FHIT

General Information

Gene Name       : FHIT
Gene ID             : ENSG00000189283.9
Essential Gene : No

Functions

Localization

Domains (AlphaFold: FHIT)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878FHITENSG00000189283.95.747.076.41ENCSR000AEF
HepG2FHITENSG00000189283.92.192.712.45ENCSR985KAT
K562FHITENSG00000189283.93.083.383.23ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for FHIT is not avaliable on ENCORE database.



Proteins bound to RNA
  • FHIT RNA is bound by 21 proteins.  







eCLIP assay for FHIT is not avaliable on ENCORE database.





21 proteins are bound to FHIT RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr35973790859738036-3'-UTR,CDS,intron-Distal,intron-Proximal3.485904.20387K562ZNF622
chr36080761260807705-5'-UTR,intron-Distal,intron-Proximal4.300014.04622HepG2GRWD1
chr36080761060807675-5'-UTR,intron-Distal,intron-Proximal3.223454.69671HepG2PPIG
chr36102771261027775-5'-UTR,intron-Distal,intron-Proximal3.419607.64107HepG2PPIG
chr36052261160522689-CDS,intron-Distal3.761624.46864HepG2BCLAF1
chr36067972960679839-intron-Distal3.110074.40834HepG2QKI
chr36110107561101198-intron-Distal4.611674.31720HepG2MATR3
chr36035224560352300-intron-Distal3.870805.42334HepG2QKI
chr36045523960455329-intron-Distal3.778013.19638K562SAFB2
chr36046999260470041-intron-Distal3.607844.31658K562EXOSC5
chr36074308860743107-intron-Distal3.892573.04224HepG2SUGP2
chr36067255360672645-intron-Distal3.221013.07152HepG2HLTF
chr36050987360509956-intron-Distal5.136896.58769K562EIF4G2
chr36072439260724510-intron-Distal4.555045.31529HepG2SUGP2
chr36046801860468112-intron-Distal3.737449.89062HepG2MATR3
chr36098731960987433-intron-Distal3.343664.38902HepG2HNRNPL
chr36053862260538701-intron-Distal4.058794.07991K562ILF3
chr36039931260399361-intron-Distal3.376783.27276HepG2HNRNPL
chr36039597360396079-intron-Distal4.328503.62238HepG2MATR3
chr36048170760481775-intron-Distal3.823163.24603K562KHSRP
chr36038106260381105-intron-Distal4.058034.10336HepG2SUGP2
chr36053708560537169-intron-Distal4.314674.70168K562CSTF2T
chr36018660560186683-intron-Distal4.231864.38266K562TARDBP
chr36046892060468952-intron-Distal4.389794.80466K562EXOSC5
chr36051411360514175-intron-Distal3.893083.76275K562PTBP1
chr36073190160731993-intron-Distal3.504573.46325HepG2SUGP2
chr36023308160233136-intron-Distal5.1825816.33654HepG2PTBP1
chr36076712860767213-intron-Distal3.788774.23286HepG2QKI
chr36023578360235902-intron-Distal4.701826.08961HepG2PTBP1
chr36117291561173033-intron-Distal3.903793.01456K562EXOSC5
chr36053743360537493-intron-Distal4.122803.14687K562CSTF2T
chr36037961960379683-intron-Distal3.600095.32485HepG2SUGP2
chr36026625160266313-intron-Distal3.834683.07980HepG2HNRNPM
chr36111930961119385-intron-Distal3.638505.54651HepG2SUGP2
chr36034642660346544-intron-Distal3.350893.68481HepG2HNRNPM
chr36039885760398995-intron-Distal4.524524.51735HepG2QKI
chr36097734460977468-intron-Distal4.610945.54528HepG2QKI
chr36074354560743585-intron-Distal4.127733.39864HepG2SUGP2
chr36046806560468106-intron-Distal3.977386.40934HepG2HNRNPM
chr36038090860380993-intron-Distal3.920217.29258HepG2SUGP2
chr36074512060745165-intron-Distal3.022843.10640HepG2SUGP2
chr36041023160410347-intron-Distal6.2979921.90838K562TARDBP
chr36046802460468111-intron-Distal5.7815813.32155K562EXOSC5
chr36014583660145942-intron-Distal4.956158.77667K562HNRNPL
chr36045730560457396-intron-Distal3.906263.74251K562SAFB2
chr36094597260946045-intron-Distal4.898508.81328HepG2CSTF2
chr36093185260931918-intron-Distal3.321564.08528HepG2SUGP2
chr36100485161004958-intron-Distal5.378317.94162K562QKI
chr36100493661004953-intron-Distal5.5375210.85098HepG2QKI
chr36046802560468140-intron-Distal5.007686.00387HepG2EXOSC5
chr36050988160509954-intron-Distal5.082828.06678K562TARDBP
chr36093070260930901-intron-Distal3.576484.23155HepG2MATR3
chr36073793960738036-intron-Distal3.589173.29239HepG2CSTF2
chr36023313660233170-intron-Distal4.833346.76922HepG2PTBP1
chr36079714460797255-intron-Distal5.101838.45817HepG2QKI
chr36093069860930856-intron-Distal4.564725.04879HepG2SUGP2
chr35995349159953597-intron-Distal3.935103.41738HepG2PTBP1
chr36038035460380421-intron-Distal3.073304.61989HepG2SUGP2
chr36046803160468126-intron-Distal5.222395.31171K562HNRNPM
chr36086709960867223-intron-Distal4.272244.61447HepG2SUGP2
chr36074373860743791-intron-Distal3.091593.46325HepG2SUGP2
chr36053696960537030-intron-Distal4.469854.49385K562ILF3
chr36008047060080547-intron-Distal4.401094.40847HepG2PTBP1
chr36100484261004936-intron-Distal6.2597820.08345HepG2QKI
chr36024374160243859-intron-Distal4.119953.34609K562TARDBP
chr36097520360975326-intron-Distal6.3242520.44285HepG2QKI
chr36053694260537033-intron-Distal4.355394.48935K562CSTF2T
chr36111932061119371-intron-Distal3.561014.53157HepG2MATR3
chr36099101060991155-intron-Distal4.058933.76460HepG2HNRNPL
chr36074494060745008-intron-Distal3.575734.84410HepG2SUGP2
chr36078315660783241-intron-Distal4.912844.85866HepG2QKI
chr36023306260233181-intron-Distal3.439705.12973HepG2MATR3
chr36112902761129130-intron-Distal3.894163.50031HepG2HNRNPL
chr36077261760772725-intron-Distal5.437089.85976HepG2PTBP1
chr36041519360415282-intron-Distal4.104973.07980HepG2HNRNPM
chr36074496660745022-intron-Distal4.000483.27829HepG2MATR3
chr36033649560336575-intron-Distal4.095934.21977HepG2HNRNPL
chr36023976760239845-intron-Distal5.117148.86284K562TARDBP
chr36112011561120164-intron-Distal4.164734.03915HepG2SUGP2
chr36045637660456463-intron-Distal3.991833.86679K562SAFB2
chr36034626860346320-intron-Distal3.839983.29248HepG2SUGP2
chr36023306160233174-intron-Distal3.583356.75305K562MATR3
chr36094604560946070-intron-Distal3.608843.10834HepG2CSTF2
chr36089418260894346-intron-Distal4.532615.41368HepG2PTBP1
chr36074385460743956-intron-Distal3.187283.34834HepG2SUGP2
chr36078964660789725-intron-Distal4.334684.64592HepG2HNRNPM
chr36035230060352365-intron-Distal5.296808.45817HepG2QKI
chr36026129860261413-intron-Distal4.991547.88729K562TARDBP
chr36046946260469513-intron-Distal3.749735.20902K562EXOSC5
chr36014575360145836-intron-Distal3.326754.26070K562HNRNPL
chr36112031961120381-intron-Distal4.146473.86809HepG2SUGP2
chr36074214060742223-intron-Distal4.016543.39864HepG2SUGP2
chr36111991861119976-intron-Distal3.450314.57452HepG2SUGP2
chr36053708260537174-intron-Distal4.5713111.67573K562ILF3
chr36007081660070912-intron-Distal4.032833.24150HepG2HLTF
chr36039422860394360-intron-Distal4.447659.21479HepG2PTBP1
chr36100503561005091-intron-Distal4.633845.05488HepG2QKI
chr36110433761104427-intron-Distal3.852933.50031HepG2HNRNPL
chr36100495361004978-intron-Distal4.452554.85866HepG2QKI
chr36046906660469113-intron-Distal3.703776.40701K562EXOSC5
chr36023580060235901-intron-Distal3.543588.20361K562PTBP1
chr36053743160537495-intron-Distal4.243326.85784K562ILF3
chr36012062360120734-intron-Distal4.615739.54872HepG2PTBP1
chr36024161460241697-intron-Distal4.322323.30440HepG2QKI
chr36014586160145936-intron-Distal3.837357.94466HepG2HNRNPL
chr36102372461023838-intron-Distal3.918093.49011K562KHSRP
chr36039930260399445-intron-Distal4.210424.02199K562HNRNPL
chr36018961360189685-intron-Distal4.002323.05187HepG2QKI
chr36022001960220103-intron-Distal4.190724.14103K562KHSRP
chr36043510360435179-intron-Distal4.191194.66266K562TARDBP
chr36051274360512825-intron-Distal6.4508316.75429HepG2XPO5
chr36039421660394343-intron-Distal5.524607.41017K562PTBP1
chr36053682960536913-intron-Distal3.649504.84851K562ILF3
chr36039936160399467-intron-Distal4.528895.29549HepG2HNRNPL
chr36094050660940565-intron-Distal4.204804.31871HepG2HNRNPM
chr36040753860407634-intron-Distal3.479554.51091HepG2HNRNPL
chr36044197660442103-intron-Distal3.926555.80877K562EXOSC5
chr36038049060380550-intron-Distal4.238154.03915HepG2SUGP2
chr36039899860399101-intron-Distal3.592405.19856HepG2PTBP1
chr36023306860233162-intron-Distal5.7767320.14210K562PTBP1
chr36012063860120719-intron-Distal4.277427.80454K562PTBP1
chr36051182060511891-intron-Distal3.985933.08314K562TARDBP
chr36110106461101191-intron-Distal3.184123.30286HepG2PTBP1
chr36027341560273461-intron-Distal4.343323.42734K562PTBP1
chr36112060261120673-intron-Distal4.516544.78128HepG2SUGP2
chr36097571260975801-intron-Distal3.552994.01088HepG2RBFOX2
chr36074560260745674-intron-Distal4.477534.78128HepG2SUGP2
chr36118107061181165-intron-Distal4.867936.37635HepG2HNRNPL
chr36049379160493893-intron-Distal4.7328411.95802HepG2HNRNPL
chr36074548160745554-intron-Distal3.450314.14346HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for FHIT is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for FHIT is not available on ENCORE database.

  • 52 RBPs can affect the levels of FHIT.  








The Knockdown/knockout RNA-Seq assay for FHIT is not available on ENCORE database.





52 RBPs can affect the gene expression of FHIT :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
FHITENSG00000189283.5106.00580164.23070-0.631601.890601.44130HepG2AKAP1
FHITENSG00000189283.5174.39420119.786000.541802.112801.49830HepG2AUH
FHITENSG00000189283.581.1737032.424701.323803.983003.17200HepG2CPSF6
FHITENSG00000189283.5113.5075056.406301.008803.866102.65800HepG2YBX3
FHITENSG00000189283.5224.60270126.150900.832105.949604.92030HepG2DAZAP1
FHITENSG00000189283.5104.52160157.31920-0.589901.863201.33950HepG2DDX3X
FHITENSG00000189283.5188.53940124.477700.598902.804601.96270HepG2EIF4G1
FHITENSG00000189283.535.2618097.17130-1.462403.360702.51940HepG2FIP1L1
FHITENSG00000189283.575.63630144.85910-0.937503.595802.81350HepG2FXR1
FHITENSG00000189283.5102.8275058.377400.816602.702301.99300HepG2HNRNPF
FHITENSG00000189283.5197.65030114.906000.782404.706903.84390HepG2HNRNPL
FHITENSG00000189283.576.0451035.075401.116302.745702.11840HepG2HNRNPLL
FHITENSG00000189283.5106.2370063.104100.751402.570401.86140HepG2ILF2
FHITENSG00000189283.571.95550145.72000-1.018003.753903.02870HepG2MATR3
FHITENSG00000189283.566.82380149.15190-1.158304.981504.14230HepG2NCBP2
FHITENSG00000189283.5116.5210060.398100.947903.788902.89700HepG2PRPF4
FHITENSG00000189283.537.5871091.86240-1.289203.182802.43030HepG2RAVER1
FHITENSG00000189283.587.32310148.91820-0.770102.811402.26730HepG2NELFE
FHITENSG00000189283.5105.2302055.013500.935603.448302.74360HepG2SAFB2
FHITENSG00000189283.532.97470120.64650-1.871409.182407.89690HepG2SF3A3
FHITENSG00000189283.568.66400139.29770-1.020504.206503.50160HepG2SF3B4
FHITENSG00000189283.516.8557079.91440-2.245204.657702.70500HepG2SFPQ
FHITENSG00000189283.5243.25750129.831800.905706.264705.59410HepG2SRFBP1
FHITENSG00000189283.566.87760145.40840-1.120504.934304.34960HepG2SRSF1
FHITENSG00000189283.5115.8786060.567700.935903.956403.30570HepG2TRIM56
FHITENSG00000189283.540.0126083.08200-1.054102.267701.69310HepG2U2AF1
FHITENSG00000189283.536.51150103.29960-1.500406.020105.19450HepG2UTP3
FHITENSG00000189283.5110.2826059.605800.887603.253502.53530HepG2ZC3H8
FHITENSG00000189283.5106.50970172.26120-0.693602.670101.51150K562AARS
FHITENSG00000189283.5328.70740473.66610-0.527102.573302.02170K562AGGF1
FHITENSG00000189283.5398.27540520.41280-0.385902.302001.41700K562AKAP8
FHITENSG00000189283.5359.50370492.85270-0.455102.360601.75590K562AKAP8L
FHITENSG00000189283.5209.89570360.36940-0.779804.815204.07960K562AQR
FHITENSG00000189283.5350.98240517.08640-0.559003.890202.79120K562ATP5C1
FHITENSG00000189283.5168.89640244.18120-0.531802.204701.43190K562BOP1
FHITENSG00000189283.5173.18230259.63190-0.584203.120702.28650K562CPSF6
FHITENSG00000189283.5260.07810363.52050-0.483103.158102.46860K562DDX47
FHITENSG00000189283.5152.94880222.64100-0.541702.313801.53810K562FIP1L1
FHITENSG00000189283.5177.15000264.17460-0.576502.809601.94880K562FMR1
FHITENSG00000189283.5101.99070218.18330-1.097107.605306.66750K562FXR1
FHITENSG00000189283.5164.25460247.88230-0.593702.835502.03090K562GPKOW
FHITENSG00000189283.5116.20450183.12250-0.656102.412501.54700K562HNRNPM
FHITENSG00000189283.5396.89400523.10430-0.398302.451101.68080K562KIF1C
FHITENSG00000189283.5382.76330585.99990-0.614404.494003.27950K562MBNL1
FHITENSG00000189283.5288.46590212.768200.439002.250001.51700K562MTPAP
FHITENSG00000189283.5100.86620209.50420-1.054506.529404.67150K562NCBP2
FHITENSG00000189283.5316.39190236.400200.420402.417801.71540K562NSUN2
FHITENSG00000189283.5505.25800323.078300.645004.224003.19550K562PCBP3
FHITENSG00000189283.589.16690183.88870-1.044304.877603.88480K562PRPF8
FHITENSG00000189283.5114.85140232.72440-1.018907.379306.33170K562PTBP1
FHITENSG00000189283.5302.63930489.62930-0.694104.814503.74120K562PUF60
FHITENSG00000189283.5152.63570223.21430-0.548302.490701.69640K562RBM22
FHITENSG00000189283.5222.49210154.175500.529102.255501.36520K562RCC2
FHITENSG00000189283.5116.04260228.13520-0.975206.109005.06620K562SRSF1
FHITENSG00000189283.5118.78240248.56230-1.065307.822206.42960K562SYNCRIP
FHITENSG00000189283.5253.44900162.445800.641602.923701.96040K562TIAL1
FHITENSG00000189283.5315.20480214.481700.555303.275302.32630K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for FHIT is not available on ENCORE database.





1 RBPs can affect the splicing of FHIT :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSFHITENSG00000189283.5chr3-5973503559735305597350355973529459737946597380470.332000.000030.02565longerK562GPKOW

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for FHIT is not avaliable on ENCORE database.