CCAR1

General Information

Gene Name : CCAR1
Gene ID : ENSG00000060339.13
Essential Gene : Yes

Functions

Spliceosome
P-body / stress granules

Localization(RBPImage: CCAR1)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Speckles
Variable Nuclear Intensity
Cytoplasm
Cytosolic
Nuclear release mitosis

Domains (AlphaFold: CCAR1)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

View validation images for all CCAR1 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	CCAR1	ENSG00000060339.13	92.74	74.66	83.70	ENCSR000AEF
HepG2	CCAR1	ENSG00000060339.13	53.52	83.89	68.70	ENCSR985KAT
K562	CCAR1	ENSG00000060339.13	84.17	94.81	89.49	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	CCAR1-BGKLV24-K562	ENCSR386YEV	CCAR1	K562	Released		ENCSR667PLJ	shRNA	KD% = 58.5,69.0
knockdown followed by RNA-seq	CCAR1-BGHLV20-HepG2	ENCSR081IAO	CCAR1	HepG2	Released		ENCSR135LXL	shRNA	KD% = 64.4,57.7

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
CCAR1	ENCAB369JZE	A300-270A	1		BGHLV20-5, Released, ENCODE3	BGKLV24-5, Released, ENCODE3
CCAR1	ENCAB492CZQ	A300-435A	2	Released, ENCODE4	BGHLV20-5, Released, ENCODE3
CCAR1	ENCAB255UNN	A300-437A	2	Released, ENCODE4	BGHLV20-5, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
CCAR1	K562	shRNA	ENCSR386YEV	ENCSR667PLJ	CCAR1_BGKLV24_5_17598,CCAR1_BGKLV24_6_17599	non-target_BGKLV24_1_17594,non-target_BGKLV24_2_17595	58.5,69.0	Released	ENCODE3
CCAR1	HepG2	shRNA			BGHLV17-47,BGHLV17-48	BGHLV17-1,BGHLV17-2		NotSatisfied	ENCODE3
CCAR1	HepG2	shRNA	ENCSR081IAO	ENCSR135LXL	CCAR1_BGHLV20-5B,CCAR1_BGHLV20-6B	NT_BGHLV20-1B,NT_BGHLV20-2B	64.4,57.7	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

CCAR1: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Speckles

Variable Nuclear Intensity

Cytoplasm

Cytosolic

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
CCAR1	Product_ID: A300-435A Lot_ID: 2 Source: Bethyl Labs Target Name: CCAR1-human
CCAR1	Product_ID: A300-437A Lot_ID: 2 Source: Bethyl Labs Target Name: CCAR1-human
CCAR1	Product_ID: A300-270A Lot_ID: 1 Source: Bethyl Labs Target Name: CCAR1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for CCAR1 is not avaliable on ENCORE database.

Proteins bound to RNA

CCAR1 RNA is bound by 61 proteins.

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eCLIP assay for CCAR1 is not avaliable on ENCORE database.

61 proteins are bound to CCAR1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr10	70514948	70514993	+	intron-Distal	4.82785	400.00000	HepG2	DKC1
chr10	70514982	70514987	+	intron-Distal	4.47546	400.00000	K562	SMNDC1
chr10	70514950	70514969	+	intron-Distal	4.29861	400.00000	K562	SMNDC1
chr10	70514987	70514997	+	intron-Distal	7.40834	400.00000	HepG2	NOLC1
chr10	70514950	70514995	+	intron-Distal	6.70943	400.00000	K562	AATF
chr10	70514954	70514982	+	intron-Distal	6.99305	400.00000	HepG2	NOLC1
chr10	70514969	70514982	+	intron-Distal	4.43241	400.00000	K562	SMNDC1
chr10	70514982	70514985	+	intron-Distal	7.33354	400.00000	HepG2	NOLC1
chr10	70514987	70514996	+	intron-Distal	4.39528	400.00000	K562	SMNDC1
chr10	70525696	70525756	+	3'-UTR,CDS	4.79975	73.58556	K562	UCHL5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 295 entries

eCLIP assay for CCAR1 is not avaliable on ENCORE database.

Diffrential Expression

6,148 differentially expressed genes after Knockdown/Knockout CCAR1 protein.

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101 RBPs can affect the levels of CCAR1.

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6,148 differentially expressed genes after Knockdown/Knockout CCAR1 protein :

Only display 100 entries as example. Please click "View All" button to see all 6,148 entries.

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
DPEP1	ENSG00000015413.5	1209.34720	282.92010	2.09570	37.67820	34.48680	HepG2	CCAR1
RTEL1-TNFRSF6B	ENSG00000026036.16	884.87690	256.14430	1.78840	25.77300	23.07650	HepG2	CCAR1
MAPK8IP2	ENSG00000008735.10	434.71360	74.53480	2.54400	25.07500	22.39550	HepG2	CCAR1
PNPLA6	ENSG00000032444.11	2063.10960	852.47100	1.27500	18.53260	16.20530	HepG2	CCAR1
ASB4	ENSG00000005981.8	839.12100	325.88660	1.36440	16.02410	13.83820	HepG2	CCAR1
CD9	ENSG00000010278.7	158.92430	470.26780	-1.56510	15.53990	13.38690	HepG2	CCAR1
WWTR1	ENSG00000018408.10	2037.70000	4198.77420	-1.04300	14.37070	12.29120	HepG2	CCAR1
MAN2B2	ENSG00000013288.4	520.38470	1110.64450	-1.09370	12.12450	10.13220	HepG2	CCAR1
FAS	ENSG00000026103.15	631.80650	301.78800	1.06580	9.39320	7.60090	HepG2	CCAR1
ATP1A2	ENSG00000018625.10	85.07980	14.17140	2.58570	9.24680	7.46930	HepG2	CCAR1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

101 RBPs can affect the gene expression of CCAR1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CCAR1	ENSG00000060339.9	4888.51990	1884.98430	1.37470	94.55260	92.70630	HepG2	SRSF1
CCAR1	ENSG00000060339.9	1262.08170	2025.88390	-0.68270	18.04020	16.59490	HepG2	HNRNPU
CCAR1	ENSG00000060339.9	1247.68970	1986.11680	-0.67070	17.73240	16.46610	HepG2	TRIM56
CCAR1	ENSG00000060339.9	1913.75580	2818.73690	-0.55860	17.52900	15.95240	HepG2	DAZAP1
CCAR1	ENSG00000060339.9	2982.46170	1930.42590	0.62750	16.96870	15.84900	HepG2	NELFE
CCAR1	ENSG00000060339.9	1149.24860	1804.15170	-0.65060	16.94890	15.54980	HepG2	SAFB2
CCAR1	ENSG00000060339.9	1175.24110	1799.96310	-0.61500	16.74180	15.26940	HepG2	DNAJC2
CCAR1	ENSG00000060339.9	1765.49940	2671.71060	-0.59770	16.19580	14.92410	HepG2	UTP3
CCAR1	ENSG00000060339.9	5541.22680	3417.38230	0.69720	16.77400	14.75780	K562	U2AF2
CCAR1	ENSG00000060339.9	2718.66730	1797.98290	0.59640	15.46200	14.19720	HepG2	RECQL
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 120 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for CCAR1 is not available on ENCORE database.

23 RBPs can affect the splicing of CCAR1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	CCAR1	ENSG00000060339.9	chr10	+	70516029	70516240			70515126	70515293	70517050	70517134	0.15100	0.00000	0.00000	included	K562	U2AF1
SE	CCAR1	ENSG00000060339.9	chr10	+	70516282	70516389			70515232	70515293	70517050	70517134	0.83400	0.00000	0.00000	included	K562	HNRNPL
SE	CCAR1	ENSG00000060339.9	chr10	+	70525644	70525836			70517050	70517134	70530962	70531058	-0.08700	0.00000	0.00118	excluded	HepG2	CDC40
SE	CCAR1	ENSG00000060339.9	chr10	+	70516029	70516240			70515126	70515293	70517050	70517134	0.15200	0.00000	0.00000	included	K562	U2AF2
MXE	CCAR1	ENSG00000060339.9	chr10	+	70500385	70500418	70502132	70502326	70497601	70497646	70506917	70507032	0.32600	0.00000	0.00000	1included	HepG2	U2AF2
MXE	CCAR1	ENSG00000060339.9	chr10	+	70497601	70497646	70502132	70502326	70496632	70496805	70506917	70507032	0.27000	0.00000	0.00000	1included	HepG2	HNRNPUL1
MXE	CCAR1	ENSG00000060339.9	chr10	+	70497601	70497646	70502184	70502326	70496632	70496805	70506917	70507032	0.27200	0.00000	0.00000	1included	HepG2	HNRNPUL1
MXE	CCAR1	ENSG00000060339.9	chr10	+	70520763	70520949	70525644	70525756	70517050	70517134	70530962	70531188	-0.06500	0.00001	0.00010	2included	K562	AQR
MXE	CCAR1	ENSG00000060339.9	chr10	+	70500385	70500418	70502184	70502326	70496632	70496805	70506917	70507032	0.22600	0.00001	0.00017	1included	HepG2	U2AF2
MXE	CCAR1	ENSG00000060339.9	chr10	+	70500385	70500418	70502132	70502326	70496632	70496805	70506917	70507032	0.22700	0.00002	0.00023	1included	HepG2	U2AF2

Showing 1 to 10 of 45 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

CCAR1

General Information

Functions

Localization(RBPImage: CCAR1)

Domains (AlphaFold: CCAR1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for CCAR1 is not avaliable on ENCORE database.

61 proteins are bound to CCAR1 RNA:

eCLIP assay for CCAR1 is not avaliable on ENCORE database.

Diffrential Expression

6,148 differentially expressed genes after Knockdown/Knockout CCAR1 protein :

101 RBPs can affect the gene expression of CCAR1 :

The Knockdown/knockout RNA-Seq assay for CCAR1 is not available on ENCORE database.

23 RBPs can affect the splicing of CCAR1 :

The Knockdown/knockout RNA-Seq assay for CCAR1 is not avaliable on ENCORE database.