SRP54

General Information

Gene Name       : SRP54
Gene ID             : ENSG00000100883.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SRP54)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SRP54ENSG00000100883.1184.8978.6381.76ENCSR000AEF
HepG2SRP54ENSG00000100883.1186.93141.45114.19ENCSR985KAT
K562SRP54ENSG00000100883.1146.7346.9546.84ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SRP54 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SRP54 RNA is bound by 25 proteins.  







eCLIP assay for SRP54 is not avaliable on ENCORE database.





25 proteins are bound to SRP54 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr143546589035465984+3'-UTR,5'-UTR,CDS3.935344.26718HepG2UCHL5
chr143548079335480848+3'-UTR,CDS4.7738327.36714HepG2BCLAF1
chr143548256735482616+3'-UTR,CDS4.6390720.54387HepG2BCLAF1
chr143549848035498546+3'-UTR3.637357.03189K562U2AF1
chr143548255135482609+3'-UTR,CDS,intron-Proximal3.827955.41973HepG2G3BP1
chr143549847035498541+3'-UTR4.2106813.53075HepG2PTBP1
chr143549847235498562+3'-UTR4.5834915.54062K562PTBP1
chr143548079235480840+3'-UTR,CDS4.059078.80691HepG2GRWD1
chr143548255335482566+3'-UTR,CDS5.530349.32793HepG2BCLAF1
chr143549830935498450+3'-UTR,CDS4.069894.13050K562LIN28B
chr143548084835480865+3'-UTR,CDS4.5406213.76815HepG2BCLAF1
chr143548261735482701+3'-UTR,CDS,intron-Proximal3.495386.13998HepG2G3BP1
chr143549859435498650+3'-UTR4.419594.23889K562TIA1
chr143549848335498573+3'-UTR4.0552519.30367HepG2U2AF2
chr143549865635498720+3'-UTR3.161176.57813HepG2ZC3H11A
chr143547797935477990+3'-UTR,CDS,intron-Proximal3.448829.25770HepG2BCLAF1
chr143549845635498483+3'-UTR3.282283.89082K562TIA1
chr143549848535498554+3'-UTR3.225663.93230HepG2U2AF1
chr143549851535498544+3'-UTR4.1478711.67911K562TIA1
chr143549826635498360+3'-UTR,CDS,intron-Proximal3.337316.17838K562ZNF622
chr143546594535465990+5'-UTR,CDS3.231587.40344HepG2PPIG
chr143545222135452282+5'-UTR,intron-Proximal3.645154.08283K562DDX3X
chr143545241135452453+5'-UTR,intron-Distal,intron-Proximal4.235954.27476HepG2AQR
chr143545241235452485+5'-UTR,intron-Distal,intron-Proximal3.8811615.98598HepG2PRPF8
chr143545234235452422+5'-UTR,intron-Distal,intron-Proximal3.431464.72220HepG2DDX3X
chr143545232235452392+5'-UTR,intron-Distal,intron-Proximal3.792216.45532K562GEMIN5
chr143548400635484036+CDS3.8631412.80995HepG2BCLAF1
chr143548394835483986+CDS,intron-Proximal3.1951313.15102HepG2BCLAF1
chr143548303535483075+CDS3.750116.46902HepG2U2AF2
chr143548817835488266+CDS3.653609.48271K562ZNF622
chr143546882235468842+CDS,intron-Distal,intron-Proximal3.343377.33138HepG2BCLAF1
chr143548818835488261+CDS4.8265425.23050HepG2BCLAF1
chr143549825835498299+CDS,intron-Proximal3.029156.31188HepG2U2AF2
chr143549728035497320+CDS,intron-Proximal7.05583123.85426K562U2AF2
chr143548789935487919+CDS4.259399.98400HepG2BCLAF1
chr143547647735476535+CDS,intron-Distal,intron-Proximal3.0973615.89452HepG2U2AF2
chr143549727935497340+CDS,intron-Proximal5.1385157.39793HepG2U2AF2
chr143549728035497334+CDS,intron-Proximal5.8486626.30885HepG2U2AF1
chr143549220335492245+CDS3.8081810.64917HepG2BCLAF1
chr143547021535470225+CDS,intron-Distal3.409623.07653K562ZNF622
chr143547654435476590+CDS,intron-Distal4.4600719.15795HepG2BCLAF1
chr143549833035498342+CDS4.042293.82000HepG2GRWD1
chr143547648035476526+CDS,intron-Distal,intron-Proximal4.502794.59919HepG2AQR
chr143547648235476533+CDS,intron-Distal,intron-Proximal3.193614.83784K562U2AF2
chr143547649035476531+CDS,intron-Distal3.4330012.94085HepG2BCLAF1
chr143547020935470227+CDS,intron-Distal,intron-Proximal4.5175712.43877HepG2BCLAF1
chr143548300135483062+CDS,intron-Proximal3.986633.88027HepG2U2AF1
chr143547016335470227+CDS,intron-Distal,intron-Proximal3.562783.23099HepG2UCHL5
chr143549228335492287+CDS,intron-Proximal3.787863.11149HepG2G3BP1
chr143549731835497327+CDS4.7752525.56565K562U2AF1
chr143549728635497318+CDS,intron-Proximal5.9171951.14693K562U2AF1
chr143549727435497327+CDS,intron-Proximal3.7299223.16112K562SF3B4
chr143547783735477899+CDS,intron-Proximal3.3037220.40388HepG2BCLAF1
chr143547783635477900+CDS,intron-Proximal3.485779.21245K562DDX24
chr143547782135477867+CDS,intron-Proximal3.079377.61934HepG2U2AF2
chr143548310235483153+CDS,intron-Proximal4.945529.97647HepG2PRPF8
chr143549727435497322+CDS,intron-Proximal3.241963.95401K562SMNDC1
chr143548793135487971+CDS4.5231915.99938HepG2BCLAF1
chr143548265035482699+CDS3.0536315.10664HepG2BCLAF1
chr143548817135488188+CDS,intron-Proximal4.0117413.23699HepG2BCLAF1
chr143548303935483068+CDS4.008153.68241HepG2G3BP1
chr143548394835483971+CDS,intron-Proximal3.941923.11282HepG2G3BP1
chr143549732035497332+CDS7.5772064.64393K562U2AF2
chr143546387435463935+intron-Distal3.447653.89405HepG2PTBP1
chr143548562435485674+intron-Distal3.788008.57718HepG2PTBP1
chr143549544035495501+intron-Distal4.3175010.47434HepG2ILF3
chr143546925335469317+intron-Distal3.786894.79983HepG2U2AF2
chr143548512835485167+intron-Distal4.040658.05781HepG2SUGP2
chr143548569235485747+intron-Distal6.0418814.72968HepG2PTBP1
chr143545242835452465+intron-Distal,intron-Proximal4.288113.12843K562PRPF8
chr143548589035485931+intron-Distal3.861657.75281HepG2SUGP2
chr143548530935485432+intron-Distal4.013369.50668HepG2PTBP1
chr143548563135485755+intron-Distal4.9615617.33398HepG2MATR3
chr143548496035484985+intron-Distal4.602243.62238HepG2MATR3
chr143547478435474856+intron-Distal4.641366.59893HepG2ILF3
chr143547010135470138+intron-Distal,intron-Proximal3.091925.24728HepG2U2AF2
chr143547462535474669+intron-Distal3.503316.63305HepG2ILF3
chr143548560535485635+intron-Distal4.022847.80398HepG2SUGP2
chr143548593135485991+intron-Distal4.0215615.18122HepG2SUGP2
chr143547449135474537+intron-Distal4.725893.98468HepG2ILF3
chr143548531035485468+intron-Distal3.802469.22841HepG2MATR3
chr143548543235485459+intron-Distal3.688584.48652HepG2PTBP1
chr143548563535485748+intron-Distal4.3539922.34417HepG2SUGP2
chr143548670135486743+intron-Distal3.311143.89405HepG2PTBP1
chr143548532035485429+intron-Distal5.060808.08294K562MATR3
chr143549494735494997+intron-Distal3.426903.81590K562HNRNPL
chr143548744535487482+intron-Distal3.105084.63410HepG2SUGP2
chr143548500735485116+intron-Distal3.7189014.54362HepG2SUGP2
chr143547462235474721+intron-Distal3.929583.08243K562ILF3
chr143549462935494808+intron-Distal3.061966.82131HepG2HNRNPL
chr143548574835485802+intron-Distal3.348268.45897HepG2SUGP2
chr143549463535494688+intron-Distal3.970633.39667K562HNRNPL
chr143548183435481910+intron-Distal3.245663.76090HepG2U2AF2
chr143548498535485059+intron-Distal3.392616.77715HepG2MATR3
chr143547009335470133+intron-Distal,intron-Proximal4.579273.93614HepG2AQR
chr143548563335485731+intron-Distal4.478058.54663K562PTBP1
chr143549258135492632+intron-Distal3.568667.61543HepG2U2AF2
chr143545243135452486+intron-Distal,intron-Proximal4.508815.66020HepG2TIAL1
chr143546858735468694+intron-Distal,intron-Proximal5.367648.68064HepG2QKI
chr143548650635486538+intron-Distal3.494044.57452HepG2SUGP2
chr143548658135486659+intron-Distal5.405237.79427HepG2PTBP1
chr143549486435494946+intron-Distal3.617315.26345K562HNRNPL
chr143548649235486545+intron-Distal3.886016.71645HepG2PTBP1
chr143547466935474756+intron-Distal4.105389.03981HepG2ILF3
chr143546886435468912+intron-Distal,intron-Proximal4.860593.62536K562AQR
chr143545298135453108+intron-Distal4.8525410.58655HepG2QKI
chr143549492735495037+intron-Distal3.405526.32590HepG2HNRNPL
chr143548559835485739+intron-Distal4.1635912.07253K562MATR3
chr143548543035485472+intron-Distal3.041416.57022HepG2SUGP2
chr143548567435485692+intron-Distal3.674537.34566HepG2PTBP1
chr143549724235497274+intron-Proximal3.176956.00009K562SF3B4
chr143549727935497286+intron-Proximal7.0749257.69771K562U2AF1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SRP54 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SRP54 is not available on ENCORE database.

  • 75 RBPs can affect the levels of SRP54.  








The Knockdown/knockout RNA-Seq assay for SRP54 is not available on ENCORE database.





75 RBPs can affect the gene expression of SRP54 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SRP54ENSG00000100883.73960.131803029.669700.386309.201908.22460HepG2ACO1
SRP54ENSG00000100883.72601.627203240.95170-0.317002.560701.60120HepG2ADAR
SRP54ENSG00000100883.75733.250004283.054700.420603.368702.78990HepG2AKAP1
SRP54ENSG00000100883.75371.763104302.703100.320103.853802.96650HepG2CALR
SRP54ENSG00000100883.73137.817604679.43790-0.576605.311104.38730HepG2CPSF6
SRP54ENSG00000100883.75028.358404170.555000.269703.985503.24010HepG2CELF1
SRP54ENSG00000100883.73530.772104484.47950-0.345008.948407.73490HepG2DAZAP1
SRP54ENSG00000100883.72470.892402802.13040-0.181502.329201.55930HepG2DDX19B
SRP54ENSG00000100883.75303.644604102.778000.370303.093502.43650HepG2DDX3X
SRP54ENSG00000100883.72400.411402898.64040-0.272103.890203.11370HepG2DKC1
SRP54ENSG00000100883.72404.728403234.64850-0.4277011.7777010.53290HepG2DNAJC2
SRP54ENSG00000100883.73109.901702413.521400.365603.232102.03470HepG2EFTUD2
SRP54ENSG00000100883.74605.044605183.18720-0.170602.059201.52440HepG2ETF1
SRP54ENSG00000100883.72875.615402363.125700.283102.514501.76360HepG2FUBP3
SRP54ENSG00000100883.72823.406303720.55520-0.398103.627202.59990HepG2G3BP2
SRP54ENSG00000100883.72510.642303294.75810-0.392104.618103.81210HepG2HNRNPA1
SRP54ENSG00000100883.72584.705203664.80030-0.503706.782405.73440HepG2HNRNPC
SRP54ENSG00000100883.73317.642104009.69040-0.273304.164003.30300HepG2HNRNPF
SRP54ENSG00000100883.73164.536904085.05070-0.3684010.196308.98040HepG2HNRNPL
SRP54ENSG00000100883.73715.410805062.50440-0.446303.581702.87550HepG2HNRNPLL
SRP54ENSG00000100883.73006.066403640.57150-0.276304.635903.86860HepG2HNRNPU
SRP54ENSG00000100883.73331.501103948.40600-0.245102.403401.72680HepG2IGF2BP1
SRP54ENSG00000100883.72542.256903562.13720-0.486605.029504.14350HepG2IGF2BP2
SRP54ENSG00000100883.74782.362503800.326900.331502.317601.73690HepG2MATR3
SRP54ENSG00000100883.74917.076502851.783200.785805.754004.43960HepG2PABPC1
SRP54ENSG00000100883.73030.784303435.25070-0.180702.062201.52560HepG2PCBP1
SRP54ENSG00000100883.74342.285803279.994800.404702.252101.31290HepG2PCBP2
SRP54ENSG00000100883.72368.248003247.10040-0.455308.353907.12070HepG2PPIL4
SRP54ENSG00000100883.75370.498603165.583600.762505.518304.54330HepG2RAVER1
SRP54ENSG00000100883.74989.616304332.199100.203702.462401.96610HepG2RBM22
SRP54ENSG00000100883.74394.642303435.763900.355004.280203.45630HepG2RBM25
SRP54ENSG00000100883.73019.254003623.26650-0.263103.969603.24820HepG2RECQL
SRP54ENSG00000100883.73626.479304319.33500-0.252202.165401.55220HepG2RPLP0
SRP54ENSG00000100883.73117.518202224.930100.486504.538403.56160HepG2RRP9
SRP54ENSG00000100883.75096.750204005.790700.347402.120401.52870HepG2SF3A3
SRP54ENSG00000100883.73502.654404070.05170-0.216603.810503.00740HepG2SLBP
SRP54ENSG00000100883.77697.382805575.640700.465102.433201.70210HepG2SNRNP70
SRP54ENSG00000100883.76307.841304893.083700.3663010.062409.26880HepG2SRFBP1
SRP54ENSG00000100883.75843.955703798.598600.6214023.9770022.88420HepG2SRSF1
SRP54ENSG00000100883.73532.134204191.10310-0.246803.813303.09950HepG2SRSF5
SRP54ENSG00000100883.73143.036503939.36890-0.325805.809304.86150HepG2SRSF7
SRP54ENSG00000100883.73702.084503090.404700.260404.373803.70980HepG2SRSF9
SRP54ENSG00000100883.73737.803104933.40700-0.400403.271202.48980HepG2TARDBP
SRP54ENSG00000100883.71540.986203537.52910-1.1989042.4474040.92450HepG2TIAL1
SRP54ENSG00000100883.72761.002803569.11590-0.370407.541906.68800HepG2TRIM56
SRP54ENSG00000100883.75755.029803732.962400.624408.326707.23560HepG2U2AF1
SRP54ENSG00000100883.73402.226402821.657600.269804.198003.39710HepG2ZC3H8
SRP54ENSG00000100883.73420.096803907.09650-0.192103.236602.65920HepG2ZNF622
SRP54ENSG00000100883.73951.716103040.443700.378104.155503.35170K562AKAP8L
SRP54ENSG00000100883.73698.420503190.142800.213202.264301.44590K562ATP5C1
SRP54ENSG00000100883.71205.111401457.47510-0.274302.572201.32070K562BCCIP
SRP54ENSG00000100883.71189.228501408.34910-0.244002.375001.48800K562BCLAF1
SRP54ENSG00000100883.72292.792901844.171300.314002.325701.53220K562BOP1
SRP54ENSG00000100883.72040.679502583.89370-0.340505.036003.51100K562CPEB4
SRP54ENSG00000100883.7864.349901068.44240-0.305802.508901.50900K562CSTF2
SRP54ENSG00000100883.73741.321103271.783500.193402.099201.34780K562DKC1
SRP54ENSG00000100883.71184.636001549.45630-0.387304.578703.56620K562EIF3G
SRP54ENSG00000100883.72708.141503291.75420-0.281603.410302.37090K562EIF4G2
SRP54ENSG00000100883.71875.467101369.846700.453105.773603.73960K562FUS
SRP54ENSG00000100883.71417.130301799.72590-0.344804.242603.51630K562FXR1
SRP54ENSG00000100883.72942.620501989.962800.564301.909101.33430K562G3BP2
SRP54ENSG00000100883.72526.325201872.183300.432204.756003.71950K562GPKOW
SRP54ENSG00000100883.71973.706302416.15430-0.291802.630001.60340K562HNRNPL
SRP54ENSG00000100883.71563.681502093.49040-0.421004.370903.31000K562MAGOH
SRP54ENSG00000100883.73508.731102533.649400.469603.483402.46790K562NAA15
SRP54ENSG00000100883.72182.815101728.006100.337003.805902.34500K562NCBP2
SRP54ENSG00000100883.72284.152701704.013200.422603.415702.49060K562PCBP3
SRP54ENSG00000100883.71643.696201307.071700.330503.317602.43580K562POLR2G
SRP54ENSG00000100883.71620.584501132.782900.516505.198604.17140K562PRPF8
SRP54ENSG00000100883.71029.423901437.97010-0.482204.542203.34060K562PSIP1
SRP54ENSG00000100883.73156.914503743.03520-0.245702.898201.91660K562PUM2
SRP54ENSG00000100883.74236.441603015.341200.490405.880305.12520K562PUS1
SRP54ENSG00000100883.73689.579302937.949900.328504.596603.85170K562RBM15
SRP54ENSG00000100883.71541.120701950.68500-0.340002.894102.03040K562RBM22
SRP54ENSG00000100883.71651.426202052.68620-0.313802.337901.35130K562NELFE
SRP54ENSG00000100883.71634.280101153.920300.502004.274103.25570K562RPS19
SRP54ENSG00000100883.71444.039801943.44260-0.428502.244101.35190K562RPS3
SRP54ENSG00000100883.7986.478501243.53070-0.334102.435601.48840K562SRFBP1
SRP54ENSG00000100883.71403.473001876.35350-0.418904.555603.14760K562SRSF4
SRP54ENSG00000100883.71663.232802018.05500-0.279001.945501.34560K562TARDBP
SRP54ENSG00000100883.7757.252001383.11170-0.8691011.046309.07440K562TIAL1
SRP54ENSG00000100883.72509.032502150.271800.222502.835302.10790K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SRP54 is not available on ENCORE database.





14 RBPs can affect the splicing of SRP54 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESRP54ENSG00000100883.7chr14+354921153549228635488171354882803549729335497389-0.078000.000000.00000excludedK562AKAP8L
SESRP54ENSG00000100883.7chr14+354701413547022635468763354688553547648835476593-0.057000.000010.00028excludedK562AQR
SESRP54ENSG00000100883.7chr14+354777133547789935476488354765933547797935478037-0.078000.000010.00016excludedK562AQR
SESRP54ENSG00000100883.7chr14+354687633546885535465882354659933547014135470226-0.169000.000010.00170excludedK562SUPV3L1
SESRP54ENSG00000100883.7chr14+354921153549228635488171354882803549729335497389-0.159000.000000.00000excludedK562PUS1
SESRP54ENSG00000100883.7chr14+354921153549228635488171354882803549729335497389-0.072000.000090.00315excludedK562U2AF1
SESRP54ENSG00000100883.7chr14+354921153549228635488171354882803549729335497389-0.101000.000000.00000excludedK562UTP18
SESRP54ENSG00000100883.7chr14+354921153549228635488171354882803549729335497389-0.055000.000120.00714excludedK562TARDBP
SESRP54ENSG00000100883.7chr14+354921153549228635488171354882803549729335497389-0.085000.000000.00000excludedK562RBM15
SESRP54ENSG00000100883.7chr14+354921153549228635488171354882803549729335497389-0.137000.000000.00000excludedK562AGGF1
MXESRP54ENSG00000100883.7chr14+35477979354780373548071435480865354764883547659335482551354827000.094000.000000.000011includedK562AQR
MXESRP54ENSG00000100883.7chr14+35468763354688553547014135470226354658823546599335476488354765930.099000.003670.027761includedK562AQR
MXESRP54ENSG00000100883.7chr14+3548071435480865354825513548270035477979354780373548300735483108-0.148000.000000.000012includedHepG2SFPQ
MXESRP54ENSG00000100883.7chr14+3546876335468850354701413547022635465882354659933547648835476593-0.085000.000400.015362includedHepG2HNRNPU
MXESRP54ENSG00000100883.7chr14+3546876335468855354701413547022635465882354659933547648835476593-0.104000.000200.008942includedHepG2HNRNPU
MXESRP54ENSG00000100883.7chr14+3546876335468855354701413547022635465882354659933547648835476593-0.098000.003780.084052includedK562DHX30
MXESRP54ENSG00000100883.7chr14+3546876335468850354701413547022635465882354659933547648835476593-0.101000.000100.006522includedHepG2TIAL1
MXESRP54ENSG00000100883.7chr14+3546876335468855354701413547022635465882354659933547648835476593-0.118000.000090.005872includedHepG2TIAL1
MXESRP54ENSG00000100883.7chr14+35468763354688553547014135470226354658823546599335476488354765930.063000.000170.006841includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SRP54 is not avaliable on ENCORE database.