PPP6C

General Information

Gene Name       : PPP6C
Gene ID             : ENSG00000119414.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PPP6C)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PPP6CENSG00000119414.1129.0326.4127.72ENCSR000AEF
HepG2PPP6CENSG00000119414.1114.8223.6919.26ENCSR985KAT
K562PPP6CENSG00000119414.1125.9827.5026.74ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PPP6C is not avaliable on ENCORE database.



Proteins bound to RNA
  • PPP6C RNA is bound by 7 proteins.  







eCLIP assay for PPP6C is not avaliable on ENCORE database.





7 proteins are bound to PPP6C RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr9127910129127910202-3'-UTR,intron-Distal5.2578720.44243K562LIN28B
chr9127911584127911619-3'-UTR,intron-Distal3.745147.06138K562LIN28B
chr9127911693127911767-3'-UTR,intron-Distal,intron-Proximal3.2843621.72308K562FAM120A
chr9127911621127911637-3'-UTR,intron-Distal4.8912712.53767K562LIN28B
chr9127911920127911994-3'-UTR,CDS,intron-Distal3.078833.34573K562IGF2BP2
chr9127933449127933459-5'-UTR,CDS,intron-Distal3.106334.97511K562YBX3
chr9127951937127951972-5'-UTR,CDS,intron-Distal4.7983615.99374K562YBX3
chr9127952004127952021-5'-UTR,intron-Distal5.694927.12859K562DDX3X
chr9127952021127952067-5'-UTR,intron-Distal,intron-Proximal4.476037.63469K562DDX3X
chr9127933404127933460-5'-UTR,CDS,intron-Distal,intron-Proximal3.443966.97927K562DDX3X
chr9127951922127952004-5'-UTR,CDS,intron-Distal4.6773416.75565K562DDX3X
chr9127951980127952003-5'-UTR,CDS,intron-Distal4.3840617.75754K562YBX3
chr9127951972127951980-5'-UTR,CDS,intron-Distal5.0197319.19863K562YBX3
chr9127923130127923184-CDS,intron-Distal3.061414.53299K562YBX3
chr9127912066127912130-CDS,intron-Distal3.119575.56979K562YBX3
chr9127912045127912119-CDS,intron-Distal4.2747441.58521K562PUM2
chr9127912088127912133-CDS,intron-Distal4.534255.86049K562LIN28B
chr9127915925127915995-CDS,intron-Distal3.530334.31744K562YBX3
chr9127920522127920580-CDS,intron-Distal3.484376.97264K562YBX3
chr9127912140127912166-CDS,intron-Distal3.341376.40723K562YBX3
chr9127912004127912045-CDS,intron-Distal4.4205539.80701K562PUM2
chr9127912166127912191-CDS,intron-Distal3.423157.02805K562YBX3
chr9127920661127920751-intron-Distal,intron-Proximal3.763023.06150K562KHSRP
chr9127916062127916169-intron-Distal,intron-Proximal4.379975.68841K562KHSRP
chr9127912215127912327-intron-Distal4.233595.19823K562KHSRP
chr9127922986127923063-intron-Distal,intron-Proximal3.720303.02234K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PPP6C is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PPP6C is not available on ENCORE database.

  • 65 RBPs can affect the levels of PPP6C.  








The Knockdown/knockout RNA-Seq assay for PPP6C is not available on ENCORE database.





65 RBPs can affect the gene expression of PPP6C :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PPP6CENSG00000119414.71352.270301111.573300.282703.330202.67270HepG2ACO1
PPP6CENSG00000119414.7673.751301000.82780-0.570903.881002.83320HepG2BCLAF1
PPP6CENSG00000119414.71069.648801658.48510-0.632705.139803.79200HepG2CCAR1
PPP6CENSG00000119414.7878.670901111.34040-0.338904.298203.50360HepG2CKAP4
PPP6CENSG00000119414.71578.167201100.057600.520602.889702.10760HepG2CNOT7
PPP6CENSG00000119414.7648.84650954.32940-0.556603.040202.32400HepG2CPSF6
PPP6CENSG00000119414.71053.366801587.39800-0.591705.086004.27150HepG2DDX6
PPP6CENSG00000119414.7934.848601163.00790-0.315103.613002.88620HepG2DNAJC2
PPP6CENSG00000119414.7353.476701525.85560-2.1099052.2388049.98450HepG2EIF2S1
PPP6CENSG00000119414.71246.609801686.17790-0.435703.066002.39380HepG2EIF4A3
PPP6CENSG00000119414.71391.443601690.00800-0.280403.335102.43110HepG2EIF4G1
PPP6CENSG00000119414.71241.275301618.91680-0.383202.221501.48620HepG2EIF4G2
PPP6CENSG00000119414.7850.211101086.21340-0.353402.885802.03380HepG2EWSR1
PPP6CENSG00000119414.7639.00770932.46910-0.545205.442603.92260HepG2FASTKD2
PPP6CENSG00000119414.71235.982901675.69250-0.439103.716502.67470HepG2G3BP2
PPP6CENSG00000119414.71046.517601241.80510-0.246802.310501.65080HepG2HNRNPF
PPP6CENSG00000119414.71154.787601598.41530-0.469004.430103.56270HepG2HNRNPK
PPP6CENSG00000119414.71073.779701560.41900-0.5392011.9676010.65580HepG2HNRNPL
PPP6CENSG00000119414.71120.293501604.24300-0.518004.742603.87990HepG2IGF2BP2
PPP6CENSG00000119414.71135.313001337.18120-0.236102.111401.46160HepG2ILF2
PPP6CENSG00000119414.71216.653601750.97700-0.525203.876702.89070HepG2LARP4
PPP6CENSG00000119414.71274.674701702.09540-0.417203.204702.49960HepG2MAGOH
PPP6CENSG00000119414.71132.748201698.62170-0.584509.524508.13560HepG2NOL12
PPP6CENSG00000119414.7989.917701295.81900-0.388504.407303.36800HepG2PARN
PPP6CENSG00000119414.71174.328801518.22270-0.370505.188104.39850HepG2PCBP1
PPP6CENSG00000119414.7937.860201167.59540-0.316102.600801.88450HepG2PPIL4
PPP6CENSG00000119414.71467.947401721.28640-0.229702.934802.32790HepG2PUM1
PPP6CENSG00000119414.71148.623301673.14040-0.542708.335207.33890HepG2QKI
PPP6CENSG00000119414.71120.669301810.99510-0.6924013.9126012.92980HepG2RBM22
PPP6CENSG00000119414.7947.974001277.87000-0.430803.222002.14700HepG2RBM27
PPP6CENSG00000119414.71402.458101719.25950-0.293803.513702.91980HepG2NELFE
PPP6CENSG00000119414.71321.225001601.21120-0.277303.219002.56040HepG2RECQL
PPP6CENSG00000119414.7858.038701165.81510-0.442205.060404.23600HepG2SAFB2
PPP6CENSG00000119414.71638.846101253.983300.386102.242801.63520HepG2SF3A3
PPP6CENSG00000119414.7750.865801021.99930-0.444802.201701.56720HepG2SF3B1
PPP6CENSG00000119414.71249.655701608.40920-0.364105.107004.34510HepG2SF3B4
PPP6CENSG00000119414.71014.305701359.58750-0.422704.358603.58360HepG2SMN1
PPP6CENSG00000119414.71896.865901137.133300.738105.712704.58120HepG2SNRNP70
PPP6CENSG00000119414.71735.643302045.45560-0.237002.895902.38680HepG2SRFBP1
PPP6CENSG00000119414.72069.994101678.809000.302104.090303.54280HepG2SRSF1
PPP6CENSG00000119414.71025.068101220.03210-0.251202.455401.79690HepG2SRSF7
PPP6CENSG00000119414.71393.262101775.94550-0.350105.194604.53530HepG2SSB
PPP6CENSG00000119414.71336.450601820.76060-0.446108.565107.57180HepG2SUCLG1
PPP6CENSG00000119414.7716.704701006.08320-0.489302.644101.93300HepG2TARDBP
PPP6CENSG00000119414.7901.690301272.19570-0.496605.983605.30120HepG2TIAL1
PPP6CENSG00000119414.7763.766001283.36560-0.7487011.8076010.75970HepG2TRIM56
PPP6CENSG00000119414.71435.879801113.059100.367302.633202.01930HepG2U2AF1
PPP6CENSG00000119414.7874.849501143.09830-0.385804.498603.19960HepG2UTP18
PPP6CENSG00000119414.7794.047801109.66040-0.482803.102302.33570HepG2XRN2
PPP6CENSG00000119414.7943.208401205.24350-0.353703.925002.09670K562AKAP1
PPP6CENSG00000119414.73981.726002648.288800.588208.209507.28670K562AQR
PPP6CENSG00000119414.71210.683401545.38620-0.352104.726703.45300K562BCLAF1
PPP6CENSG00000119414.7534.72550777.87170-0.540704.378302.99310K562CCAR1
PPP6CENSG00000119414.71898.170502446.66750-0.366205.269503.70930K562CPEB4
PPP6CENSG00000119414.7874.339701172.40560-0.423204.490503.10180K562CSTF2
PPP6CENSG00000119414.7807.017001341.42300-0.7331015.4174012.61620K562EIF2S1
PPP6CENSG00000119414.71965.101001326.867200.5665010.900809.78570K562FXR1
PPP6CENSG00000119414.71810.781301408.420300.362402.057501.46070K562G3BP2
PPP6CENSG00000119414.71882.903701406.119300.421104.663803.90830K562HNRNPC
PPP6CENSG00000119414.72075.989201636.474600.343102.337201.48600K562HNRNPM
PPP6CENSG00000119414.7974.461301274.53470-0.387302.141001.33190K562KRR1
PPP6CENSG00000119414.71453.015901680.35300-0.209702.228401.49920K562MTPAP
PPP6CENSG00000119414.71510.489801867.10770-0.305805.406404.41500K562NSUN2
PPP6CENSG00000119414.72593.460303330.43660-0.360804.070602.36120K562PNPT1
PPP6CENSG00000119414.71850.635801285.731500.525305.597504.52920K562PRPF8
PPP6CENSG00000119414.7894.327001260.74150-0.495405.287903.98420K562PSIP1
PPP6CENSG00000119414.72033.362301721.313800.240301.980801.37040K562SRSF1
PPP6CENSG00000119414.71592.833601218.157400.386804.264603.23830K562SYNCRIP
PPP6CENSG00000119414.7975.497001288.29360-0.401303.248502.20480K562TRIM56
PPP6CENSG00000119414.71740.578901410.062400.303702.912902.08880K562U2AF2
PPP6CENSG00000119414.72146.982002983.51090-0.474705.926304.58670K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PPP6C is not available on ENCORE database.





17 RBPs can affect the splicing of PPP6C :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPPP6CENSG00000119414.7chr9-127923119127923185127916232127916264127933363127933459-0.178000.000280.07907excludedK562IGF2BP2
SEPPP6CENSG00000119414.7chr9-127915843127916021127908851127912200127916184127916264-0.067000.001530.02961excludedK562SRSF1
SEPPP6CENSG00000119414.7chr9-127920519127920661127916184127916264127933363127933459-0.199000.000000.00003excludedK562SF3B4
SEPPP6CENSG00000119414.7chr9-127923119127923185127920519127920661127933363127933459-0.094000.000560.01259excludedHepG2U2AF1
SEPPP6CENSG00000119414.7chr9-127923119127923185127916232127916264127933363127933459-0.118000.000040.00260excludedK562AKAP8L
SEPPP6CENSG00000119414.7chr9-127920519127920661127916158127916264127933363127933506-0.284000.000000.00000excludedK562AQR
SEPPP6CENSG00000119414.7chr9-127920519127920661127916184127916264127933363127933459-0.117000.000920.06804excludedK562SUPV3L1
SEPPP6CENSG00000119414.7chr9-127923119127923185127920519127920661127933363127933459-0.067000.006630.07700excludedK562PUS1
SEPPP6CENSG00000119414.7chr9-127915811127916014127911775127912200127916184127916264-0.078000.000210.00453excludedK562PUS1
SEPPP6CENSG00000119414.7chr9-127920519127920661127916184127916264127933363127933459-0.067000.000520.07157excludedK562LARP4
SEPPP6CENSG00000119414.7chr9-1279231191279231851279205191279206611279333631279334590.067000.000080.00559includedHepG2MATR3
SEPPP6CENSG00000119414.7chr9-127923119127923185127920519127920661127933363127933459-0.181000.000000.00008excludedK562U2AF1
SEPPP6CENSG00000119414.7chr9-127920519127920661127916184127916264127933363127933459-0.092000.000010.00256excludedK562HNRNPUL1
SEPPP6CENSG00000119414.7chr9-127923119127923185127920519127920661127933363127933459-0.086000.001610.04869excludedK562UTP18
SEPPP6CENSG00000119414.7chr9-127923119127923185127920519127920661127933363127933459-0.096000.002120.03653excludedK562U2AF2
SEPPP6CENSG00000119414.7chr9-127923119127923185127920519127920661127933363127933459-0.094000.000250.00917excludedK562RBM15
SEPPP6CENSG00000119414.7chr9-127915811127916014127911775127912200127916184127916264-0.062000.002510.05454excludedK562RBM15
SEPPP6CENSG00000119414.7chr9-127920519127920661127916184127916264127933363127933459-0.137000.000000.00011excludedK562AGGF1
SEPPP6CENSG00000119414.7chr9-127920519127920661127916184127916264127933363127933459-0.124000.000050.00429excludedK562HNRNPK
SEPPP6CENSG00000119414.7chr9-1279341871279342801279333631279334591279519221279520620.074000.000040.00267includedHepG2HNRNPC
SEPPP6CENSG00000119414.7chr9-1279231191279231851279205191279206611279333631279334590.070000.004650.06567includedK562HNRNPC
SEPPP6CENSG00000119414.7chr9-1279341871279342801279333631279334591279519221279520620.353000.000000.00000includedK562HNRNPC
MXEPPP6CENSG00000119414.7chr9-127920519127920661127923119127923185127916184127916264127933363127933459-0.149000.000030.002152includedK562RBM15
MXEPPP6CENSG00000119414.7chr9-127920519127920661127923119127923185127916184127916264127933363127933459-0.099000.004910.067992includedK562PUS1
MXEPPP6CENSG00000119414.7chr9-127920519127920648127923119127923185127916232127916264127933363127933459-0.082000.011850.072562includedK562AQR
MXEPPP6CENSG00000119414.7chr9-127920519127920661127923119127923185127916232127916264127933363127933459-0.095000.001290.011352includedK562AQR
MXEPPP6CENSG00000119414.7chr9-127920535127920661127923119127923185127916232127916264127933363127933459-0.249000.000000.000002includedK562AQR
MXEPPP6CENSG00000119414.7chr9-127920519127920661127923119127923185127916184127916264127933363127933459-0.115000.000920.038692includedK562AKAP8L

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PPP6C is not avaliable on ENCORE database.