PPP2CA

General Information

Gene Name       : PPP2CA
Gene ID             : ENSG00000113575.9
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PPP2CA)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PPP2CAENSG00000113575.952.9358.0755.50ENCSR000AEF
HepG2PPP2CAENSG00000113575.979.6179.1579.38ENCSR985KAT
K562PPP2CAENSG00000113575.968.5460.7564.65ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PPP2CA is not avaliable on ENCORE database.



Proteins bound to RNA
  • PPP2CA RNA is bound by 20 proteins.  







eCLIP assay for PPP2CA is not avaliable on ENCORE database.





20 proteins are bound to PPP2CA RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr5133533254133533285-3'-UTR,intron-Distal,intron-Proximal3.7443911.60152K562YBX3
chr5133541697133541823-3'-UTR,CDS,intron-Distal,intron-Proximal4.018203.35081HepG2G3BP1
chr5133533302133533356-3'-UTR,intron-Distal,intron-Proximal4.067758.72318K562YBX3
chr5133533385133533449-3'-UTR,intron-Distal4.096203.39686HepG2G3BP1
chr5133533073133533151-3'-UTR,intron-Distal3.215463.82829K562IGF2BP2
chr5133532795133532904-3'-UTR,intron-Distal5.2031434.44054HepG2SUB1
chr5133532254133532350-3'-UTR,intron-Distal4.3074214.36548K562PUM2
chr5133541701133541823-3'-UTR,CDS,intron-Distal,intron-Proximal3.836585.37552K562PUM1
chr5133533066133533132-3'-UTR,intron-Distal3.6893711.07688K562IGF2BP1
chr5133533367133533419-3'-UTR,intron-Distal3.992093.51789K562IGF2BP2
chr5133533394133533451-3'-UTR,intron-Distal3.6229718.21232K562PUM2
chr5133533385133533470-3'-UTR,CDS,intron-Distal3.171633.17233HepG2BCLAF1
chr5133532870133532933-3'-UTR,intron-Distal3.417006.25289K562IGF2BP1
chr5133533285133533302-3'-UTR,intron-Distal,intron-Proximal4.4102410.96719K562YBX3
chr5133533358133533447-3'-UTR,intron-Distal5.8972314.60304K562IGF2BP1
chr5133533310133533348-3'-UTR,intron-Distal,intron-Proximal4.340245.48238K562IGF2BP1
chr5133561454133561575-5'-UTR,CDS,intron-Distal3.5544314.36757K562UCHL5
chr5133561542133561637-5'-UTR,CDS,intron-Distal3.3148916.42912K562DDX3X
chr5133561492133561565-5'-UTR,CDS,intron-Distal3.6238510.87852HepG2GRWD1
chr5133561422133561647-5'-UTR,CDS,intron-Distal3.404108.18487HepG2SRSF1
chr5133561637133561758-5'-UTR,intron-Distal4.0309234.01079K562DDX3X
chr5133561652133561753-5'-UTR,intron-Distal4.153705.44438HepG2DDX3X
chr5133561457133561562-5'-UTR,CDS,intron-Distal3.6769011.67526K562GEMIN5
chr5133561403133561458-CDS,intron-Distal3.565467.02084HepG2PRPF8
chr5133536024133536102-CDS,intron-Distal,intron-Proximal3.761635.98815HepG2G3BP1
chr5133537638133537704-CDS,intron-Distal4.049053.79347HepG2GRWD1
chr5133536102133536177-CDS,intron-Distal3.958383.39686HepG2G3BP1
chr5133534793133534861-CDS,intron-Distal3.368118.65339K562YBX3
chr5133537661133537675-CDS,intron-Distal3.530927.86995K562YBX3
chr5133534673133534779-CDS,intron-Distal,intron-Proximal4.234828.79285K562AQR
chr5133561504133561549-CDS,intron-Distal4.046636.70275K562RBM15
chr5133537649133537760-CDS,intron-Distal,intron-Proximal3.246027.90194K562SF3B4
chr5133536095133536187-CDS,intron-Distal4.6233213.05138K562RPS3
chr5133561406133561458-CDS,intron-Distal5.103316.75320K562AQR
chr5133534651133534791-CDS,intron-Distal,intron-Proximal4.545393.85435K562PRPF8
chr5133539656133539766-intron-Distal3.877693.86679K562SAFB2
chr5133552021133552071-intron-Distal3.258734.41834HepG2HNRNPC
chr5133541543133541605-3'-UTR,CDS,intron-Distal,intron-Proximal3.334663.76553K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PPP2CA is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PPP2CA is not available on ENCORE database.

  • 86 RBPs can affect the levels of PPP2CA.  








The Knockdown/knockout RNA-Seq assay for PPP2CA is not available on ENCORE database.





86 RBPs can affect the gene expression of PPP2CA :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PPP2CAENSG00000113575.52966.762201980.473000.5829017.3841016.13880HepG2ACO1
PPP2CAENSG00000113575.54729.363502553.408000.8891012.4478011.40180HepG2AKAP1
PPP2CAENSG00000113575.52667.199401989.688900.422707.346206.16200HepG2AKAP8L
PPP2CAENSG00000113575.52668.608402112.730800.336902.542101.78770HepG2ASCC1
PPP2CAENSG00000113575.51378.388902010.08830-0.544306.492105.62060HepG2BOP1
PPP2CAENSG00000113575.52391.049601787.102700.419902.134501.46950HepG2CNOT7
PPP2CAENSG00000113575.51286.448801845.38290-0.520505.282804.36120HepG2CPSF6
PPP2CAENSG00000113575.53459.736102835.988900.286704.075503.32360HepG2CELF1
PPP2CAENSG00000113575.52521.065603049.44280-0.274505.117004.15490HepG2DAZAP1
PPP2CAENSG00000113575.53175.260002445.971800.376403.021102.37130HepG2DDX3X
PPP2CAENSG00000113575.52715.189102101.140200.369802.606702.00690HepG2DDX6
PPP2CAENSG00000113575.52156.765201894.748300.186801.902901.32460HepG2DKC1
PPP2CAENSG00000113575.51567.657801846.50170-0.236202.328201.67690HepG2DNAJC21
PPP2CAENSG00000113575.51526.294801830.07150-0.261903.818403.07670HepG2DNAJC2
PPP2CAENSG00000113575.52001.192101458.516600.456304.265503.14370HepG2EEF2
PPP2CAENSG00000113575.51542.359801215.923600.343002.541201.47600HepG2EFTUD2
PPP2CAENSG00000113575.51578.613301184.009700.414903.324502.33940HepG2EIF3D
PPP2CAENSG00000113575.51904.334901555.270600.292002.589901.54580HepG2EIF3G
PPP2CAENSG00000113575.53135.847002173.361600.528803.845003.03890HepG2EIF4B
PPP2CAENSG00000113575.53495.770003008.412100.216502.658501.83500HepG2EIF4G1
PPP2CAENSG00000113575.52466.079701935.181100.349702.711201.88450HepG2EWSR1
PPP2CAENSG00000113575.51198.228101654.24240-0.465302.695301.59680HepG2GRSF1
PPP2CAENSG00000113575.51838.779702623.51340-0.5128011.6258010.29290HepG2HNRNPF
PPP2CAENSG00000113575.52386.862602777.82680-0.218803.434202.69120HepG2HNRNPL
PPP2CAENSG00000113575.51894.717201402.005200.434405.047903.80390HepG2HNRNPM
PPP2CAENSG00000113575.51698.727902059.81970-0.278102.290001.73300HepG2HNRNPU
PPP2CAENSG00000113575.51874.197402583.40020-0.463006.746805.66100HepG2IGF2BP1
PPP2CAENSG00000113575.51858.366202104.04470-0.179102.176101.51700HepG2ILF2
PPP2CAENSG00000113575.51571.174901810.33420-0.204402.485401.51790HepG2KIF1C
PPP2CAENSG00000113575.53540.993902265.593800.644207.024006.05380HepG2MATR3
PPP2CAENSG00000113575.51102.089301380.96060-0.325402.550401.38500HepG2NAA15
PPP2CAENSG00000113575.52487.208103023.81810-0.281803.251402.42720HepG2NOL12
PPP2CAENSG00000113575.51255.059601837.20180-0.549809.708208.37350HepG2PPIL4
PPP2CAENSG00000113575.52602.819302058.409300.338405.551204.83160HepG2PTBP1
PPP2CAENSG00000113575.51004.882701912.27740-0.928306.984305.89090HepG2RAVER1
PPP2CAENSG00000113575.53216.779002290.845400.4896010.883609.94280HepG2NELFE
PPP2CAENSG00000113575.52388.736002826.34050-0.242701.885401.30950HepG2RPLP0
PPP2CAENSG00000113575.51266.455701834.38500-0.5345012.0797010.88160HepG2SAFB2
PPP2CAENSG00000113575.53302.099601943.719400.764505.825004.82250HepG2SF3A3
PPP2CAENSG00000113575.52526.911002143.142000.237502.808102.21290HepG2SF3B4
PPP2CAENSG00000113575.52142.585302767.64750-0.369308.127207.02110HepG2SLBP
PPP2CAENSG00000113575.55100.701403660.122800.4787015.5120014.57910HepG2SRFBP1
PPP2CAENSG00000113575.55006.969502236.946801.1623070.2951068.64880HepG2SRSF1
PPP2CAENSG00000113575.52096.249102577.55540-0.298204.635303.76910HepG2SRSF7
PPP2CAENSG00000113575.52136.205801819.850000.231102.763802.21220HepG2SRSF9
PPP2CAENSG00000113575.53688.544903241.207300.186402.235301.66560HepG2SUCLG1
PPP2CAENSG00000113575.51488.553201945.73730-0.386403.412702.61690HepG2TARDBP
PPP2CAENSG00000113575.51311.776102001.65520-0.609708.460607.67210HepG2TIAL1
PPP2CAENSG00000113575.51305.836702019.38160-0.6289015.8680014.67060HepG2TRIM56
PPP2CAENSG00000113575.52648.740501738.243700.607607.528206.49820HepG2U2AF1
PPP2CAENSG00000113575.51048.177101330.55840-0.344102.065301.40890HepG2UCHL5
PPP2CAENSG00000113575.52840.132001664.242000.7710026.4274024.86820HepG2UTP3
PPP2CAENSG00000113575.51783.295101368.644300.381706.838305.85890HepG2ZC3H8
PPP2CAENSG00000113575.52253.385401895.829200.249203.982303.35840HepG2ZNF622
PPP2CAENSG00000113575.53336.318402372.988000.491505.440503.72380K562AARS
PPP2CAENSG00000113575.55280.143003911.649700.4327010.680209.65990K562AGGF1
PPP2CAENSG00000113575.55158.369504298.106000.263102.197501.33270K562AKAP8
PPP2CAENSG00000113575.59311.372905967.631500.6417010.848609.79870K562AQR
PPP2CAENSG00000113575.52681.991003144.86030-0.229703.322502.26910K562BCLAF1
PPP2CAENSG00000113575.51727.757902480.53060-0.521705.728904.46140K562BOP1
PPP2CAENSG00000113575.5874.324101318.41800-0.592602.316401.36910K562CCAR1
PPP2CAENSG00000113575.52113.176802637.58830-0.319803.394702.52290K562CPSF6
PPP2CAENSG00000113575.52023.191802385.84550-0.237902.355601.39410K562CSTF2
PPP2CAENSG00000113575.55088.494604417.633900.203902.778102.12560K562DDX47
PPP2CAENSG00000113575.51629.471602872.26400-0.8178011.314108.30020K562DDX51
PPP2CAENSG00000113575.55183.722104380.142200.242903.020302.09870K562DKC1
PPP2CAENSG00000113575.53159.659404448.29510-0.4935010.943609.65850K562EIF2S2
PPP2CAENSG00000113575.52318.720702776.24550-0.259802.038901.33200K562EIF4A3
PPP2CAENSG00000113575.51731.355202203.23110-0.347703.622302.14620K562EXOSC5
PPP2CAENSG00000113575.51775.754102683.54300-0.595705.892504.63550K562FMR1
PPP2CAENSG00000113575.54302.276502887.181900.5753014.8638013.57420K562FXR1
PPP2CAENSG00000113575.53970.488802800.280200.503603.162002.39750K562G3BP2
PPP2CAENSG00000113575.53648.925305927.98950-0.7001014.4270012.67460K562GRSF1
PPP2CAENSG00000113575.52042.220302597.09500-0.346802.765702.16900K562HNRNPC
PPP2CAENSG00000113575.51803.332302318.95820-0.362803.410902.13490K562HNRNPF
PPP2CAENSG00000113575.54347.699103454.504800.331702.735301.51080K562HNRNPK
PPP2CAENSG00000113575.53558.370302725.919800.384402.787501.85460K562HNRNPM
PPP2CAENSG00000113575.51658.490602150.16690-0.374602.278201.43950K562KRR1
PPP2CAENSG00000113575.55044.623004134.848000.286802.537201.52260K562MAK16
PPP2CAENSG00000113575.51657.053603197.23780-0.9482040.7059038.28720K562MTPAP
PPP2CAENSG00000113575.54939.502603391.844700.542203.236302.26750K562NAA15
PPP2CAENSG00000113575.52876.287903552.42980-0.304607.803806.63780K562NSUN2
PPP2CAENSG00000113575.54271.120702588.452400.7224011.9797010.41080K562PRPF8
PPP2CAENSG00000113575.5864.032602328.49790-1.4302032.8882029.30580K562PSIP1
PPP2CAENSG00000113575.58968.689707228.687200.311103.379402.47750K562PUF60
PPP2CAENSG00000113575.56382.369404036.882100.6608010.123109.13080K562PUS1
PPP2CAENSG00000113575.55034.902303933.033200.356204.558503.81640K562RBM15
PPP2CAENSG00000113575.51579.375402124.11630-0.427503.573002.44730K562RCC2
PPP2CAENSG00000113575.51572.670702013.64030-0.356603.097401.99780K562SRFBP1
PPP2CAENSG00000113575.54105.504203461.858600.245902.375801.71270K562SRSF1
PPP2CAENSG00000113575.51898.196502506.73170-0.401202.944801.89470K562SUPV3L1
PPP2CAENSG00000113575.52864.642802156.095000.409805.636004.45670K562SYNCRIP
PPP2CAENSG00000113575.52061.947202918.57230-0.501305.735403.41950K562TBRG4
PPP2CAENSG00000113575.51575.449302239.66640-0.507504.864803.59300K562TIAL1
PPP2CAENSG00000113575.51695.393202378.98060-0.488705.774904.29410K562TRIM56
PPP2CAENSG00000113575.53579.892302803.098900.352804.475703.45940K562U2AF2
PPP2CAENSG00000113575.52091.428502652.79140-0.343002.593601.61190K562UCHL5
PPP2CAENSG00000113575.52603.219903223.06110-0.308103.185902.25070K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PPP2CA is not available on ENCORE database.





7 RBPs can affect the splicing of PPP2CA :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSPPP2CAENSG00000113575.5chr5-1335333261335335741335333261335335351335347761335349930.117000.000000.00000longerK562AQR
A3SSPPP2CAENSG00000113575.5chr5-1335347761335349931335347761335348951335360251335361980.094000.000000.00000longerK562AQR
A5SSPPP2CAENSG00000113575.5chr5-133541612133541822133541783133541822133537538133537712-0.057000.000100.02078shorterK562SUPV3L1
MXEPPP2CAENSG00000113575.5chr5-133537538133537712133541612133541822133536675133536765133561450133561833-0.105000.000000.000302includedK562DROSHA
MXEPPP2CAENSG00000113575.5chr5-133534776133534895133536025133536187133530024133533535133536675133536765-0.102000.001770.030482includedK562U2AF1
MXEPPP2CAENSG00000113575.5chr5-133537538133537712133541612133541822133536675133536765133561450133561833-0.084000.006590.091992includedK562PRPF8
MXEPPP2CAENSG00000113575.5chr5-133534776133534895133536025133536187133530024133533535133536675133536765-0.055000.000940.078772includedK562FMR1
MXEPPP2CAENSG00000113575.5chr5-133537538133537712133541612133541822133536675133536765133561450133561833-0.065000.002280.039602includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PPP2CA is not avaliable on ENCORE database.