KEAP1

General Information

Gene Name       : KEAP1
Gene ID             : ENSG00000079999.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: KEAP1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878KEAP1ENSG00000079999.1310.8324.9917.91ENCSR000AEF
HepG2KEAP1ENSG00000079999.1383.2851.5567.41ENCSR985KAT
K562KEAP1ENSG00000079999.1340.5041.5441.02ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for KEAP1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • KEAP1 RNA is bound by 16 proteins.  







eCLIP assay for KEAP1 is not avaliable on ENCORE database.





16 proteins are bound to KEAP1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr191059709410597175-3'-UTR,intron-Distal4.336283.92497HepG2UPF1
chr191059711710597184-3'-UTR,intron-Distal3.252803.89838K562PABPC4
chr191059719510597267-3'-UTR,intron-Distal,intron-Proximal4.115533.07376K562PABPC4
chr191059682210596916-3'-UTR,intron-Distal5.252897.70404K562UPF1
chr191059709810597172-3'-UTR,intron-Distal3.067284.00349K562FAM120A
chr191060284310602935-3'-UTR,CDS,intron-Distal,intron-Proximal3.137068.41462K562YBX3
chr191059738010597492-3'-UTR,CDS,intron-Distal,intron-Proximal4.444694.54659HepG2G3BP1
chr191059690210596992-3'-UTR,intron-Distal4.6025012.93841HepG2GRSF1
chr191059736710597481-3'-UTR,CDS,intron-Distal,intron-Proximal3.938423.34184HepG2GRWD1
chr191060281110602842-3'-UTR,CDS,intron-Distal,intron-Proximal3.664073.19539K562YBX3
chr191061070710610836-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.521533.59236HepG2AQR
chr191059685410596943-3'-UTR,intron-Distal7.6859559.51753K562PUM2
chr191059694310596985-3'-UTR,intron-Distal4.710868.29571K562PUM2
chr191059712010597296-3'-UTR,intron-Distal,intron-Proximal3.265775.00851HepG2LARP4
chr191059691610596983-3'-UTR,intron-Distal3.963623.66308K562UPF1
chr191061066110610755-3'-UTR,5'-UTR,CDS,intron-Distal3.241947.12525K562DDX3X
chr191059682710596854-3'-UTR,intron-Distal6.614789.84608K562PUM2
chr191061314710613194-5'-UTR,intron-Distal3.497233.19512HepG2FKBP4
chr191061016010610211-5'-UTR,CDS,intron-Distal,intron-Proximal4.448364.48994K562RBM15
chr191061336410613376-5'-UTR,intron-Distal,intron-Proximal3.648517.47181HepG2PRPF8
chr191060206210602277-CDS,intron-Distal,intron-Proximal5.130367.46464K562PRPF8
chr191060246210602515-CDS,intron-Distal,intron-Proximal4.590623.81597K562RBM15
chr191060046710600548-CDS,intron-Distal,intron-Proximal4.006968.26514HepG2U2AF2
chr191060244710602521-CDS,intron-Distal,intron-Proximal4.621177.88170HepG2RBM15
chr191059734110597383-CDS,intron-Distal,intron-Proximal4.886288.41567K562YBX3
chr191060219010602254-CDS,intron-Distal,intron-Proximal3.8470710.79642HepG2PRPF8
chr191060241110602462-CDS,intron-Distal,intron-Proximal4.165567.03491K562RBM15
chr191061042410610517-CDS,intron-Distal3.702536.27135HepG2RBM15
chr191060222610602239-intron-Distal,intron-Proximal3.860594.00320K562AQR
chr191060223910602252-intron-Distal,intron-Proximal4.784594.13847K562AQR
chr191060220410602226-intron-Distal,intron-Proximal3.518343.49168K562AQR
chr191060214810602249-intron-Distal,intron-Proximal4.709655.61554HepG2EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for KEAP1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for KEAP1 is not available on ENCORE database.

  • 71 RBPs can affect the levels of KEAP1.  








The Knockdown/knockout RNA-Seq assay for KEAP1 is not available on ENCORE database.





71 RBPs can affect the gene expression of KEAP1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
KEAP1ENSG00000079999.9438.48900599.22080-0.450502.964801.85990HepG2AATF
KEAP1ENSG00000079999.91805.286001196.708000.593105.073004.37970HepG2AKAP1
KEAP1ENSG00000079999.91384.86750990.130800.484004.011603.07250HepG2ASCC1
KEAP1ENSG00000079999.91280.505101540.91820-0.267102.895302.19520HepG2AUH
KEAP1ENSG00000079999.9522.17140701.57450-0.426102.547501.68370HepG2BCLAF1
KEAP1ENSG00000079999.9390.19960612.15700-0.649705.552404.74010HepG2BOP1
KEAP1ENSG00000079999.91285.73610967.658300.409906.473005.53330HepG2CKAP4
KEAP1ENSG00000079999.9362.79490561.97500-0.631404.739003.85960HepG2CPSF6
KEAP1ENSG00000079999.9417.72740613.66440-0.554903.079501.62210HepG2CSTF2T
KEAP1ENSG00000079999.91181.81650952.747500.310703.153102.47590HepG2CELF1
KEAP1ENSG00000079999.9616.92760515.626000.258701.991101.42090HepG2DNAJC2
KEAP1ENSG00000079999.9345.62700608.72810-0.816606.217704.56890HepG2AGO1
KEAP1ENSG00000079999.91862.297101018.599900.870408.425507.25720HepG2EIF4B
KEAP1ENSG00000079999.9807.362101010.66920-0.324003.067402.19420HepG2EIF4G1
KEAP1ENSG00000079999.91428.998101055.661900.436803.399102.63700HepG2FXR1
KEAP1ENSG00000079999.9704.11510924.04260-0.392104.606303.37530HepG2HDGF
KEAP1ENSG00000079999.9619.96400437.005200.504402.666601.32720HepG2HNRNPA0
KEAP1ENSG00000079999.91296.18190991.838600.386002.950402.22960HepG2HNRNPK
KEAP1ENSG00000079999.91210.85300933.172100.375705.517804.59430HepG2HNRNPL
KEAP1ENSG00000079999.9399.76490607.89760-0.604704.418403.63890HepG2HNRNPLL
KEAP1ENSG00000079999.91295.39680971.775900.414602.451201.67210HepG2LARP4
KEAP1ENSG00000079999.91513.375901061.889100.511003.956203.21420HepG2MATR3
KEAP1ENSG00000079999.9507.61580722.09690-0.508504.165203.18260HepG2MSI2
KEAP1ENSG00000079999.9410.70680620.08720-0.594402.877801.88800HepG2MTPAP
KEAP1ENSG00000079999.91833.106101029.374600.8324023.6120022.22520HepG2PUM1
KEAP1ENSG00000079999.9318.09610618.57750-0.959503.468302.68100HepG2RAVER1
KEAP1ENSG00000079999.9787.859101002.85650-0.348103.065202.16660HepG2RBM15
KEAP1ENSG00000079999.91036.21260726.110900.513003.721002.56180HepG2RBM27
KEAP1ENSG00000079999.91295.304001028.418600.332802.434101.78670HepG2RPLP0
KEAP1ENSG00000079999.9683.50340488.629500.484102.789601.47520HepG2SART3
KEAP1ENSG00000079999.91272.23460880.657200.530603.711502.92670HepG2SF3A3
KEAP1ENSG00000079999.9836.72260602.599200.473506.408005.49380HepG2SMN1
KEAP1ENSG00000079999.91113.698101670.16170-0.5846012.9964012.12430HepG2SRFBP1
KEAP1ENSG00000079999.91436.00260957.433900.584708.922607.88320HepG2SRSF5
KEAP1ENSG00000079999.9773.26760912.83570-0.239401.959901.48030HepG2SRSF9
KEAP1ENSG00000079999.91282.580201088.862900.236102.417401.82830HepG2SUCLG1
KEAP1ENSG00000079999.9511.687601008.57320-0.9790018.6789017.40970HepG2TAF15
KEAP1ENSG00000079999.9459.07870592.64620-0.368402.114801.46910HepG2TARDBP
KEAP1ENSG00000079999.9686.21720926.67050-0.433403.816902.84220HepG2TIA1
KEAP1ENSG00000079999.91041.50010568.894800.8723019.0363017.72780HepG2TRIM56
KEAP1ENSG00000079999.91022.88800763.233500.422403.245802.57020HepG2U2AF1
KEAP1ENSG00000079999.9527.66560781.00900-0.565707.451106.39820HepG2UPF1
KEAP1ENSG00000079999.9912.30400754.032400.274802.465101.89270HepG2UTP3
KEAP1ENSG00000079999.9987.96100858.959400.201801.782301.31740HepG2ZNF622
KEAP1ENSG00000079999.92160.608401679.987700.362903.700102.24040K562APOBEC3C
KEAP1ENSG00000079999.92110.857701745.115200.274402.017601.50120K562AQR
KEAP1ENSG00000079999.91430.447301151.033300.313403.294202.08070K562CPEB4
KEAP1ENSG00000079999.91749.941201191.069600.5549010.896109.69980K562DDX47
KEAP1ENSG00000079999.91421.18560893.716400.669105.280503.47380K562EEF2
KEAP1ENSG00000079999.91148.78450863.378300.411902.743001.83460K562EFTUD2
KEAP1ENSG00000079999.9727.98910490.774000.568806.173205.00180K562EIF3G
KEAP1ENSG00000079999.92530.195301903.892100.410207.238605.73100K562EIF4G2
KEAP1ENSG00000079999.91077.80510862.142500.322002.294301.52150K562FIP1L1
KEAP1ENSG00000079999.9295.00870433.89490-0.556603.894702.27360K562FUS
KEAP1ENSG00000079999.91520.17870869.096400.806608.515607.52490K562FXR1
KEAP1ENSG00000079999.9138.90580360.22960-1.3748011.391109.75750K562G3BP2
KEAP1ENSG00000079999.91428.929301076.393900.408602.539101.53110K562HNRNPL
KEAP1ENSG00000079999.9942.34630709.168400.410002.627901.72310K562HNRNPM
KEAP1ENSG00000079999.91026.30210662.510400.631307.682406.25520K562MAGOH
KEAP1ENSG00000079999.9955.23340661.116700.530805.682104.29590K562MATR3
KEAP1ENSG00000079999.9620.19930833.18620-0.425902.204601.43740K562NAA15
KEAP1ENSG00000079999.9642.34570834.55550-0.377703.140301.83070K562NCBP2
KEAP1ENSG00000079999.91205.45820851.234400.501903.241701.81420K562NONO
KEAP1ENSG00000079999.91325.56720978.765600.437503.869302.87520K562PPIG
KEAP1ENSG00000079999.91137.39580840.171900.436903.244402.43120K562PRPF8
KEAP1ENSG00000079999.91060.79630643.694800.7206010.322709.09710K562PTBP1
KEAP1ENSG00000079999.9648.93700991.59310-0.611705.946405.18790K562PUS1
KEAP1ENSG00000079999.9160.71940343.69410-1.096604.119402.32560K562RAVER1
KEAP1ENSG00000079999.9939.79820649.385900.533204.657703.19690K562NELFE
KEAP1ENSG00000079999.9544.52260386.918700.492902.524101.57380K562RPS3
KEAP1ENSG00000079999.9772.182201207.91020-0.6455012.8152010.99910K562SRPK2
KEAP1ENSG00000079999.91337.51690631.072201.0836019.4167017.55150K562SRSF1
KEAP1ENSG00000079999.9580.34980373.486200.635805.146903.63530K562SRSF4
KEAP1ENSG00000079999.91227.92340638.607100.9431013.8489012.03200K562TARDBP
KEAP1ENSG00000079999.9986.09680616.029500.678608.706407.14090K562TIA1
KEAP1ENSG00000079999.9804.84070604.695300.412402.994801.85030K562TRA2A
KEAP1ENSG00000079999.9238.54150349.13650-0.549602.746101.65810K562U2AF1
KEAP1ENSG00000079999.91344.345201127.243500.254002.928402.05750K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for KEAP1 is not available on ENCORE database.





2 RBPs can affect the splicing of KEAP1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEKEAP1ENSG00000079999.9chr19-105998671060004410597393105974941060032310600529-0.061000.001040.02162excludedK562SRSF1
A3SSKEAP1ENSG00000079999.9chr19-1059986710600110105998671060004410600323106003770.055000.000000.00004longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for KEAP1 is not avaliable on ENCORE database.