-0.64230	20.76970	18.99670	HepG2	PRPF4
EIF4H	ENSG00000106682.10	4079.15430	8065.78240	-0.98350	17.80480	16.29130	HepG2	NCBP2
EIF4H	ENSG00000106682.10	4836.83420	7000.36570	-0.53340	16.60020	15.24820	HepG2	SRSF5
EIF4H	ENSG00000106682.10	4650.39020	8506.79290	-0.87130	14.91700	13.57700	HepG2	DDX3X
EIF4H	ENSG00000106682.10	3073.20460	4397.15560	-0.51680	13.77000	12.12710	HepG2	PARN
EIF4H	ENSG00000106682.10	1981.19880	6932.57600	-1.80700	13.71630	11.72200	HepG2	IGF2BP3
EIF4H	ENSG00000106682.10	9859.89480	12086.71540	-0.29380	11.72330	10.33400	K562	NSUN2
EIF4H	ENSG00000106682.10	5206.20840	7212.85590	-0.47030	10.14440	9.17810	HepG2	TAF15
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 90 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for EIF4H is not available on ENCORE database.

44 RBPs can affect the splicing of EIF4H :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.28900	0.00000	included	K562	SF3B4
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.13100	0.00005	included	K562	PRPF8
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.12800	0.00000	included	HepG2	U2AF1
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.07700	0.00010	included	HepG2	HNRNPK
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.08900	0.00000	included	HepG2	U2AF2
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.12600	0.00000	included	HepG2	AKAP1
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.12900	0.00038	included	HepG2	LARP7
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609034	73609208	-0.14900	0.00000	excluded	K562	AQR
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.19000	0.00000	included	K562	FXR1
SE	EIF4H	ENSG00000106682.10	chr7	+	73604576	73604636	73604151	73604248	73609070	73609208	0.12200	0.00000	included	HepG2	DDX3X

Showing 1 to 10 of 53 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

EIF4H

General Information

Functions

Localization(RBPImage: EIF4H)

Domains (AlphaFold: EIF4H)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for EIF4H is not avaliable on ENCORE database.

32 proteins are bound to EIF4H RNA:

eCLIP assay for EIF4H is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for EIF4H is not available on ENCORE database.

85 RBPs can affect the gene expression of EIF4H :

The Knockdown/knockout RNA-Seq assay for EIF4H is not available on ENCORE database.

44 RBPs can affect the splicing of EIF4H :

The Knockdown/knockout RNA-Seq assay for EIF4H is not avaliable on ENCORE database.