SENP3

General Information

Gene Name       : SENP3
Gene ID             : ENSG00000161956.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SENP3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SENP3ENSG00000161956.1284.4876.9180.69ENCSR000AEF
HepG2SENP3ENSG00000161956.1247.7749.0948.43ENCSR985KAT
K562SENP3ENSG00000161956.1271.3068.3969.84ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
SENP35591S1Submitted, ENCORE2BGHcLV45-61, Experimented, ENCORE2BGKcLV44-61, Submitting, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
SENP3K562CRISPRBGKcLV42-85,BGKcLV42-86BGKcLV42-1,BGKcLV42-20.0,0.0NotSatisfiedENCORE2
SENP3K562CRISPRSENP3-BGKcLV44-61,SENP3-BGKcLV44-62NT-BGKcLV44-1,NT-BGKcLV44-270.9,63.6SequencedENCORE2
SENP3HepG2CRISPRBGHcLV45-61,BGHcLV45-62BGHcLV45-1,BGHcLV45-291.0,84.6SequencingENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
SENP3Product_ID: 5591S
Lot_ID: 1
Source: Cell Signaling Technology
Target Name: SENP3-human		 SENP3-HEPG2-CRISPR-5591S.png<br>Caption: Western blot following CRISPR against SENP3 in HepG2 whole cell lysate using SENP3 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SENP3. SENP3 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
 CST_5591S_1_SENP3.png<br>Caption: IP-WB analysis of 5591S whole cell lysate using the SENP3 specific antibody, 5591S. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the SENP3-specific antibody, 5591S. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
 SENP3-K562-CRISPR-5591S.png<br>Caption: Western blot following CRISPR against SENP3 in K562 whole cell lysate using SENP3 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SENP3. SENP3 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for SENP3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SENP3 RNA is bound by 20 proteins.  







eCLIP assay for SENP3 is not avaliable on ENCORE database.





20 proteins are bound to SENP3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1774750727475098+3'-UTR,intron-Distal3.525303.68829K562YBX3
chr1774749497475066+3'-UTR,intron-Distal,intron-Proximal3.877245.09919K562DDX55
chr1774749547475011+3'-UTR,intron-Distal,intron-Proximal4.133033.59284HepG2LSM11
chr1774749547475008+3'-UTR,intron-Distal,intron-Proximal4.7269844.09871K562PABPC4
chr1774749587475037+3'-UTR,intron-Distal,intron-Proximal4.398519.71303HepG2DDX55
chr1774748687474926+3'-UTR,intron-Distal,intron-Proximal3.150556.91621HepG2PCBP2
chr1774749497475102+3'-UTR,intron-Distal,intron-Proximal3.000395.56734HepG2LARP4
chr1774749797475098+3'-UTR,intron-Distal,intron-Proximal5.243707.04291K562DDX6
chr1774749557475020+3'-UTR,intron-Distal,intron-Proximal3.458594.23616K562TIA1
chr1774653537465425+5'-UTR4.003163.01017K562CPSF6
chr1774653577465471+5'-UTR3.519909.60639K562DDX3X
chr1774654627465555+5'-UTR3.276473.39306HepG2GRWD1
chr1774652857465333+5'-UTR4.634716.05264HepG2DDX3X
chr1774655517465613+5'-UTR,intron-Proximal5.013025.01842HepG2PRPF8
chr1774663567466431+5'-UTR,CDS,intron-Proximal3.559329.76884HepG2BUD13
chr1774653637465438+5'-UTR3.652135.96826K562FTO
chr1774663637466438+5'-UTR,CDS,intron-Proximal4.8256411.38882K562BUD13
chr1774652727465352+5'-UTR4.656965.23978HepG2PRPF4
chr1774653627465430+5'-UTR4.002945.37959K562GEMIN5
chr1774653547465442+5'-UTR4.556964.21542HepG2SRSF1
chr1774653597465416+5'-UTR3.685933.14867K562DDX55
chr1774653527465423+5'-UTR3.457805.82976HepG2PRPF4
chr1774655597465660+5'-UTR,intron-Proximal5.395797.23718K562AQR
chr1774687567468775+CDS,intron-Proximal4.584685.52963HepG2PPIG
chr1774690767469125+CDS,intron-Proximal3.965815.90868HepG2PRPF8
chr1774683757468387+CDS4.695875.56813HepG2PPIG
chr1774702877470318+CDS,intron-Distal,intron-Proximal3.267183.05161HepG2PPIG
chr1774682777468329+CDS3.196224.69671HepG2PPIG
chr1774702627470312+CDS,intron-Distal,intron-Proximal4.026883.02457HepG2BCLAF1
chr1774662947466356+intron-Proximal3.348516.43421HepG2BUD13
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SENP3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SENP3 is not available on ENCORE database.

  • 64 RBPs can affect the levels of SENP3.  








The Knockdown/knockout RNA-Seq assay for SENP3 is not available on ENCORE database.





64 RBPs can affect the gene expression of SENP3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SENP3ENSG00000161956.8533.52600738.15790-0.468405.415404.62060HepG2ACO1
SENP3ENSG00000161956.8954.268601143.60210-0.261102.499601.84130HepG2AUH
SENP3ENSG00000161956.81248.00660779.372200.679108.127707.16670HepG2BOP1
SENP3ENSG00000161956.8518.60280678.85810-0.388502.772001.99890HepG2CALR
SENP3ENSG00000161956.8458.49940715.48000-0.642005.027404.12490HepG2CPSF6
SENP3ENSG00000161956.8649.13500837.81980-0.368103.672202.95250HepG2CELF1
SENP3ENSG00000161956.8414.35590593.50300-0.518403.941402.78440HepG2DHX30
SENP3ENSG00000161956.8680.61690905.21050-0.411402.911501.79130HepG2ESF1
SENP3ENSG00000161956.8454.10960636.00030-0.486003.740602.83450HepG2FUBP3
SENP3ENSG00000161956.81010.36130766.968800.397502.651201.97380HepG2FXR1
SENP3ENSG00000161956.8385.05460810.98070-1.0746012.1976010.94240HepG2GPKOW
SENP3ENSG00000161956.8615.46590827.98390-0.427904.754503.58080HepG2HNRNPA2B1
SENP3ENSG00000161956.8557.84810773.94030-0.472403.076602.41710HepG2HNRNPLL
SENP3ENSG00000161956.8521.78820717.10840-0.458703.391002.04330HepG2NAA15
SENP3ENSG00000161956.8469.58990686.29810-0.547403.490302.64850HepG2NSUN2
SENP3ENSG00000161956.8320.43830473.62480-0.563702.363201.55480HepG2PABPC1
SENP3ENSG00000161956.8666.32590809.33150-0.280502.324601.60910HepG2PRPF4
SENP3ENSG00000161956.8322.28910516.93360-0.681605.273404.19430HepG2PRPF8
SENP3ENSG00000161956.8681.25990852.81960-0.324002.378701.81960HepG2PUF60
SENP3ENSG00000161956.81169.08810905.256500.368904.829004.09050HepG2PUM1
SENP3ENSG00000161956.8557.52550784.17450-0.492102.891302.20460HepG2RBM25
SENP3ENSG00000161956.8650.44770478.692000.442203.122102.47410HepG2RPS19
SENP3ENSG00000161956.8602.68500766.00660-0.346002.123901.49990HepG2SF3B1
SENP3ENSG00000161956.8699.72930817.62020-0.224601.971001.36080HepG2SLBP
SENP3ENSG00000161956.8786.32240566.250800.473602.674801.73500HepG2SMNDC1
SENP3ENSG00000161956.8331.13720852.33150-1.3640013.5203011.81520HepG2SNRNP70
SENP3ENSG00000161956.8924.026001239.52620-0.423805.848805.19520HepG2SRFBP1
SENP3ENSG00000161956.8584.09000841.97630-0.527606.941006.01200HepG2SRSF5
SENP3ENSG00000161956.8526.55270705.28330-0.421602.084001.59120HepG2SRSF9
SENP3ENSG00000161956.8789.854401076.16960-0.446205.899505.20470HepG2SSB
SENP3ENSG00000161956.81212.84040957.609400.340803.896503.18090HepG2SUCLG1
SENP3ENSG00000161956.8501.68620712.53250-0.506204.204803.05750HepG2SUPT6H
SENP3ENSG00000161956.8430.89830667.32330-0.631004.893204.03260HepG2SUPV3L1
SENP3ENSG00000161956.8493.00200779.11530-0.660204.402103.71980HepG2TAF15
SENP3ENSG00000161956.8558.66800672.97200-0.268601.984501.49170HepG2TRIM56
SENP3ENSG00000161956.81355.71220750.454200.8531020.9932019.57430HepG2UTP3
SENP3ENSG00000161956.8606.00230854.88230-0.496407.116006.34380HepG2ZNF622
SENP3ENSG00000161956.82027.238301599.009600.342203.653502.20510K562APOBEC3C
SENP3ENSG00000161956.81227.100601473.92560-0.264401.854901.35610K562AQR
SENP3ENSG00000161956.8697.80740897.80880-0.363602.872802.07560K562CPSF6
SENP3ENSG00000161956.81772.200102227.81480-0.330103.215502.16710K562CELF1
SENP3ENSG00000161956.82495.153601579.014500.660007.155106.17520K562DDX47
SENP3ENSG00000161956.81236.158401474.56890-0.254402.489001.80020K562EIF2S2
SENP3ENSG00000161956.81011.92390727.587700.475802.355601.43450K562EIF3A
SENP3ENSG00000161956.8846.93100475.080700.8340013.1353011.36500K562EIF3G
SENP3ENSG00000161956.8582.65480788.85740-0.437102.835101.69260K562FKBP4
SENP3ENSG00000161956.8574.17890774.20090-0.431202.795001.87550K562FTO
SENP3ENSG00000161956.81355.71880604.101801.1661031.8051029.88780K562FXR1
SENP3ENSG00000161956.8166.48880325.92490-0.969106.163205.01630K562G3BP2
SENP3ENSG00000161956.81358.332501009.593000.428003.153602.15430K562HNRNPM
SENP3ENSG00000161956.8761.16070526.836600.530705.063203.91950K562MAGOH
SENP3ENSG00000161956.8745.36010525.734200.503504.590603.37390K562MATR3
SENP3ENSG00000161956.8430.06640708.96950-0.721203.069502.01570K562PABPN1
SENP3ENSG00000161956.81162.475201468.74490-0.337402.229701.48400K562PCBP3
SENP3ENSG00000161956.8937.538201126.52540-0.264902.001901.31900K562POLR2G
SENP3ENSG00000161956.81040.07850511.871301.0227018.8821017.22560K562PTBP1
SENP3ENSG00000161956.8657.83050490.702700.422802.961102.08900K562RBM22
SENP3ENSG00000161956.8731.78110516.414300.502802.470901.44730K562NELFE
SENP3ENSG00000161956.81260.66050845.739800.575804.758203.68460K562RPS19
SENP3ENSG00000161956.8768.72840453.473400.761404.613103.27880K562RPS3
SENP3ENSG00000161956.81343.863801003.924700.420603.858902.57140K562SAFB
SENP3ENSG00000161956.8450.74590338.729300.412102.662001.82570K562SF3B4
SENP3ENSG00000161956.8890.71210501.829300.8277011.350709.92890K562SRSF1
SENP3ENSG00000161956.81722.036001130.006200.607709.477407.95250K562SYNCRIP
SENP3ENSG00000161956.8666.09310507.830600.391302.458001.78880K562TARDBP
SENP3ENSG00000161956.8987.883301229.16800-0.315302.108201.34560K562WDR3
SENP3ENSG00000161956.81534.728601278.089800.263903.108802.21340K562WDR43
SENP3ENSG00000161956.81239.032101660.56510-0.422504.296803.18400K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SENP3 is not available on ENCORE database.






No RBPs affect the alternative splcing events of SENP3 on ENCORE database.





The Knockdown/knockout RNA-Seq assay for SENP3 is not avaliable on ENCORE database.