METTL22

General Information

Gene Name       : METTL22
Gene ID             : ENSG00000067365.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: METTL22)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878METTL22ENSG00000067365.1410.7512.0711.41ENCSR000AEF
HepG2METTL22ENSG00000067365.1437.9528.3533.15ENCSR985KAT
K562METTL22ENSG00000067365.1416.3214.2715.29ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for METTL22 is not avaliable on ENCORE database.



Proteins bound to RNA
  • METTL22 RNA is bound by 24 proteins.  







eCLIP assay for METTL22 is not avaliable on ENCORE database.





24 proteins are bound to METTL22 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1687329888733065+3'-UTR,CDS,intron-Proximal3.9309015.94497HepG2PRPF8
chr1687349768735074+3'-UTR,CDS,intron-Proximal3.356067.68340K562EFTUD2
chr1687348858735060+3'-UTR,CDS,intron-Distal,intron-Proximal3.602613.41960K562GTF2F1
chr1687399538740000+3'-UTR,CDS,intron-Proximal3.701934.97118HepG2U2AF2
chr1687290018729061+3'-UTR,CDS,intron-Proximal4.826397.34636HepG2U2AF1
chr1687194158719514+3'-UTR,5'-UTR3.268807.22448HepG2GRWD1
chr1687329578733021+3'-UTR,CDS,intron-Proximal3.873523.29519HepG2UCHL5
chr1687194418719523+3'-UTR,5'-UTR3.941907.83545HepG2PPIG
chr1687227288722770+3'-UTR,CDS,intron-Proximal3.179783.07152HepG2HLTF
chr1687329518733024+3'-UTR,CDS,intron-Proximal4.552518.70622HepG2GRWD1
chr1687329338733063+3'-UTR,CDS,intron-Proximal3.074993.80333HepG2AQR
chr1687350288735119+3'-UTR,CDS,intron-Proximal4.033647.90583K562AQR
chr1687227498722793+3'-UTR,CDS,intron-Proximal3.255563.31745K562ZNF622
chr1687363518736424+3'-UTR,5'-UTR,CDS,intron-Proximal3.317304.34695HepG2BCLAF1
chr1687289928729055+3'-UTR,CDS,intron-Proximal3.515075.13777HepG2PRPF8
chr1687349858735053+3'-UTR,CDS,intron-Proximal3.540686.68812HepG2BUD13
chr1687385748738590+3'-UTR,CDS,intron-Proximal3.513027.83009HepG2PRPF8
chr1687288798728946+3'-UTR,CDS,intron-Distal,intron-Proximal3.443623.27712HepG2U2AF1
chr1687291498729211+3'-UTR,CDS,intron-Proximal5.7889911.46503HepG2PRPF8
chr1687290058729058+3'-UTR,CDS,intron-Proximal4.8538210.46182HepG2U2AF2
chr1687229658723009+3'-UTR,CDS,intron-Proximal4.708594.13847K562AQR
chr1687385208738579+3'-UTR,CDS3.094594.14618K562ZNF622
chr1687290208729057+3'-UTR,CDS,intron-Proximal3.341488.54450HepG2PPIG
chr1687288778728953+3'-UTR,CDS,intron-Distal,intron-Proximal4.1219911.12507HepG2U2AF2
chr1687349748735073+3'-UTR,CDS,intron-Proximal3.8443021.76853HepG2EFTUD2
chr1687349768735041+3'-UTR,CDS,intron-Proximal3.2676610.16174HepG2U2AF2
chr1687363338736419+3'-UTR,5'-UTR,CDS4.357873.11168K562ZNF622
chr1687359778736017+3'-UTR,CDS,intron-Proximal5.209316.50173HepG2U2AF2
chr1687329588733044+3'-UTR,CDS,intron-Proximal4.2044112.96553HepG2PPIG
chr1687363788736432+3'-UTR,5'-UTR,CDS,intron-Proximal3.712687.10944HepG2PPIG
chr1687349838735059+3'-UTR,CDS,intron-Proximal3.180533.65461K562BUD13
chr1687349658735046+3'-UTR,CDS,intron-Proximal3.533733.84340K562CSTF2T
chr1687330178733036+3'-UTR,CDS,intron-Proximal3.292564.83230K562AQR
chr1687349868735041+3'-UTR,CDS,intron-Proximal3.176766.70384HepG2PPIG
chr1687289778729052+3'-UTR,CDS,intron-Proximal3.769515.00154HepG2AQR
chr1687349768735053+3'-UTR,CDS,intron-Proximal4.502696.53595K562U2AF2
chr1687290068729050+3'-UTR,CDS,intron-Proximal4.5298810.90788HepG2EFTUD2
chr1687385908738624+CDS,intron-Proximal3.252087.45900HepG2PRPF8
chr1687226878722723+CDS,intron-Proximal3.919605.73400HepG2PPIG
chr1687196218719658+CDS,intron-Proximal4.732414.67689HepG2PPIG
chr1687225768722640+CDS,intron-Distal,intron-Proximal4.028596.02363HepG2U2AF2
chr1687226128722671+CDS,intron-Distal,intron-Proximal3.270004.77136HepG2PPIG
chr1687348378734912+intron-Distal,intron-Proximal4.066667.23771HepG2CSTF2T
chr1687340758734123+intron-Distal3.601693.56210K562EIF4G2
chr1687330328733123+intron-Distal,intron-Proximal3.915854.75435K562EFTUD2
chr1687344098734461+intron-Distal4.260603.40229HepG2CSTF2T
chr1687348298734868+intron-Distal3.565224.57758HepG2FAM120A
chr1687390618739125+intron-Distal3.851983.80060HepG2HNRNPC
chr1687341408734233+intron-Distal3.091363.12316HepG2PRPF4
chr1687344208734469+intron-Distal4.651444.57154HepG2FAM120A
chr1687340608734133+intron-Distal3.378997.93684HepG2CSTF2T
chr1687334328733514+intron-Distal3.293863.93112K562RBM15
chr1687346878734725+intron-Distal3.968113.44758HepG2CSTF2T
chr1687342158734263+intron-Distal4.349393.56427K562FAM120A
chr1687213858721458+intron-Distal4.540374.80665HepG2QKI
chr1687346848734724+intron-Distal5.9424311.10871HepG2FAM120A
chr1687340938734218+intron-Distal4.251488.71856K562CSTF2T
chr1687236078723678+intron-Distal3.773443.35727HepG2FUS
chr1687330338733154+intron-Distal,intron-Proximal3.4820320.95366HepG2EFTUD2
chr1687348088734883+intron-Distal4.670444.67055K562EIF4G2
chr1687340808734140+intron-Distal4.064443.63122HepG2PRPF4
chr1687171108717164+intron-Distal3.865273.60408HepG2XPO5
chr1687289538729017+intron-Proximal6.0736518.27992HepG2SF3B4
chr1687289618729023+intron-Proximal4.063165.63851K562SF3B4
chr1687359058735963+intron-Proximal5.435878.71620K562SF3B4
chr1687330368733082+intron-Proximal4.747598.01338K562AQR
chr1687289628729012+intron-Proximal5.5014412.50933HepG2SF3A3
chr1687350738735137+intron-Proximal4.899083.94390HepG2EFTUD2
chr1687330198733098+intron-Proximal3.042346.12136HepG2BUD13
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for METTL22 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for METTL22 is not available on ENCORE database.

  • 59 RBPs can affect the levels of METTL22.  








The Knockdown/knockout RNA-Seq assay for METTL22 is not available on ENCORE database.





59 RBPs can affect the gene expression of METTL22 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
METTL22ENSG00000067365.10585.62470819.65860-0.485003.475502.42370HepG2ABCF1
METTL22ENSG00000067365.10762.29670627.670000.280202.360001.79130HepG2ACO1
METTL22ENSG00000067365.10641.94200418.335900.617703.462002.41460HepG2BCCIP
METTL22ENSG00000067365.10851.26620612.363500.475103.818803.12740HepG2BOP1
METTL22ENSG00000067365.10405.15730562.17920-0.472502.906902.20460HepG2CPSF6
METTL22ENSG00000067365.10608.71030734.02720-0.270101.960701.32050HepG2DAZAP1
METTL22ENSG00000067365.10604.23350411.331900.554702.825702.04480HepG2DDX55
METTL22ENSG00000067365.10915.48800597.107600.616404.673203.88870HepG2DDX6
METTL22ENSG00000067365.10549.59400451.238300.284402.110801.52680HepG2DNAJC2
METTL22ENSG00000067365.10769.57610573.934900.423102.604802.02950HepG2EIF2S1
METTL22ENSG00000067365.101027.16840617.582300.733905.397104.45860HepG2EIF4B
METTL22ENSG00000067365.10341.49800637.26340-0.900007.982606.93340HepG2GPKOW
METTL22ENSG00000067365.10750.87740620.848200.274202.085901.45710HepG2HNRNPF
METTL22ENSG00000067365.10963.91400601.272400.680806.903905.83850HepG2HNRNPK
METTL22ENSG00000067365.10789.77010668.611100.240202.147301.54370HepG2HNRNPL
METTL22ENSG00000067365.10446.49350608.15320-0.445802.672002.05150HepG2HNRNPLL
METTL22ENSG00000067365.10770.59940507.844600.601508.036207.04310HepG2HNRNPU
METTL22ENSG00000067365.10647.67740518.745300.320102.672801.95250HepG2ILF2
METTL22ENSG00000067365.10748.68280573.752200.383804.153502.91570HepG2KIF1C
METTL22ENSG00000067365.10435.27040643.81310-0.564703.558102.85040HepG2MATR3
METTL22ENSG00000067365.10553.14030825.04590-0.576802.692401.81790HepG2PABPC1
METTL22ENSG00000067365.10681.31700502.670300.438604.219803.20030HepG2PARN
METTL22ENSG00000067365.10751.31200567.603200.404404.196903.47710HepG2PCBP1
METTL22ENSG00000067365.10578.48960452.955600.352802.582301.86900HepG2PPIL4
METTL22ENSG00000067365.10832.67370577.606100.527606.749805.96950HepG2PTBP1
METTL22ENSG00000067365.10982.84730625.458100.652008.883207.86130HepG2QKI
METTL22ENSG00000067365.101034.30460801.657700.367503.257902.33580HepG2RBM15
METTL22ENSG00000067365.10715.51750598.735300.257001.921601.39510HepG2RECQL
METTL22ENSG00000067365.10895.86350668.808900.421603.183402.45860HepG2RPLP0
METTL22ENSG00000067365.10550.55220412.476000.416502.703902.09480HepG2RPS19
METTL22ENSG00000067365.10593.15240906.88330-0.612502.642801.86070HepG2RPS3A
METTL22ENSG00000067365.10692.78330452.253900.615208.189407.16850HepG2SAFB2
METTL22ENSG00000067365.101062.15820601.275300.8208016.0211014.77740HepG2SF3B4
METTL22ENSG00000067365.10440.72890669.77200-0.603803.096502.26960HepG2SNRNP70
METTL22ENSG00000067365.10390.97410627.63690-0.682907.006106.33660HepG2SRSF1
METTL22ENSG00000067365.10736.63000609.963600.272102.013701.40960HepG2SRSF7
METTL22ENSG00000067365.10631.03850956.41950-0.599909.379308.54350HepG2SSB
METTL22ENSG00000067365.10811.00130564.243200.523305.251304.51980HepG2TAF15
METTL22ENSG00000067365.10750.68870518.357900.534205.411904.25470HepG2TIA1
METTL22ENSG00000067365.10658.10860497.878900.402403.856303.21290HepG2TRIM56
METTL22ENSG00000067365.10459.36110707.82740-0.623805.264804.41370HepG2U2AF1
METTL22ENSG00000067365.10864.65070614.359300.492905.946805.12440HepG2UTP3
METTL22ENSG00000067365.10429.28220643.25000-0.583506.621105.65550HepG2ZC3H8
METTL22ENSG00000067365.101012.74990699.849400.533109.025708.18370HepG2ZNF622
METTL22ENSG00000067365.10532.87410389.352100.452602.659502.08160K562AQR
METTL22ENSG00000067365.10473.18550653.88030-0.466603.793102.38330K562CCDC124
METTL22ENSG00000067365.10304.64020442.23970-0.537704.390803.59590K562DDX47
METTL22ENSG00000067365.1092.99080151.08530-0.700202.367001.72090K562G3BP2
METTL22ENSG00000067365.10308.94470215.983900.516302.243101.34760K562IGF2BP2
METTL22ENSG00000067365.10433.02560325.132800.413302.794301.98050K562MTPAP
METTL22ENSG00000067365.10447.70060361.238800.309501.971301.32810K562NSUN2
METTL22ENSG00000067365.10334.45810221.798600.592503.864202.25430K562PCBP1
METTL22ENSG00000067365.10364.28130245.331100.570203.244802.25290K562PSIP1
METTL22ENSG00000067365.10490.35550620.41750-0.339402.035101.33480K562PUF60
METTL22ENSG00000067365.10442.04140550.14560-0.315601.868401.36380K562RBM15
METTL22ENSG00000067365.10293.93120211.233600.476502.377701.60370K562RBM22
METTL22ENSG00000067365.10458.33480356.469800.362502.321301.56850K562SF3A3
METTL22ENSG00000067365.10300.82760157.089900.937207.848006.36530K562SF3B4
METTL22ENSG00000067365.10468.10720365.212700.358002.449901.56310K562SRPK2
METTL22ENSG00000067365.10385.48100250.698900.620603.831002.68280K562TRIM56
METTL22ENSG00000067365.1097.50790151.24200-0.633302.470101.71050K562U2AF2
METTL22ENSG00000067365.10483.91560383.030100.337202.291601.63410K562UPF1
METTL22ENSG00000067365.10505.76970327.745100.625805.304604.07230K562WDR3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for METTL22 is not available on ENCORE database.





22 RBPs can affect the splicing of METTL22 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMETTL22ENSG00000067365.10chr16+873841387385828736319873642287399648740081-0.463000.003650.05898excludedK562SRSF1
SEMETTL22ENSG00000067365.10chr16+8728895872893687227568722967872902487291390.194000.000210.01815includedHepG2RBM22
SEMETTL22ENSG00000067365.10chr16+873335087335338732947873301987349878735041-0.098000.000050.00572excludedHepG2RBM22
SEMETTL22ENSG00000067365.10chr16+872889587289368722862872296787290248729139-0.326000.000040.00116excludedHepG2U2AF1
SEMETTL22ENSG00000067365.10chr16+8735259873542587349878735041873598387360640.052000.002470.05534includedHepG2HNRNPK
SEMETTL22ENSG00000067365.10chr16+872889587289368722862872296787290248729139-0.388000.000000.00000excludedHepG2HNRNPK
SEMETTL22ENSG00000067365.10chr16+872889587289368722756872296787290248729139-0.535000.000030.00068excludedHepG2U2AF2
SEMETTL22ENSG00000067365.10chr16+8728895872893687228628722967872902487291390.259000.000050.00579includedHepG2AKAP1
SEMETTL22ENSG00000067365.10chr16+8728895872893687227568722967872902487291390.206000.001440.06744includedHepG2PTBP1
SEMETTL22ENSG00000067365.10chr16+872889587289368722756872296787290248729139-0.362000.000470.03389excludedHepG2FTO
SEMETTL22ENSG00000067365.10chr16+8733350873353387329478733019873498787350410.175000.000430.04040includedHepG2DDX6
SEMETTL22ENSG00000067365.10chr16+872889587289368722756872296787290248729139-0.315000.000000.00001excludedHepG2SF3A3
SEMETTL22ENSG00000067365.10chr16+873335087335338732947873301987349878735041-0.106000.000260.03832excludedHepG2SSB
SEMETTL22ENSG00000067365.10chr16+872889587289368722862872296787290248729139-0.449000.000100.01201excludedHepG2TIAL1
SEMETTL22ENSG00000067365.10chr16+8735520873563687349878735041873598387360640.097000.001730.05133includedK562UTP18
SEMETTL22ENSG00000067365.10chr16+8733350873353387329478733019873498787350410.186000.000010.00386includedHepG2TAF15
SEMETTL22ENSG00000067365.10chr16+8728895872893687228628722967872902487291390.309000.000350.01668includedK562HNRNPU
SEMETTL22ENSG00000067365.10chr16+873841387385828736319873642287399648740081-0.371000.001470.05037excludedK562HNRNPU
SEMETTL22ENSG00000067365.10chr16+8735520873563687349878735041873598387360640.133000.000320.01111includedK562RBM15
SEMETTL22ENSG00000067365.10chr16+872889587289368722756872296787290248729139-0.198000.004330.08224excludedK562RBM15
SEMETTL22ENSG00000067365.10chr16+873841387385828736319873642287399648740081-0.254000.005080.09217excludedK562RBM15
SEMETTL22ENSG00000067365.10chr16+8735259873534487349878735041873598387360640.053000.005390.09855includedK562AGGF1
SEMETTL22ENSG00000067365.10chr16+8728895872893687227568722967872902487291390.366000.000040.01782includedHepG2EIF3D
SEMETTL22ENSG00000067365.10chr16+872889587289368722862872296787290248729139-0.321000.000270.06541excludedHepG2FUBP3
SEMETTL22ENSG00000067365.10chr16+8728895872893687228628722967872902487291390.386000.000010.02954includedHepG2DDX52
A5SSMETTL22ENSG00000067365.10chr16+8732947873313487329478733019873498787350410.102000.000210.02180longerHepG2SF3A3
RIMETTL22ENSG00000067365.10chr16+872258687229678722586872273387228658722967-0.081000.003180.06521excludedHepG2UCHL5
MXEMETTL22ENSG00000067365.10chr16+872902487291698732947873301987225868722967873498787350410.256000.001680.074061includedK562UTP18
MXEMETTL22ENSG00000067365.10chr16+87290248729169873498787350418722586872296787359838736064-0.186000.000500.046772includedK562PUM1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for METTL22 is not avaliable on ENCORE database.